second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 112 RGDLGELPFPCPDGfSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaASGDPPVVTLHDISPDIFIHV 191
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1375023207 192 LYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLE 235
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023207 234 LEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHV 305
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 112 RGDLGELPFPCPDGfSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaASGDPPVVTLHDISPDIFIHV 191
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1375023207 192 LYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLE 235
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023207 234 LEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHV 305
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaasgdpPVVTLHDISPDIFIHVLYYVYSDHTeLPPELAYDV 210
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSV-------SEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|....
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLL 234
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375023207   19 INPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLDDLEAKCEK 68
Cdd:smart00225  46 VSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLK 95

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 112 RGDLGELPFPCPDGfSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaASGDPPVVTLHDISPDIFIHV 191
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1375023207 192 LYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLE 235
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023207 234 LEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHV 305
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207  131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPaasgdppVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-------EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....
gi 1375023207  211 LSVADMYLLPGLKRLCGRSLAQLL 234
Cdd:smart00225  74 LELADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 127 SSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPAasgdppvVTLHDISPDIFIHVLYYVYSDHTELPPEL 206
Cdd:cd18314     4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEEN 76

                          90       100
                  ....*....|....*....|
gi 1375023207 207 AYDVLSVADMYLLPGLKRLC 226
Cdd:cd18314    77 VLDLLMLASKYQVPDLEKLC 96

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEpaasgdpPVVTLHDISPDIFIHVLYYVYSDHTeLPPELAYDV 210
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSV-------SEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|....
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLL 234
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQEseepaasGDPPVVTLHDISPDIFIHVLYYVYSDHTE---LPPELA 207
Cdd:cd18297    14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTE-------AQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1375023207 208 YDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 238
Cdd:cd18297    87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDhfqeseePAASGDPPVVTLHDISPDIFIHVLYYVY------------SD 198
Cdd:cd18280    16 DVTFNVDGEKFRAHKLVLAARSPVFRSMLFG-------PMREENEGEIVIEDVEPPVFKALLHFIYkdelpddvepagSD 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1375023207 199 HTELPPELAYDVLSVADMYLLPGLKRLCGRSL 230
Cdd:cd18280    89 SSSLDTTMAQHLLAAADRYALERLRLLCESRL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 111 LRGDLGEL---PFpcpdgFSSCpdiCFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESeepaaSGDPpvVTLHDISPDI 187
Cdd:cd18344    10 LTDDLGELwenSL-----FTDC---CLLVAGHEFRAHKAILAARSPVFRAMFEHEMEER-----LKNP--IEIHDLDPQV 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1375023207 188 FIHVLYYVYsdhTELPPEL-----AYDVLSVADMYLLPGLKRLCGRSLAQLL 234
Cdd:cd18344    75 FKEMMGFIY---TGKAPHLhshsmACDVLAAADKYGLEGLKVLCEDALCRNL 123

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 141 FLCYKAFFCGRSDYFRALLDDHFQESEEPAAsgdppvVTLhDISPDIFIHVLYYVYSDHTELPP-----ELAYDVLSVAD 215
Cdd:cd18302    18 FPCHKCVLVARLEYFHSMLSSSWIEASSCSA------LTM-PIPSDILEIILDYLYTDEASAVKesqnvEFLCNVLVIAD 90

                          90
                  ....*....|....*....
gi 1375023207 216 MYLLPGLKRLCGRSLAQLL 234
Cdd:cd18302    91 QLLITRLKEICEVALVELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQEseepaasGDPPVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNE-------DDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGL 86

                          90       100
                  ....*....|....*....|..
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQ 232
Cdd:cd18298    87 LDLANSYCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375023207 152 SDYFRALLDDHFqeseePAASGDPPVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLC 226
Cdd:cd18245    37 SPYFRAKLNYNP-----PKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLC 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHfqeSEEPAASGDPPVVTLHDISPDIFIHVLYYVYSD 198
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSS---LLTSEDAVGCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPAasgdppvVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:cd18343    23 DCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNR-------VEINDVDPEVFKEMMRFIYTGKAPNLDKMADNL 95

                          90       100
                  ....*....|....*....|....
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLL 234
Cdd:cd18343    96 LAAADKYALERLKVMCEEALCNNL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHfqeseepaasgDPPVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:cd18354    22 DLKFLVDGKYIYVHKVLLKIRCEHFRSLLNEN-----------EEEIIEMSQFSYPVYRAFLEYLYTDSISLSPEDAIGL 90

                          90       100
                  ....*....|....*....|....*..
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLLEED 237
Cdd:cd18354    91 LDLATFYRENRLKKLCQQTIKQGICEE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPAasgdppvVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADR-------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEAL 95

                          90       100
                  ....*....|....*....|....*....
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLLEEDSV 239
Cdd:cd18250    96 LRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375023207   1 MLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQC 53
Cdd:cd18186    30 MFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALlddhFQESEEPAASGDppvVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:cd18269    29 DCVLKIGDKEFPCHRLVLAACSPYFRAM----FLSDLEESKKKE---VVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDI 101

                          90       100
                  ....*....|....*....|....
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLL 234
Cdd:cd18269   102 FALASRFQIPSIFTVCVSYLQKRL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 127 SSCPDICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPAasgdppvVTLHDISPDIFIHVLYYVYSDHTELPPEL 206
Cdd:cd18345    16 SAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNR-------VEITDVDHEVMREMLRFIYTGKAPNLDKM 88

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1375023207 207 AYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSV 239
Cdd:cd18345    89 ADDLLAAADKYALERLKVMCEEALCSNLSVENV 121

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 127 SSCPD-ICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEepaasgdppvVTL-HDIspDIFIHVLYYVYSDHTELPP 204
Cdd:PHA03098    8 KFCDEsIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE----------INLnIDY--DSFNEVIKYIYTGKINITS 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375023207 205 ELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDF 275
Cdd:PHA03098   76 NNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDF 146

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1375023207 182 DISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLC 226
Cdd:cd18282    56 DVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARAC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 131 DICFRVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPaasgdppVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDV 210
Cdd:cd18272    34 DVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNR-------VIELKDVSESVFQLLVDYIYHGTVKLRVEELQET 106

                          90       100
                  ....*....|....*....|....*
gi 1375023207 211 LSVADMYLLPGLKRLCGRSLAQLLE 235
Cdd:cd18272   107 YEVADMYQLTALFEECSRFLARTVQ 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375023207 150 GRSDYFRALLDDHFQESeepaasGDPPVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDVLSVA 214
Cdd:cd18329    42 ASSGYFKMLLSQNAKET------GQPTVATFDVFSPDTFTIILDFVYSGKLSLTSQNVIEVMSAA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375023207 178 VTLHDISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 238
Cdd:cd18346    73 IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023207 141 FLCYKAFFCGRSDYFRALLDDHFQES-----EEPAASGDPpvvtlhDISPDIFIHVLYYVYSDHTELPPELAYDVLSVAD 215
Cdd:cd18241    38 FRAHRSVLAAATEYFTPLLSGQFSESrsgrvEMRKWSSEP------GPDPDTVEAVIQYMYTGRIRVSTGNVHEVLELAD 111

                          90
                  ....*....|....*....
gi 1375023207 216 MYLLPGLKRLCGRSLAQLL 234
Cdd:cd18241   112 RFLLIRLKEFCGEFLKKKL 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1375023207 182 DISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLC 226
Cdd:cd18349    57 DVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKAC 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375023207 178 VTLHDISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDS 238
Cdd:cd18347    67 IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127