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Conserved domains on  [gi|1227523143|ref|NP_001340974|]
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WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Frtz super family cl28777
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
79-600 0e+00

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


The actual alignment was detected with superfamily member pfam11768:

Pssm-ID: 432059  Cd Length: 544  Bit Score: 899.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143  79 KQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGK 158
Cdd:pfam11768   1 KQQWAESRGIPWTLKNKRPEKLRDSLKELEELMQSSSCVLSKWKTKYNCQLLFGSGVLVSVSLSGPQLEKVVIDRSLVGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 159 LISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRV 238
Cdd:pfam11768  81 LISDHISDAVLTDSFIILSFLDKNKLCFIQFGKKPSSFDINKKLEKLSALDLKISYADIPGPPNRKIDRHLAVNSRQDLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 239 VCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCI 318
Cdd:pfam11768 161 LCWWPTQNDDVWPWSPVSSEKDRANIILLGISGSKLEVLSYCRTECDPLHVAFSFNQPYQVHTVEQSLPGSKEPMADSCI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 319 YECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQ 398
Cdd:pfam11768 241 YEYVRNKIECVSVTRIPLRSPVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLAQAAVTPHLIRWHPAGAIILVCSAQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 399 GELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKL 478
Cdd:pfam11768 321 GELQIFDMALSPIMIQLLAENPQPQSTLQLHKYFPVSSKLDKMSWSAPPVSNQTESSVGIHDLLVLRFDRGPLGVLRFKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 479 GVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPL 558
Cdd:pfam11768 401 GVMSHGQLGCVELISQYIKHSEVEEAVNFLNSMNWNTEGNTCFACMSLIVNHLLRQRLTPIREAQLEASLGTFYAPTRPL 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1227523143 559 LDSTILEYRDQISKYARRFFHHLLRWSlalspRLECSDVIAV 600
Cdd:pfam11768 481 LDVTVLEYRDPISRYARRFFHHLLRYK-----RFEKAFLLAV 517
 
Name Accession Description Interval E-value
Frtz pfam11768
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
79-600 0e+00

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


Pssm-ID: 432059  Cd Length: 544  Bit Score: 899.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143  79 KQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGK 158
Cdd:pfam11768   1 KQQWAESRGIPWTLKNKRPEKLRDSLKELEELMQSSSCVLSKWKTKYNCQLLFGSGVLVSVSLSGPQLEKVVIDRSLVGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 159 LISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRV 238
Cdd:pfam11768  81 LISDHISDAVLTDSFIILSFLDKNKLCFIQFGKKPSSFDINKKLEKLSALDLKISYADIPGPPNRKIDRHLAVNSRQDLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 239 VCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCI 318
Cdd:pfam11768 161 LCWWPTQNDDVWPWSPVSSEKDRANIILLGISGSKLEVLSYCRTECDPLHVAFSFNQPYQVHTVEQSLPGSKEPMADSCI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 319 YECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQ 398
Cdd:pfam11768 241 YEYVRNKIECVSVTRIPLRSPVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLAQAAVTPHLIRWHPAGAIILVCSAQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 399 GELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKL 478
Cdd:pfam11768 321 GELQIFDMALSPIMIQLLAENPQPQSTLQLHKYFPVSSKLDKMSWSAPPVSNQTESSVGIHDLLVLRFDRGPLGVLRFKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 479 GVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPL 558
Cdd:pfam11768 401 GVMSHGQLGCVELISQYIKHSEVEEAVNFLNSMNWNTEGNTCFACMSLIVNHLLRQRLTPIREAQLEASLGTFYAPTRPL 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1227523143 559 LDSTILEYRDQISKYARRFFHHLLRWSlalspRLECSDVIAV 600
Cdd:pfam11768 481 LDVTVLEYRDPISRYARRFFHHLLRYK-----RFEKAFLLAV 517
 
Name Accession Description Interval E-value
Frtz pfam11768
WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable ...
79-600 0e+00

WD repeat-containing and planar cell polarity effector protein Fritz; Fritz is a probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. In Drosophila melanogaster, fritz regulates both the location and the number of wing cell prehair initiation sites.


Pssm-ID: 432059  Cd Length: 544  Bit Score: 899.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143  79 KQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGK 158
Cdd:pfam11768   1 KQQWAESRGIPWTLKNKRPEKLRDSLKELEELMQSSSCVLSKWKTKYNCQLLFGSGVLVSVSLSGPQLEKVVIDRSLVGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 159 LISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRV 238
Cdd:pfam11768  81 LISDHISDAVLTDSFIILSFLDKNKLCFIQFGKKPSSFDINKKLEKLSALDLKISYADIPGPPNRKIDRHLAVNSRQDLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 239 VCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCI 318
Cdd:pfam11768 161 LCWWPTQNDDVWPWSPVSSEKDRANIILLGISGSKLEVLSYCRTECDPLHVAFSFNQPYQVHTVEQSLPGSKEPMADSCI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 319 YECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQ 398
Cdd:pfam11768 241 YEYVRNKIECVSVTRIPLRSPVISCARNHAEDKLLLGCEDSSLILYEGHRKITLLAQAAVTPHLIRWHPAGAIILVCSAQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 399 GELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKL 478
Cdd:pfam11768 321 GELQIFDMALSPIMIQLLAENPQPQSTLQLHKYFPVSSKLDKMSWSAPPVSNQTESSVGIHDLLVLRFDRGPLGVLRFKL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227523143 479 GVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPL 558
Cdd:pfam11768 401 GVMSHGQLGCVELISQYIKHSEVEEAVNFLNSMNWNTEGNTCFACMSLIVNHLLRQRLTPIREAQLEASLGTFYAPTRPL 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1227523143 559 LDSTILEYRDQISKYARRFFHHLLRWSlalspRLECSDVIAV 600
Cdd:pfam11768 481 LDVTVLEYRDPISRYARRFFHHLLRYK-----RFEKAFLLAV 517
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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