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Conserved domains on  [gi|1336503556|ref|NP_001347181|]
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small ribosomal subunit protein uS12m isoform a precursor [Mus musculus]

Protein Classification

30S ribosomal protein S12( domain architecture ID 10130119)

30S ribosomal protein S12 assists in rRNA folding and the binding of other proteins during small subunit assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 32-138 4.02e-57

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


:

Pssm-ID: 239466  Cd Length: 108  Bit Score: 173.09  E-value: 4.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  32 TLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLV 110
Cdd:cd03368     1 TINQLIRKGRKKKKKKSKSPAlEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLV 80

                          90       100
                  ....*....|....*....|....*...
gi 1336503556 111 EGGRTQDLPGVKLKVVRGKYDCGHVQKK 138
Cdd:cd03368    81 RGGRVKDLPGVRYHIVRGVLDLAGVKNR 108
 
Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 32-138 4.02e-57

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 173.09  E-value: 4.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  32 TLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLV 110
Cdd:cd03368     1 TINQLIRKGRKKKKKKSKSPAlEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLV 80

                          90       100
                  ....*....|....*....|....*...
gi 1336503556 111 EGGRTQDLPGVKLKVVRGKYDCGHVQKK 138
Cdd:cd03368    81 RGGRVKDLPGVRYHIVRGVLDLAGVKNR 108
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 30-139 1.32e-42

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 136.87  E-value: 1.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  30 MATLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVV 108
Cdd:COG0048     1 MPTINQLVRKGRKKKKKKSKSPAlKGCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1336503556 109 LVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK 139
Cdd:COG0048    81 LVRGGRVKDLPGVRYHIVRGALDTAGVKGRK 111
rpsL_bact TIGR00981
ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of ...
 30-139 2.64e-39

ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of Bacteria, mitochondria, and chloroplasts. The homologous ribosomal proteins of Archaea and Eukarya, termed S23 in Eukarya and S12 or S23 in Archaea, score below the trusted cutoff. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130054  Cd Length: 124  Bit Score: 128.36  E-value: 2.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  30 MATLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVV 108
Cdd:TIGR00981   1 MPTINQLIRKGRKKKKKKSKSPAlEACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTAYIPGEGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1336503556 109 LVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK 139
Cdd:TIGR00981  81 LIRGGRVKDLPGVRYHIVRGALDTAGVKNRK 111
rps12 CHL00051
ribosomal protein S12
 30-139 4.40e-37

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 122.83  E-value: 4.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  30 MATLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVV 108
Cdd:CHL00051    1 MPTIKQLIRNTRQPIRNKTKSPAlRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1336503556 109 LVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK 139
Cdd:CHL00051   81 LVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQ 111
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 51-127 1.84e-25

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 92.90  E-value: 1.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  51 PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLST-GKEAVCFIPGEG--HTLQEHHVVLVEGGRTQ-----DLPGVK 122
Cdd:pfam00164  12 PLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIKnGKEVTAFIPGEGaiHFLQEHDEVLIRGGGGPghavgDLPGVR 91


                  ....*
gi 1336503556 123 LKVVR 127
Cdd:pfam00164  92 YKVVR 96
 
Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 32-138 4.02e-57

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 173.09  E-value: 4.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  32 TLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLV 110
Cdd:cd03368     1 TINQLIRKGRKKKKKKSKSPAlEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLV 80

                          90       100
                  ....*....|....*....|....*...
gi 1336503556 111 EGGRTQDLPGVKLKVVRGKYDCGHVQKK 138
Cdd:cd03368    81 RGGRVKDLPGVRYHIVRGVLDLAGVKNR 108
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 30-139 1.32e-42

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 136.87  E-value: 1.32e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  30 MATLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVV 108
Cdd:COG0048     1 MPTINQLVRKGRKKKKKKSKSPAlKGCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1336503556 109 LVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK 139
Cdd:COG0048    81 LVRGGRVKDLPGVRYHIVRGALDTAGVKGRK 111
rpsL_bact TIGR00981
ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of ...
 30-139 2.64e-39

ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of Bacteria, mitochondria, and chloroplasts. The homologous ribosomal proteins of Archaea and Eukarya, termed S23 in Eukarya and S12 or S23 in Archaea, score below the trusted cutoff. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130054  Cd Length: 124  Bit Score: 128.36  E-value: 2.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  30 MATLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVV 108
Cdd:TIGR00981   1 MPTINQLIRKGRKKKKKKSKSPAlEACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTAYIPGEGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1336503556 109 LVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK 139
Cdd:TIGR00981  81 LIRGGRVKDLPGVRYHIVRGALDTAGVKNRK 111
rps12 CHL00051
ribosomal protein S12
 30-139 4.40e-37

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 122.83  E-value: 4.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  30 MATLNQMHRLGPRKEPPKRLGPT-EGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVV 108
Cdd:CHL00051    1 MPTIKQLIRNTRQPIRNKTKSPAlRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVV 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1336503556 109 LVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK 139
Cdd:CHL00051   81 LVRGGRVKDLPGVRYHIVRGTLDAVGVKDRQ 111
PTZ00115 PTZ00115
40S ribosomal protein S12; Provisional
 41-131 1.61e-30

40S ribosomal protein S12; Provisional


Pssm-ID: 240276  Cd Length: 290  Bit Score: 110.70  E-value: 1.61e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  41 PRKEPPKRLGP-TEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLVEGGRTQDLP 119
Cdd:PTZ00115  108 PKLKPKNRRSKwLEGAPQKKGICVKVRVQTPRKPNSGLRKVARVRLSTGRTVTVYIPGIGHNLNTHSVVLVRGGRCKDVP 187

                          90
                  ....*....|..
gi 1336503556 120 GVKLKVVRGKYD 131
Cdd:PTZ00115  188 GCNYKAVRGVYD 199
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 51-127 1.84e-25

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 92.90  E-value: 1.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  51 PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLST-GKEAVCFIPGEG--HTLQEHHVVLVEGGRTQ-----DLPGVK 122
Cdd:pfam00164  12 PLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIKnGKEVTAFIPGEGaiHFLQEHDEVLIRGGGGPghavgDLPGVR 91


                  ....*
gi 1336503556 123 LKVVR 127
Cdd:pfam00164  92 YKVVR 96
Ribosomal_S12_like cd00319
Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, ...
 51-128 1.35e-18

Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding center. They play an important role in translocation during the peptide elongation step of protein synthesis. They are also involved in important RNA and protein interactions. Ribosomal protein S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. S23 interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes translocation. Mutations in S12 and S23 have been found to affect translational accuracy. Antibiotics such as streptomycin may also bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 238196  Cd Length: 95  Bit Score: 75.13  E-value: 1.35e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1336503556  51 PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRLSTGKEAVCFIPGEGHTLQEHHVVLVEGGRTQDLPGVKLKVVRG 128
Cdd:cd00319     8 ALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRG 85
Ribosomal_S23 cd03367
S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the ...
 51-127 9.77e-16

S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the large and small ribosomal subunits of eukaryotes, adjacent to the decoding center. It interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes the translocation of the growing peptidyl-tRNA to the P site to make room for the next aminoacyl-tRNA at the A (acceptor) site. Through its interaction with eEF2, S23 may play an important role in translocation. Also members of this subfamily are the archaeal 30S ribosomal S12 proteins. Prokaryotic S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as control element for the rRNA- and tRNA-driven movements of translocation. S12 and S23 are also implicated in translation accuracy. Antibiotics such as streptomycin bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 239465  Cd Length: 115  Bit Score: 68.06  E-value: 9.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  51 PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRL-STGKEAVCFIPGEG--HTLQEHHVVLVEG----GRTQ-DLPGVK 122
Cdd:cd03367    15 PLGGAPHAKGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKKITAFVPGDGclNFIDENDEVLVAGfgrkGRAVgDIPGVR 94


                  ....*
gi 1336503556 123 LKVVR 127
Cdd:cd03367    95 FKVVK 99
rps12P PRK04211
30S ribosomal protein S12P; Reviewed
 51-126 1.07e-13

30S ribosomal protein S12P; Reviewed


Pssm-ID: 235257  Cd Length: 145  Bit Score: 63.43  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  51 PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRL-STGKEAVCFIPGEG--HTLQEHHVVLVEG-----GRTQ-DLPGV 121
Cdd:PRK04211   41 PLEGAPMARGIVLEKVGVEAKQPNSAIRKCVRVQLiKNGKQVTAFCPGDGaiNFIDEHDEVVIEGiggpkGRSMgDIPGV 120


                  ....*
gi 1336503556 122 KLKVV 126
Cdd:PRK04211  121 RYKVI 125
uS12_E_A TIGR00982
ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and ...
 24-127 1.55e-12

ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and archaeal forms of ribosomal protein uS12. This protein was known previously as S23 in eukaryotes and as either S12 or S23 in the Archaea. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273377  Cd Length: 139  Bit Score: 60.66  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  24 LWAARSMATLNQMHRLGPRKEPPKRLG------PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRL-STGKEAVCFIP 96
Cdd:TIGR00982   2 LFAARKLKLKRKKFRWSDRRYKRRVLRlkekadPLEGAPQARGIVLEKIGVEAKQPNSAIRKAVRVQLiKNGKVVTAFCP 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1336503556  97 GEGHTL--QEHHVVLVEG-----GRTQ-DLPGVKLKVVR 127
Cdd:TIGR00982  82 GDGAINfiDEHDEVIIEGiggpkGRSMgDIPGVRYKVVK 120
PTZ00067 PTZ00067
40S ribosomal S23; Provisional
 24-127 1.65e-11

40S ribosomal S23; Provisional


Pssm-ID: 185422  Cd Length: 143  Bit Score: 57.83  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1336503556  24 LWAARSMATLNQMHRLGPRKEPPKRLG------PTEGRPQLKGVVLRTFIRKPKKPNSANRKCCRVRL-STGKEAVCFIP 96
Cdd:PTZ00067    7 LRAARKLRRHRRVNRWADKEYKKAHLGtrykanPFGGASHAKGIVVEKIGIEAKQPNSAIRKCVRVQLiKNGKKITAFVP 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1336503556  97 GEG--HTLQEHHVVLVEG-GRT----QDLPGVKLKVVR 127
Cdd:PTZ00067   87 NDGclNFINENDEVLVSGfGRSghavGDIPGVRFKVVK 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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