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Conserved domains on  [gi|1677531564|ref|NP_001339573|]
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pericentriolar material 1 protein isoform 16 [Homo sapiens]

Protein Classification

pericentriolar material 1 protein( domain architecture ID 12174360)

pericentriolar material 1 protein (PCM-1) is required for centrosome assembly and function

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PCM1_C pfam15717
Pericentriolar material 1 C terminus;
1317-1943 0e+00

Pericentriolar material 1 C terminus;


:

Pssm-ID: 464821  Cd Length: 615  Bit Score: 837.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1317 GSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK-GENVKSVNSG 1395
Cdd:pfam15717    1 SSDFSLFEALRETIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVTRHLTEKSAKeDQCTPPLGSA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1396 TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDA---DNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREY 1472
Cdd:pfam15717   81 AWAASNSELTPSESLATSDDEVVEKNLRMPACTEKRRNDAdsvDNDSTMSTSSNLEPFANDDLGNTVIHLDKALARMREY 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1473 ERMKTEAESNSNMRCTCriiedgdgAGAGTTVNNLEETPVIENRSSQQPvSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF 1552
Cdd:pfam15717  161 ERMKLEAEFNPDSASPA--------SATTSAASSAEGPSANPAESTEGS-GAASDVPCPRIDTQQLDRQIKAIMTEVIPF 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1553 LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFF 1632
Cdd:pfam15717  232 LKEHMDEVCSPQLLTSVRRMVLTLTQQNDESKEFVRFFHKQLGGILQDSLSKFVGRKLKDCGEDLLVEISEILFNELAFF 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1633 KLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQtSEVYDG---PKNVR 1709
Cdd:pfam15717  312 RLMQDLDNSSSAVKQKCKRKSEAAGPKQSGAKEEKKTLGGDKSSSPEYTDEDKDQDETETAKHTL-QELYLQtevKSSKS 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1710 SDISDQEEDE----ESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEhdeqvlq 1785
Cdd:pfam15717  391 SDASEGQEEEedeeMGEELPLSISLSKAETQALTNYGSGEDENEEEEIEEFEAGPVDVQTSLQASADGQDENE------- 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1786 rdfkktAESKNVPLER-EATSKNDQNNCPVKPCYLNILEDEQPLNSAAhKESPPTVDSTQQPNPLPLRLPEMEPLVPRVK 1864
Cdd:pfam15717  464 ------QESGQVSSEQpEETSSEQKGSLPALPHQLSPVGPLEAHESVV-TVDSPVEEHSFKPSSLPENEGGAAASGTASE 536
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1677531564 1865 EVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEI 1943
Cdd:pfam15717  537 GSKSQVVTPESSETSSPDTESPVLVNVDEAGSGNTSQKSDEEDFVKVEDLPLQLTVMCEEELQKRIVEEQQNNNLSVEI 615
 
Name Accession Description Interval E-value
PCM1_C pfam15717
Pericentriolar material 1 C terminus;
1317-1943 0e+00

Pericentriolar material 1 C terminus;


Pssm-ID: 464821  Cd Length: 615  Bit Score: 837.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1317 GSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK-GENVKSVNSG 1395
Cdd:pfam15717    1 SSDFSLFEALRETIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVTRHLTEKSAKeDQCTPPLGSA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1396 TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDA---DNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREY 1472
Cdd:pfam15717   81 AWAASNSELTPSESLATSDDEVVEKNLRMPACTEKRRNDAdsvDNDSTMSTSSNLEPFANDDLGNTVIHLDKALARMREY 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1473 ERMKTEAESNSNMRCTCriiedgdgAGAGTTVNNLEETPVIENRSSQQPvSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF 1552
Cdd:pfam15717  161 ERMKLEAEFNPDSASPA--------SATTSAASSAEGPSANPAESTEGS-GAASDVPCPRIDTQQLDRQIKAIMTEVIPF 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1553 LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFF 1632
Cdd:pfam15717  232 LKEHMDEVCSPQLLTSVRRMVLTLTQQNDESKEFVRFFHKQLGGILQDSLSKFVGRKLKDCGEDLLVEISEILFNELAFF 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1633 KLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQtSEVYDG---PKNVR 1709
Cdd:pfam15717  312 RLMQDLDNSSSAVKQKCKRKSEAAGPKQSGAKEEKKTLGGDKSSSPEYTDEDKDQDETETAKHTL-QELYLQtevKSSKS 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1710 SDISDQEEDE----ESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEhdeqvlq 1785
Cdd:pfam15717  391 SDASEGQEEEedeeMGEELPLSISLSKAETQALTNYGSGEDENEEEEIEEFEAGPVDVQTSLQASADGQDENE------- 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1786 rdfkktAESKNVPLER-EATSKNDQNNCPVKPCYLNILEDEQPLNSAAhKESPPTVDSTQQPNPLPLRLPEMEPLVPRVK 1864
Cdd:pfam15717  464 ------QESGQVSSEQpEETSSEQKGSLPALPHQLSPVGPLEAHESVV-TVDSPVEEHSFKPSSLPENEGGAAASGTASE 536
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1677531564 1865 EVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEI 1943
Cdd:pfam15717  537 GSKSQVVTPESSETSSPDTESPVLVNVDEAGSGNTSQKSDEEDFVKVEDLPLQLTVMCEEELQKRIVEEQQNNNLSVEI 615
 
Name Accession Description Interval E-value
PCM1_C pfam15717
Pericentriolar material 1 C terminus;
1317-1943 0e+00

Pericentriolar material 1 C terminus;


Pssm-ID: 464821  Cd Length: 615  Bit Score: 837.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1317 GSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK-GENVKSVNSG 1395
Cdd:pfam15717    1 SSDFSLFEALRETIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVTRHLTEKSAKeDQCTPPLGSA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1396 TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDA---DNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREY 1472
Cdd:pfam15717   81 AWAASNSELTPSESLATSDDEVVEKNLRMPACTEKRRNDAdsvDNDSTMSTSSNLEPFANDDLGNTVIHLDKALARMREY 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1473 ERMKTEAESNSNMRCTCriiedgdgAGAGTTVNNLEETPVIENRSSQQPvSEVSTIPCPRIDTQQLDRQIKAIMKEVIPF 1552
Cdd:pfam15717  161 ERMKLEAEFNPDSASPA--------SATTSAASSAEGPSANPAESTEGS-GAASDVPCPRIDTQQLDRQIKAIMTEVIPF 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1553 LKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFF 1632
Cdd:pfam15717  232 LKEHMDEVCSPQLLTSVRRMVLTLTQQNDESKEFVRFFHKQLGGILQDSLSKFVGRKLKDCGEDLLVEISEILFNELAFF 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1633 KLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQtSEVYDG---PKNVR 1709
Cdd:pfam15717  312 RLMQDLDNSSSAVKQKCKRKSEAAGPKQSGAKEEKKTLGGDKSSSPEYTDEDKDQDETETAKHTL-QELYLQtevKSSKS 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1710 SDISDQEEDE----ESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEhdeqvlq 1785
Cdd:pfam15717  391 SDASEGQEEEedeeMGEELPLSISLSKAETQALTNYGSGEDENEEEEIEEFEAGPVDVQTSLQASADGQDENE------- 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677531564 1786 rdfkktAESKNVPLER-EATSKNDQNNCPVKPCYLNILEDEQPLNSAAhKESPPTVDSTQQPNPLPLRLPEMEPLVPRVK 1864
Cdd:pfam15717  464 ------QESGQVSSEQpEETSSEQKGSLPALPHQLSPVGPLEAHESVV-TVDSPVEEHSFKPSSLPENEGGAAASGTASE 536
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1677531564 1865 EVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEI 1943
Cdd:pfam15717  537 GSKSQVVTPESSETSSPDTESPVLVNVDEAGSGNTSQKSDEEDFVKVEDLPLQLTVMCEEELQKRIVEEQQNNNLSVEI 615
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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