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Conserved domains on  [gi|1335348543|ref|NP_001347087|]
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troponin T, fast skeletal muscle isoform 17 [Mus musculus]

Protein Classification

troponin( domain architecture ID 12013160)

troponin such as troponin I (TnI, inhibitory) and T (TnT, tropomyosin binding) subunits, which together with troponin C (TnC, Ca2+ binding) subunit, form the troponin complex that regulates Ca2+ induced muscle contraction

CATH:  1.20.5.350
Gene Ontology:  GO:0005861|GO:0003009
PubMed:  18154728

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 59-195 4.24e-18

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


:

Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 77.99  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335348543  59 KRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAER--AEQQRIRAEKERERQNRLAEEKARREEEDAKRRAED 136
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGlsAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1335348543 137 DMKKKKALSSMGAnyssylAKADQKRGKKQTAREMKKKILAERRKpLNIDHLSDDKLRD 195
Cdd:pfam00992  81 NDLKKKVNDLRGK------FKKPLLKKVRKTADAMLKALLGSKHK-VSMDFRANLKQVK 132
 
Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 59-195 4.24e-18

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 77.99  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335348543  59 KRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAER--AEQQRIRAEKERERQNRLAEEKARREEEDAKRRAED 136
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGlsAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1335348543 137 DMKKKKALSSMGAnyssylAKADQKRGKKQTAREMKKKILAERRKpLNIDHLSDDKLRD 195
Cdd:pfam00992  81 NDLKKKVNDLRGK------FKKPLLKKVRKTADAMLKALLGSKHK-VSMDFRANLKQVK 132
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 48-134 8.50e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 37.41  E-value: 8.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335348543   48 GEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIAlKERIEKRRAERAEQQRIRAEK-----------ERERQN 116
Cdd:PTZ00266   427 GGRVDKDHAERARIEKENAHRKALEMKILEKKRIERLEREE-RERLERERMERIERERLERERlererlerdrlERDRLD 505

                           90
                   ....*....|....*...
gi 1335348543  117 RLAEEKARREEEDAKRRA 134
Cdd:PTZ00266   506 RLERERVDRLERDRLEKA 523
 
Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 59-195 4.24e-18

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 77.99  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335348543  59 KRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAER--AEQQRIRAEKERERQNRLAEEKARREEEDAKRRAED 136
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGlsAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1335348543 137 DMKKKKALSSMGAnyssylAKADQKRGKKQTAREMKKKILAERRKpLNIDHLSDDKLRD 195
Cdd:pfam00992  81 NDLKKKVNDLRGK------FKKPLLKKVRKTADAMLKALLGSKHK-VSMDFRANLKQVK 132
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
 48-134 8.50e-03

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 37.41  E-value: 8.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1335348543   48 GEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIAlKERIEKRRAERAEQQRIRAEK-----------ERERQN 116
Cdd:PTZ00266   427 GGRVDKDHAERARIEKENAHRKALEMKILEKKRIERLEREE-RERLERERMERIERERLERERlererlerdrlERDRLD 505

                           90
                   ....*....|....*...
gi 1335348543  117 RLAEEKARREEEDAKRRA 134
Cdd:PTZ00266   506 RLERERVDRLERDRLEKA 523
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 78-146 1.00e-02

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 37.05  E-value: 1.00e-02
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1335348543  78 ARKKEEEelialkerIEKrrAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAeddmkkkKALSS 146
Cdd:pfam03154 586 AKKREEA--------LEK--AKREAEQKAREEKEREKEKEKEREREREREREAERAA-------KASSS 637
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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