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Conserved domains on  [gi|1183596714|ref|NP_001337559|]
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protein dispatched homolog 1 isoform 2 [Homo sapiens]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
253-884 4.59e-43

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 169.66  E-value: 4.59e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  253 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 330
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  331 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 410
Cdd:COG1033    289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  411 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 490
Cdd:COG1033    367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  491 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 570
Cdd:COG1033    419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  571 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 650
Cdd:COG1033    465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  651 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 726
Cdd:COG1033    528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  727 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 806
Cdd:COG1033    593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  807 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 884
Cdd:COG1033    673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
253-884 4.59e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 169.66  E-value: 4.59e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  253 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 330
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  331 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 410
Cdd:COG1033    289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  411 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 490
Cdd:COG1033    367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  491 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 570
Cdd:COG1033    419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  571 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 650
Cdd:COG1033    465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  651 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 726
Cdd:COG1033    528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  727 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 806
Cdd:COG1033    593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  807 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 884
Cdd:COG1033    673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
192-850 1.70e-26

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 117.46  E-value: 1.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  192 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 268
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  269 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 335
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  336 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:pfam02460  301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  416 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 487
Cdd:pfam02460  378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  488 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 567
Cdd:pfam02460  451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  568 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 644
Cdd:pfam02460  513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  645 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 722
Cdd:pfam02460  573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  723 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 802
Cdd:pfam02460  623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 1183596714  803 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVA 850
Cdd:pfam02460  703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILG 750
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
736-882 1.06e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 63.09  E-value: 1.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  736 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 809
Cdd:TIGR03480  266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714  810 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 882
Cdd:TIGR03480  340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
742-881 7.88e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 40.18  E-value: 7.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  742 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 813
Cdd:cd13134    134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  814 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 880
Cdd:cd13134    208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284

                   .
gi 1183596714  881 T 881
Cdd:cd13134    285 Q 285
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
253-884 4.59e-43

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 169.66  E-value: 4.59e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  253 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 330
Cdd:COG1033    212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  331 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 410
Cdd:COG1033    289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  411 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 490
Cdd:COG1033    367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  491 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 570
Cdd:COG1033    419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  571 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 650
Cdd:COG1033    465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  651 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 726
Cdd:COG1033    528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  727 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 806
Cdd:COG1033    593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  807 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 884
Cdd:COG1033    673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
192-850 1.70e-26

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 117.46  E-value: 1.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  192 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 268
Cdd:pfam02460  144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  269 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 335
Cdd:pfam02460  222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  336 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:pfam02460  301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  416 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 487
Cdd:pfam02460  378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  488 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 567
Cdd:pfam02460  451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  568 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 644
Cdd:pfam02460  513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  645 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 722
Cdd:pfam02460  573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  723 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 802
Cdd:pfam02460  623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 1183596714  803 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVA 850
Cdd:pfam02460  703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILG 750
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
731-884 1.91e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 84.91  E-value: 1.91e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  731 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 810
Cdd:COG1033    210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1183596714  811 VHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLIMCISWAFATFFF 884
Cdd:COG1033    290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
265-419 7.52e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.52  E-value: 7.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 343
Cdd:COG1033    612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714  344 DKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 419
Cdd:COG1033    687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
264-428 2.77e-13

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 68.76  E-value: 2.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  264 PAIAIVIVLLVMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfhfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 343
Cdd:pfam12349    6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  344 DKPhaeTSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----Y 419
Cdd:pfam12349   67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143

                   ....*....
gi 1183596714  420 LLNIFTCFK 428
Cdd:pfam12349  144 RLDVACCIR 152
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
736-882 1.06e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 63.09  E-value: 1.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  736 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 809
Cdd:TIGR03480  266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714  810 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 882
Cdd:TIGR03480  340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
212-840 1.15e-09

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 63.00  E-value: 1.15e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  212 FSPTEKGESMM---NIYLDNFENWNSSDGVTTITgieFGIKHSLfQDYLLMDTVYPAIAIVIVLLVMCVYT--------- 279
Cdd:TIGR00917  522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  280 -KSMFITLMTMFAIISSLIVsyfLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 343
Cdd:TIGR00917  598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  344 DKPHAETSE-TVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HER 418
Cdd:TIGR00917  675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  419 YLLNIFTCFKKPQQQIYDNKSCwTVACQKCHKVLFAISEASRIFFEKVLPCIVIkfrylwlFWFLALTVGGAYIVCINP- 497
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKGS-GQRKAGLLTRYFKEVYAPVLLHWIVKIVVIA-------FFVGLLMAGIALSTRVEIg 826
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  498 ---KMKLPSleLSEFQVFRSShpFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNpkskgklTLDSSFN 574
Cdd:TIGR00917  827 ldqQIVLPQ--DSYLQIYFAS--LTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN-------VFNNLSY 895
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  575 IASPASqAWILHF-----------CQKLRNQTFFYQTDEQDFtSCFIET-----------FKQWMENQDCDEPAlyPCCS 632
Cdd:TIGR00917  896 IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNALPS--ADCA 971
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  633 HWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPgprfdiNDTIRAVvlefQSTYLFTlayekmhqfykevdswissel 712
Cdd:TIGR00917  972 KGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNTQ------VDFINAM----RAAQEFA--------------------- 1020
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  713 SSAPEGLSNGWFVSNL--EFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGW 789
Cdd:TIGR00917 1021 AKVSRSSKMEVYPYSVfyVFFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSI 1100
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1183596714  790 ELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAM 840
Cdd:TIGR00917 1101 SLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
209-415 9.91e-09

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 59.85  E-value: 9.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  209 SMLFSPTEKgESMMNIYLDNFENWNSSDGVT-TITG--IEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVmcVY---TKSM 282
Cdd:TIGR00921  519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  283 FiTLMTMFAIISSLIVSYFLYRVVFhfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPHAETS--ETVSITLQ 359
Cdd:TIGR00921  596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714  360 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:TIGR00921  664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
732-868 1.20e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  732 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 807
Cdd:pfam03176  135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714  808 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 868
Cdd:pfam03176  214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
265-431 4.48e-07

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 54.59  E-value: 4.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 339
Cdd:TIGR00833  180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  340 YTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 419
Cdd:TIGR00833  256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335
                          170
                   ....*....|..
gi 1183596714  420 LLniftcFKKPQ 431
Cdd:TIGR00833  336 GL-----MKPGR 342
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
729-867 5.46e-07

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 54.00  E-value: 5.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  729 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLV--------LLGWELNVLESVT-- 798
Cdd:COG2409    507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  799 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRVGS-----AMAMAAltTFVAgamMMPSTVLAYT 863
Cdd:COG2409    587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRvitsaALIMAA--VFAA---FATSPLVFLK 655

                   ....
gi 1183596714  864 QLGT 867
Cdd:COG2409    656 QIGF 659
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
265-415 9.44e-06

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 50.00  E-value: 9.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYRVVFHFeffpfmNL--TALIIL-VGIGADDA--FVLcdvw 338
Cdd:TIGR03480  276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAaFATLAVGHL------NLisVAFAVLfIGLGVDFAiqFSL---- 345
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1183596714  339 NYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:TIGR03480  346 RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRL 422
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
265-415 9.96e-06

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 49.21  E-value: 9.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPfMNLTAL----IILVGIGADDAFVLcdVWNY 340
Cdd:pfam03176  149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIG-LSTFALnllvVLLIAVGTDYALFL--VSRY 225
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714  341 TKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 415
Cdd:pfam03176  226 REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
COG4258 COG4258
Predicted exporter [General function prediction only];
800-884 1.60e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.47  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  800 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRVGSAMAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLIMCISW 877
Cdd:COG4258    310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383

                   ....*..
gi 1183596714  878 AFATFFF 884
Cdd:COG4258    384 LTTLLWL 390
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
730-882 1.91e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 49.07  E-value: 1.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  730 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 809
Cdd:TIGR00921  558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714  810 AVHygVAYRLAPDPDREGKV---IFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLIMCISWAFATF 882
Cdd:TIGR00921  638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
313-430 2.94e-05

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 48.72  E-value: 2.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  313 PFMNLtaliilvGIGADDAFVLCDVWNYTKFDKPHAETSETVsitLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGV 392
Cdd:TIGR00918  464 PFLAL-------GVGVDDVFLLAHAFSETGQNIPFEERTGEC---LKRTGASVVLTSISNVTAFFMAALIPIPALRAFSL 533
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1183596714  393 YAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 430
Cdd:TIGR00918  534 QAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSP 575
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
265-417 6.06e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.52  E-value: 6.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  265 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSlivsyflyrVVFHFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 336
Cdd:TIGR00921  200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  337 vwnyTKFDKPHAE---TSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVV 413
Cdd:TIGR00921  269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344

                   ....
gi 1183596714  414 VLHE 417
Cdd:TIGR00921  345 QSID 348
COG4258 COG4258
Predicted exporter [General function prediction only];
745-847 5.40e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 44.46  E-value: 5.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  745 MGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 824
Cdd:COG4258    645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718
                           90       100
                   ....*....|....*....|...
gi 1183596714  825 REGkvifSLSRVGSAMAMAALTT 847
Cdd:COG4258    719 DKG----ELARTLLSILLAALTT 737
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
731-874 6.50e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.06  E-value: 6.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  731 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 810
Cdd:TIGR00921  185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1183596714  811 VHYGVAYRlapDPDREGK-----VIFSLSRVGSAMAMAALTTfVAGAMMMPSTVLAYTQ---LGTFMMLIMC 874
Cdd:TIGR00921  265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTT-SAGFAALALSEFPMVSefgLGLVAGLITA 332
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
730-868 7.14e-04

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 43.99  E-value: 7.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  730 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 805
Cdd:COG2409    160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1183596714  806 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 868
Cdd:COG2409    239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
751-885 3.29e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 41.91  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  751 VAFSVMLLTTW-NIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDregkv 829
Cdd:TIGR03480  723 VAITVLLLLTLrRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHRWRNGVDSG----- 797
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1183596714  830 ifslSRVGSAMAMA----ALTTFVA-GAMMMPStvlaytQLGTFMM-LIMCISWAF---ATFFFQ 885
Cdd:TIGR03480  798 ----NLLQSSTARAvffsALTTATAfGSLAVSS------HPGTASMgILLSLGLGLtllCTLIFL 852
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
742-857 6.71e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 41.02  E-value: 6.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  742 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIISIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 818
Cdd:TIGR00918  968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1183596714  819 LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 857
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
742-881 7.88e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 40.18  E-value: 7.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  742 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 813
Cdd:cd13134    134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596714  814 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 880
Cdd:cd13134    208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284

                   .
gi 1183596714  881 T 881
Cdd:cd13134    285 Q 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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