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Conserved domains on  [gi|1220516010|ref|NP_001340809|]
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transmembrane 6 superfamily member 1 isoform 6 [Homo sapiens]

Protein Classification

DUF2781 domain-containing protein( domain architecture ID 15340014)

DUF2781 domain-containing protein similar to Homo sapiens sigma intracellular receptor 2 (also known as transmembrane protein 97, TMEM97) that corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM6SF1-like cd21106
transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes ...
 1-238 8.33e-129

transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).


:

Pssm-ID: 411047  Cd Length: 356  Bit Score: 368.43  E-value: 8.33e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010   1 MTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAF 80
Cdd:cd21106    88 MEFYLKEGEPYLNTAHGTMICYWDGIVHYLLYLMMIAAISWNKSYREVGLYWVGSILNSMIVLLPGAVIGKYGSEIRPSF 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010  81 FLSIPYTCLPVWAGFRIYNQPSENYNyPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGL--------------- 145
Cdd:cd21106   168 LLNVPYVLLPIWAGVRLLHQPRQQPS-TADAVEAEQKKSLLKRPLDLLLVLYLLLAIFFTVFRGLaalgcpadlcftylk 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010 146 ----------------MLAYMFYSVPYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEA 209
Cdd:cd21106   247 qyepylkdpsafpkvqMLVYLFYFVPYYLLAIYGLLVPGCSWMPDWSLIHAGAAAQAQFSHIGASLHSRTPYTYRVPSDG 326

                         250       260
                  ....*....|....*....|....*....
gi 1220516010 210 KILFLALNIAYGVLPQLLAYRCIYKPEFF 238
Cdd:cd21106   327 RWAFWLINLLLLVVPQLLAYRCLRDPEFF 355
 
Name Accession Description Interval E-value
TM6SF1-like cd21106
transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes ...
 1-238 8.33e-129

transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).


Pssm-ID: 411047  Cd Length: 356  Bit Score: 368.43  E-value: 8.33e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010   1 MTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAF 80
Cdd:cd21106    88 MEFYLKEGEPYLNTAHGTMICYWDGIVHYLLYLMMIAAISWNKSYREVGLYWVGSILNSMIVLLPGAVIGKYGSEIRPSF 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010  81 FLSIPYTCLPVWAGFRIYNQPSENYNyPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGL--------------- 145
Cdd:cd21106   168 LLNVPYVLLPIWAGVRLLHQPRQQPS-TADAVEAEQKKSLLKRPLDLLLVLYLLLAIFFTVFRGLaalgcpadlcftylk 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010 146 ----------------MLAYMFYSVPYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEA 209
Cdd:cd21106   247 qyepylkdpsafpkvqMLVYLFYFVPYYLLAIYGLLVPGCSWMPDWSLIHAGAAAQAQFSHIGASLHSRTPYTYRVPSDG 326

                         250       260
                  ....*....|....*....|....*....
gi 1220516010 210 KILFLALNIAYGVLPQLLAYRCIYKPEFF 238
Cdd:cd21106   327 RWAFWLINLLLLVVPQLLAYRCLRDPEFF 355
EBP pfam05241
EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved ...
 141-231 2.73e-05

EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved among the following protein families: TM6SF1 (Transmembrane 6 Superfamily Member 1), TM6SF2 (Transmembrane 6 Superfamily Member 2), MAC30 (Meningioma-associated protein 30 also known as TMEM97, or Transmembrane protein 97), and EBP (Emopamil binding protein). EBP is an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. Mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.


Pssm-ID: 461600  Cd Length: 112  Bit Score: 42.14  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010 141 LFRGLMLAYMFYSVPYFVTALYGLVvpgCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEA---KILFLALN 217
Cdd:pfam05241  22 PFVSFELLEAFFQGPLFFLAAYALL---KSPWRLLLLRYALQTATTTLQCYGDVLYFATEWLEGGLSLSrpfWVYLVFLN 98

                          90
                  ....*....|....
gi 1220516010 218 IAYGVLPQLLAYRC 231
Cdd:pfam05241  99 LPWLVIPLLLLVDS 112
 
Name Accession Description Interval E-value
TM6SF1-like cd21106
transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes ...
 1-238 8.33e-129

transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).


Pssm-ID: 411047  Cd Length: 356  Bit Score: 368.43  E-value: 8.33e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010   1 MTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAF 80
Cdd:cd21106    88 MEFYLKEGEPYLNTAHGTMICYWDGIVHYLLYLMMIAAISWNKSYREVGLYWVGSILNSMIVLLPGAVIGKYGSEIRPSF 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010  81 FLSIPYTCLPVWAGFRIYNQPSENYNyPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGL--------------- 145
Cdd:cd21106   168 LLNVPYVLLPIWAGVRLLHQPRQQPS-TADAVEAEQKKSLLKRPLDLLLVLYLLLAIFFTVFRGLaalgcpadlcftylk 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010 146 ----------------MLAYMFYSVPYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEA 209
Cdd:cd21106   247 qyepylkdpsafpkvqMLVYLFYFVPYYLLAIYGLLVPGCSWMPDWSLIHAGAAAQAQFSHIGASLHSRTPYTYRVPSDG 326

                         250       260
                  ....*....|....*....|....*....
gi 1220516010 210 KILFLALNIAYGVLPQLLAYRCIYKPEFF 238
Cdd:cd21106   327 RWAFWLINLLLLVVPQLLAYRCLRDPEFF 355
EBP pfam05241
EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved ...
 141-231 2.73e-05

EXPERA (EXPanded EBP superfamily); The EXPERA (EXPanded EBP superfamily) domain is conserved among the following protein families: TM6SF1 (Transmembrane 6 Superfamily Member 1), TM6SF2 (Transmembrane 6 Superfamily Member 2), MAC30 (Meningioma-associated protein 30 also known as TMEM97, or Transmembrane protein 97), and EBP (Emopamil binding protein). EBP is an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. Mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.


Pssm-ID: 461600  Cd Length: 112  Bit Score: 42.14  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516010 141 LFRGLMLAYMFYSVPYFVTALYGLVvpgCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEA---KILFLALN 217
Cdd:pfam05241  22 PFVSFELLEAFFQGPLFFLAAYALL---KSPWRLLLLRYALQTATTTLQCYGDVLYFATEWLEGGLSLSrpfWVYLVFLN 98

                          90
                  ....*....|....
gi 1220516010 218 IAYGVLPQLLAYRC 231
Cdd:pfam05241  99 LPWLVIPLLLLVDS 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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