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Conserved domains on  [gi|1243457555|ref|NP_001342429|]
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macoilin isoform 3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Macoilin super family cl25928
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 1-485 0e+00

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


The actual alignment was detected with superfamily member pfam09726:

Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 657.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555   1 MRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILiHHNGGIPANKKLSTTLPEIEYREKGK 80
Cdd:pfam09726 177 MRLRKQREVQKENEFYMQLLQQALPKEQQMLDRQERETSETAKGLSEVDPLAL-NQNGHSLNKKDSTLQLPELEYREKKN 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  81 EKDKDAKKHNLG-INNNNILQPVDSKIQEIEYMENHINSKRLNND-LVGSTENLLKEDSC--------TASSKNYKNAS- 149
Cdd:pfam09726 256 SGTSSGSDSKKShNHNIHNLNHVDSKLQEKEYMENHSNSKRLNIStSPGSEEDLLVRESVssksssssSSSNKNYKNASg 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 150 ---GVVNSSPRSHSATNGSIPSSSS-KNEKKQKC-TSKGPSAHKDLMENCIPNNQLSKPDALVRLEQDIKKLKADLQASR 224
Cdd:pfam09726 336 gsaNSSNSSPRSHSHNSGSVTSSSSsKNSKKQKGpGGKSGARHKDPAENCIPNNQLSKPDALVRLEQDIKKLKAELQASR 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 225 QVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQEARSFVEKQLMEEKKRK 304
Cdd:pfam09726 416 QTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQEARASAEKQLAEEKKRK 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 305 KLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELRKYKENEKDTEVLMSALSAM 384
Cdd:pfam09726 496 KEEEATAARAVALAAASRGECTESLKQRKRELESEIKKLTHDIKLKEEQIRELEIKVQELRKYKESEKDTEVLMSALSAM 575

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 385 QDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSitysaaTSPLSPVSPHYS 464
Cdd:pfam09726 576 QDKNQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIYQKDQEIKDLKQKIAEVMAVMPS------TSRITPVTPHYS 649

                         490       500
                  ....*....|....*....|.
gi 1243457555 465 SKFVETSPSGLDPNASVYQPL 485
Cdd:pfam09726 650 SKFMDTSPSMRDPNASVYPPL 670
 
Name Accession Description Interval E-value
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 1-485 0e+00

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 657.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555   1 MRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILiHHNGGIPANKKLSTTLPEIEYREKGK 80
Cdd:pfam09726 177 MRLRKQREVQKENEFYMQLLQQALPKEQQMLDRQERETSETAKGLSEVDPLAL-NQNGHSLNKKDSTLQLPELEYREKKN 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  81 EKDKDAKKHNLG-INNNNILQPVDSKIQEIEYMENHINSKRLNND-LVGSTENLLKEDSC--------TASSKNYKNAS- 149
Cdd:pfam09726 256 SGTSSGSDSKKShNHNIHNLNHVDSKLQEKEYMENHSNSKRLNIStSPGSEEDLLVRESVssksssssSSSNKNYKNASg 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 150 ---GVVNSSPRSHSATNGSIPSSSS-KNEKKQKC-TSKGPSAHKDLMENCIPNNQLSKPDALVRLEQDIKKLKADLQASR 224
Cdd:pfam09726 336 gsaNSSNSSPRSHSHNSGSVTSSSSsKNSKKQKGpGGKSGARHKDPAENCIPNNQLSKPDALVRLEQDIKKLKAELQASR 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 225 QVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQEARSFVEKQLMEEKKRK 304
Cdd:pfam09726 416 QTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQEARASAEKQLAEEKKRK 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 305 KLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELRKYKENEKDTEVLMSALSAM 384
Cdd:pfam09726 496 KEEEATAARAVALAAASRGECTESLKQRKRELESEIKKLTHDIKLKEEQIRELEIKVQELRKYKESEKDTEVLMSALSAM 575

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 385 QDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSitysaaTSPLSPVSPHYS 464
Cdd:pfam09726 576 QDKNQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIYQKDQEIKDLKQKIAEVMAVMPS------TSRITPVTPHYS 649

                         490       500
                  ....*....|....*....|.
gi 1243457555 465 SKFVETSPSGLDPNASVYQPL 485
Cdd:pfam09726 650 SKFMDTSPSMRDPNASVYPPL 670
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 204-439 5.27e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.79  E-value: 5.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 204 DALVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKL 283
Cdd:COG1196   253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEEL 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 284 KAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTmdmKVKEEQIRELELKVQE 363
Cdd:COG1196   333 EELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR---AAAELAAQLEELEEAE 409

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1243457555 364 ---LRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAE 439
Cdd:COG1196   410 ealLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 197-439 9.40e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 9.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  197 NNQLSKPDALVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNI 276
Cdd:TIGR02168  670 SSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERI 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  277 SQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECtETLRSRIRELEAEGKKLTMDMKVKEEQI-- 354
Cdd:TIGR02168  750 AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL-KALREALDELRAELTLLNEEAANLRERLes 828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  355 --RELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFS----ALGDAKRQLEIAQGQILQKDQ 428
Cdd:TIGR02168  829 leRRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleeALALLRSELEELSEELRELES 908

                          250
                   ....*....|.
gi 1243457555  429 EIKDLKQKIAE 439
Cdd:TIGR02168  909 KRSELRRELEE 919
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
209-439 2.86e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.43  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 209 LEQDIKKLKADLQASRQVEQELRSQ----------ISALSSTERGIRSEMGQLR---QENELLQNKLHNAVQMKQKDKQN 275
Cdd:PRK03918  174 IKRRIERLEKFIKRTENIEELIKEKekeleevlreINEISSELPELREELEKLEkevKELEELKEEIEELEKELESLEGS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 276 ISQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASrgECTETLRSRIRELEAEGKKLTMDMKVKEEQIR 355
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLS--EFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 356 ELELKVQELR----KYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDlfsALGDAKRQLEIAQGQILQKDQEIK 431
Cdd:PRK03918  332 ELEEKEERLEelkkKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGL---TPEKLEKELEELEKAKEEIEEEIS 408


                  ....*...
gi 1243457555 432 DLKQKIAE 439
Cdd:PRK03918  409 KITARIGE 416
 
Name Accession Description Interval E-value
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 1-485 0e+00

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 657.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555   1 MRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILiHHNGGIPANKKLSTTLPEIEYREKGK 80
Cdd:pfam09726 177 MRLRKQREVQKENEFYMQLLQQALPKEQQMLDRQERETSETAKGLSEVDPLAL-NQNGHSLNKKDSTLQLPELEYREKKN 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  81 EKDKDAKKHNLG-INNNNILQPVDSKIQEIEYMENHINSKRLNND-LVGSTENLLKEDSC--------TASSKNYKNAS- 149
Cdd:pfam09726 256 SGTSSGSDSKKShNHNIHNLNHVDSKLQEKEYMENHSNSKRLNIStSPGSEEDLLVRESVssksssssSSSNKNYKNASg 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 150 ---GVVNSSPRSHSATNGSIPSSSS-KNEKKQKC-TSKGPSAHKDLMENCIPNNQLSKPDALVRLEQDIKKLKADLQASR 224
Cdd:pfam09726 336 gsaNSSNSSPRSHSHNSGSVTSSSSsKNSKKQKGpGGKSGARHKDPAENCIPNNQLSKPDALVRLEQDIKKLKAELQASR 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 225 QVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQEARSFVEKQLMEEKKRK 304
Cdd:pfam09726 416 QTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQEARASAEKQLAEEKKRK 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 305 KLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELRKYKENEKDTEVLMSALSAM 384
Cdd:pfam09726 496 KEEEATAARAVALAAASRGECTESLKQRKRELESEIKKLTHDIKLKEEQIRELEIKVQELRKYKESEKDTEVLMSALSAM 575

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 385 QDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSitysaaTSPLSPVSPHYS 464
Cdd:pfam09726 576 QDKNQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIYQKDQEIKDLKQKIAEVMAVMPS------TSRITPVTPHYS 649

                         490       500
                  ....*....|....*....|.
gi 1243457555 465 SKFVETSPSGLDPNASVYQPL 485
Cdd:pfam09726 650 SKFMDTSPSMRDPNASVYPPL 670
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 204-439 5.27e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.79  E-value: 5.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 204 DALVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKL 283
Cdd:COG1196   253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEEL 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 284 KAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTmdmKVKEEQIRELELKVQE 363
Cdd:COG1196   333 EELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR---AAAELAAQLEELEEAE 409

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1243457555 364 ---LRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAE 439
Cdd:COG1196   410 ealLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 197-439 9.40e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 9.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  197 NNQLSKPDALVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNI 276
Cdd:TIGR02168  670 SSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERI 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  277 SQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECtETLRSRIRELEAEGKKLTMDMKVKEEQI-- 354
Cdd:TIGR02168  750 AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL-KALREALDELRAELTLLNEEAANLRERLes 828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  355 --RELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFS----ALGDAKRQLEIAQGQILQKDQ 428
Cdd:TIGR02168  829 leRRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleeALALLRSELEELSEELRELES 908

                          250
                   ....*....|.
gi 1243457555  429 EIKDLKQKIAE 439
Cdd:TIGR02168  909 KRSELRRELEE 919
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 206-447 1.68e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 1.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  206 LVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAvqmkqkdKQNISQLEKKLKA 285
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYAL-------ANEISRLEQQKQI 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  286 EQEARSFVEKQLmEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELR 365
Cdd:TIGR02168  307 LRERLANLERQL-EELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLR 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  366 -KYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAkrQLEIAQGQILQKDQEIKDLKQKIAEVMAVM 444
Cdd:TIGR02168  386 sKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEAL 463


                   ...
gi 1243457555  445 PSI 447
Cdd:TIGR02168  464 EEL 466
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 208-439 1.17e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 208 RLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAvqmkqkdKQNISQLEKKLKAEQ 287
Cdd:COG1196   236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYEL-------LAELARLEQDIARLE 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 288 EARSFVEKQLMEEKKRKKLEEATAARAVAFAaasrgectETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELRky 367
Cdd:COG1196   309 ERRRELEERLEELEEELAELEEELEELEEEL--------EELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-- 378

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1243457555 368 KENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLfSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAE 439
Cdd:COG1196   379 EELEELAEELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELEELEEALAELEEEEEEEEEALEEAAE 449
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 208-431 3.33e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.94  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 208 RLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQ 287
Cdd:COG1196   299 RLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 288 EARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTmdmKVKEEQIRELELKVQELRKY 367
Cdd:COG1196   379 EELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE---EEEEEEEALEEAAEEEAELE 455

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1243457555 368 KENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLdLFSALGDAKRQLEIAQGQILQKDQEIK 431
Cdd:COG1196   456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAA-RLLLLLEAEADYEGFLEGVKAALLLAG 518
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 204-439 9.58e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 9.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  204 DALVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKL 283
Cdd:TIGR02168  719 KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL 798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  284 KAEQEARSFVEKQLmEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQE 363
Cdd:TIGR02168  799 KALREALDELRAEL-TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  364 LRK-YKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQK---------------- 426
Cdd:TIGR02168  878 LLNeRASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLqerlseeysltleeae 957

                          250       260
                   ....*....|....*....|....*.
gi 1243457555  427 -------------DQEIKDLKQKIAE 439
Cdd:TIGR02168  958 alenkieddeeeaRRRLKRLENKIKE 983
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 206-441 2.55e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.98  E-value: 2.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  206 LVRLEQDIKKLKADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNaVQMKQKD------KQNISQL 279
Cdd:TIGR02169  718 IGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHK-LEEALNDlearlsHSRIPEI 796

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  280 EKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTEtLRSRIRELEAEGKKLTMDMKVKEEQIRELEL 359
Cdd:TIGR02169  797 QAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRID-LKEQIKSIEKEIENLNGKKEELEEELEELEA 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  360 KVQELRK-YKENEKDTEVLMSALSAMQDKTQHLENSLSaetriklDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIA 438
Cdd:TIGR02169  876 ALRDLESrLGDLKKERDELEAQLRELERKIEELEAQIE-------KKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPE 948


                   ...
gi 1243457555  439 EVM 441
Cdd:TIGR02169  949 EEL 951
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 204-439 4.57e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 204 DALVRLEQDIKKLKADLQASR----QVEQELRSQISALSSTERgirsEMGQLRQENELLQNKLHNAVQMKQKDKQNISQL 279
Cdd:COG1196   274 LELEELELELEEAQAEEYELLaelaRLEQDIARLEERRRELEE----RLEELEEELAELEEELEELEEELEELEEELEEA 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 280 EKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTEtLRSRIRELEAEGKKLTMDMKVKEEQIRELEL 359
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAE-LAAQLEELEEAEEALLERLERLEEELEELEE 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 360 KVQELRKYKENEKDtevlmsALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAE 439
Cdd:COG1196   429 ALAELEEEEEEEEE------ALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
204-436 1.58e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 1.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  204 DALVRLEQDIKKLkADLQASRQVEQELRSQISALSSTERGIRSEMGQLRQEneLLQNKLHNAVQMKQKDKQNISQLEKKL 283
Cdd:COG4913    242 EALEDAREQIELL-EPIRELAERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  284 KAEQEARSFVEKQLMEEKkrkkleeataaravafaaasrGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQE 363
Cdd:COG4913    319 DALREELDELEAQIRGNG---------------------GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPA 377

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1243457555  364 LRKykenekdtevlmsALSAMQDKTQHLENSLSAETRiklDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQK 436
Cdd:COG4913    378 SAE-------------EFAALRAEAAALLEALEEELE---ALEEALAEAEAALRDLRRELRELEAEIASLERR 434
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
205-461 1.80e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 205 ALVRLEQDIKKLKADLQASRQVEQELRSQISALSSTErgirsEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLK 284
Cdd:COG3206   176 ALEFLEEQLPELRKELEEAEAALEEFRQKNGLVDLSE-----EAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLG 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 285 AEQEARSFVekqlmeekkrkkleeataaravafaaaSRGECTETLRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQEL 364
Cdd:COG3206   251 SGPDALPEL---------------------------LQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAAL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 365 RKYKENEKDTEV--LMSALSAMQDKTQHLENSLsAETRIKLDLFSA----LGDAKRQLEIAQG---QILQKDQEIkdlkq 435
Cdd:COG3206   304 RAQLQQEAQRILasLEAELEALQAREASLQAQL-AQLEARLAELPEleaeLRRLEREVEVARElyeSLLQRLEEA----- 377

                         250       260
                  ....*....|....*....|....*.
gi 1243457555 436 KIAEVMAVMPSITYSAATSPLSPVSP 461
Cdd:COG3206   378 RLAEALTVGNVRVIDPAVVPLKPVSP 403
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 218-474 2.29e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 218 ADLQASRQVE-QELRSQISALSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQEARSFVEKQ 296
Cdd:COG4942    19 ADAAAEAEAElEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 297 LMEEKKRKKLEEATAARAVAFAAA----SRGECTETLRSRIREleaegKKLTMDMKVKEEQIRELELKVQELRKYKENEK 372
Cdd:COG4942    99 LEAQKEELAELLRALYRLGRQPPLalllSPEDFLDAVRRLQYL-----KYLAPARREQAEELRADLAELAALRAELEAER 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 373 DTevLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSITYSAA 452
Cdd:COG4942   174 AE--LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251

                         250       260
                  ....*....|....*....|...
gi 1243457555 453 TSPLS-PVSPHYSSKFVETSPSG 474
Cdd:COG4942   252 KGKLPwPVSGRVVRRFGERDGGG 274
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
209-439 2.86e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.43  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 209 LEQDIKKLKADLQASRQVEQELRSQ----------ISALSSTERGIRSEMGQLR---QENELLQNKLHNAVQMKQKDKQN 275
Cdd:PRK03918  174 IKRRIERLEKFIKRTENIEELIKEKekeleevlreINEISSELPELREELEKLEkevKELEELKEEIEELEKELESLEGS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 276 ISQLEKKLKAEQEARSFVEKQLMEEKKRKKLEEATAARAVAFAAASrgECTETLRSRIRELEAEGKKLTMDMKVKEEQIR 355
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLS--EFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555 356 ELELKVQELR----KYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDlfsALGDAKRQLEIAQGQILQKDQEIK 431
Cdd:PRK03918  332 ELEEKEERLEelkkKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGL---TPEKLEKELEELEKAKEEIEEEIS 408


                  ....*...
gi 1243457555 432 DLKQKIAE 439
Cdd:PRK03918  409 KITARIGE 416
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
329-398 4.00e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 4.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1243457555 329 LRSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELRK--YKENEKDTEVlmsalSAMQDKTQHLENSLSAE 398
Cdd:COG2433   418 LEEQVERLEAEVEELEAELEEKDERIERLERELSEARSeeRREIRKDREI-----SRLDREIERLERELEEE 484
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
330-439 7.96e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 7.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457555  330 RSRIRELEAEGKKLTMDMKVKEEQIRELELKVQELRK----------YKENEKDTEVLMSALSAMQDKTQHLENSLSAET 399
Cdd:COG4913    609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQErrealqrlaeYSWDEIDVASAEREIAELEAELERLDASSDDLA 688

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1243457555  400 RIKldlfSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAE 439
Cdd:COG4913    689 ALE----EQLEELEAELEELEEELDELKGEIGRLEKELEQ 724
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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