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Conserved domains on  [gi|1200005345|ref|NP_001338899|]
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COX assembly mitochondrial protein 2 homolog isoform 1 [Homo sapiens]

Protein Classification

COX assembly mitochondrial protein( domain architecture ID 10554202)

COX assembly mitochondrial protein is required for mitochondrial cytochrome c oxidase (COX) assembly and respiration

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmc1 pfam08583
Cytochrome c oxidase biogenesis protein Cmc1 like; Cmc1 is a metallo-chaperone like protein ...
 1-70 2.81e-16

Cytochrome c oxidase biogenesis protein Cmc1 like; Cmc1 is a metallo-chaperone like protein which is known to localize to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase.


:

Pssm-ID: 400756  Cd Length: 70  Bit Score: 65.83  E-value: 2.81e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005345  1 MHPDLSPHLHtEECNVLINLLKECHKNHNILKFFGYCNDVDRELRKCLKNEYVENRTKSREHGIAMRKKL 70
Cdd:pfam08583  1 MHPQLRKKAF-KKCAELIKALAECHKGGRTLKAFGKCNKEKRAMNKCLREYRTDEALRDRERDREIKERL 69
 
Name Accession Description Interval E-value
Cmc1 pfam08583
Cytochrome c oxidase biogenesis protein Cmc1 like; Cmc1 is a metallo-chaperone like protein ...
 1-70 2.81e-16

Cytochrome c oxidase biogenesis protein Cmc1 like; Cmc1 is a metallo-chaperone like protein which is known to localize to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase.


Pssm-ID: 400756  Cd Length: 70  Bit Score: 65.83  E-value: 2.81e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005345  1 MHPDLSPHLHtEECNVLINLLKECHKNHNILKFFGYCNDVDRELRKCLKNEYVENRTKSREHGIAMRKKL 70
Cdd:pfam08583  1 MHPQLRKKAF-KKCAELIKALAECHKGGRTLKAFGKCNKEKRAMNKCLREYRTDEALRDRERDREIKERL 69
 
Name Accession Description Interval E-value
Cmc1 pfam08583
Cytochrome c oxidase biogenesis protein Cmc1 like; Cmc1 is a metallo-chaperone like protein ...
 1-70 2.81e-16

Cytochrome c oxidase biogenesis protein Cmc1 like; Cmc1 is a metallo-chaperone like protein which is known to localize to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase.


Pssm-ID: 400756  Cd Length: 70  Bit Score: 65.83  E-value: 2.81e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005345  1 MHPDLSPHLHtEECNVLINLLKECHKNHNILKFFGYCNDVDRELRKCLKNEYVENRTKSREHGIAMRKKL 70
Cdd:pfam08583  1 MHPQLRKKAF-KKCAELIKALAECHKGGRTLKAFGKCNKEKRAMNKCLREYRTDEALRDRERDREIKERL 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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