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Conserved domains on  [gi|1217323391|ref|NP_001340565|]
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NEDD4-binding protein 2-like 1 isoform 14 [Homo sapiens]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4639 super family cl44097
Predicted kinase [General function prediction only];
41-77 1.66e-08

Predicted kinase [General function prediction only];


The actual alignment was detected with superfamily member COG4639:

Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.06  E-value: 1.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1217323391  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF 77
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDI 34
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 45-115 5.86e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd00009:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 151  Bit Score: 34.43  E-value: 5.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1217323391  45 YLLRGLPGSGKTTLARQLQHdfpraLIFSTDDFFFREDGAYEFNPDFLEEAHEWNQKREETFMVSQEKKST 115
Cdd:cd00009    22 LLLYGPPGTGKTTLARAIAN-----ELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGV 87
 
Name Accession Description Interval E-value
COG4639 COG4639
Predicted kinase [General function prediction only];
41-77 1.66e-08

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.06  E-value: 1.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1217323391  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF 77
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDI 34
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 47-82 2.78e-05

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 41.16  E-value: 2.78e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1217323391  47 LRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFRED 82
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPED 39
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-102 5.50e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.99  E-value: 5.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1217323391  44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKR 102
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHEL 62
PRK06762 PRK06762
hypothetical protein; Provisional
 44-71 5.84e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 37.26  E-value: 5.84e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1217323391  44 LYLLRGLPGSGKTTLARQLQHDFPR--ALI 71
Cdd:PRK06762    4 LIIIRGNSGSGKTTIAKQLQERLGRgtLLV 33
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-78 1.30e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 1.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1217323391   41 RKHLYLLRGLPGSGKTTL----ARQLQHDFPRALIFSTDDFF 78
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLaralARELGPPGGGVIYIDGEDIL 42
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 45-115 5.86e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 34.43  E-value: 5.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1217323391  45 YLLRGLPGSGKTTLARQLQHdfpraLIFSTDDFFFREDGAYEFNPDFLEEAHEWNQKREETFMVSQEKKST 115
Cdd:cd00009    22 LLLYGPPGTGKTTLARAIAN-----ELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGV 87
 
Name Accession Description Interval E-value
COG4639 COG4639
Predicted kinase [General function prediction only];
41-77 1.66e-08

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 49.06  E-value: 1.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1217323391  41 RKHLYLLRGLPGSGKTTLARQLqhdFPRALIFSTDDF 77
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRL---FAPTEVVSSDDI 34
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
44-76 1.16e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.52  E-value: 1.16e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1217323391  44 LYLLRGLPGSGKTTLARQLQHDFPrALIFSTDD 76
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLG-AVRLRSDV 32
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 44-97 1.89e-05

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 41.64  E-value: 1.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1217323391  44 LYLLRGLPGSGKTTLARQLQHDFPR----ALIFSTDDffFREDGAYEFNPDfleEAHE 97
Cdd:COG4088     6 LLILTGPPGSGKTTFAKALAQRLYAegiaVALLHSDD--FRRFLVNESFPK---ETYE 58
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 49-98 2.02e-05

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 41.75  E-value: 2.02e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1217323391  49 GLPGSGKTTLARQLQHDFP--RALIFSTDDFFF-REDGAYE--FNPDFLE-EAHEW 98
Cdd:COG0572    14 GPSGSGKTTFARRLAEQLGadKVVVISLDDYYKdREHLPLDerGKPNFDHpEAFDL 69
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 47-82 2.78e-05

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 41.16  E-value: 2.78e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1217323391  47 LRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFRED 82
Cdd:cd02024     4 ISGVTNSGKTTLAKLLQRILPNCCVIHQDDFFKPED 39
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 44-102 5.50e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 39.99  E-value: 5.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1217323391  44 LYLLRGLPGSGKTTLARQLqHDFPRALIFSTDDFFFR----EDGAYEFNPDFLEEAHEWNQKR 102
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRL-LEELGAVRLSSDDERKRlfgeGRPSISYYTDATDRTYERLHEL 62
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 41-61 2.22e-04

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 38.87  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|.
gi 1217323391  41 RKHLYLLRGLPGSGKTTLARQ 61
Cdd:cd19488    18 PRRLYLVEGAPGTGKTTLALQ 38
PRK06762 PRK06762
hypothetical protein; Provisional
 44-71 5.84e-04

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 37.26  E-value: 5.84e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1217323391  44 LYLLRGLPGSGKTTLARQLQHDFPR--ALI 71
Cdd:PRK06762    4 LIIIRGNSGSGKTTIAKQLQERLGRgtLLV 33
pseT PHA02530
polynucleotide kinase; Provisional
 42-88 6.65e-04

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 37.69  E-value: 6.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1217323391  42 KHLYLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFF-----REDGAYEFN 88
Cdd:PHA02530    2 MKIILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLRQslfghGEWGEYKFT 53
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 41-62 1.23e-03

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 36.68  E-value: 1.23e-03
                          10        20
                  ....*....|....*....|..
gi 1217323391  41 RKHLyLLRGLPGSGKTTLARQL 62
Cdd:COG0714    31 GGHL-LLEGVPGVGKTTLAKAL 51
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 41-78 1.30e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.20  E-value: 1.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1217323391   41 RKHLYLLRGLPGSGKTTL----ARQLQHDFPRALIFSTDDFF 78
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLaralARELGPPGGGVIYIDGEDIL 42
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 41-93 1.31e-03

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 36.57  E-value: 1.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1217323391  41 RKHLYLLRGLPGSGKTTLARQLQHDFPR---ALIFSTDDffFRedgayEFNPDFLE 93
Cdd:pfam06414  10 RPKAILLGGQPGAGKTELARALLDELGRqgnVVRIDPDD--FR-----ELHPHYRE 58
PRK08233 PRK08233
hypothetical protein; Provisional
 49-79 2.28e-03

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 35.87  E-value: 2.28e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1217323391  49 GLPGSGKTTLARQLQHDFPRALIFSTDDFFF 79
Cdd:PRK08233   10 AVSGGGKTTLTERLTHKLKNSKALYFDRYDF 40
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 45-115 5.86e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 34.43  E-value: 5.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1217323391  45 YLLRGLPGSGKTTLARQLQHdfpraLIFSTDDFFFREDGAYEFNPDFLEEAHEWNQKREETFMVSQEKKST 115
Cdd:cd00009    22 LLLYGPPGTGKTTLARAIAN-----ELFRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGV 87
AAA_24 pfam13479
AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.
 45-76 6.27e-03

AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.


Pssm-ID: 433243  Cd Length: 199  Bit Score: 34.61  E-value: 6.27e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1217323391  45 YLLRGLPGSGKTTLARQlqhdFPRALIFSTDD 76
Cdd:pfam13479   5 ILIYGPSGIGKTTFAKT----LPKPLFLDTEK 32
KTI12 pfam08433
Chromatin associated protein KTI12; This is a family of chromatin associated proteins which ...
 44-63 6.30e-03

Chromatin associated protein KTI12; This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II. The Elongator complex has histone acetyltransferase activity.


Pssm-ID: 400643  Cd Length: 269  Bit Score: 34.58  E-value: 6.30e-03
                          10        20
                  ....*....|....*....|
gi 1217323391  44 LYLLRGLPGSGKTTLARQLQ 63
Cdd:pfam08433   1 LVLLTGLPSSGKSTRAKQLA 20
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 49-64 6.71e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 34.29  E-value: 6.71e-03
                          10
                  ....*....|....*.
gi 1217323391  49 GLPGSGKTTLARQLQH 64
Cdd:COG0529    23 GLSGSGKSTLANALER 38
AAA_17 pfam13207
AAA domain;
49-81 8.58e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 33.75  E-value: 8.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1217323391  49 GLPGSGKTTLARQLQH--DFPralIFSTDDFFFRE 81
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEklGFP---HISAGDLLREE 33
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 44-66 8.87e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 32.69  E-value: 8.87e-03
                          10        20
                  ....*....|....*....|...
gi 1217323391  44 LYLLRGLPGSGKTTLARQLQHDF 66
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQL 23
aroK PRK00131
shikimate kinase; Reviewed
 41-66 9.76e-03

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 34.01  E-value: 9.76e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1217323391  41 RKHLYLLrGLPGSGKTT----LARQLQHDF 66
Cdd:PRK00131    4 GPNIVLI-GFMGAGKSTigrlLAKRLGYDF 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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