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Conserved domains on  [gi|1169100944|ref|NP_001336780|]
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DNA topoisomerase 3-beta-1 isoform 3 [Homo sapiens]

Protein Classification

TOP1Ac domain-containing protein( domain architecture ID 10075991)

TOP1Ac domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 36-457 4.30e-154

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


:

Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 447.44  E-value: 4.30e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  36 HNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQakvntdk 115
Cdd:cd00186     1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRKGV------LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 116 drsllldwdrvrvfdreiaqmflnmtklekEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ 195
Cdd:cd00186    68 ------------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 196 GYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWR 271
Cdd:cd00186   118 GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFK 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 272 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQ 351
Cdd:cd00186   197 LYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKE 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 352 TNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQ 431
Cdd:cd00186   277 TQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEK 355

                         410       420
                  ....*....|....*....|....*.
gi 1169100944 432 LNLIAQGKADYRQVLGHTLDVFKRKF 457
Cdd:cd00186   356 LDEIAEGKKDYQEVLEEFYEEFKKIV 381
 
Name Accession Description Interval E-value
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 36-457 4.30e-154

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 447.44  E-value: 4.30e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  36 HNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQakvntdk 115
Cdd:cd00186     1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRKGV------LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 116 drsllldwdrvrvfdreiaqmflnmtklekEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ 195
Cdd:cd00186    68 ------------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 196 GYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWR 271
Cdd:cd00186   118 GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFK 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 272 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQ 351
Cdd:cd00186   197 LYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKE 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 352 TNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQ 431
Cdd:cd00186   277 TQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEK 355

                         410       420
                  ....*....|....*....|....*.
gi 1169100944 432 LNLIAQGKADYRQVLGHTLDVFKRKF 457
Cdd:cd00186   356 LDEIAEGKKDYQEVLEEFYEEFKKIV 381
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 33-446 2.16e-143

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 421.27  E-value: 2.16e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  33 EPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKygdldsSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVN 112
Cdd:pfam01131   1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKGN------KLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 113 TDKDRSLLLDWDRVRVFDREIAQMFLNmtKLEK-EAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAER 191
Cdd:pfam01131  75 DGGGVFANAKWKRGRIFDKEEAEAILE--KLKKgTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 192 LYTQ-GYISYPRTETTHYPENFDLKGSLR-QQANHPYWADTVKRLLAEG-INRPRKGHDAGDHPPITPMKSAT-EAELGG 267
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEyLTKNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPvLPELSD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 268 DAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKM 347
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEELPELKEGEELKVTQVEV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 348 LEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDaELVLPTIRSA 427
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERK-KKSLVPTELGKALVEALEKFP-DLVDPELTAE 390

                         410
                  ....*....|....*....
gi 1169100944 428 VEKQLNLIAQGKADYRQVL 446
Cdd:pfam01131 391 LEEKLDEIAEGKLDWKDVL 409
PRK07219 PRK07219
DNA topoisomerase I; Validated
 5-555 1.55e-118

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 370.87  E-value: 1.55e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   5 HGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFqGKYGDLDssLISFGPCQTP 84
Cdd:PRK07219  124 EVCQVPVKRARFSSLTKKEIRKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLSV-RQLGRWD--FLSVGRVQTP 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  85 TLGFCVERHDKIQSFKPETYWVLQAKVNTD---KDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQR 161
Cdd:PRK07219  201 TLAFIVDREREIRAFDPEDYWKIEALLDKEaqyFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISP 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 162 PLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINR 241
Cdd:PRK07219  281 PAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIK 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 242 PRKG-HDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVM 320
Cdd:PRK07219  361 PTEGkKETTDHPPIHPVDVPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVY 440

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 321 PWQSvPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVtVESGrRLK 400
Cdd:PRK07219  441 PYEK-FDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGD-PPR 517

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 401 PTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGM-DELMEvSFSPLA 479
Cdd:PRK07219  518 PTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIgDHLAG-SLKAEN 596

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 480 ATGKPLSRCGKCHRFMKYIQAKPSR--LHCS---HCDETYTLPQNGTIKLYKELrCPLDDFELVLWssgSRGKSYPL--C 552
Cdd:PRK07219  597 RSLKTIGKCPECGGDLIIIRTDKGSrfVGCSgypDCRNTFPLPSTGRIKVLDEV-CEKCGLPVIKI---LRGKQTFVvgC 672


                  ...
gi 1169100944 553 PYC 555
Cdd:PRK07219  673 PDC 675
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 154-408 4.59e-107

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 322.27  E-value: 4.59e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  154 RKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHP-YWADTVK 232
Cdd:smart00437   2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGkEYLDLAV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  233 RLLAEGInrPRKGHDA-GDHPPITPMKSAT----EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCS 307
Cdd:smart00437  82 VLLKPRK--PRKGKKAqGAHEAIRPTKPIFtpelEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  308 GKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQ 387
Cdd:smart00437 160 GKTLLFDGWLKVYPEEKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239

                          250       260
                   ....*....|....*....|.
gi 1169100944  388 RNYVTVEsGRRLKPTNLGIVL 408
Cdd:smart00437 240 RGYVTKK-KKKLIPTELGIAV 259
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
3-458 3.90e-88

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 283.14  E-value: 3.90e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   3 KAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNeaLsVDA---RQELDLRIGCAFTRFQTKYFQGKygdldsslISFG 79
Cdd:COG0550    94 ELLGDKKPVKRVVFNEITKKAIKEAFKNPRDIDMN--L-VDAqqaRRILDRLVGYNLSPLLWKKVKRG--------LSAG 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  80 PCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKD--RSLLLDWDRVRVFDREIAQMFLNMTKlEKEAQVEATSRKEK 157
Cdd:COG0550   163 RVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGefTAKLVKIDGKKILDEEEAEAILAALK-GKTFTVTSVEKKPK 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 158 AKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPEnfDLKGSLRQQANhpywADTVKRLLAE 237
Cdd:COG0550   242 KRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSE--DAVAAAREYIE----ALYGKEYLPE 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 238 GINRPRKGHDA-GDHPPITP-MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPG 315
Cdd:COG0550   316 KPRVYKTSKNAqEAHEAIRPtGVTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPG 395

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 316 FTEVMPWQSVPLEE----SLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQR 388
Cdd:COG0550   396 FLKVYGEGKDDEEEeeekRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGrpsTYASI---IETLQDR 472

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169100944 389 NYVTVEsGRRLKPTNLGIV---LVHGYYKidaELVLPTIRSAVEKQLNLIAQGKADYRQVLGHtldvFKRKFH 458
Cdd:COG0550   473 GYVERE-GKRLVPTELGFIvidLLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVLEE----FYKPFK 537
 
Name Accession Description Interval E-value
TOP1Ac cd00186
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ...
 36-457 4.30e-154

DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.


Pssm-ID: 238110 [Multi-domain]  Cd Length: 381  Bit Score: 447.44  E-value: 4.30e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  36 HNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQakvntdk 115
Cdd:cd00186     1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRKGV------LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 116 drsllldwdrvrvfdreiaqmflnmtklekEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ 195
Cdd:cd00186    68 ------------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 196 GYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAeGINRPRKGHDAGDHPPITPMK----SATEAELGGDAWR 271
Cdd:cd00186   118 GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLG-RRNPKRGKKEQGAHEAIRPTKvaptPELEANLSEDEFK 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 272 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQ 351
Cdd:cd00186   197 LYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEEPPPLKEGDELKLEEVELEEKE 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 352 TNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQ 431
Cdd:cd00186   277 TQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKE-KKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEK 355

                         410       420
                  ....*....|....*....|....*.
gi 1169100944 432 LNLIAQGKADYRQVLGHTLDVFKRKF 457
Cdd:cd00186   356 LDEIAEGKKDYQEVLEEFYEEFKKIV 381
Topoisom_bac pfam01131
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ...
 33-446 2.16e-143

DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.


Pssm-ID: 426069 [Multi-domain]  Cd Length: 410  Bit Score: 421.27  E-value: 2.16e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  33 EPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKygdldsSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVN 112
Cdd:pfam01131   1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKGN------KLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 113 TDKDRSLLLDWDRVRVFDREIAQMFLNmtKLEK-EAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAER 191
Cdd:pfam01131  75 DGGGVFANAKWKRGRIFDKEEAEAILE--KLKKgTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 192 LYTQ-GYISYPRTETTHYPENFDLKGSLR-QQANHPYWADTVKRLLAEG-INRPRKGHDAGDHPPITPMKSAT-EAELGG 267
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEyLTKNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPvLPELSD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 268 DAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKM 347
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEELPELKEGEELKVTQVEV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 348 LEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDaELVLPTIRSA 427
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERK-KKSLVPTELGKALVEALEKFP-DLVDPELTAE 390

                         410
                  ....*....|....*....
gi 1169100944 428 VEKQLNLIAQGKADYRQVL 446
Cdd:pfam01131 391 LEEKLDEIAEGKLDWKDVL 409
PRK07219 PRK07219
DNA topoisomerase I; Validated
 5-555 1.55e-118

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 370.87  E-value: 1.55e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   5 HGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFqGKYGDLDssLISFGPCQTP 84
Cdd:PRK07219  124 EVCQVPVKRARFSSLTKKEIRKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLSV-RQLGRWD--FLSVGRVQTP 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  85 TLGFCVERHDKIQSFKPETYWVLQAKVNTD---KDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQR 161
Cdd:PRK07219  201 TLAFIVDREREIRAFDPEDYWKIEALLDKEaqyFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISP 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 162 PLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINR 241
Cdd:PRK07219  281 PAPFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIK 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 242 PRKG-HDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVM 320
Cdd:PRK07219  361 PTEGkKETTDHPPIHPVDVPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVY 440

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 321 PWQSvPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVtVESGrRLK 400
Cdd:PRK07219  441 PYEK-FDEKELPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGD-PPR 517

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 401 PTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGM-DELMEvSFSPLA 479
Cdd:PRK07219  518 PTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIgDHLAG-SLKAEN 596

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 480 ATGKPLSRCGKCHRFMKYIQAKPSR--LHCS---HCDETYTLPQNGTIKLYKELrCPLDDFELVLWssgSRGKSYPL--C 552
Cdd:PRK07219  597 RSLKTIGKCPECGGDLIIIRTDKGSrfVGCSgypDCRNTFPLPSTGRIKVLDEV-CEKCGLPVIKI---LRGKQTFVvgC 672


                  ...
gi 1169100944 553 PYC 555
Cdd:PRK07219  673 PDC 675
TOP1Ac smart00437
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ...
 154-408 4.59e-107

Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit


Pssm-ID: 214663 [Multi-domain]  Cd Length: 259  Bit Score: 322.27  E-value: 4.59e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  154 RKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHP-YWADTVK 232
Cdd:smart00437   2 EKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGkEYLDLAV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  233 RLLAEGInrPRKGHDA-GDHPPITPMKSAT----EAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCS 307
Cdd:smart00437  82 VLLKPRK--PRKGKKAqGAHEAIRPTKPIFtpelEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAK 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  308 GKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQ 387
Cdd:smart00437 160 GKTLLFDGWLKVYPEEKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239

                          250       260
                   ....*....|....*....|.
gi 1169100944  388 RNYVTVEsGRRLKPTNLGIVL 408
Cdd:smart00437 240 RGYVTKK-KKKLIPTELGIAV 259
TopA COG0550
DNA topoisomerase IA [Replication, recombination and repair];
3-458 3.90e-88

DNA topoisomerase IA [Replication, recombination and repair];


Pssm-ID: 440316 [Multi-domain]  Cd Length: 541  Bit Score: 283.14  E-value: 3.90e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   3 KAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNeaLsVDA---RQELDLRIGCAFTRFQTKYFQGKygdldsslISFG 79
Cdd:COG0550    94 ELLGDKKPVKRVVFNEITKKAIKEAFKNPRDIDMN--L-VDAqqaRRILDRLVGYNLSPLLWKKVKRG--------LSAG 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  80 PCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKD--RSLLLDWDRVRVFDREIAQMFLNMTKlEKEAQVEATSRKEK 157
Cdd:COG0550   163 RVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGefTAKLVKIDGKKILDEEEAEAILAALK-GKTFTVTSVEKKPK 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 158 AKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPEnfDLKGSLRQQANhpywADTVKRLLAE 237
Cdd:COG0550   242 KRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSE--DAVAAAREYIE----ALYGKEYLPE 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 238 GINRPRKGHDA-GDHPPITP-MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPG 315
Cdd:COG0550   316 KPRVYKTSKNAqEAHEAIRPtGVTRTPESLSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPG 395

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 316 FTEVMPWQSVPLEE----SLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQR 388
Cdd:COG0550   396 FLKVYGEGKDDEEEeeekRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGrpsTYASI---IETLQDR 472

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169100944 389 NYVTVEsGRRLKPTNLGIV---LVHGYYKidaELVLPTIRSAVEKQLNLIAQGKADYRQVLGHtldvFKRKFH 458
Cdd:COG0550   473 GYVERE-GKRLVPTELGFIvidLLEEHFP---DLVDYEFTAKMEEKLDEIAEGKLDWKDVLEE----FYKPFK 537
PRK07220 PRK07220
DNA topoisomerase I; Validated
 13-522 6.39e-87

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 285.50  E-value: 6.39e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  13 RARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRfqtkYFQGKYGDLDSSLISFGPCQTPTLGFCVER 92
Cdd:PRK07220  133 RVRYSAITKKEIERAFSNPVEVDFNLADAGHSRQVIDLVWGAALTR----YISLAAGRLGKMFLSVGRVQSPTLALIVDR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  93 HDKIQSFKPETYWVLQAKVnTDKDRSLLLDWDRVRVFDREIAQMFLNmtKLEKEAQVEATSRKEKAKQRPLALNTVEMLR 172
Cdd:PRK07220  209 EKEREAFVPTPYWEIYATL-ENNGETFVAQHSTRRFWEKEEADRVFE--KLGKTAEVTEVEKGTKTDKPPTPFNTTEFIS 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 173 vASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYwADTVKRLLAEGINRPRKG-HDAGDH 251
Cdd:PRK07220  286 -AANSIGFSAANAMRIAESLYTNGYISYPRTDNTVYPESLDLREQIEIFAEGPF-GEYAQKLLEKGELVPTRGkKETTDH 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 252 PPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWqSVPLEESL 331
Cdd:PRK07220  364 PPIYPASLAKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPY-NAPEDRLL 442

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 332 PTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVtveSGRRLKPTNLGIVLVHG 411
Cdd:PRK07220  443 PELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYI---HGNPIQPTNTAFAVVDA 519

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 412 YYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSiagMDELMEVSFSPLAATgKPLSRCGKC 491
Cdd:PRK07220  520 LEKYAPTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKN---REKIRESLREGLRED-KIIGKCPLC 595

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1169100944 492 -HRFMKYIQAKPSR-LHCS---HCDETYTLPQNGTI 522
Cdd:PRK07220  596 gSDLMVRRSKRGSRfIGCEgypECTFSLPLPKSGQI 631
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 13-485 5.11e-69

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 240.52  E-value: 5.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  13 RARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTkyFQGKYGDldSSLISFGPCQTPTLGFCVER 92
Cdd:PRK14973  132 RARFSAITKEEIVTAFAEPTDLDFALAAAGEARQIIDLIWGASLTRFIS--LAAHRGG--DNILSVGRVQSPTLAMIVDR 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  93 HDKIQSFKPETYWVLQakVNTDKD-RSLLLDWDRVRVFDREIAQMFLNMTKlekeAQVEATSRKEKAKQ--RPLALNTVE 169
Cdd:PRK14973  208 EKEIEAFVPEKYWMLS--LATEKDgEGIEARHTHGRFTDSAAAEAAYDATK----EPLVVTEVKEGHKVdrAPTPFDTTT 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 170 MLrVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADtVKRLLAEGINRPRKGH-DA 248
Cdd:PRK14973  282 FI-VAASRLGFSAANAMRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLATLAKGAFSKD-VAWVKDNRRPVPTRGKkSS 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 249 GDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWqSVPLE 328
Cdd:PRK14973  360 TDHPPIHPTGVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPY-SEAKE 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 329 ESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVtveSGRRLKPTNLGIVL 408
Cdd:PRK14973  439 NILPAFALGEKLPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKYI---EGNPLRPTLVGRAV 515

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 409 VHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGM-DELM-----EVSFSPLAATG 482
Cdd:PRK14973  516 TESLEEHAGTITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDELEANEAVIgRDIMertaeELTIGPCPVCG 595


                  ...
gi 1169100944 483 KPL 485
Cdd:PRK14973  596 KDL 598
PRK05776 PRK05776
DNA topoisomerase I; Provisional
 3-493 8.34e-60

DNA topoisomerase I; Provisional


Pssm-ID: 235602 [Multi-domain]  Cd Length: 670  Bit Score: 211.00  E-value: 8.34e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   3 KAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQT---KYFQGKygdldSSLISFG 79
Cdd:PRK05776  119 KYLGDPKKAKRMKFSALTKSDIRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMssvRDASGK-----RVILSAG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  80 PCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTdKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAK 159
Cdd:PRK05776  194 RVQSPTLKYVVEREIERNLFVPLPYFSVSIIIEK-NGYEFTLKYENKKFETKEEAKEILEEIKKTGYLKVTKVEVKIEIL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 160 QRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAE-- 237
Cdd:PRK05776  273 EPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKLPPTLNIRNILKGLSRSPQYRPLVNLLLKEtk 352

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 238 GINRPRKG-HDAGDHPPITPMKSATEaELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIG--PELFTCSGKTVLSP 314
Cdd:PRK05776  353 GVLKPVQGpKDDPAHPAIYPTGEPPK-NLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPgfPLVFSASGQRIEER 431

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 315 GFTEVMPWqSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTvE 394
Cdd:PRK05776  432 GWLKYYPF-HKFDEEELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLT-S 509

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 395 SGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHT-------LDVFKRKFHYFVDSIAGM 467
Cdd:PRK05776  510 NGKYIEVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLEMIRTGKATREEVIEEAketlnklLEEFKKNKDEIGEELAKA 589

                         490       500
                  ....*....|....*....|....*.
gi 1169100944 468 DELMevsfsplaatgKPLSRCGKCHR 493
Cdd:PRK05776  590 LGLI-----------KPVGKCKICGR 604
PRK07726 PRK07726
DNA topoisomerase 3;
38-510 1.08e-49

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 182.67  E-value: 1.08e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  38 EALsvdARQELDLRIGCAFTR-FQTKYFQGKYGDLdsslISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKD 116
Cdd:PRK07726  155 SAL---ARSRADWLVGINMTRaYTLLGRKAGYNGV----LSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGER 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 117 RSLLldW--------DRVRVFDREIAQMFLNMTKlEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQT 188
Cdd:PRK07726  228 FTAK--WqpsepyqdEEGRLLDRPLAEQVVARIQ-GQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDI 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 189 AERLY-TQGYISYPRTETTHYPEnfDLKGSLRQ-----QANHPYwadtvKRLLAEGINRPRKGH---DA--GDHPPITP- 256
Cdd:PRK07726  305 AQSLYeTHKLITYPRTDSRYLPE--DMVATLPEvlnaiSKVDPY-----LLLAPPVLDPSIRSRawnDKkvTAHHAIIPt 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 257 MKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEES--LPTC 334
Cdd:PRK07726  378 EQPPNLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEKEqpLPVL 457

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 335 QRGDAFPVGEVKMLEKQTNPPDYLTEAELITLM-----------------EKHGIGTDA---SIpvhINNICQRNYVTVE 394
Cdd:PRK07726  458 AKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAMeniarfvqdkelkktlkETDGLGTEAtraGI---IEKLFKRGYLEKK 534

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 395 sGRRLKPTNLGIVLvhgyykIDA---ELVLPTIRSAVEKQLNLIAQGKADYRQvlghtldvfkrkfhyFVDSIAG-MDEL 470
Cdd:PRK07726  535 -GKYIHATDKGKQL------IDAlpeELTSPDMTAKWEQALDQISEGQLSYQD---------------FMQPLKQwLKQL 592

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1169100944 471 ME---VSFSPLAATGKPLSRCGKCHRFMKyiQAKPSRLHCSHC 510
Cdd:PRK07726  593 VEqakQSSEKYKFDNLTGPKCPDCGKPML--KVKGKNGKMLVC 633
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 90-495 1.12e-35

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 143.01  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  90 VERHDKIQSFKPETYWVLQAKVNTDKDRSLLLD--------WDRVRVFDREIAQMFLnmTKLEKeAQVEATSRKEKAKQR 161
Cdd:PRK07561  189 VEREREIEAFVPEEYWDIHADLTTPRGDAFEARlthldgkkFAPVDLLNEAQAEAAV--AALEG-ARYSVASVEDKPTTR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 162 -PLALNTVEMLRVASSS-LGMGPQHAMQTAERLYTQGYISYPRTETTHY-PENFDlkgSLRQQANHPYWADtvkrLLAEG 238
Cdd:PRK07561  266 kPSAPFTTSTLQQEASRkLGFSVKKTMRIAQRLYEAGYITYMRTDSTNLsQEAIN---AARGYIGDNYGKK----YLPEK 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 239 inrPR------KG----HDAgdhppITP---MKSATE-AELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELF 304
Cdd:PRK07561  339 ---PRqysskaKNaqeaHEA-----IRPsdvFRTPDQlKGLEGDAQRLYELIWKRFVASQMAPARYDSTTVTIAAGDAEL 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 305 TCSGKTVLSPGFTEVMPWQS--VPLEES--LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIG---TDAS 377
Cdd:PRK07561  411 RATGRVLRFDGFLKVYVEGRddALDDEDrrLPALKVGDALTLEKLDPTQHFTKPPARYSEASLVKELEKLGIGrpsTYAS 490

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 378 IpvhINNICQRNYVTVEsGRRLKPTNLG-IV--LVHGYYkidAELVLPTIRSAVEKQLNLIAQGKADYRQVlghtLDVFK 454
Cdd:PRK07561  491 I---ISTIQDRGYVRLE-NRRFYPEKMGrIVtdRLEEFF---PRLVDYDFTARMEEELDDIANGEADWKPV----LDDFY 559

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1169100944 455 RKFHYFVDSIA------GMDELMEVsfsplaatgkPLSR-CGKCHRFM 495
Cdd:PRK07561  560 KDFSQQLEKAEelreegGMRPNQMV----------ITDRdCPTCGRGM 597
PRK06599 PRK06599
DNA topoisomerase I; Validated
 9-552 3.37e-34

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 138.07  E-value: 3.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   9 KTVFRARFSSITDTDICNAMAclgEP-DHNEALsVD---ARQELDLRIGcaftrFQ------TKYFQGKygdldssliSF 78
Cdd:PRK06599  106 KNVKRVVFNEITKKAVQEAIE---NPrDIDMDL-VDaqqARRALDYLVG-----FKlspllwKKVRRGL---------SA 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  79 GPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSL---LLDWD-----RVRVFDREIAQmflnmtKLEKEAQ-- 148
Cdd:PRK06599  168 GRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEPFtakLVEVNgkkleKFSITNEEQAK------ALVKALEgq 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 149 ---VEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY--------TQGYISYPRTETThypenfdlkgs 217
Cdd:PRK06599  242 aytVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYegidlgegTVGLITYMRTDSV----------- 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 218 lrqqanhpywadtvkRLLAEGINRPRK------GHD-AGDHPPI--TPMKSATEAE------------------LGGDAW 270
Cdd:PRK06599  311 ---------------RLSNEALDEARKyitkkyGKEyLPAKPRVykKKSKNAQEAHeairptsinrtpeslkpyLTPDQF 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 271 RLYEYITRHFIATVSHDCKYLQSTISF--RIGPELFTCSGKTVLSPGFTEVMPwQSVPLEES-----LPTCQRGDAFPVG 343
Cdd:PRK06599  376 KLYELIWKRTVASQMAPAILDQTSVDIasENGKYVFRATGSVILFPGFLKVYG-ESKDDEEEddeklLPPLKEGEKLKLD 454

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 344 EVkmLEKQ--TNPPDYLTEAELITLMEKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLG-IV---LVHGY-- 412
Cdd:PRK06599  455 EL--LPEQhfTEPPPRYSEASLVKKLEEYGIGrpsTYASI---ISTLQDREYVELE-KKRFIPTDLGrIVndfLVEHFpk 528

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 413 ---YKIDAELvlptirsavEKQLNLIAQGKADYRQVlghtLDVFKRKFHYFVDSIAGMDELMEVSFSPLAAT-----GKP 484
Cdd:PRK06599  529 yvdYDFTAGL---------EDELDEIAEGKKDWKPV----LREFWEPFISNLEKVEEDVRTEKVTQEETDETcpkcgGGP 595

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 485 LS-RCGKCHRFmkyiqakpsrLHCSH---CDETYTLPQNG-----TIKLYKELRCPLDDFELVLwSSGSRGK-----SYP 550
Cdd:PRK06599  596 LVlKLGKNGKF----------LGCSGypeCKYTKNITRDEdepieEEEIVEEEKCPKCGGPLVL-KKGRYGKflacsGYP 664


                  ..
gi 1169100944 551 LC 552
Cdd:PRK06599  665 EC 666
TOP1Bc smart00436
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ...
 11-106 5.34e-33

Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit


Pssm-ID: 214662 [Multi-domain]  Cd Length: 89  Bit Score: 121.54  E-value: 5.34e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   11 VFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYgdldsslISFGPCQTPTLGFCV 90
Cdd:smart00436   1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNGV-------LSAGRVQTPTLGLIV 73

                           90
                   ....*....|....*.
gi 1169100944   91 ERHDKIQSFKPETYWV 106
Cdd:smart00436  74 EREREIKNFVPKPYWE 89
PRK08780 PRK08780
DNA topoisomerase I; Provisional
 8-499 1.02e-28

DNA topoisomerase I; Provisional


Pssm-ID: 181555 [Multi-domain]  Cd Length: 780  Bit Score: 121.79  E-value: 1.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   8 EKTVFRARFSSITDTDICNAMAclgepdHNEALSVD------ARQELDLRIGCAFTRFQTKYFQgkygdldsSLISFGPC 81
Cdd:PRK08780  106 DKPMQRVVFTEITPRAIKEAMA------KPRDIASDlvdaqqARRALDYLVGFNLSPLLWRKIQ--------RGLSAGRV 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  82 QTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKD----RSLLLDWDRVRVF---DREIAQMFLNmtKLEKEAQ----VE 150
Cdd:PRK08780  172 QSPALRMIVEREEEIEAFIAREYWSIEADCAHPSQpfnaKLIKLDGQKFEQFtitDGDTAEAARL--RIQQAAQgtlhVT 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 151 ATSRKEKaKQRPLALNTVEMLRV-ASSSLGMGPQHAMQTAERLY---------TQGYISYPRTETTHYPEnfDLKGSLRQ 220
Cdd:PRK08780  250 DVESKER-KRNPAPPFTTSTLQQeASRKLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDSVNLSQ--DALAEIRD 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 221 QANHPYWADTVKRLLAEGINRPRKGHDAgdHPPITP---MKSATE--AELGGDAWRLYEYITRHFIATVSHDCKYLQSTI 295
Cdd:PRK08780  327 VIARDYGTASLPDQPNTYKTKSKNAQEA--HEAVRPtsaLRTPAQvaRFLSDDQRRLYELIWKRAVACQMIPATLNTVSV 404

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 296 SFRIGPE-LFTCSGKTVLSPGFTEVM-------PWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLM 367
Cdd:PRK08780  405 DLAAGSEhVFRATGSTVVVPGFLAVYeegkddkSAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKAL 484

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 368 EKHGIG---TDASIpvhINNICQRNYVTVEsGRRLKPTNLGIVlVHGY----------YKIDAELvlptirsavEKQLNL 434
Cdd:PRK08780  485 EEYGIGrpsTYASI---ISTLQFRKYVEME-GRRFRPTDVGRA-VNKFltghftryvdYDFTARL---------EDDLDA 550

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169100944 435 IAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLS-RCGkchRFMKYIQ 499
Cdd:PRK08780  551 VSRGEKEWIPLMEKFWGPFKELVEEKKDSVDRTEAGQVRELGTDPKSGKPVSvRIG---RFGPMVQ 613
PRK08173 PRK08173
DNA topoisomerase III; Validated
 6-511 5.98e-27

DNA topoisomerase III; Validated


Pssm-ID: 236172 [Multi-domain]  Cd Length: 862  Bit Score: 116.30  E-value: 5.98e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   6 GGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSvDA---RQELDLRIGCAFTRFQTKyFQGKYGDLdsSLISFGPCQ 82
Cdd:PRK08173  122 KAKKPVKRLWLQSMTPQAIRDGFANLRSDEDMQPLA-DAarcRSEADWLVGINGTRAMTA-FNSKGGGF--FLTTVGRVQ 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  83 TPTLGFCVERHDKIQSFKPETYWVLQA-------------------KVNTDKDRsllldwdRV-RVFDREIAQMFLNMTK 142
Cdd:PRK08173  198 TPTLSIVVEREEKIRRFVPRDYWEVRAefvaaagfyegrwfdpkfkKDEFDPEK-------RAsRLWSEAAAEAIVAACR 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 143 lEKEAQVEATSrKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ-GYISYPRTETTHYPENF--DLKGSLR 219
Cdd:PRK08173  271 -GKPGTVTEES-KPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYlgTVKQTLE 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 220 QQANHPYWADTVKRLLAEGINRPRK----GHDAGDHPPITPM----KSATEAELggdawRLYEYITRHFIATVSHDCKYL 291
Cdd:PRK08173  349 MLKESNNYLPHAKQILDKGWVKPNKrifdNSKISDHFAIIPTlqapKSLSEPEQ-----KLYDLVVKRFLAVFFPAAEFL 423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 292 QSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLME--- 368
Cdd:PRK08173  424 VTTRITEVAGHHFKTEGKVLVNPGWLAVYGKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgag 503

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 369 -------------KHGIGTDASIPVHINNICQRNYVtVESGRRLKPT----NLgIVLVHGyYKIDaELVLPTIRSAVEKQ 431
Cdd:PRK08173  504 klveddelreamaEKGLGTPATRAAIIEGLLGEKYL-VREGRELIPTakafQL-MTLLRG-LGVE-ELTSPELTGEWEYK 579

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 432 LNLIAQGK----ADYRQVLGHTLDVFKRKFHYFVDSIAGmdelmevSFSPLAAtgkPLSRCGkchrfmKYIQAKPSRLHC 507
Cdd:PRK08173  580 LSQIERGKlsrdAFMQEIAQMTQQIVKRAKEYDSDTIPG-------DYATLQT---PCPNCG------GVVKENYRRFAC 643


                  ....
gi 1169100944 508 SHCD 511
Cdd:PRK08173  644 TKCD 647
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 13-453 1.83e-17

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 86.41  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  13 RARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGdldsslISFGPCQTPTLGFCVER 92
Cdd:PRK06319  106 RISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQRRSG------VSAGRVQSVALKLVVDR 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  93 HDKIQSFKPETYWVLQAKVNTDKDRSLLL---------DWDR-----------VRVFDREIAQMFLNMtkLEKEA-QVEA 151
Cdd:PRK06319  180 EKAIEAFVPVEYWNIRVHLKDPKTQKTFWahlysvdgkKWEKeipegktedevLLINSKEKADHIVEL--LESATyTVTR 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 152 TSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLY---------TQGYISYPRTETTHY-PENFDlkgSLRQQ 221
Cdd:PRK06319  258 VESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYegvdldsegATGLITYMRTDSVRTdPEALK---QVRKY 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 222 ANHPYWAD---------TVKRLLA---EGInRPRKGHdagdhppITPMKsaTEAELGGDAWRLYEYITRHFIATVSHDCK 289
Cdd:PRK06319  335 IEGTFGKEflpsspnvyTTKKMAQdahEAI-RPTDIT-------LTPEK--LRSKLTEDQYKLYSLIWKRFVASQMIPAI 404

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 290 Y--LQSTISFRIGPELfTCSGKTVLSPGFTEV---MPWQSVPLEE--SLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAE 362
Cdd:PRK06319  405 YdtLAIRITTNKGIDL-RATGSLLKFKGFLAVyeeKRDDEGDEEEniHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEAS 483

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 363 LITLMEKHGIGTDASIPVHINNICQRNYvTVESGRRLKPTNLGIVLVHGYykidaELVLPTI-----RSAVEKQLNLIAQ 437
Cdd:PRK06319  484 LVKELEKSGIGRPSTYATIMNKIQSREY-TLKENQRLRPTELGKIISQFL-----ETNFPRImdigfTALMEDELELIAD 557

                         490
                  ....*....|....*.
gi 1169100944 438 GKADYRQVLGHTLDVF 453
Cdd:PRK06319  558 NKKPWKLLLQEFWELF 573
PRK14724 PRK14724
DNA topoisomerase III; Provisional
 3-466 3.30e-17

DNA topoisomerase III; Provisional


Pssm-ID: 237803 [Multi-domain]  Cd Length: 987  Bit Score: 85.78  E-value: 3.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944   3 KAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDAR--QELDLRIGCAFTRFQTKyFQGKYGDLdsSLISFGP 80
Cdd:PRK14724  127 AKGGLGKPVKRLWLQSMTPQAIRDGFDNLRSDAQMQGLASAARsrSEADWLVGINGTRAMTA-FNSRDGGF--FLTTVGR 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  81 CQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSL--LLD--WDRV---------RVFDREIAQMFLNMTKlEKEA 147
Cdd:PRK14724  204 VQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLgkWFDpqWKKAsddpearadRVWSEREARAIADAVR-GKAA 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 148 QVEATSrKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQ-GYISYPRTETTHYPEN--------FDL--KG 216
Cdd:PRK14724  283 TVTEES-KPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDylpvakqtFEMlaTS 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 217 SLRQQANHPYWAdtvkrlLAEGINRPRK----GHDAGDHPPITPMKSA----TEAElggdaWRLYEYITRHFIATVSHDC 288
Cdd:PRK14724  362 GMRHLAPFAQQA------LDGNYVRPSKrifdNSKVSDHFAIIPTTQApsglSEAE-----QKLYDLVVRRFMAVFFPSA 430

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 289 KYLQST-ISFRIGPElFTCSGKTVLSPGF---------TEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYL 358
Cdd:PRK14724  431 EYQVTTrISQVVGHS-FKTEGKVLVKPGWlaiygkeaaNEVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARY 509

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 359 TEAELITLME----------------KHGIGTDASIPVHINNICQRNYVTVEsGRRLKPTNLGIVLVHGYYKIDA-ELVL 421
Cdd:PRK14724  510 SEATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLRE-GRELIPTAKAFQLMTLLRGLGVeELSR 588

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1169100944 422 PTIRSAVEKQLNLIAQGK----ADYRQVLGHTLDVFKRKFHYFVDSIAG 466
Cdd:PRK14724  589 AELTGEWEYKLAQMEKGQlsreAFMQQIAAMTEKLVKKAKEYDRDTIPG 637
PTZ00407 PTZ00407
DNA topoisomerase IA; Provisional
 13-437 1.00e-09

DNA topoisomerase IA; Provisional


Pssm-ID: 173597 [Multi-domain]  Cd Length: 805  Bit Score: 61.50  E-value: 1.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  13 RARFSSITDTDICNAMA--CLGEPDHNEALSVDARQELDlRIgcaftrfqtkyfqgkYGDLDSSLI--------SFGPCQ 82
Cdd:PTZ00407  162 RAYMHSITEDGIRKAMRerHVEACDYDLANAAETRHAMD-RI---------------FGFLGSSVVraansqmrSIGRVQ 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944  83 TPTLGFCVERHDKIQSF--KPETYWVLQA----------------KVNTDKdRSLLLDWDRVRVFDREIAQMFLNMT--- 141
Cdd:PTZ00407  226 TPALILINEREDKIKAFleSNKSTFEVQAmcqfpsphgttfsqvvTITPDR-KGGASHWATEAEARRCLEQWKLNNCtgf 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 142 KLEKEAQVEATsrkEKAKQRPLALNTveMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENF--DLKGSLR 219
Cdd:PTZ00407  305 SVPLEPKPQPS---VVPPPQPFTMAT--AIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESAlpDIYAAVK 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 220 QQANhpywadtvKRLLAEGINRPRKGHDaGDHPPITPMKSATEAELGGDAWR---------------------------- 271
Cdd:PTZ00407  380 KEFG--------KEFLYRLEDRTVSAQE-GKGSKKTGKKRSTKQKKGADTPVgnvedaheairptnidttgeslslsppt 450

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 272 --LYEYITRHFIAT--VSHDCKYLQSTISFRI--GPEL-FTCSGKTVLSPGFTE-------------------------- 318
Cdd:PTZ00407  451 raVYDLVRRNTLAVfmIPMKTEKIVATVKFTSgsGEKLeFELQGKRVVEPGWTRafhkgdkgttgpaeetdeditaveeg 530

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169100944 319 --VMPWQS-------VPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRN 389
Cdd:PTZ00407  531 apVVPSLSqeefkaiMNLRSQLGSGVQKGFFELRSPQVRENRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARG 610

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1169100944 390 YVTVESGRRLKPTNLGIVLVHgyykiDAELVLPTI-----RSAVEKQLNLIAQ 437
Cdd:PTZ00407  611 YIAVNPKGRCETTPVGRMLVE-----TAKSTFPSIvdigfTAAFEKKLDRIAK 658
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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