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Conserved domains on  [gi|1344545525|ref|NP_001347845|]
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zinc finger protein 771 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-194 1.25e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525  39 PFACTECGRCFSQKSALTKHGRT--HTGE--RPYQCPE--CDKRFSAASNLRQHRRRHTGEKPYAC--AHCGRRFAQSSN 110
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525 111 YAQHLRVH-----TGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYAC--ADCGTRFAQSSALAKHRRVHTGEKPHR 181
Cdd:COG5048   369 NEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*
gi 1344545525 182 CAVCG--RRFGHRSN 194
Cdd:COG5048   449 CSILKsfRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
194-217 2.24e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|....
gi 1344545525 194 NLAEHARTHTGERPYPCTECGRRF 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-194 1.25e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525  39 PFACTECGRCFSQKSALTKHGRT--HTGE--RPYQCPE--CDKRFSAASNLRQHRRRHTGEKPYAC--AHCGRRFAQSSN 110
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525 111 YAQHLRVH-----TGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYAC--ADCGTRFAQSSALAKHRRVHTGEKPHR 181
Cdd:COG5048   369 NEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*
gi 1344545525 182 CAVCG--RRFGHRSN 194
Cdd:COG5048   449 CSILKsfRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-107 2.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 1344545525  82 NLRQHRRRHTGEKPYACAHCGRRFAQ 107
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
194-217 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|....
gi 1344545525 194 NLAEHARTHTGERPYPCTECGRRF 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-194 1.25e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525  39 PFACTECGRCFSQKSALTKHGRT--HTGE--RPYQCPE--CDKRFSAASNLRQHRRRHTGEKPYAC--AHCGRRFAQSSN 110
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525 111 YAQHLRVH-----TGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYAC--ADCGTRFAQSSALAKHRRVHTGEKPHR 181
Cdd:COG5048   369 NEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                         170
                  ....*....|....*
gi 1344545525 182 CAVCG--RRFGHRSN 194
Cdd:COG5048   449 CSILKsfRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
38-111 2.72e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 2.72e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1344545525  38 RPFACTECGRCFSQKSALTKHGRTHTGERPYQC--PECDKRFSAASNLRQHRRRHTGEKPYACAHCGRRFAQSSNY 111
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 97-203 1.15e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525  97 ACAHCGRRFAQSSnyAQHLRVhTGEKPYACP--DCGRAFGGSSCLARHRRThtgerpyacADCGTRFAQSSALAKHRRVH 174
Cdd:COG5189   326 KLAHGGERNIDTP--SRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFS 393

                          90       100
                  ....*....|....*....|....*....
gi 1344545525 175 TGEKPHRCAVCGRRFGHRSNLAEHaRTHT 203
Cdd:COG5189   394 AKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 64-147 4.63e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 4.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525  64 GERPYQCP--ECDKRFSAASNLRQHRRRhtgekpyacAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRAFGGSSCLAR 141
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1344545525 142 HrRTHT 147
Cdd:COG5189   417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
8-170 6.49e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 6.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525   8 PARPHACP--DCGRAFARRSTLAKHARTHTGERPFACTECGRCFSQKSALTKHGRTHTgerpyqcpecdkrfsaasnlrQ 85
Cdd:COG5048   318 SLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSL---------------------Q 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525  86 HRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYACADCGtRF 161
Cdd:COG5048   377 QYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SF 455


                  ....*....
gi 1344545525 162 AQSSALAKH 170
Cdd:COG5048   456 RRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-158 2.24e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 2.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1344545525  94 KPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRA--FGGSSCLARHRRTHTGERPYACADCG 158
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSL 98
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-107 2.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 2.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 1344545525  82 NLRQHRRRHTGEKPYACAHCGRRFAQ 107
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-202 1.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344545525 122 KPYACPDCGRAFGGSSCLARHRRTHTGERPYACADCGTRFAQS--SALAKHRRVHTGEKPHRCA--VCGRRFGHRSNLAE 197
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111


                  ....*
gi 1344545525 198 HARTH 202
Cdd:COG5048   112 SSSSN 116
zf-H2C2_2 pfam13465
Zinc-finger double domain;
194-217 2.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.24e-03
                          10        20
                  ....*....|....*....|....
gi 1344545525 194 NLAEHARTHTGERPYPCTECGRRF 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
54-78 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*
gi 1344545525  54 ALTKHGRTHTGERPYQCPECDKRFS 78
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
110-133 2.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.87e-03
                          10        20
                  ....*....|....*....|....
gi 1344545525 110 NYAQHLRVHTGEKPYACPDCGRAF 133
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 68-90 5.70e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 5.70e-03
                          10        20
                  ....*....|....*....|...
gi 1344545525  68 YQCPECDKRFSAASNLRQHRRRH 90
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-189 6.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 6.88e-03
                          10        20
                  ....*....|....*....|....
gi 1344545525 166 ALAKHRRVHTGEKPHRCAVCGRRF 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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