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Conserved domains on  [gi|1150561126|ref|NP_001335919|]
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NXPE family member 3 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Neurexophilin super family cl05683
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
74-284 4.64e-78

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


The actual alignment was detected with superfamily member pfam06312:

Pssm-ID: 428882  Cd Length: 209  Bit Score: 244.77  E-value: 4.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150561126  74 ERMEEDSLLAALHrqvpdVGPVPfvkstDPSSSYFVILNSAAFFKVG---SQLEVLVHvqdFQRKPKKYG-GDYlQARIH 149
Cdd:pfam06312   2 ERLENDSLLALLQ-----VGPVP-----DPSQEFWVILNSASFLRVPplrSKLEPLVK---TQKKKKKFGwGDF-YSNIK 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150561126 150 SLKLQAGAVGRVVDYQNGFYKVFFTLLWPGKVKVSVSLVHPSEGIRV---LQRLQEDKPDRVyFKSLFRSGRISETTECN 226
Cdd:pfam06312  68 TVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFdleQQYVIEAKDSKI-FNCRVESEKVDRTTKTN 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1150561126 227 VCLPGNLPLCNFTDLYTGEPWFCFKPKKLPCsSRITHFKGGYlkGLLTAA--------ESAFFQSG 284
Cdd:pfam06312 147 LCNYDPSKTCNQEHTQSHVSWFCSKPFKVIC-IYISFYSTDY--RLVQKVcpdynyhnDTPYYPSG 209
 
Name Accession Description Interval E-value
Neurexophilin pfam06312
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
74-284 4.64e-78

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


Pssm-ID: 428882  Cd Length: 209  Bit Score: 244.77  E-value: 4.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150561126  74 ERMEEDSLLAALHrqvpdVGPVPfvkstDPSSSYFVILNSAAFFKVG---SQLEVLVHvqdFQRKPKKYG-GDYlQARIH 149
Cdd:pfam06312   2 ERLENDSLLALLQ-----VGPVP-----DPSQEFWVILNSASFLRVPplrSKLEPLVK---TQKKKKKFGwGDF-YSNIK 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150561126 150 SLKLQAGAVGRVVDYQNGFYKVFFTLLWPGKVKVSVSLVHPSEGIRV---LQRLQEDKPDRVyFKSLFRSGRISETTECN 226
Cdd:pfam06312  68 TVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFdleQQYVIEAKDSKI-FNCRVESEKVDRTTKTN 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1150561126 227 VCLPGNLPLCNFTDLYTGEPWFCFKPKKLPCsSRITHFKGGYlkGLLTAA--------ESAFFQSG 284
Cdd:pfam06312 147 LCNYDPSKTCNQEHTQSHVSWFCSKPFKVIC-IYISFYSTDY--RLVQKVcpdynyhnDTPYYPSG 209
 
Name Accession Description Interval E-value
Neurexophilin pfam06312
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
74-284 4.64e-78

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


Pssm-ID: 428882  Cd Length: 209  Bit Score: 244.77  E-value: 4.64e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150561126  74 ERMEEDSLLAALHrqvpdVGPVPfvkstDPSSSYFVILNSAAFFKVG---SQLEVLVHvqdFQRKPKKYG-GDYlQARIH 149
Cdd:pfam06312   2 ERLENDSLLALLQ-----VGPVP-----DPSQEFWVILNSASFLRVPplrSKLEPLVK---TQKKKKKFGwGDF-YSNIK 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150561126 150 SLKLQAGAVGRVVDYQNGFYKVFFTLLWPGKVKVSVSLVHPSEGIRV---LQRLQEDKPDRVyFKSLFRSGRISETTECN 226
Cdd:pfam06312  68 TVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFdleQQYVIEAKDSKI-FNCRVESEKVDRTTKTN 146
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1150561126 227 VCLPGNLPLCNFTDLYTGEPWFCFKPKKLPCsSRITHFKGGYlkGLLTAA--------ESAFFQSG 284
Cdd:pfam06312 147 LCNYDPSKTCNQEHTQSHVSWFCSKPFKVIC-IYISFYSTDY--RLVQKVcpdynyhnDTPYYPSG 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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