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Conserved domains on  [gi|1219862434|ref|NP_001340749|]
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zinc finger protein 334 isoform d [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-669 8.12e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 8.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 314 KSYECNECGKTFFRKSALAEHFRSHTGEKPYEC--KECGNAFSKKSYLVVHQRTHRGEKPNECKECGKTffCQSALTAHQ 391
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 392 RIHTGEKPYECSECEKTFFCQSAL-----NVHRRSHTGEKPYECSQCGKFLCTKSALIAHQITHrgkksyecNECGKFFC 466
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRdpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA--------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 467 HKSTLTIHQRTHTGEKHGVFNKCGRISIVKSNCSQCKRMNTKENLYECSEHGHAVSKN----SHLIVHQRTIWERPYECN 542
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 543 ECGRTY---CRKSALTHHQRTHTGQR-PYECNECGKTFCQKFSFVEHQRT--HTGE--KPYECNE--CGKSFCHKSAFRV 612
Cdd:COG5048   262 RSSLPTassQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1219862434 613 HRRIHTGEKPYEC--NQCGKTYRRL-----WTLTEHQKIHTGEKPYEC--NKCEKTFRHKSNFLLH 669
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH 407
KRAB super family cl42959
krueppel associated box;
45-65 2.36e-06

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 45.28  E-value: 2.36e-06
                           10        20
                   ....*....|....*....|.
gi 1219862434   45 GYHVSKPDVIFKLEQGEEPWI 65
Cdd:smart00349  41 GFQVPKPDLISQLEQGEEPWI 61
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 286-335 5.37e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 5.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1219862434 286 RPYeCSECRKTFIDKSALIVHQKihggEKSYECNECGKTFFRKSALAEHF 335
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-669 8.12e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 8.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 314 KSYECNECGKTFFRKSALAEHFRSHTGEKPYEC--KECGNAFSKKSYLVVHQRTHRGEKPNECKECGKTffCQSALTAHQ 391
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 392 RIHTGEKPYECSECEKTFFCQSAL-----NVHRRSHTGEKPYECSQCGKFLCTKSALIAHQITHrgkksyecNECGKFFC 466
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRdpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA--------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 467 HKSTLTIHQRTHTGEKHGVFNKCGRISIVKSNCSQCKRMNTKENLYECSEHGHAVSKN----SHLIVHQRTIWERPYECN 542
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 543 ECGRTY---CRKSALTHHQRTHTGQR-PYECNECGKTFCQKFSFVEHQRT--HTGE--KPYECNE--CGKSFCHKSAFRV 612
Cdd:COG5048   262 RSSLPTassQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1219862434 613 HRRIHTGEKPYEC--NQCGKTYRRL-----WTLTEHQKIHTGEKPYEC--NKCEKTFRHKSNFLLH 669
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH 407
KRAB smart00349
krueppel associated box;
45-65 2.36e-06

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 45.28  E-value: 2.36e-06
                           10        20
                   ....*....|....*....|.
gi 1219862434   45 GYHVSKPDVIFKLEQGEEPWI 65
Cdd:smart00349  41 GFQVPKPDLISQLEQGEEPWI 61
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 286-335 5.37e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 5.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1219862434 286 RPYeCSECRKTFIDKSALIVHQKihggEKSYECNECGKTFFRKSALAEHF 335
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-297 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....
gi 1219862434 274 SLTRHRRIHTGERPYECSECRKTF 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-669 8.12e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 8.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 314 KSYECNECGKTFFRKSALAEHFRSHTGEKPYEC--KECGNAFSKKSYLVVHQRTHRGEKPNECKECGKTffCQSALTAHQ 391
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 392 RIHTGEKPYECSECEKTFFCQSAL-----NVHRRSHTGEKPYECSQCGKFLCTKSALIAHQITHrgkksyecNECGKFFC 466
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRdpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA--------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 467 HKSTLTIHQRTHTGEKHGVFNKCGRISIVKSNCSQCKRMNTKENLYECSEHGHAVSKN----SHLIVHQRTIWERPYECN 542
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 543 ECGRTY---CRKSALTHHQRTHTGQR-PYECNECGKTFCQKFSFVEHQRT--HTGE--KPYECNE--CGKSFCHKSAFRV 612
Cdd:COG5048   262 RSSLPTassQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1219862434 613 HRRIHTGEKPYEC--NQCGKTYRRL-----WTLTEHQKIHTGEKPYEC--NKCEKTFRHKSNFLLH 669
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLH 407
KRAB smart00349
krueppel associated box;
45-65 2.36e-06

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 45.28  E-value: 2.36e-06
                           10        20
                   ....*....|....*....|.
gi 1219862434   45 GYHVSKPDVIFKLEQGEEPWI 65
Cdd:smart00349  41 GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-675 7.67e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 7.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 258 KPYVCSDCRKTFRVKTSLTRHRRIHTGERPYECS--ECRKTFIDKSALIVHQKIHGGEKSYECNECGKTFFRKSALAEHF 335
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 336 RSHTGE-KPYECKECGNAFSKKSYLV--VHQRTHRGEKPNEcKECGKTFFCQSALTAHQRIHTGEKPyecseceKTFFCQ 412
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLP-GNNSSSVNTPQSNSLHPPLPANSLS-------KDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 413 SALNVHRRSHTGEKPYECSQCGKFLCTKSALIAHQITHRGKKSYECNECGkFFCHKStLTIHQRTHTGEKHgvfnkcgri 492
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKS-LLSQSPSSLSSSD--------- 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 493 sivksNCSQCKRMNTKENLYEcsehGHAVSKNSHLIVHQRTIWERPYECNECGRTYCRKSALTHHQRT--HTGQ--RPYE 568
Cdd:COG5048   253 -----SSSSASESPRSSLPTA----SSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFS 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 569 CNE--CGKTFCQKFSFVEHQRTHTGEKPYEC--NECGKSFCHKS-----AFRVHRRIHTGEKPYEC--NQCGKTYRRLWT 637
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSN 403

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1219862434 638 LTEHQKIHTGEKPYECN--KCEKTFRHKSNFLLHQKSHKE 675
Cdd:COG5048   404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-661 1.90e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 221 TQKGRQTERKPNECNECRKTFSKRSTLIVHQRIHTGEKPYVCSD--CRKTFRVKTSLTRHRRIHTGERPYECS-ECRKTF 297
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 298 IDKSALIVHQKIHGGEKSYECNECGKTFFRKSALAEHFRSHTgeKPYECKECGNAFSKKSYLVVHQRTHRGEKPNECKEc 377
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 378 gkTFFCQSALTAHQRIHTGEKPYECSECEKtffcQSALNVHRRSHTGEKPYECSQCGKFLCTKSALIAHQITHRGKKSYE 457
Cdd:COG5048   180 --PSSNLSLLISSNVSTSIPSSSENSPLSS----SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 458 CNECGKFFCHKSTLTIHQRTHTGEKHGVFNKCGRISIVKSNCSQCkrmntkenlyeCSEHGHAVSKNSHLIVHQRTIweR 537
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS-----------FSRSSPLTRHLRSVNHSGESL--K 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219862434 538 PYECNE--CGRTYCRKSALTHHQRTHTGQRPYEC--NECGKTFCQK-----FSFVEHQRTHTGEKPYEC--NECGKSFCH 606
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1219862434 607 KSAFRVHRRIHTGEKPYECN--QCGKTYRRLWTLTEHQKIHTGEKPYECNKCEKTFR 661
Cdd:COG5048   401 DSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 286-335 5.37e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 5.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1219862434 286 RPYeCSECRKTFIDKSALIVHQKihggEKSYECNECGKTFFRKSALAEHF 335
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-297 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....
gi 1219862434 274 SLTRHRRIHTGERPYECSECRKTF 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-604 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....
gi 1219862434 581 SFVEHQRTHTGEKPYECNECGKSF 604
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 2.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.82e-03
                          10        20
                  ....*....|....*....|....*.
gi 1219862434 330 ALAEHFRSHTGEKPYECKECGNAFSK 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
638-662 4.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1219862434 638 LTEHQKIHTGEKPYECNKCEKTFRH 662
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 456-478 6.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|...
gi 1219862434 456 YECNECGKFFCHKSTLTIHQRTH 478
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-409 6.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.70e-03
                          10        20
                  ....*....|....*....|....
gi 1219862434 386 ALTAHQRIHTGEKPYECSECEKTF 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 539-561 7.42e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.42e-03
                          10        20
                  ....*....|....*....|...
gi 1219862434 539 YECNECGRTYCRKSALTHHQRTH 561
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
609-634 8.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 1219862434 609 AFRVHRRIHTGEKPYECNQCGKTYRR 634
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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