|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
253-884 |
4.59e-43 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 169.66 E-value: 4.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 253 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 330
Cdd:COG1033 212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 331 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 410
Cdd:COG1033 289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 411 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 490
Cdd:COG1033 367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 491 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 570
Cdd:COG1033 419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 571 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 650
Cdd:COG1033 465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 651 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 726
Cdd:COG1033 528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 727 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 806
Cdd:COG1033 593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 807 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 884
Cdd:COG1033 673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
192-850 |
1.70e-26 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 117.46 E-value: 1.70e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 192 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 268
Cdd:pfam02460 144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 269 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 335
Cdd:pfam02460 222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 336 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:pfam02460 301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 416 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 487
Cdd:pfam02460 378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 488 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 567
Cdd:pfam02460 451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 568 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 644
Cdd:pfam02460 513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 645 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 722
Cdd:pfam02460 573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 723 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 802
Cdd:pfam02460 623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 1183596714 803 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVA 850
Cdd:pfam02460 703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILG 750
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
731-884 |
1.91e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 84.91 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 731 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 810
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1183596714 811 VHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLIMCISWAFATFFF 884
Cdd:COG1033 290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
265-419 |
7.52e-15 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 79.52 E-value: 7.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 343
Cdd:COG1033 612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714 344 DKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 419
Cdd:COG1033 687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
264-428 |
2.77e-13 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 68.76 E-value: 2.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 264 PAIAIVIVLLVMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfhfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 343
Cdd:pfam12349 6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 344 DKPhaeTSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----Y 419
Cdd:pfam12349 67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143
|
....*....
gi 1183596714 420 LLNIFTCFK 428
Cdd:pfam12349 144 RLDVACCIR 152
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
736-882 |
1.06e-09 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 63.09 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 736 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 809
Cdd:TIGR03480 266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714 810 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 882
Cdd:TIGR03480 340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
212-840 |
1.15e-09 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 63.00 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 212 FSPTEKGESMM---NIYLDNFENWNSSDGVTTITgieFGIKHSLfQDYLLMDTVYPAIAIVIVLLVMCVYT--------- 279
Cdd:TIGR00917 522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 280 -KSMFITLMTMFAIISSLIVsyfLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 343
Cdd:TIGR00917 598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 344 DKPHAETSE-TVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HER 418
Cdd:TIGR00917 675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 419 YLLNIFTCFKKPQQQIYDNKSCwTVACQKCHKVLFAISEASRIFFEKVLPCIVIkfrylwlFWFLALTVGGAYIVCINP- 497
Cdd:TIGR00917 755 KRVDCFPCIKTSKSSISAEKGS-GQRKAGLLTRYFKEVYAPVLLHWIVKIVVIA-------FFVGLLMAGIALSTRVEIg 826
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 498 ---KMKLPSleLSEFQVFRSShpFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNpkskgklTLDSSFN 574
Cdd:TIGR00917 827 ldqQIVLPQ--DSYLQIYFAS--LTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN-------VFNNLSY 895
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 575 IASPASqAWILHF-----------CQKLRNQTFFYQTDEQDFtSCFIET-----------FKQWMENQDCDEPAlyPCCS 632
Cdd:TIGR00917 896 IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNALPS--ADCA 971
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 633 HWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPgprfdiNDTIRAVvlefQSTYLFTlayekmhqfykevdswissel 712
Cdd:TIGR00917 972 KGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNTQ------VDFINAM----RAAQEFA--------------------- 1020
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 713 SSAPEGLSNGWFVSNL--EFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGW 789
Cdd:TIGR00917 1021 AKVSRSSKMEVYPYSVfyVFFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSI 1100
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 1183596714 790 ELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAM 840
Cdd:TIGR00917 1101 SLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
209-415 |
9.91e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 59.85 E-value: 9.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 209 SMLFSPTEKgESMMNIYLDNFENWNSSDGVT-TITG--IEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVmcVY---TKSM 282
Cdd:TIGR00921 519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 283 FiTLMTMFAIISSLIVSYFLYRVVFhfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPHAETS--ETVSITLQ 359
Cdd:TIGR00921 596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714 360 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:TIGR00921 664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
732-868 |
1.20e-07 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 55.38 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 732 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 807
Cdd:pfam03176 135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714 808 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 868
Cdd:pfam03176 214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
265-431 |
4.48e-07 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 54.59 E-value: 4.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 339
Cdd:TIGR00833 180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 340 YTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 419
Cdd:TIGR00833 256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335
|
170
....*....|..
gi 1183596714 420 LLniftcFKKPQ 431
Cdd:TIGR00833 336 GL-----MKPGR 342
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
729-867 |
5.46e-07 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 54.00 E-value: 5.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 729 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLV--------LLGWELNVLESVT-- 798
Cdd:COG2409 507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 799 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRVGS-----AMAMAAltTFVAgamMMPSTVLAYT 863
Cdd:COG2409 587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRvitsaALIMAA--VFAA---FATSPLVFLK 655
|
....
gi 1183596714 864 QLGT 867
Cdd:COG2409 656 QIGF 659
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
265-415 |
9.44e-06 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 50.00 E-value: 9.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYRVVFHFeffpfmNL--TALIIL-VGIGADDA--FVLcdvw 338
Cdd:TIGR03480 276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAaFATLAVGHL------NLisVAFAVLfIGLGVDFAiqFSL---- 345
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1183596714 339 NYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:TIGR03480 346 RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRL 422
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
265-415 |
9.96e-06 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 49.21 E-value: 9.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPfMNLTAL----IILVGIGADDAFVLcdVWNY 340
Cdd:pfam03176 149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIG-LSTFALnllvVLLIAVGTDYALFL--VSRY 225
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714 341 TKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:pfam03176 226 REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
800-884 |
1.60e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 49.47 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 800 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRVGSAMAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLIMCISW 877
Cdd:COG4258 310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383
|
....*..
gi 1183596714 878 AFATFFF 884
Cdd:COG4258 384 LTTLLWL 390
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
730-882 |
1.91e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 49.07 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 730 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 809
Cdd:TIGR00921 558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714 810 AVHygVAYRLAPDPDREGKV---IFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLIMCISWAFATF 882
Cdd:TIGR00921 638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
313-430 |
2.94e-05 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 48.72 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 313 PFMNLtaliilvGIGADDAFVLCDVWNYTKFDKPHAETSETVsitLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGV 392
Cdd:TIGR00918 464 PFLAL-------GVGVDDVFLLAHAFSETGQNIPFEERTGEC---LKRTGASVVLTSISNVTAFFMAALIPIPALRAFSL 533
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1183596714 393 YAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 430
Cdd:TIGR00918 534 QAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSP 575
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
265-417 |
6.06e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.52 E-value: 6.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSlivsyflyrVVFHFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 336
Cdd:TIGR00921 200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 337 vwnyTKFDKPHAE---TSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVV 413
Cdd:TIGR00921 269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
|
....
gi 1183596714 414 VLHE 417
Cdd:TIGR00921 345 QSID 348
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
745-847 |
5.40e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.46 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 745 MGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 824
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718
|
90 100
....*....|....*....|...
gi 1183596714 825 REGkvifSLSRVGSAMAMAALTT 847
Cdd:COG4258 719 DKG----ELARTLLSILLAALTT 737
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
731-874 |
6.50e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.06 E-value: 6.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 731 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 810
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1183596714 811 VHYGVAYRlapDPDREGK-----VIFSLSRVGSAMAMAALTTfVAGAMMMPSTVLAYTQ---LGTFMMLIMC 874
Cdd:TIGR00921 265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTT-SAGFAALALSEFPMVSefgLGLVAGLITA 332
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
730-868 |
7.14e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 43.99 E-value: 7.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 730 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 805
Cdd:COG2409 160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714 806 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 868
Cdd:COG2409 239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
751-885 |
3.29e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 41.91 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 751 VAFSVMLLTTW-NIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDregkv 829
Cdd:TIGR03480 723 VAITVLLLLTLrRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHRWRNGVDSG----- 797
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714 830 ifslSRVGSAMAMA----ALTTFVA-GAMMMPStvlaytQLGTFMM-LIMCISWAF---ATFFFQ 885
Cdd:TIGR03480 798 ----NLLQSSTARAvffsALTTATAfGSLAVSS------HPGTASMgILLSLGLGLtllCTLIFL 852
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
742-857 |
6.71e-03 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 41.02 E-value: 6.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 742 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIISIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 818
Cdd:TIGR00918 968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043
|
90 100 110
....*....|....*....|....*....|....*....
gi 1183596714 819 LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 857
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
742-881 |
7.88e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 40.18 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 742 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 813
Cdd:cd13134 134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714 814 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 880
Cdd:cd13134 208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284
|
.
gi 1183596714 881 T 881
Cdd:cd13134 285 Q 285
|
|
|