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Conserved domains on  [gi|1238280216|ref|NP_001341855|]
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serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform d [Homo sapiens]

Protein Classification

phosphatase 2A regulatory subunit B56 family protein( domain architecture ID 706874)

phosphatase 2A regulatory subunit B56 family protein may function as the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulating substrate specificity, subcellular localization, and responsiveness to phosphorylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B56 super family cl27532
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 55-120 3.02e-25

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


The actual alignment was detected with superfamily member pfam01603:

Pssm-ID: 474937  Cd Length: 404  Bit Score: 98.84  E-value: 3.02e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238280216  55 PSSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVS 120
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIA 66
B56 super family cl27532
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 2-67 1.75e-06

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


The actual alignment was detected with superfamily member PLN00122:

Pssm-ID: 474937  Cd Length: 170  Bit Score: 45.09  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238280216   2 SSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIEltPLPLLKDVPSSEQPELFLKKL 67
Cdd:PLN00122    4 ASSGSSAPAVNSSPSSSSSGKSSNSSKSASSAVNPASVVAGYE--PLPSFRDVPNSEKQNLFVRKL 67
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 55-120 3.02e-25

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 98.84  E-value: 3.02e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238280216  55 PSSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVS 120
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIA 66
PLN00122 PLN00122
serine/threonine protein phosphatase 2A; Provisional
 2-67 1.75e-06

serine/threonine protein phosphatase 2A; Provisional


Pssm-ID: 215064  Cd Length: 170  Bit Score: 45.09  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238280216   2 SSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIEltPLPLLKDVPSSEQPELFLKKL 67
Cdd:PLN00122    4 ASSGSSAPAVNSSPSSSSSGKSSNSSKSASSAVNPASVVAGYE--PLPSFRDVPNSEKQNLFVRKL 67
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
 55-120 3.02e-25

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 98.84  E-value: 3.02e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238280216  55 PSSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVS 120
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIA 66
PLN00122 PLN00122
serine/threonine protein phosphatase 2A; Provisional
 2-67 1.75e-06

serine/threonine protein phosphatase 2A; Provisional


Pssm-ID: 215064  Cd Length: 170  Bit Score: 45.09  E-value: 1.75e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238280216   2 SSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIEltPLPLLKDVPSSEQPELFLKKL 67
Cdd:PLN00122    4 ASSGSSAPAVNSSPSSSSSGKSSNSSKSASSAVNPASVVAGYE--PLPSFRDVPNSEKQNLFVRKL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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