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Conserved domains on  [gi|1315144671|ref|NP_001345963|]
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guanine nucleotide-binding protein subunit alpha-13 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G_alpha super family cl29918
G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding ...
 29-172 2.65e-62

G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding site


The actual alignment was detected with superfamily member smart00275:

Pssm-ID: 214595 [Multi-domain]  Cd Length: 342  Bit Score: 195.49  E-value: 2.65e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671   29 RKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHI 108
Cdd:smart00275   2 RRNKEIEKQLEEERKKKKREVKLLLLGAGESGKSTILKQMRILHGDGFSQEERREYRPLIYSNILESMKALVDAMEELNI 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1315144671  109 PWGDNKNQLHGDKLMAFDTRAPMAaqgmvETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:smart00275  82 PFEDPESILDIRIITEQFNKTDET-----ENVLPKEIAKAIKALWKDEGIQECYRRRNEFQLND 140
 
Name Accession Description Interval E-value
G_alpha smart00275
G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding ...
 29-172 2.65e-62

G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding site


Pssm-ID: 214595 [Multi-domain]  Cd Length: 342  Bit Score: 195.49  E-value: 2.65e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671   29 RKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHI 108
Cdd:smart00275   2 RRNKEIEKQLEEERKKKKREVKLLLLGAGESGKSTILKQMRILHGDGFSQEERREYRPLIYSNILESMKALVDAMEELNI 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1315144671  109 PWGDNKNQLHGDKLMAFDTRAPMAaqgmvETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:smart00275  82 PFEDPESILDIRIITEQFNKTDET-----ENVLPKEIAKAIKALWKDEGIQECYRRRNEFQLND 140
G-alpha cd00066
Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins ...
 49-172 4.40e-53

Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins contains the guanine nucleotide binding site. The heterotrimeric GNP-binding proteins are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. Extracellular signals are received by receptors, which activate the G proteins, which in turn route the signals to several distinct intracellular signaling pathways. The alpha subunit of G proteins is a weak GTPase. In the resting state, heterotrimeric G proteins are associated at the cytosolic face of the plasma membrane and the alpha subunit binds to GDP. Upon activation by a receptor GDP is replaced with GTP, and the G-alpha/GTP complex dissociates from the beta and gamma subunits. This results in activation of downstream signaling pathways, such as cAMP synthesis by adenylyl cyclase, which is terminated when GTP is hydrolized and the heterotrimers reconstitute.


Pssm-ID: 206639 [Multi-domain]  Cd Length: 315  Bit Score: 171.17  E-value: 4.40e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671  49 VKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQLHGDKLMAFDTR 128
Cdd:cd00066     1 VKLLLLGAGESGKSTILKQMKILHGNGFSDEERREFRPVIYSNILQSMKALLRAMETLNIPYGDPENEKDAKKILSLAPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1315144671 129 APmaaqgmvETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:cd00066    81 AE-------EGPLPPELAEAIKRLWKDPGIQACYDRRNEYQLND 117
G-alpha pfam00503
G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular ...
 46-172 1.17e-43

G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.


Pssm-ID: 459835 [Multi-domain]  Cd Length: 316  Bit Score: 146.96  E-value: 1.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671  46 KRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQLHGDKLMAF 125
Cdd:pfam00503   3 KKEVKLLLLGAGESGKSTILKQMKIIHGGGFSEEERKQYRPVIYSNILRSLKTLIEAMERLGIELSNPENKERLDDLLSL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1315144671 126 DtrapmaAQGMVETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:pfam00503  83 D------SSLKNETEFTPELAEDIKRLWNDPGIQECYERRNEFQLPD 123
 
Name Accession Description Interval E-value
G_alpha smart00275
G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding ...
 29-172 2.65e-62

G protein alpha subunit; Subunit of G proteins that contains the guanine nucleotide binding site


Pssm-ID: 214595 [Multi-domain]  Cd Length: 342  Bit Score: 195.49  E-value: 2.65e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671   29 RKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHI 108
Cdd:smart00275   2 RRNKEIEKQLEEERKKKKREVKLLLLGAGESGKSTILKQMRILHGDGFSQEERREYRPLIYSNILESMKALVDAMEELNI 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1315144671  109 PWGDNKNQLHGDKLMAFDTRAPMAaqgmvETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:smart00275  82 PFEDPESILDIRIITEQFNKTDET-----ENVLPKEIAKAIKALWKDEGIQECYRRRNEFQLND 140
G-alpha cd00066
Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins ...
 49-172 4.40e-53

Alpha subunit of G proteins (guanine nucleotide binding); The alpha subunit of G proteins contains the guanine nucleotide binding site. The heterotrimeric GNP-binding proteins are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. Extracellular signals are received by receptors, which activate the G proteins, which in turn route the signals to several distinct intracellular signaling pathways. The alpha subunit of G proteins is a weak GTPase. In the resting state, heterotrimeric G proteins are associated at the cytosolic face of the plasma membrane and the alpha subunit binds to GDP. Upon activation by a receptor GDP is replaced with GTP, and the G-alpha/GTP complex dissociates from the beta and gamma subunits. This results in activation of downstream signaling pathways, such as cAMP synthesis by adenylyl cyclase, which is terminated when GTP is hydrolized and the heterotrimers reconstitute.


Pssm-ID: 206639 [Multi-domain]  Cd Length: 315  Bit Score: 171.17  E-value: 4.40e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671  49 VKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQLHGDKLMAFDTR 128
Cdd:cd00066     1 VKLLLLGAGESGKSTILKQMKILHGNGFSDEERREFRPVIYSNILQSMKALLRAMETLNIPYGDPENEKDAKKILSLAPR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1315144671 129 APmaaqgmvETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:cd00066    81 AE-------EGPLPPELAEAIKRLWKDPGIQACYDRRNEYQLND 117
G-alpha pfam00503
G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular ...
 46-172 1.17e-43

G-protein alpha subunit; G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.


Pssm-ID: 459835 [Multi-domain]  Cd Length: 316  Bit Score: 146.96  E-value: 1.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315144671  46 KRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNKNQLHGDKLMAF 125
Cdd:pfam00503   3 KKEVKLLLLGAGESGKSTILKQMKIIHGGGFSEEERKQYRPVIYSNILRSLKTLIEAMERLGIELSNPENKERLDDLLSL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1315144671 126 DtrapmaAQGMVETRVFLQYLPAIRALWEDSGIQNAYDRRREFQLME 172
Cdd:pfam00503  83 D------SSLKNETEFTPELAEDIKRLWNDPGIQECYERRNEFQLPD 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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