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Conserved domains on  [gi|1162503515|ref|NP_001336554|]
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calmodulin-binding transcription activator 1 isoform o [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
82-187 5.83e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 5.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  82 IHSKTFRGMTLLHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLykWDRRA- 160
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL--LEAGAd 178

                          90       100
                  ....*....|....*....|....*..
gi 1162503515 161 ISIPDSLGRLPLGIARSRGHVKLAECL 187
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
82-187 5.83e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 5.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  82 IHSKTFRGMTLLHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLykWDRRA- 160
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL--LEAGAd 178

                          90       100
                  ....*....|....*....|....*..
gi 1162503515 161 ISIPDSLGRLPLGIARSRGHVKLAECL 187
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
93-185 3.75e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  93 LHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAA-VVLYKWDRRAisipDSLGRLP 171
Cdd:pfam12796   1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNL----KDNGRTA 64

                          90
                  ....*....|....
gi 1162503515 172 LGIARSRGHVKLAE 185
Cdd:pfam12796  65 LHYAARSGHLEIVK 78
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
82-187 5.83e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 5.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  82 IHSKTFRGMTLLHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLykWDRRA- 160
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL--LEAGAd 178

                          90       100
                  ....*....|....*....|....*..
gi 1162503515 161 ISIPDSLGRLPLGIARSRGHVKLAECL 187
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-187 7.00e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 7.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  76 AKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYk 155
Cdd:COG0666    74 LAAGADINAKDDGGNTLLHAAARNGDLEIVKLL------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL- 140

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1162503515 156 wDRRA-ISIPDSLGRLPLGIARSRGHVKLAECL 187
Cdd:COG0666   141 -EAGAdVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
93-185 3.75e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  93 LHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAA-VVLYKWDRRAisipDSLGRLP 171
Cdd:pfam12796   1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNL----KDNGRTA 64

                          90
                  ....*....|....
gi 1162503515 172 LGIARSRGHVKLAE 185
Cdd:pfam12796  65 LHYAARSGHLEIVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
82-155 6.12e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 6.12e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1162503515  82 IHSKTFRGMTLLHLAAAQGYATLIQTLIKwrtkHADsidlelevdpLNVDHFSCTPLMWACALGHLEAAVVLYK 155
Cdd:pfam12796  23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE----HAD----------VNLKDNGRTALHYAARSGHLEIVKLLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
82-198 6.59e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.03  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  82 IHSKTFRGMTLLHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKwDRRAI 161
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL------------LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADL 245

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1162503515 162 SIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQL 198
Cdd:COG0666   246 NAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-187 1.38e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1162503515  76 AKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYk 155
Cdd:COG0666    29 ALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL- 107

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1162503515 156 wDRRA-ISIPDSLGRLPLGIARSRGHVKLAECL 187
Cdd:COG0666   108 -EAGAdVNARDKDGETPLHLAAYNGNLEIVKLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
136-187 1.68e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1162503515 136 TPLMWACALGHLEAAVVLY--KWDrraISIPDSLGRLPLGIARSRGHVKLAECL 187
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLekGAD---INAVDGNGETALHFAASNGNVEVLKLL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
89-153 5.03e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 5.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1162503515  89 GMTLLHLAAAQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVL 153
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLL------------LEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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