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Conserved domains on  [gi|1220516031|ref|NP_001340833|]
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katanin p60 ATPase-containing subunit A-like 2 isoform 7 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 14291541)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to yeast Pch2 which is required for the meiotic checkpoint that prevents chromosome segregation when recombination and chromosome synapsis are defective, and to IQCA1 (dynein regulatory complex subunit 11) which is an ATPase subunit of the nexin-dynein regulatory complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 127-276 1.82e-74

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19509:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 163  Bit Score: 228.78  E-value: 1.82e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 127 AVV--SRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:cd19509    14 AVIlpSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARELQPS 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 205 TIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19509    94 IIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVlNKPEDRVLVLGATNRPWELDEAFLRRFEKRIYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 54-378 3.34e-73

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 231.43  E-value: 3.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  54 LHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGA--TSELALNTFDHNPDPSERLLKP---LSAFIGMNSEMRELAAV 128
Cdd:COG1222    14 LLALIDALQERLGVELALLLQPVKALELLEEAPALLlnDANLTQKRLGTPRGTAVPAESPdvtFDDIGGLDEQIEEIREA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 129 VS---RYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:COG1222    94 VElplKNPELFRKYgIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPS 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 205 TIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILVDLPSRE 282
Cdd:COG1222   174 IIFIDEIDAIAARRT--DDGTSGEVQRTVNQLLAELDGFESRGD-VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEE 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 283 ARQAMIYHWLppvsksRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKifdalenhqsessdlpriQLDIVT 362
Cdd:COG1222   251 AREEILKIHL------RDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE------------------GRDTVT 306

                         330
                  ....*....|....*.
gi 1220516031 363 TADFLDVLTHTKPSAK 378
Cdd:COG1222   307 MEDLEKAIEKVKKKTE 322
 
Name Accession Description Interval E-value
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 127-276 1.82e-74

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 228.78  E-value: 1.82e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 127 AVV--SRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:cd19509    14 AVIlpSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARELQPS 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 205 TIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19509    94 IIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVlNKPEDRVLVLGATNRPWELDEAFLRRFEKRIYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 54-378 3.34e-73

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 231.43  E-value: 3.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  54 LHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGA--TSELALNTFDHNPDPSERLLKP---LSAFIGMNSEMRELAAV 128
Cdd:COG1222    14 LLALIDALQERLGVELALLLQPVKALELLEEAPALLlnDANLTQKRLGTPRGTAVPAESPdvtFDDIGGLDEQIEEIREA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 129 VS---RYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:COG1222    94 VElplKNPELFRKYgIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPS 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 205 TIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILVDLPSRE 282
Cdd:COG1222   174 IIFIDEIDAIAARRT--DDGTSGEVQRTVNQLLAELDGFESRGD-VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEE 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 283 ARQAMIYHWLppvsksRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKifdalenhqsessdlpriQLDIVT 362
Cdd:COG1222   251 AREEILKIHL------RDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE------------------GRDTVT 306

                         330
                  ....*....|....*.
gi 1220516031 363 TADFLDVLTHTKPSAK 378
Cdd:COG1222   307 MEDLEKAIEKVKKKTE 322
cell_div_CdvC NF041006
cell division protein CdvC;
127-391 1.61e-62

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 204.97  E-value: 1.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 127 AVV--SRYPQLFtgilsP--W-KGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYH 201
Cdd:NF041006  118 AIVypSKRPDLF-----PlgWpRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREK 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 202 A-----PSTIFLDELESVMSQRGTASGGEhegsLRMKTELLVQMDGLA-RSEDL-VFVLAASNLPWELDCAMLRRLEKRI 274
Cdd:NF041006  193 SkeegkPAIIFIDEIDALLGVYSSEVGGE----VRVRNQFLKEMDGLQdKSENYhVYVIGATNKPWRLDEPFLRRFQKRI 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 275 LVDLPSREARQAMIYHWlppvskSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFdalENHQSEssdlP 354
Cdd:NF041006  269 YIPLPDREQRLELLKYY------TSKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMF---EKGLGE----P 335

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1220516031 355 RiqldIVTTADFLDVLTHTKPSA-KNLAQRYSDWQREF 391
Cdd:NF041006  336 R----PITMEDFKEVLKIRKPSVnQEMLKAYEAWHEKF 369
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 111-379 1.11e-55

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 188.20  E-value: 1.11e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 111 PLSAFIGMNS---EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGD 186
Cdd:COG0464   155 ILDDLGGLEEvkeELRELVALPLKRPELREEYgLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 187 SEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEgslRMKTELLVQMDGLarsEDLVFVLAASNLPWELDCAM 266
Cdd:COG0464   235 TEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGR---RVVNTLLTEMEEL---RSDVVVIAATNRPDLLDPAL 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 267 LRRLEKRILVDLPSREARQAMIYHWLPPvsksraLELHTELEYSVLSQETEGYSGSDIKLVCREAAMRpvrkifdALenh 346
Cdd:COG0464   309 LRRFDEIIFFPLPDAEERLEIFRIHLRK------RPLDEDVDLEELAEATEGLSGADIRNVVRRAALQ-------AL--- 372

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1220516031 347 qsessdlpRIQLDIVTTADFLDVLTHTKPSAKN 379
Cdd:COG0464   373 --------RLGREPVTTEDLLEALEREDIFLKR 397
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 121-394 1.23e-52

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 186.65  E-value: 1.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMgIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGgeHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLPWELDCAMLR--RLEKRILVD 277
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFD--TSVTDRIVNQLLTEMDGIQELSNVV-VIAATNRPDILDPALLRpgRFDRLILVP 620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 278 LPSREARQAMI-YHwlppvskSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRI 356
Cdd:TIGR01243 621 PPDEEARKEIFkIH-------TRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKEKLEVGEEEFL 693

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1220516031 357 QLDIVTTADFLDVLTHTKPS-AKNLAQRYSDWQREFESV 394
Cdd:TIGR01243 694 KDLKVEMRHFLEALKKVKPSvSKEDMLRYERLAKELKRL 732
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 117-368 1.85e-49

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 171.55  E-value: 1.85e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNSEMRELAAVVS---RYPQLFT--GIlSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 191
Cdd:PRK03992  135 GLEEQIREVREAVElplKKPELFEevGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLV 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 192 RVLFELARYHAPSTIFLDELESVMSQR---GTasGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR 268
Cdd:PRK03992  214 RELFELAREKAPSIIFIDEIDAIAAKRtdsGT--SGDREVQ-RTLMQLLAEMDGFDPRGN-VKIIAATNRIDILDPAILR 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 269 --RLEKRILVDLPSREARqAMIyhwlppvsksraLELHT-------ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRki 339
Cdd:PRK03992  290 pgRFDRIIEVPLPDEEGR-LEI------------LKIHTrkmnladDVDLEELAELTEGASGADLKAICTEAGMFAIR-- 354

                         250       260
                  ....*....|....*....|....*....
gi 1220516031 340 fdalENHqsessdlpriqlDIVTTADFLD 368
Cdd:PRK03992  355 ----DDR------------TEVTMEDFLK 367
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 146-278 1.88e-48

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 160.45  E-value: 1.88e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGE 225
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 226 HEgslRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDL 278
Cdd:pfam00004  81 SR---RVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 142-279 4.45e-15

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 72.02  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  142 PWKGLLLYGPPGTGKTLLAKAVATECKTT---FFNISASTI--------------VSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1220516031  205 TIFLDELESVMSQRGTAsggehegsLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLP 279
Cdd:smart00382  81 VLILDEITSLLDAEQEA--------LLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLI 147
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 306-350 2.21e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 2.21e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1220516031 306 ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSES 350
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQEDLEE 45
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 146-211 3.30e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 41.69  E-value: 3.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATEC-----KTTFFniSASTIVSKWRG--DSEKLVRVLFELARYHApstIFLDEL 211
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFT--TAADLVEQLAQarADGRLGRLLRRLARYDL---LIIDEL 160
 
Name Accession Description Interval E-value
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 127-276 1.82e-74

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 228.78  E-value: 1.82e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 127 AVV--SRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:cd19509    14 AVIlpSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARELQPS 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 205 TIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19509    94 IIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVlNKPEDRVLVLGATNRPWELDEAFLRRFEKRIYI 163
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 133-276 2.12e-73

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 226.40  E-value: 2.12e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 133 PQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELE 212
Cdd:cd19522    23 PEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEID 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 213 SVMSQRGTasGGEHEGSLRMKTELLVQMDGLARSED------LVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19522   103 SICSRRGT--SEEHEASRRVKSELLVQMDGVGGASEnddpskMVMVLAATNFPWDIDEALRRRLEKRIYI 170
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 54-378 3.34e-73

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 231.43  E-value: 3.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  54 LHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGA--TSELALNTFDHNPDPSERLLKP---LSAFIGMNSEMRELAAV 128
Cdd:COG1222    14 LLALIDALQERLGVELALLLQPVKALELLEEAPALLlnDANLTQKRLGTPRGTAVPAESPdvtFDDIGGLDEQIEEIREA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 129 VS---RYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:COG1222    94 VElplKNPELFRKYgIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPS 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 205 TIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILVDLPSRE 282
Cdd:COG1222   174 IIFIDEIDAIAARRT--DDGTSGEVQRTVNQLLAELDGFESRGD-VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEE 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 283 ARQAMIYHWLppvsksRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKifdalenhqsessdlpriQLDIVT 362
Cdd:COG1222   251 AREEILKIHL------RDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE------------------GRDTVT 306

                         330
                  ....*....|....*.
gi 1220516031 363 TADFLDVLTHTKPSAK 378
Cdd:COG1222   307 MEDLEKAIEKVKKKTE 322
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 131-276 3.55e-64

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 202.78  E-value: 3.55e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 131 RYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDE 210
Cdd:cd19521    28 KFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDE 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1220516031 211 LESVMSQRGTasgGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19521   108 VDSLCGTRGE---GESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFEKRIYI 170
cell_div_CdvC NF041006
cell division protein CdvC;
127-391 1.61e-62

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 204.97  E-value: 1.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 127 AVV--SRYPQLFtgilsP--W-KGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYH 201
Cdd:NF041006  118 AIVypSKRPDLF-----PlgWpRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREK 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 202 A-----PSTIFLDELESVMSQRGTASGGEhegsLRMKTELLVQMDGLA-RSEDL-VFVLAASNLPWELDCAMLRRLEKRI 274
Cdd:NF041006  193 SkeegkPAIIFIDEIDALLGVYSSEVGGE----VRVRNQFLKEMDGLQdKSENYhVYVIGATNKPWRLDEPFLRRFQKRI 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 275 LVDLPSREARQAMIYHWlppvskSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFdalENHQSEssdlP 354
Cdd:NF041006  269 YIPLPDREQRLELLKYY------TSKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMF---EKGLGE----P 335

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1220516031 355 RiqldIVTTADFLDVLTHTKPSA-KNLAQRYSDWQREF 391
Cdd:NF041006  336 R----PITMEDFKEVLKIRKPSVnQEMLKAYEAWHEKF 369
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 122-276 1.82e-57

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 185.05  E-value: 1.82e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 122 MRELAAVVSRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYH 201
Cdd:cd19524    12 LQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVAREL 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1220516031 202 APSTIFLDELESVMSQRgtaSGGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19524    92 QPSIIFIDEVDSLLSER---SEGEHEASRRLKTEFLIEFDGVqSNGDDRVLVMGATNRPQELDDAVLRRFTKRVYV 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 117-276 3.68e-57

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 185.19  E-value: 3.68e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNSEMRELAAVVSRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFE 196
Cdd:cd19525    29 FAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 197 LARYHAPSTIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLPWELDCAMLRRLEKRIL 275
Cdd:cd19525   109 VARCKQPAVIFIDEIDSLLSQRGE---GEHESSRRIKTEFLVQLDGAtTSSEDRILVVGATNRPQEIDEAARRRLVKRLY 185


                  .
gi 1220516031 276 V 276
Cdd:cd19525   186 I 186
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 111-379 1.11e-55

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 188.20  E-value: 1.11e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 111 PLSAFIGMNS---EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGD 186
Cdd:COG0464   155 ILDDLGGLEEvkeELRELVALPLKRPELREEYgLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 187 SEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEgslRMKTELLVQMDGLarsEDLVFVLAASNLPWELDCAM 266
Cdd:COG0464   235 TEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGR---RVVNTLLTEMEEL---RSDVVVIAATNRPDLLDPAL 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 267 LRRLEKRILVDLPSREARQAMIYHWLPPvsksraLELHTELEYSVLSQETEGYSGSDIKLVCREAAMRpvrkifdALenh 346
Cdd:COG0464   309 LRRFDEIIFFPLPDAEERLEIFRIHLRK------RPLDEDVDLEELAEATEGLSGADIRNVVRRAALQ-------AL--- 372

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1220516031 347 qsessdlpRIQLDIVTTADFLDVLTHTKPSAKN 379
Cdd:COG0464   373 --------RLGREPVTTEDLLEALEREDIFLKR 397
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 121-394 1.23e-52

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 186.65  E-value: 1.23e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMgIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGgeHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLPWELDCAMLR--RLEKRILVD 277
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFD--TSVTDRIVNQLLTEMDGIQELSNVV-VIAATNRPDILDPALLRpgRFDRLILVP 620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 278 LPSREARQAMI-YHwlppvskSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRI 356
Cdd:TIGR01243 621 PPDEEARKEIFkIH-------TRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKEKLEVGEEEFL 693

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1220516031 357 QLDIVTTADFLDVLTHTKPS-AKNLAQRYSDWQREFESV 394
Cdd:TIGR01243 694 KDLKVEMRHFLEALKKVKPSvSKEDMLRYERLAKELKRL 732
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 117-368 1.85e-49

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 171.55  E-value: 1.85e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNSEMRELAAVVS---RYPQLFT--GIlSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 191
Cdd:PRK03992  135 GLEEQIREVREAVElplKKPELFEevGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLV 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 192 RVLFELARYHAPSTIFLDELESVMSQR---GTasGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR 268
Cdd:PRK03992  214 RELFELAREKAPSIIFIDEIDAIAAKRtdsGT--SGDREVQ-RTLMQLLAEMDGFDPRGN-VKIIAATNRIDILDPAILR 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 269 --RLEKRILVDLPSREARqAMIyhwlppvsksraLELHT-------ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRki 339
Cdd:PRK03992  290 pgRFDRIIEVPLPDEEGR-LEI------------LKIHTrkmnladDVDLEELAELTEGASGADLKAICTEAGMFAIR-- 354

                         250       260
                  ....*....|....*....|....*....
gi 1220516031 340 fdalENHqsessdlpriqlDIVTTADFLD 368
Cdd:PRK03992  355 ----DDR------------TEVTMEDFLK 367
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 146-278 1.88e-48

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 160.45  E-value: 1.88e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGE 225
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 226 HEgslRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDL 278
Cdd:pfam00004  81 SR---RVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 120-276 2.08e-47

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 159.13  E-value: 2.08e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 120 SEMRELAAVVSRYPQLF--TGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFEL 197
Cdd:cd19520    10 TELKELVILPLQRPELFdnSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQKLVAAVFSL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 198 ARYHAPSTIFLDELESVMSQRgtaSGGEHEGSLRMKTELLVQMDGLARS-EDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19520    90 ASKLQPSIIFIDEIDSFLRQR---SSTDHEATAMMKAEFMSLWDGLSTDgNCRVIVMGATNRPQDLDEAILRRMPKRFHI 166
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 121-377 2.33e-45

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 166.24  E-value: 2.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:TIGR01243 189 KIREMVELPMKHPELFEHLgIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAE 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGgehEGSLRMKTELLVQMDGLaRSEDLVFVLAASNLPWELDCAMLR--RLEKRILVD 277
Cdd:TIGR01243 269 ENAPSIIFIDEIDAIAPKREEVTG---EVEKRVVAQLLTLMDGL-KGRGRVIVIGATNRPDALDPALRRpgRFDREIVIR 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 278 LPSREARQAMiyhwLPPVSKSRALELHTELEYsvLSQETEGYSGSDIKLVCREAAMRPVRKIFDAlENHQSESSDLPRIQ 357
Cdd:TIGR01243 345 VPDKRARKEI----LKVHTRNMPLAEDVDLDK--LAEVTHGFVGADLAALAKEAAMAALRRFIRE-GKINFEAEEIPAEV 417

                         250       260
                  ....*....|....*....|..
gi 1220516031 358 LD--IVTTADFLDVLTHTKPSA 377
Cdd:TIGR01243 418 LKelKVTMKDFMEALKMVEPSA 439
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 131-276 3.07e-45

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 153.21  E-value: 3.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 131 RYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLD 209
Cdd:cd19511    14 KHPDAFKRLgIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKARQAAPCIIFFD 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 210 ELESVMSQRGTASGGehEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:cd19511    94 EIDSLAPRRGQSDSS--GVTDRVVSQLLTELDGIESLKG-VVVIAATNRPDMIDPALLRpgRLDKLIYV 159
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 121-274 9.78e-45

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 152.06  E-value: 9.78e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:cd19503    11 SLKELIELPLKYPELFRALgLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKNLREIFEEAR 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGGEHEgslRMKTELLVQMDGLArSEDLVFVLAASNLPWELDCAMLR--RLEKRI 274
Cdd:cd19503    91 SHAPSIIFIDEIDALAPKREEDQREVER---RVVAQLLTLMDGMS-SRGKVVVIAATNRPDAIDPALRRpgRFDREV 163
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 121-276 8.48e-44

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 149.58  E-value: 8.48e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:cd19528     4 ELQELVQYPVEHPDKFLKFgMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKAR 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:cd19528    84 AAAPCVLFFDELDSIAKARGGNIGDAGGAADRVINQILTEMDGMNTKKN-VFIIGATNRPDIIDPAILRpgRLDQLIYI 161
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 117-276 2.39e-42

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 146.22  E-value: 2.39e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNSEMRELAAVVS--RYPQLFT--GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVR 192
Cdd:cd19501     8 GCEEAKEELKEVVEflKNPEKFTklGAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 193 VLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RL 270
Cdd:cd19501    87 DLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVEMDGFESNTG-VIVIAATNRPDVLDPALLRpgRF 165


                  ....*.
gi 1220516031 271 EKRILV 276
Cdd:cd19501   166 DRQVYV 171
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 123-276 1.06e-41

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 143.96  E-value: 1.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 123 RELAAVVSRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHA 202
Cdd:cd19481     6 REAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLA 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1220516031 203 PSTIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:cd19481    86 PCILFIDEIDAIGRKRD--SSGESGELRRVLNQLLTELDGVNSRSK-VLVIAATNRPDLLDPALLRpgRFDEVIEF 158
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 117-274 1.42e-41

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 144.02  E-value: 1.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNSEMRELAAVVS---RYPQLFT--GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 191
Cdd:cd19502     7 GLDEQIREIREVVElplKHPELFEelGIEPP-KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGARLV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 192 RVLFELARYHAPSTIFLDELESVMSQR-GTASGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR-- 268
Cdd:cd19502    86 RELFEMAREKAPSIIFIDEIDAIGAKRfDSGTGGDREVQ-RTMLELLNQLDGFDPRGN-IKVIMATNRPDILDPALLRpg 163


                  ....*.
gi 1220516031 269 RLEKRI 274
Cdd:cd19502   164 RFDRKI 169
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 121-276 1.33e-40

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 141.09  E-value: 1.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:cd19529     4 ELKEAVEWPLLKPEVFKRLgIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKAR 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTasGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:cd19529    84 QVAPCVIFFDEIDSIAPRRGT--TGDSGVTERVVNQLLTELDGLEEMNGVV-VIAATNRPDIIDPALLRagRFDRLIYI 159
ftsH CHL00176
cell division protein; Validated
 117-338 5.27e-40

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 150.20  E-value: 5.27e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNSEMRELAAVVS--RYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRV 193
Cdd:CHL00176  187 GIEEAKEEFEEVVSflKKPERFTAVgAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGVGAARVRD 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 194 LFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLPWELDCAMLR--RLE 271
Cdd:CHL00176  267 LFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKGVI-VIAATNRVDILDAALLRpgRFD 345

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1220516031 272 KRILVDLPSREARQAMiyhwLPPVSKSRALELHTELEysVLSQETEGYSGSDIKLVCREAAMRPVRK 338
Cdd:CHL00176  346 RQITVSLPDREGRLDI----LKVHARNKKLSPDVSLE--LIARRTPGFSGADLANLLNEAAILTARR 406
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 121-338 1.27e-38

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 142.98  E-value: 1.27e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:PTZ00454  156 EIREAVELPLTCPELYEQIgIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLAR 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILVD 277
Cdd:PTZ00454  236 ENAPSIIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTN-VKVIMATNRADTLDPALLRpgRLDRKIEFP 314

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220516031 278 LPSREARQaMIYHWLppVSKsraLELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 338
Cdd:PTZ00454  315 LPDRRQKR-LIFQTI--TSK---MNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
120-337 1.78e-38

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 146.33  E-value: 1.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 120 SEMRELAAVVSRYPQLFTGIlsPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:PRK10733  165 AELVEYLREPSRFQKLGGKI--P-KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAK 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLPWELDCAMLR--RLEKRILVD 277
Cdd:PRK10733  242 KAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGII-VIAATNRPDVLDPALLRpgRFDRQVVVG 320

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 278 LPSREARQAMIYHWLppvsksRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVR 337
Cdd:PRK10733  321 LPDVRGREQILKVHM------RRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 121-337 2.14e-37

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 140.29  E-value: 2.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:PTZ00361  194 EIKEAVELPLTHPELYDDIgIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAE 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQR-GTASGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:PTZ00361  274 ENAPSIVFIDEIDAIGTKRyDATSGGEKEIQ-RTMLELLNQLDGFDSRGD-VKVIMATNRIESLDPALIRpgRIDRKIEF 351

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 277 DLPSREarqamiyhwlppvSKSRALELHT---------ELEYSVLSQETegYSGSDIKLVCREAAMRPVR 337
Cdd:PTZ00361  352 PNPDEK-------------TKRRIFEIHTskmtlaedvDLEEFIMAKDE--LSGADIKAICTEAGLLALR 406
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
140-331 2.17e-37

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 135.40  E-value: 2.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 140 LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARyHAPSTIFLDELESVMSQRG 219
Cdd:COG1223    32 LWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFAR-RAPCVIFFDEFDAIAKDRG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 220 TASG-GEhegSLRMKTELLVQMDGLARSedlVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIyhwlppVSKS 298
Cdd:COG1223   111 DQNDvGE---VKRVVNALLQELDGLPSG---SVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEIL------ELNL 178

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1220516031 299 RALELHTELEYSVLSQETEGYSGSDIKLVCREA 331
Cdd:COG1223   179 KKFPLPFELDLKKLAKKLEGLSGADIEKVLKTA 211
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
124-338 6.89e-37

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 140.94  E-value: 6.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 124 ELAAVVS--RYPQLFT--G--IlsPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVskwrgdsEKLV-----R 192
Cdd:COG0465   153 ELQEIVDflKDPEKFTrlGakI--P-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV-------EMFVgvgasR 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 193 V--LFELARYHAPSTIFLDELESVMSQRGTASGG---EHEGSLrmkTELLVQMDGLARSEDLVfVLAASNLPWELDCAML 267
Cdd:COG0465   223 VrdLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGghdEREQTL---NQLLVEMDGFEGNEGVI-VIAATNRPDVLDPALL 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 268 R--RLEKRILVDLPSREARQAmIyhwlppvsksraLELHT-------ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 338
Cdd:COG0465   299 RpgRFDRQVVVDLPDVKGREA-I------------LKVHArkkplapDVDLEVIARRTPGFSGADLANLVNEAALLAARR 365
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 131-276 7.08e-37

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 131.46  E-value: 7.08e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 131 RYPQLFT--GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFL 208
Cdd:cd19530    17 KRPDIYKalGIDLP-TGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRARASAPCVIFF 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1220516031 209 DELESVMSQRGtasGGEHEGSLRMKTELLVQMDGL-ARSEdlVFVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:cd19530    96 DEVDALVPKRG---DGGSWASERVVNQLLTEMDGLeERSN--VFVIAATNRPDIIDPAMLRpgRLDKTLYV 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 131-276 9.24e-36

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 128.40  E-value: 9.24e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 131 RYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDE 210
Cdd:cd19527    14 EHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKARDAKPCVIFFDE 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 211 LESVMSQRGTA--SGGEHEgslRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILV 276
Cdd:cd19527    94 LDSLAPSRGNSgdSGGVMD---RVVSQLLAELDGMSSSGQDVFVIGATNRPDLLDPALLRpgRFDKLLYL 160
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 121-269 2.69e-35

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 127.55  E-value: 2.69e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELAR 199
Cdd:cd19519    11 QIREMVELPLRHPELFKAIgIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAE 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 200 YHAPSTIFLDELESVMSQRGTASGgehEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAmLRR 269
Cdd:cd19519    91 KNAPAIIFIDEIDAIAPKREKTHG---EVERRIVSQLLTLMDGLKQRAH-VIVMAATNRPNSIDPA-LRR 155
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 130-275 5.32e-32

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 118.30  E-value: 5.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 130 SRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFL 208
Cdd:cd19526    13 SKYPKIFASSpLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQSAKPCILFF 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 209 DELESVMSQRGTASGGEHEgslRMKTELLVQMDGlARSEDLVFVLAASNLPWELDCAMLR--RLEKRIL 275
Cdd:cd19526    93 DEFDSIAPKRGHDSTGVTD---RVVNQLLTQLDG-VEGLDGVYVLAATSRPDLIDPALLRpgRLDKLVY 157
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 133-276 7.04e-32

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 118.45  E-value: 7.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 133 PQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELE 212
Cdd:cd19523    23 PDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKILQASFLAARCRQPSVLFISDLD 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1220516031 213 SVMSQRGTasggEHEGSLRMKTELLVQMDG-LARSEDLVFVLAASNLPWELDCAMLRRLEKRILV 276
Cdd:cd19523   103 ALLSSQDD----EASPVGRLQVELLAQLDGvLGSGEDGVLVVCTTSKPEEIDESLRRYFSKRLLV 163
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 117-274 1.32e-31

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 117.89  E-value: 1.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 117 GMNS---EMRELAAVVSRYPQLF--TGILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 191
Cdd:cd19518     4 GMDStlkELCELLIHPILPPEYFqhLGVEPP-RGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEKI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 192 RVLFELARYHAPSTIFLDELESVMSQRGTASggeHEGSLRMKTELLVQMDGL---ARSEDLVFVLAASNLPWELDCAMLR 268
Cdd:cd19518    83 RELFDQAISNAPCIVFIDEIDAITPKRESAQ---REMERRIVSQLLTCMDELnneKTAGGPVLVIGATNRPDSLDPALRR 159


                  ....*...
gi 1220516031 269 --RLEKRI 274
Cdd:cd19518   160 agRFDREI 167
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 121-269 3.48e-27

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 106.05  E-value: 3.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATEC-----KTTFFNISASTIVSKWRGDSEKLVRVL 194
Cdd:cd19517    11 QLKEMVFFPLLYPEVFAKFkITPPRGVLFHGPPGTGKTLMARALAAECskggqKVSFFMRKGADCLSKWVGEAERQLRLL 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1220516031 195 FELARYHAPSTIFLDELESVMSQRGTASGGEHEGslrMKTELLVQMDGL-ARSEdlVFVLAASNLPWELDCAmLRR 269
Cdd:cd19517    91 FEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHAS---IVSTLLALMDGLdNRGQ--VVVIGATNRPDALDPA-LRR 160
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 116-278 1.05e-22

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 93.36  E-value: 1.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 116 IGMNSEMRELAAVVSRypqlftgilSPWKGLLLYGPPGTGKTLLAKAVATEC---KTTFFNISASTIVSKWRGDSEK--- 189
Cdd:cd00009     1 VGQEEAIEALREALEL---------PPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghf 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 190 LVRVLFELARYHAPSTIFLDELESVmsqrgtaSGGEHEGSLRMkteLLVQMDGLARSEDlVFVLAASNLPWELDCAM--L 267
Cdd:cd00009    72 LVRLLFELAEKAKPGVLFIDEIDSL-------SRGAQNALLRV---LETLNDLRIDREN-VRVIGATNRPLLGDLDRalY 140

                         170
                  ....*....|.
gi 1220516031 268 RRLEKRILVDL 278
Cdd:cd00009   141 DRLDIRIVIPL 151
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 144-271 7.74e-17

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 77.53  E-value: 7.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 144 KGLLLYGPPGTGKTLLAKAV-----ATECKTtffnISASTIVSKWRGDSEKLVRVLF-----ELARYHAPS---TIFLDE 210
Cdd:cd19504    36 KGILLYGPPGTGKTLMARQIgkmlnAREPKI----VNGPEILNKYVGESEANIRKLFadaeeEQRRLGANSglhIIIFDE 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 211 LESVMSQRGTASGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLPWELDCAMLR--RLE 271
Cdd:cd19504   112 IDAICKQRGSMAGSTGVHD-TVVNQLLSKIDGVEQLNN-ILVIGMTNRKDLIDEALLRpgRLE 172
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 142-279 4.45e-15

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 72.02  E-value: 4.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  142 PWKGLLLYGPPGTGKTLLAKAVATECKTT---FFNISASTI--------------VSKWRGDSEKLVRVLFELARYHAPS 204
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1220516031  205 TIFLDELESVMSQRGTAsggehegsLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLP 279
Cdd:smart00382  81 VLILDEITSLLDAEQEA--------LLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLI 147
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 138-262 4.63e-15

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 72.40  E-value: 4.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 138 GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSq 217
Cdd:cd19507    27 GLPTP-KGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFS- 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1220516031 218 rGTASGGEHEGSLRMKTELLVQMdglARSEDLVFVLAASN----LPWEL 262
Cdd:cd19507   105 -NADSKGDSGTSSRVLGTFLTWL---QEKKKPVFVVATANnvqsLPPEL 149
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 146-269 1.53e-14

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 71.71  E-value: 1.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 146 LLLYGPPGTGKTLLAKAVA---------TECKTTFFNISASTIVSKWRGDSEKLVRVLF----ELAR-YHAPSTIFLDEL 211
Cdd:cd19508    55 VLLHGPPGTGKTSLCKALAqklsirlssRYRYGQLIEINSHSLFSKWFSESGKLVTKMFqkiqELIDdKDALVFVLIDEV 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 212 ESVMSQRGTA-SGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLPWELDCAMLRR 269
Cdd:cd19508   135 ESLAAARSASsSGTEPSDAIRVVNAVLTQIDRIKRYHNNV-ILLTSNLLEKIDVAFVDR 192
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 144-275 3.35e-13

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 66.78  E-value: 3.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 144 KGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDS--EKLVRVLFELARYHAPSTIFLDELESVMSQRGTA 221
Cdd:cd19506    27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKVPK 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1220516031 222 SGGEHEGSlRMKTElLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRIL 275
Cdd:cd19506   107 TEKQLDPK-RLKKD-LPKILKSLKPEDRVLIVGTTSRPFEADLKSFCKVYNKII 158
ycf46 CHL00195
Ycf46; Provisional
 138-331 1.07e-12

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 69.28  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 138 GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSq 217
Cdd:CHL00195  255 GLPTP-RGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFS- 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 218 rGTASGGEHEGSLRMKTELLVQmdgLARSEDLVFVLAASN----LPWEldcaMLR--RLEKRILVDLPSREARQAMIYHW 291
Cdd:CHL00195  333 -NSESKGDSGTTNRVLATFITW---LSEKKSPVFVVATANnidlLPLE----ILRkgRFDEIFFLDLPSLEEREKIFKIH 404

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1220516031 292 LppvSKSRALELHTeLEYSVLSQETEGYSGSDIKLVCREA 331
Cdd:CHL00195  405 L---QKFRPKSWKK-YDIKKLSKLSNKFSGAEIEQSIIEA 440
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 306-350 2.21e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 2.21e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1220516031 306 ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSES 350
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVTQEDLEE 45
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 146-210 6.40e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 54.29  E-value: 6.40e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTivskwrgDSEKLVRVLFELA---RYHAPSTI-FLDE 210
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVALSAVT-------SGVKDIREVIEEArerRAYGRRTIlFVDE 113
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 146-210 7.92e-08

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 53.94  E-value: 7.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTivskwrgDSEKLVRVLFELARYHAPS---TI-FLDE 210
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDAPFEALSAVT-------SGVKDLREVIEEARQRRSAgrrTIlFIDE 100
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 142-269 1.22e-07

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 50.81  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 142 PWK-GLLLYGPPGTGKTLLAKAVATECKTTFFNISASTivskwRGDSEKLVRVLfeLARYHAPSTIFLDELESVMSQR-- 218
Cdd:cd19510    21 PYRrGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSE-----VVLTDDRLNHL--LNTAPKQSIILLEDIDAAFESReh 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1220516031 219 ----GTASGGEHEGSLrmkTELLVQMDGLARSEDLVFVLaASNLPWELDCAMLRR 269
Cdd:cd19510    94 nkknPSAYGGLSRVTF---SGLLNALDGVASSEERIVFM-TTNHIERLDPALIRP 144
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 141-274 2.19e-07

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 49.83  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 141 SPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVlFELARYHAPSTI-FLDELESVMSQRG 219
Cdd:cd19512    20 GLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKV-FDWANTSRRGLLlFVDEADAFLRKRS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1220516031 220 TASGGEhegSLRMKTELLVQMDGlARSEDLVFVLaASNLPWELDCAMLRRLEKRI 274
Cdd:cd19512    99 TEKISE---DLRAALNAFLYRTG-EQSNKFMLVL-ASNQPEQFDWAINDRIDEMV 148
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
144-194 4.07e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 48.43  E-value: 4.07e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 144 KGLLLYGPPGTGKTLLAKAVATEC--KTTFFNISASTIVSKWRGDSEKLVRVL 194
Cdd:COG1224    65 KGILIVGPPGTGKTALAVAIARELgeDTPFVAISGSEIYSAELKKTEFLMQAL 117
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 144-181 1.18e-04

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 43.84  E-value: 1.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1220516031 144 KGLLLYGPPGTGKTLLAKAVATEC--KTTFFNISASTIVS 181
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKELgeDTPFTSISGSEVYS 90
PRK08116 PRK08116
hypothetical protein; Validated
 145-166 2.05e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 42.70  E-value: 2.05e-04
                          10        20
                  ....*....|....*....|..
gi 1220516031 145 GLLLYGPPGTGKTLLAKAVATE 166
Cdd:PRK08116  116 GLLLWGSVGTGKTYLAACIANE 137
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 147-212 2.44e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 41.41  E-value: 2.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 147 LLYGPPGTGKTLLAKAVA-----TECKTTFFNISA---STIVSKWRGDSEKLVRV-----LFELARYHAPSTIFLDELE 212
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAellfgDERALIRIDMSEymeEHSVSRLIGAPPGYVGYeeggqLTEAVRRKPYSIVLIDEIE 85
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 146-175 2.54e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 41.39  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATECKTTFFNIS 175
Cdd:cd19500    40 LCLVGPPGVGKTSLGKSIARALGRKFVRIS 69
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
146-170 2.83e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 42.43  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*....
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATE----CKTT 170
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEmgvnIRIT 82
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 146-211 3.30e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 41.69  E-value: 3.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATEC-----KTTFFniSASTIVSKWRG--DSEKLVRVLFELARYHApstIFLDEL 211
Cdd:NF038214   93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFT--TAADLVEQLAQarADGRLGRLLRRLARYDL---LIIDEL 160
PRK04195 PRK04195
replication factor C large subunit; Provisional
 141-166 4.26e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 42.22  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 1220516031 141 SPWKGLLLYGPPGTGKTLLAKAVATE 166
Cdd:PRK04195   37 KPKKALLLYGPPGVGKTSLAHALAND 62
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 43-225 4.30e-04

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 42.52  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  43 DNTRLESANFGLHisRIRKDSGEENAHPRRGQIIDFQglltdaikgATSELALNTFDHNPDPSERL--LKPLsafIGMNS 120
Cdd:PRK11034  128 EVSRLDVVNFISH--GTRKDEPSQSSDPGSQPNSEEQ---------AGGEERMENFTTNLNQLARVggIDPL---IGREK 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 121 EMRELAAVVSRYPQlftgilspwKGLLLYGPPGTGKTLLAKAVA------------TECKTTFFNISASTIVSKWRGDSE 188
Cdd:PRK11034  194 ELERAIQVLCRRRK---------NNPLLVGESGVGKTAIAEGLAwrivqgdvpevmADCTIYSLDIGSLLAGTKYRGDFE 264

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1220516031 189 KLVRVLFELARYHAPSTIFLDELESVMSQrGTASGGE 225
Cdd:PRK11034  265 KRFKALLKQLEQDTNSILFIDEIHTIIGA-GAASGGQ 300
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
115-166 4.77e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.14  E-value: 4.77e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1220516031 115 FIGMNSEMRELAAVVSrypQLFTGILSPwkGLLLYGPPGTGKTLLAKAVATE 166
Cdd:COG1474    28 LPHREEEIEELASALR---PALRGERPS--NVLIYGPTGTGKTAVAKYVLEE 74
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 134-165 6.27e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 41.31  E-value: 6.27e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1220516031 134 QLFTGILSpwKG-LLLYGPPGTGKTLLAKAVAT 165
Cdd:COG0714    23 LVLIALLA--GGhLLLEGVPGVGKTTLAKALAR 53
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 140-206 7.03e-04

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 40.05  E-value: 7.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 140 LSPWKGLLLYGPPGTGKTLLAKAVATEC---------------KTTFFNISASTIVSKWRgDSEKLVRVLFELARYHAPS 204
Cdd:cd19505     9 LSPSKGILLIGSIETGRSYLIKSLAANSyvplirislnkllynKPDFGNDDWIDGMLILK-ESLHRLNLQFELAKAMSPC 87


                  ..
gi 1220516031 205 TI 206
Cdd:cd19505    88 II 89
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 112-254 9.92e-04

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 41.37  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031 112 LSAFIGMNSEMRELAAVVSrypQLFTGILSPWKGL---------LLYGPPGTGKTLLAKAVATE-C------KTTFFNIS 175
Cdd:TIGR03922 275 LAEQIGLERVKRQVAALKS---STAMALARAERGLpvaqtsnhmLFAGPPGTGKTTIARVVAKIyCglgvlrKPLVREVS 351

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1220516031 176 ASTIVSKWRGDSEKLVRVLFELAryhAPSTIFLDELESVMSQRGTAsgGEHEGSLRMKTeLLVQMDglARSEDLVFVLA 254
Cdd:TIGR03922 352 RADLIGQYIGESEAKTNEIIDSA---LGGVLFLDEAYTLVETGYGQ--KDPFGLEAIDT-LLARME--NDRDRLVVIGA 422
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
144-173 1.33e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 40.15  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1220516031 144 KGLLLYGPPGTGKTLLAKAVATEC-----KTTFFN 173
Cdd:COG1484   100 ENLILLGPPGTGKTHLAIALGHEAcragyRVRFTT 134
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 145-212 1.39e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.43  E-value: 1.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1220516031 145 GLLLYGPPGTGKTLLAK--AVATECKTTFF-----NISASTIVSKWRGDSEKLVRVLFELARyhA---PSTIFLDELE 212
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErlAAALSNRPVFYvqltrDTTEEDLFGRRNIDPGGASWVDGPLVR--AareGEIAVLDEIN 76
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 146-165 1.68e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.41  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|
gi 1220516031 146 LLLYGPPGTGKTLLAKAVAT 165
Cdd:COG0606   214 LLMIGPPGSGKTMLARRLPG 233
PRK13341 PRK13341
AAA family ATPase;
146-176 1.79e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 40.42  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATECKTTFFNISA 176
Cdd:PRK13341   55 LILYGPPGVGKTTLARIIANHTRAHFSSLNA 85
PspF COG1221
Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain ...
 78-162 2.21e-03

Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription, Signal transduction mechanisms];


Pssm-ID: 440834 [Multi-domain]  Cd Length: 835  Bit Score: 40.09  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1220516031  78 FQGLLTDAIKGATSELALNTFDHNPDPSErllKPLSAFIGMNSEMRElaAVvsryPQLFTGILSPWKGL--LLYGPPGTG 155
Cdd:COG1221    72 FEEQFGTKLKSEYSFVELLAEKENNEEEE---DPFDNLIGANGSLKN--AI----EQAKAAILYPPKGLhtLILGPTGVG 142


                  ....*..
gi 1220516031 156 KTLLAKA 162
Cdd:COG1221   143 KSFFAEL 149
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 146-165 2.34e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.06  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|
gi 1220516031 146 LLLYGPPGTGKTLLAKAVAT 165
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRLPG 44
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 146-170 2.91e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 38.25  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*....
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATE----CKTT 170
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEmgvnIRIT 64
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 144-164 3.73e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.37  E-value: 3.73e-03
                          10        20
                  ....*....|....*....|.
gi 1220516031 144 KGLLLYGPPGTGKTLLAKAVA 164
Cdd:COG1401   222 KNVILAGPPGTGKTYLARRLA 242
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 133-165 4.33e-03

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 38.44  E-value: 4.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1220516031 133 PQLFTGILSPW----KG----LLLYGPPGTGKTLLAKAVAT 165
Cdd:pfam01057  95 PAEVGSVLLAWlskqFGkrntVWFYGPASTGKTNLAQAIAH 135
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 144-164 4.76e-03

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 39.23  E-value: 4.76e-03
                          10        20
                  ....*....|....*....|...
gi 1220516031 144 KG--LLLYGPPGTGKTLLAKAVA 164
Cdd:COG0466   351 KGpiLCLVGPPGVGKTSLGKSIA 373
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 146-170 6.36e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 38.14  E-value: 6.36e-03
                          10        20
                  ....*....|....*....|....*....
gi 1220516031 146 LLLYGPPGTGKTLLAKAVATE----CKTT 170
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEmgvnIRIT 85
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 146-170 7.06e-03

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 38.05  E-value: 7.06e-03
                          10        20
                  ....*....|....*....|....*....
gi 1220516031 146 LLLYGPPGTGKTLLAKAVA----TECKTT 170
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIAnemgVNLKIT 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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