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Conserved domains on  [gi|1229385524|ref|NP_001341176|]
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lactosylceramide alpha-2,3-sialyltransferase isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 1-160 7.52e-115

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23983:

Pssm-ID: 480271  Cd Length: 211  Bit Score: 324.38  E-value: 7.52e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDI 80
Cdd:cd23983    52 MTYPEGAPKSEQEYDPTSLFVAVLFKSVDFAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDI 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  81 LQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 160
Cdd:cd23983   132 LQYPEPQSRLWGWDKNVPTLGVTAVVLATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 1-160 7.52e-115

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 324.38  E-value: 7.52e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDI 80
Cdd:cd23983    52 MTYPEGAPKSEQEYDPTSLFVAVLFKSVDFAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDI 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  81 LQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 160
Cdd:cd23983   132 LQYPEPQSRLWGWDKNVPTLGVTAVVLATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 1-165 1.34e-55

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 175.87  E-value: 1.34e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFRILNPVI 72
Cdd:pfam00777  93 TMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVLFLHPDF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  73 IKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTT 152
Cdd:pfam00777 171 LRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPF 243

                         170
                  ....*....|...
gi 1229385524 153 ETKFLLKLVKEGV 165
Cdd:pfam00777 244 EFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 1-160 7.52e-115

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 324.38  E-value: 7.52e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDI 80
Cdd:cd23983    52 MTYPEGAPKSEQEYDPTSLFVAVLFKSVDFAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDI 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  81 LQYSEPQSRFWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 160
Cdd:cd23983   132 LQYPEPQSRLWGWDKNVPTLGVTAVVLATHLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 1-160 6.46e-84

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 246.05  E-value: 6.46e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFWVrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDI 80
Cdd:cd23967    52 MFYPESAFRDPEEYDSDWLLVLVPFKSMDLLWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  81 LQYSEPQsrfwGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 160
Cdd:cd23967   130 IGLPMNG----KQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 1-165 1.34e-55

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 175.87  E-value: 1.34e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFRILNPVI 72
Cdd:pfam00777  93 TMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVLFLHPDF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  73 IKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTT 152
Cdd:pfam00777 171 LRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPF 243

                         170
                  ....*....|...
gi 1229385524 153 ETKFLLKLVKEGV 165
Cdd:pfam00777 244 EFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 1-160 4.83e-44

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 144.68  E-value: 4.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETlpfwVRLF--FWKQVAEKIPLQPKHFRILNPVIIKETAF 78
Cdd:cd23981    52 ITYPEGAIQKPEQYEKDSLFVLAGFKWQDFKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  79 DILQYSEpQSRFWGRDkNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLL 158
Cdd:cd23981   128 SFIGLPF-NNGLMGRG-NIPTLGSVAITMALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLR 205


                  ..
gi 1229385524 159 KL 160
Cdd:cd23981   206 KL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 1-160 5.15e-37

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 126.70  E-value: 5.15e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSND-LFVAVLFKSVDFNWLQAMVKKETLpfwVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFD 79
Cdd:cd23982    52 LFYPESAQFDPGIENDPDtLLVLVPFKPLDFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATK 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  80 ILQYSEPQSrfwgrDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQ-PRTPLHYFDSQCMAAM-NFQtmHNVTTETKFL 157
Cdd:cd23982   129 LLQVPGQRK-----KKQKPTTGLLAITLALHLCDEVHIAGFGYPDNGnSNQPIHYYNQITLKSMaNSG--HNLNAEAQAI 201


                  ...
gi 1229385524 158 LKL 160
Cdd:cd23982   202 QRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 1-160 1.12e-33

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 118.31  E-value: 1.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   1 MTYPEGAPLSDLEYYSNDLFVAVLFKSVDFNWL-QAMVKKETLPFWvrlfFWKQVAEKIPLQPKHFRILNPVIIKETAFD 79
Cdd:cd23984    52 LCYPESIFSDPSHYDPNTTVVLIPFKPHDLRWLlDLLMGKKVSAKG----FWKKPALNLIYKPNQIRILNPFILRIAAYE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  80 ILQYSEpqsRFWGRDKNV-PTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLL 158
Cdd:cd23984   128 LLHFPK---RFPKEKKPKhPTTGIIAITLALHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLK 204


                  ..
gi 1229385524 159 KL 160
Cdd:cd23984   205 DL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 3-167 8.60e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 78.45  E-value: 8.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   3 YPEGAPLSDLEYYSND---LFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPviiketafD 79
Cdd:cd23964   134 FPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRLLHP--------D 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  80 ILQYSEpqsRFWGRDKNV--PTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDSQCMAAMNFQTMHNVTTETKFL 157
Cdd:cd23964   206 FIRYLF---NRWLNSSTSyrPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDFTNERKLW 279

                         170
                  ....*....|
gi 1229385524 158 LKLVKEGVVK 167
Cdd:cd23964   280 RKLHEEGIIN 289
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 76-167 2.47e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 60.35  E-value: 2.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  76 TAFDILQYSEPQSRFWGRDKN--VPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSqcMAAMNFQTMHNV 150
Cdd:cd23963   177 VVYSNPEHFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYDD--LSPSTKNKVHNM 254

                          90
                  ....*....|....*..
gi 1229385524 151 TTETKFLLKLVKEGVVK 167
Cdd:cd23963   255 PEEFKLLRELHKKGVLK 271
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 70-160 2.75e-11

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 59.30  E-value: 2.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  70 PVIIKETAFDILQY---SEPQSR-FWGRDKNVPTIGVIAVVLATHLCDEVSLAGFGYD-LNQPRTPLHYFDsqCMAAMNF 144
Cdd:cd19952   100 VLLLTDPAPDLLSYvrkRLEKLGlKSFFGGNAPSSGLLAVLLALQLCDSVDLYGFGVDsGHAPKVPYHYYD--LVEAEEG 177

                          90
                  ....*....|....*.
gi 1229385524 145 QTMHNVTTETKFLLKL 160
Cdd:cd19952   178 TAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 3-167 7.75e-09

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 53.44  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   3 YPEGAPLSDLEYYsndlFVAVLFKSVDFNWLQAMVKKETLpfwvrLFFWKQVAEKIPLQPKHFRILNPVIIKETAFdilQ 82
Cdd:cd23966   129 YPESAVDLDPGVH----LVLVPFKVLDLQWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHD---N 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  83 YSEPQSRFwgrdknvPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTplHYFDSQcMAAMNFQ--TMHNVTTETKFLLKL 160
Cdd:cd23966   197 WTEHHGRY-------PSTGFLALIFALHICDEVSVFGFGADSKGNWH--HYWEKN-RSAGAFRktGVHDADFESDIIKKL 266


                  ....*..
gi 1229385524 161 VKEGVVK 167
Cdd:cd23966   267 AKEGKIR 273
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 29-167 3.68e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 45.90  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  29 DFNWLQAMVKKETLPfwvRLFFWKQVAEKI---PLQPKHFRILNPviiketafDILQYSepQSRFWgRDKNV-------- 97
Cdd:cd23973   171 DYQWLEALLKNKTIP---SGAYYGRRPRSYfsgDFTEDKYLVLHP--------DFLRYV--KNRFL-RSKTLkgkywaiy 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1229385524  98 -PTIGVIAVVLATHLCDEVSLAGF---GYDlnqpRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 167
Cdd:cd23973   237 rPTTGAFLLLTALHLCDTVSAYGFiteDYR----KYPDHYYDKK-KTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 63-167 4.23e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 45.48  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  63 KHFRILNPVIIKE-----TAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPL 131
Cdd:cd23969   160 EHVQWTNEIILKHklnvkTAYPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKY 239

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1229385524 132 HYFDSQCMAAMNFQtmHNVTTETKFLLKLVKEGVVK 167
Cdd:cd23969   240 HYYDNRKYLTTARP--HKMPEEFRALRSLHQRGALR 273
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 3-123 5.18e-06

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 45.26  E-value: 5.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   3 YPEgaplSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFwvrlfFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQ 82
Cdd:cd23980   133 YPE----SFRELAQNVSMILVPFKTLDLEWVISATTTGTISH-----TYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQ 203

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1229385524  83 YSepqsrfwGRdknVPTIGVIAVVLATHLCDEVSLAGFGYD 123
Cdd:cd23980   204 GH-------GR---YPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 44-167 7.74e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 44.93  E-value: 7.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  44 FWVRLFFWKQVAEKIplqpkhfRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEV 115
Cdd:cd23987   148 LWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPSLRLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRI 220

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1229385524 116 SLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVK 167
Cdd:cd23987   221 HLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 63-167 1.21e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 44.17  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  63 KHFRILNPVIIK-----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPL 131
Cdd:cd23988   160 KHVEWVNALILKnklkvRTAYPSLRLIHAVRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKY 239

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1229385524 132 HYFDSQCMAAMNFQTMHNVTTETKFLLKLVKEGVVK 167
Cdd:cd23988   240 HYYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALK 275
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 79-167 1.46e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 43.92  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  79 DILQYSepqSRFWGRDKNVP---TIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSQ-CMAAMNFQTMHNVT 151
Cdd:cd23970   189 NIMQHV---NRYWKTKHLSPkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLP 265

                          90
                  ....*....|....*.
gi 1229385524 152 TETKFLLKLVKEGVVK 167
Cdd:cd23970   266 AEFVLLYKMHGAGVLK 281
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 3-167 3.63e-05

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 42.94  E-value: 3.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524   3 YPEGAPlsdlEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPFwvrlfFWKQVAEKIPLQPKHFRILNPVIIKetaFDILQ 82
Cdd:cd23979   132 YPESAK----NLPANVSFVLVPFKTLDLLWITSALSTGQIRF-----TYAPVKQFLRVDKDKVQIYNPAFFK---YIHDR 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  83 YSEPQSRFwgrdknvPTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDSQCMAAMNFQT--MHNVTTETKFLLKL 160
Cdd:cd23979   200 WTEHHGRY-------PSTGMLVLFFALHVCDEVNVYGFGAD---SRGNWHHYWENNRYAGEFRKtgVHDADFEAHIIDML 269


                  ....*..
gi 1229385524 161 VKEGVVK 167
Cdd:cd23979   270 AKAGKIK 276
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 63-160 4.11e-05

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 42.64  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  63 KHFRILNPVIIKEtAFDILQYSEPQSRFwgrdKNVPTIGVIAVVLATHLCDEVSLagFGYDLNQPRTPL-HYFDSQCMAA 141
Cdd:cd23968   156 EPFYLIDPRFLWR-LWDILQEYTPEKIK----PNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVEKDLA 228

                          90
                  ....*....|....*....
gi 1229385524 142 MNFQTMHNVTTETKFLLKL 160
Cdd:cd23968   229 CTLGAWHPLAAEKLLVRHL 247
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 88-167 1.82e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 40.70  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  88 SRFWgRDKNVPTI----GVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDsQCMAAMNFqtmHNVTTETKFLLKL 160
Cdd:cd23971   187 SRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYYD-NVLPKKGV---HAMPEEFLRYLKL 261


                  ....*..
gi 1229385524 161 VKEGVVK 167
Cdd:cd23971   262 HSQGVLR 268
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 62-167 2.17e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 37.50  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  62 PKHFRILNPVIIKETAFDILQySEPQSRFWGrDKNVPTIGVIAVVLATHLCDEVSLAGFGYDlNQPRTPLHYFDSQcMAA 141
Cdd:cd23972   203 AKKFKLLHPDFISYLTDRFLK-SKLLNTHYG-HLYMPSTGALMLLTALHTCDQVSAYGFITS-NYWKFSDHYYERK-KKP 278

                          90       100
                  ....*....|....*....|....*.
gi 1229385524 142 MNFQTMHNVTTETKFLLKLVKEGVVK 167
Cdd:cd23972   279 LVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 63-167 4.96e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 36.65  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385524  63 KHFRILNPviiketafDILQYSepQSRF-WG-------RDKNVPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPrtpl 131
Cdd:cd23974   206 EKFKIYHP--------DFIRYL--RNRFlWSpilntkqRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD---- 271

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1229385524 132 HYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 167
Cdd:cd23974   272 HYYDKT-YHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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