NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1237937960|ref|NP_001341275|]
View 

complement C1r subcomponent isoform 2 preproprotein [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 12185826)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to Sus scrofa major seminal plasma glycoprotein PSP-II

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 477-711 1.22e-72

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


:

Pssm-ID: 214473  Cd Length: 229  Bit Score: 235.26  E-value: 1.22e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  477 RIIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYPKeheaqSNASLDVFLGHTNVEELMKLGNHPIRR 553
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRhfcGGSLISPRWVLTAAHCVRGS-----DPSNIRVRLGSHDLSSGEEGQVIKVSK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  554 VSVHPDYRqdeSYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE---KIAHDLRFVRLPVAN 630
Cdd:smart00020  76 VIIHPNYN---PSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEgagSLPDTLQEVNVPIVS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  631 PQACENWLRGknrMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPntdRWVATGIVSWGIGCSRG--YGFYTKVLNYV 708
Cdd:smart00020 153 NATCRRAYSG---GGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGSGCARPgkPGVYTRVSSYL 226


                   ...
gi 1237937960  709 DWI 711
Cdd:smart00020 227 DWI 229
CUB pfam00431
CUB domain;
207-316 3.03e-36

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 132.03  E-value: 3.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 207 CSSELyTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFlEPFDIDDHQQvhCPYDQLQIY----ANGKNIGEFC 282
Cdd:pfam00431   1 CGGVL-TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1237937960 283 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 316
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 41-152 2.58e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


:

Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 117.88  E-value: 2.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960   41 GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQLGSPlgnppgk 116
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSEAPP------- 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1237937960  117 KEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 152
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQ-------KRGFSARY 102
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 175-203 1.72e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.10  E-value: 1.72e-10
                          10        20
                  ....*....|....*....|....*....
gi 1237937960 175 CQHLCHNYVGGYFCSCRPGYELQEDRHSC 203
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
323-385 4.51e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 4.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937960 323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLiEGNQVLHsftavCQDDGTWHRAMPRC 385
Cdd:pfam00084   1 CPPPPDI-PNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTIT-----CQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 390-461 7.49e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 7.49e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1237937960 390 CGQPRNLPNGDFRYTttMGVNTYKARIQYYCHEPYykmqTRAGSRESeqgvyTCTAQGIWKNEqkgekIPRC 461
Cdd:cd00033     1 CPPPPVPENGTVTGS--KGSYSYGSTVTYSCNEGY----TLVGSSTI-----TCTENGGWSPP-----PPTC 56
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 477-711 1.22e-72

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 235.26  E-value: 1.22e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  477 RIIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYPKeheaqSNASLDVFLGHTNVEELMKLGNHPIRR 553
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRhfcGGSLISPRWVLTAAHCVRGS-----DPSNIRVRLGSHDLSSGEEGQVIKVSK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  554 VSVHPDYRqdeSYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE---KIAHDLRFVRLPVAN 630
Cdd:smart00020  76 VIIHPNYN---PSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEgagSLPDTLQEVNVPIVS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  631 PQACENWLRGknrMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPntdRWVATGIVSWGIGCSRG--YGFYTKVLNYV 708
Cdd:smart00020 153 NATCRRAYSG---GGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGSGCARPgkPGVYTRVSSYL 226


                   ...
gi 1237937960  709 DWI 711
Cdd:smart00020 227 DWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 478-713 3.77e-71

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 231.40  E-value: 3.77e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 478 IIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYPKEHEaqsnaSLDVFLGHTNVEELMKLG-NHPIRR 553
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRhfcGGSLISPRWVLTAAHCVYSSAPS-----NYTVRLGSHDLSSNEGGGqVIKVKK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 554 VSVHPDYRQDESYNfegDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE--KIAHDLRFVRLPVANP 631
Cdd:cd00190    76 VIVHPNYNPSTYDN---DIALLKLKRPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSEggPLPDVLQEVNVPIVSN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 632 QACENWLRGKNrmdVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNtdRWVATGIVSWGIGCSRG--YGFYTKVLNYVD 709
Cdd:cd00190   153 AECKRAYSYGG---TITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGSGCARPnyPGVYTRVSSYLD 227


                  ....
gi 1237937960 710 WIKK 713
Cdd:cd00190   228 WIQK 231
Trypsin pfam00089
Trypsin;
478-711 2.10e-50

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 175.32  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 478 IIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYpkeheaqSNASLDVFLG-HTNVEELMKLGNHPIRR 553
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKhfcGGSLISENWVLTAAHCVS-------GASDVKVVLGaHNIVLREGGEQKFDVEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 554 VSVHPDYRQDESYNfegDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFG-VMEEKIAHDLRFVRLPVANPQ 632
Cdd:pfam00089  74 IIVHPNYNPDTLDN---DIALLKLESPVTLGDTVRPICLPDASSDLPVGTTCTVSGWGnTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 633 ACENWLRGKnrmdvFSQNMFCAGhpSLKQDACQGDSGGVFAVRDPntdrwVATGIVSWGIGCSRG--YGFYTKVLNYVDW 710
Cdd:pfam00089 151 TCRSAYGGT-----VTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGnyPGVYTPVSSYLDW 218


                  .
gi 1237937960 711 I 711
Cdd:pfam00089 219 I 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 462-715 6.24e-47

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 167.13  E-value: 6.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 462 LPVCGKPVNPVEQRqrIIGGQKAKMGNFPWQVFtnIHGRGG-------GALLGDRWILTAAHTLYPkeheaQSNASLDVF 534
Cdd:COG5640    17 LALAAAPAADAAPA--IVGGTPATVGEYPWMVA--LQSSNGpsgqfcgGTLIAPRWVLTAAHCVDG-----DGPSDLRVV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 535 LGHTNveelmkLGN-----HPIRRVSVHPDYRqdeSYNFEGDIALLELENSVTLGPnllPICLPDNDTFYDLGLMGYVSG 609
Cdd:COG5640    88 IGSTD------LSTsggtvVKVARIVVHPDYD---PATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPATVAG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 610 FGVMEE---KIAHDLRFVRLPVANPQACENWLrgknrmDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPntDRWVATG 686
Cdd:COG5640   156 WGRTSEgpgSQSGTLRKADVPVVSDATCAAYG------GFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVG 227

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1237937960 687 IVSWGIG-CSRG-YGFYTKVLNYVDWIKKEM 715
Cdd:COG5640   228 VVSWGGGpCAAGyPGVYTRVSAYRDWIKSTA 258
CUB pfam00431
CUB domain;
207-316 3.03e-36

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 132.03  E-value: 3.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 207 CSSELyTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFlEPFDIDDHQQvhCPYDQLQIY----ANGKNIGEFC 282
Cdd:pfam00431   1 CGGVL-TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1237937960 283 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 316
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 41-152 2.58e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 117.88  E-value: 2.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960   41 GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQLGSPlgnppgk 116
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSEAPP------- 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1237937960  117 KEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 152
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQ-------KRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 30-154 5.52e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.35  E-value: 5.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  30 GGSIPIPQklFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQ 105
Cdd:cd00041     2 GGTLTAST--SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1237937960 106 lgsplgNPPGkkEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYYQA 154
Cdd:cd00041    80 ------TLPP--PIISSGNSLTVRFRSDSSVT-------GRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 207-318 6.97e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.35  E-value: 6.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 207 CSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEpFDIDDHQQvhCPYDQLQIY----ANGKNIGEFC 282
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYdgpsTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1237937960 283 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTT 318
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 217-316 1.07e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 101.70  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  217 GYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFlEPFDIDDHQQvhCPYDQLQIY----ANGKNIGEFCGKQRPPD-LD 291
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 1237937960  292 TSSNAVDLLFFTDESGDSRGWKLRY 316
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
38-152 2.15e-24

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 98.14  E-value: 2.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  38 KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQlgsplGNP 113
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGS-----GIP 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1237937960 114 PgkkEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 152
Cdd:pfam00431  82 E---DIVSSSNQMTIKFVSDASVQ-------KRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 175-203 1.72e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.10  E-value: 1.72e-10
                          10        20
                  ....*....|....*....|....*....
gi 1237937960 175 CQHLCHNYVGGYFCSCRPGYELQEDRHSC 203
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
323-385 4.51e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 4.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937960 323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLiEGNQVLHsftavCQDDGTWHRAMPRC 385
Cdd:pfam00084   1 CPPPPDI-PNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTIT-----CQEDGTWSPPFPEC 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-204 2.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 2.24e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1237937960  156 DLDECASRSksgeedpqpQCQH--LCHNYVGGYFCSCRPGYelqEDRHSCQ 204
Cdd:smart00179   1 DIDECASGN---------PCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 323-385 2.74e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.82  E-value: 2.74e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937960  323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLIEgnqvlhSFTAVCQDDGTWHRAMPRC 385
Cdd:smart00032   1 CPPPPDI-ENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 323-386 4.01e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 4.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1237937960 323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLIegnqvlHSFTAVCQDDGTWHRAMPRCK 386
Cdd:cd00033     1 CPPPPVP-ENGTVTGSKGSYSYGSTVTYSCNEGYTLV------GSSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-197 9.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 9.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1237937960 156 DLDECASRSksgeedpqpQCQH--LCHNYVGGYFCSCRPGYELQ 197
Cdd:cd00054     1 DIDECASGN---------PCQNggTCVNTVGSYRCSCPPGYTGR 35
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 312-385 5.02e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.72  E-value: 5.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1237937960 312 WKLRYTTEIIKCPQPKTLDEFtIIQNLQPQYQFRDYFIATCKQGYQLIegnqvlHSFTAVCQDDGTWHRAMPRC 385
Cdd:PHA02927  195 WSDPPTCQIVKCPHPTISNGY-LSSGFKRSYSYNDNVDFKCKYGYKLS------GSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 390-461 7.49e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 7.49e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1237937960 390 CGQPRNLPNGDFRYTttMGVNTYKARIQYYCHEPYykmqTRAGSRESeqgvyTCTAQGIWKNEqkgekIPRC 461
Cdd:cd00033     1 CPPPPVPENGTVTGS--KGSYSYGSTVTYSCNEGY----TLVGSSTI-----TCTENGGWSPP-----PPTC 56
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 477-711 1.22e-72

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 235.26  E-value: 1.22e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  477 RIIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYPKeheaqSNASLDVFLGHTNVEELMKLGNHPIRR 553
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGRhfcGGSLISPRWVLTAAHCVRGS-----DPSNIRVRLGSHDLSSGEEGQVIKVSK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  554 VSVHPDYRqdeSYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE---KIAHDLRFVRLPVAN 630
Cdd:smart00020  76 VIIHPNYN---PSTYDNDIALLKLKEPVTLSDNVRPICLPSSNYNVPAGTTCTVSGWGRTSEgagSLPDTLQEVNVPIVS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  631 PQACENWLRGknrMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPntdRWVATGIVSWGIGCSRG--YGFYTKVLNYV 708
Cdd:smart00020 153 NATCRRAYSG---GGAITDNMLCAGGLEGGKDACQGDSGGPLVCNDG---RWVLVGIVSWGSGCARPgkPGVYTRVSSYL 226


                   ...
gi 1237937960  709 DWI 711
Cdd:smart00020 227 DWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 478-713 3.77e-71

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 231.40  E-value: 3.77e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 478 IIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYPKEHEaqsnaSLDVFLGHTNVEELMKLG-NHPIRR 553
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGRhfcGGSLISPRWVLTAAHCVYSSAPS-----NYTVRLGSHDLSSNEGGGqVIKVKK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 554 VSVHPDYRQDESYNfegDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE--KIAHDLRFVRLPVANP 631
Cdd:cd00190    76 VIVHPNYNPSTYDN---DIALLKLKRPVTLSDNVRPICLPSSGYNLPAGTTCTVSGWGRTSEggPLPDVLQEVNVPIVSN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 632 QACENWLRGKNrmdVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNtdRWVATGIVSWGIGCSRG--YGFYTKVLNYVD 709
Cdd:cd00190   153 AECKRAYSYGG---TITDNMLCAGGLEGGKDACQGDSGGPLVCNDNG--RGVLVGIVSWGSGCARPnyPGVYTRVSSYLD 227


                  ....
gi 1237937960 710 WIKK 713
Cdd:cd00190   228 WIQK 231
Trypsin pfam00089
Trypsin;
478-711 2.10e-50

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 175.32  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 478 IIGGQKAKMGNFPWQVFTNIHGRG---GGALLGDRWILTAAHTLYpkeheaqSNASLDVFLG-HTNVEELMKLGNHPIRR 553
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGKhfcGGSLISENWVLTAAHCVS-------GASDVKVVLGaHNIVLREGGEQKFDVEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 554 VSVHPDYRQDESYNfegDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFG-VMEEKIAHDLRFVRLPVANPQ 632
Cdd:pfam00089  74 IIVHPNYNPDTLDN---DIALLKLESPVTLGDTVRPICLPDASSDLPVGTTCTVSGWGnTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 633 ACENWLRGKnrmdvFSQNMFCAGhpSLKQDACQGDSGGVFAVRDPntdrwVATGIVSWGIGCSRG--YGFYTKVLNYVDW 710
Cdd:pfam00089 151 TCRSAYGGT-----VTDTMICAG--AGGKDACQGDSGGPLVCSDG-----ELIGIVSWGYGCASGnyPGVYTPVSSYLDW 218


                  .
gi 1237937960 711 I 711
Cdd:pfam00089 219 I 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 462-715 6.24e-47

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 167.13  E-value: 6.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 462 LPVCGKPVNPVEQRqrIIGGQKAKMGNFPWQVFtnIHGRGG-------GALLGDRWILTAAHTLYPkeheaQSNASLDVF 534
Cdd:COG5640    17 LALAAAPAADAAPA--IVGGTPATVGEYPWMVA--LQSSNGpsgqfcgGTLIAPRWVLTAAHCVDG-----DGPSDLRVV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 535 LGHTNveelmkLGN-----HPIRRVSVHPDYRqdeSYNFEGDIALLELENSVTLGPnllPICLPDNDTFYDLGLMGYVSG 609
Cdd:COG5640    88 IGSTD------LSTsggtvVKVARIVVHPDYD---PATPGNDIALLKLATPVPGVA---PAPLATSADAAAPGTPATVAG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 610 FGVMEE---KIAHDLRFVRLPVANPQACENWLrgknrmDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPntDRWVATG 686
Cdd:COG5640   156 WGRTSEgpgSQSGTLRKADVPVVSDATCAAYG------GFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVG 227

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1237937960 687 IVSWGIG-CSRG-YGFYTKVLNYVDWIKKEM 715
Cdd:COG5640   228 VVSWGGGpCAAGyPGVYTRVSAYRDWIKSTA 258
CUB pfam00431
CUB domain;
207-316 3.03e-36

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 132.03  E-value: 3.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 207 CSSELyTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFlEPFDIDDHQQvhCPYDQLQIY----ANGKNIGEFC 282
Cdd:pfam00431   1 CGGVL-TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRdgpsASSPLLGRFC 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1237937960 283 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 316
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 41-152 2.58e-31

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 117.88  E-value: 2.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960   41 GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQLGSPlgnppgk 116
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgpSASSPLLGRFCGSEAPP------- 73

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1237937960  117 KEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 152
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQ-------KRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 30-154 5.52e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.35  E-value: 5.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  30 GGSIPIPQklFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQ 105
Cdd:cd00041     2 GGTLTAST--SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgpSTSSPLLGRFCGS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1237937960 106 lgsplgNPPGkkEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYYQA 154
Cdd:cd00041    80 ------TLPP--PIISSGNSLTVRFRSDSSVT-------GRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 207-318 6.97e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 111.35  E-value: 6.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 207 CSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEpFDIDDHQQvhCPYDQLQIY----ANGKNIGEFC 282
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN--CSYDYLEIYdgpsTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1237937960 283 GKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTT 318
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 217-316 1.07e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 101.70  E-value: 1.07e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  217 GYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFlEPFDIDDHQQvhCPYDQLQIY----ANGKNIGEFCGKQRPPD-LD 291
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77

                           90       100
                   ....*....|....*....|....*
gi 1237937960  292 TSSNAVDLLFFTDESGDSRGWKLRY 316
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
38-152 2.15e-24

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 98.14  E-value: 2.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960  38 KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADKKSLGRFCGQlgsplGNP 113
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpSASSPLLGRFCGS-----GIP 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1237937960 114 PgkkEFMSQGNKMLLTFHTDFSNEengtimfYKGFLAYY 152
Cdd:pfam00431  82 E---DIVSSSNQMTIKFVSDASVQ-------KRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 175-203 1.72e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.10  E-value: 1.72e-10
                          10        20
                  ....*....|....*....|....*....
gi 1237937960 175 CQHLCHNYVGGYFCSCRPGYELQEDRHSC 203
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
323-385 4.51e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 55.58  E-value: 4.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937960 323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLiEGNQVLHsftavCQDDGTWHRAMPRC 385
Cdd:pfam00084   1 CPPPPDI-PNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTIT-----CQEDGTWSPPFPEC 56
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 492-699 3.94e-08

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 53.91  E-value: 3.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 492 QVFTNIHGRGG-GALLGDRWILTAAHTLYPKEHeAQSNASLDVFLGHTNVEElmklGNHPIRRVSVHPDYRQDESYNFeg 570
Cdd:COG3591     4 RLETDGGGGVCtGTLIGPNLVLTAGHCVYDGAG-GGWATNIVFVPGYNGGPY----GTATATRFRVPPGWVASGDAGY-- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937960 571 DIALLELENSVTLGPNLLPIclpDNDTFYDLGLMGYVSGFGvmEEKIAHDLRFVRLPVANPQacENWLRgknrmdvfsqn 650
Cdd:COG3591    77 DYALLRLDEPLGDTTGWLGL---AFNDAPLAGEPVTIIGYP--GDRPKDLSLDCSGRVTGVQ--GNRLS----------- 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1237937960 651 MFCaghpslkqDACQGDSGG-VFAVRDpntDRWVATGIVSWGIGCSRGYG 699
Cdd:COG3591   139 YDC--------DTTGGSSGSpVLDDSD---GGGRVVGVHSAGGADRANTG 177
EGF_CA smart00179
Calcium-binding EGF-like domain;
156-204 2.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 2.24e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1237937960  156 DLDECASRSksgeedpqpQCQH--LCHNYVGGYFCSCRPGYelqEDRHSCQ 204
Cdd:smart00179   1 DIDECASGN---------PCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 323-385 2.74e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.82  E-value: 2.74e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1237937960  323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLIEgnqvlhSFTAVCQDDGTWHRAMPRC 385
Cdd:smart00032   1 CPPPPDI-ENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 323-386 4.01e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 4.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1237937960 323 CPQPKTLdEFTIIQNLQPQYQFRDYFIATCKQGYQLIegnqvlHSFTAVCQDDGTWHRAMPRCK 386
Cdd:cd00033     1 CPPPPVP-ENGTVTGSKGSYSYGSTVTYSCNEGYTLV------GSSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 156-197 9.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 9.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1237937960 156 DLDECASRSksgeedpqpQCQH--LCHNYVGGYFCSCRPGYELQ 197
Cdd:cd00054     1 DIDECASGN---------PCQNggTCVNTVGSYRCSCPPGYTGR 35
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 312-385 5.02e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.72  E-value: 5.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1237937960 312 WKLRYTTEIIKCPQPKTLDEFtIIQNLQPQYQFRDYFIATCKQGYQLIegnqvlHSFTAVCQDDGTWHRAMPRC 385
Cdd:PHA02927  195 WSDPPTCQIVKCPHPTISNGY-LSSGFKRSYSYNDNVDFKCKYGYKLS------GSSSSTCSPGNTWQPELPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 390-461 7.49e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 7.49e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1237937960 390 CGQPRNLPNGDFRYTttMGVNTYKARIQYYCHEPYykmqTRAGSRESeqgvyTCTAQGIWKNEqkgekIPRC 461
Cdd:cd00033     1 CPPPPVPENGTVTGS--KGSYSYGSTVTYSCNEGY----TLVGSSTI-----TCTENGGWSPP-----PPTC 56
EGF_CA pfam07645
Calcium-binding EGF domain;
156-193 1.28e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1237937960 156 DLDECAsrsksgeeDPQPQCQH--LCHNYVGGYFCSCRPG 193
Cdd:pfam07645   1 DVDECA--------TGTHNCPAntVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 175-204 7.93e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 34.76  E-value: 7.93e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1237937960 175 CQH--LCHNYVGGYFCSCRPGYELQedrHSCQ 204
Cdd:cd00053     8 CSNggTCVNTPGSYRCVCPPGYTGD---RSCE 36
EGF smart00181
Epidermal growth factor-like domain;
170-199 9.20e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 34.41  E-value: 9.20e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1237937960  170 DPQPQCQH-LCHNYVGGYFCSCRPGYELQED 199
Cdd:smart00181   3 ASGGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 188-204 9.39e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 33.92  E-value: 9.39e-03
                          10
                  ....*....|....*..
gi 1237937960 188 CSCRPGYELQEDRHSCQ 204
Cdd:pfam12662   2 CSCPPGYQLDPDGRTCV 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH