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Conserved domains on  [gi|1274095736|ref|NP_001344486|]
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zinc finger protein OZF [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-260 2.42e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736   1 MSQLSQQRILSGGSPFACKVCGKLFSHKSNLTEHEHFHSREKPFECNECGKAFSQKQYVIKHQSTHSGEKLFECSDCGKA 80
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736  81 FSQKENLLTHQKIHTGE-------KPFECKDCGKAFIQKSNLIRHQRT--HTGE--KPFICKE--CGKTFSGKSNLTEHE 147
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736 148 KIHIGEKPFKC--NECGTAFGQKKYLIKHQNIH-----TGEKPYEC--NECGKAFSQRTSLIVHVRIHSGDKPYECN--V 216
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1274095736 217 CGKAFSQSSSLTVHVRSHTgEKPYGCNECGKAFSQFSTLALHLR 260
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 1.71e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*
gi 1274095736 255 LALHLRIHTGKKPYQCSECGKAFSQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-260 2.42e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736   1 MSQLSQQRILSGGSPFACKVCGKLFSHKSNLTEHEHFHSREKPFECNECGKAFSQKQYVIKHQSTHSGEKLFECSDCGKA 80
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736  81 FSQKENLLTHQKIHTGE-------KPFECKDCGKAFIQKSNLIRHQRT--HTGE--KPFICKE--CGKTFSGKSNLTEHE 147
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736 148 KIHIGEKPFKC--NECGTAFGQKKYLIKHQNIH-----TGEKPYEC--NECGKAFSQRTSLIVHVRIHSGDKPYECN--V 216
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1274095736 217 CGKAFSQSSSLTVHVRSHTgEKPYGCNECGKAFSQFSTLALHLR 260
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
86-111 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1274095736  86 NLLTHQKIHTGEKPFECKDCGKAFIQ 111
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*
gi 1274095736 255 LALHLRIHTGKKPYQCSECGKAFSQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-260 2.42e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736   1 MSQLSQQRILSGGSPFACKVCGKLFSHKSNLTEHEHFHSREKPFECNECGKAFSQKQYVIKHQSTHSGEKLFECSDCGKA 80
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736  81 FSQKENLLTHQKIHTGE-------KPFECKDCGKAFIQKSNLIRHQRT--HTGE--KPFICKE--CGKTFSGKSNLTEHE 147
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736 148 KIHIGEKPFKC--NECGTAFGQKKYLIKHQNIH-----TGEKPYEC--NECGKAFSQRTSLIVHVRIHSGDKPYECN--V 216
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1274095736 217 CGKAFSQSSSLTVHVRSHTgEKPYGCNECGKAFSQFSTLALHLR 260
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
15-292 3.22e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736  15 PFACKVCGKLFSHKSNLTEHEHFHSREKPFECNECGKAFSQKQYVIK--HQSTHSGEKLFECSDCG-----KAFSQKENL 87
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLplsnsKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736  88 --------------LTHQKIHTGEKPFECKDC--GKAFIQKSNLIRHQRTHTGEKPFIC--KECGKTFSGKSNLTEHEKI 149
Cdd:COG5048   113 sssnsndnnllsshSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLpaNSLSKDPSSNLSLLISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736 150 HIGEKPFKCNECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAF------SQRTSLIVHVRIHSGDKPYECNVCGKAFSQ 223
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1274095736 224 SSSLTVHVRSHTG-EKPYGCNECGKAFSQFSTLALHLR--IHTGK--KPYQCSE--CGKAFSQKSHHIRHQKIHTH 292
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-211 3.77e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736  70 KLFECSDCGKAFSQKENLLTHQKIHTGEKPFECKD--CGKAFIQKSNLIRHQRTHTGEKPFIC-KECGKTFSGKSNLTEH 146
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1274095736 147 EKIHIGEKPFKCNECGTAFGQKKYLIK--HQNIHTGEKPYE-CNECGKAFSQRTSLIVHVRIHSGDKP 211
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPANSLSKD 179
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-292 6.43e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1274095736 209 DKPYECNVCGKAFSQSSSLTVHVRS--HTGE--KPYGCNE--CGKAFSQFSTLALHLRIHTGKKPYQC--SECGKAFSQK 280
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPL 366

                          90
                  ....*....|..
gi 1274095736 281 SHHIRHQKIHTH 292
Cdd:COG5048   367 LNNEPPQSLQQY 378
zf-H2C2_2 pfam13465
Zinc-finger double domain;
86-111 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1274095736  86 NLLTHQKIHTGEKPFECKDCGKAFIQ 111
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 100-122 1.43e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|...
gi 1274095736 100 FECKDCGKAFIQKSNLIRHQRTH 122
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*
gi 1274095736 255 LALHLRIHTGKKPYQCSECGKAFSQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-195 3.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 3.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 1274095736 170 YLIKHQNIHTGEKPYECNECGKAFSQ 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
114-138 4.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.17e-03
                          10        20
                  ....*....|....*....|....*
gi 1274095736 114 NLIRHQRTHTGEKPFICKECGKTFS 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-223 4.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1274095736 198 SLIVHVRIHSGDKPYECNVCGKAFSQ 223
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-271 9.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.37  E-value: 9.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1274095736 209 DKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCN--ECGKAFSQFSTLALHLRIHTGKKPYQCS 271
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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