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Conserved domains on  [gi|1377224692|ref|NP_001349332|]
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DNA excision repair protein ERCC-8 isoform 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-248 4.14e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 4.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  83 PrHDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSS 162
Cdd:COG2319   256 P-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 163 SGD--NTLVNYGKVCND---SRKGLQFAVSCGcssefvfvphGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELY 237
Cdd:COG2319   319 TGKllRTLTGHTGAVRSvafSPDGKTLASGSD----------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         250
                  ....*....|.
gi 1377224692 238 SGSRDCNILAW 248
Cdd:COG2319   389 SGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-248 4.14e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 4.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  83 PrHDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSS 162
Cdd:COG2319   256 P-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 163 SGD--NTLVNYGKVCND---SRKGLQFAVSCGcssefvfvphGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELY 237
Cdd:COG2319   319 TGKllRTLTGHTGAVRSvafSPDGKTLASGSD----------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         250
                  ....*....|.
gi 1377224692 238 SGSRDCNILAW 248
Cdd:COG2319   389 SGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-248 7.67e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 7.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  83 PRHDYIlATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSS 162
Cdd:cd00200   145 PDGTFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 163 SGDNTlvnygKVCNDSRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRD 242
Cdd:cd00200   208 TGKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*.
gi 1377224692 243 CNILAW 248
Cdd:cd00200   283 GTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-102 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1377224692   62 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 102
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
63-102 2.88e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 2.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1377224692  63 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 102
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 59-168 1.30e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  59 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA----------------SGCLLT---LDQH 116
Cdd:PTZ00420  113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwniKGNLLSgtcVGKH 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1377224692 117 ----NGKKSQAAESANTaHNGKVNGLCFTSDGL-----HLLTIG-TDNRMR---LW---NSSSGDNTL 168
Cdd:PTZ00420  191 mhiiDPRKQEIASSFHI-HDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWdlkNTTSALVTM 257
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-248 4.14e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 4.14e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  83 PrHDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSS 162
Cdd:COG2319   256 P-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 163 SGD--NTLVNYGKVCND---SRKGLQFAVSCGcssefvfvphGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELY 237
Cdd:COG2319   319 TGKllRTLTGHTGAVRSvafSPDGKTLASGSD----------DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                         250
                  ....*....|.
gi 1377224692 238 SGSRDCNILAW 248
Cdd:COG2319   389 SGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-248 7.67e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 7.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  83 PRHDYIlATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSS 162
Cdd:cd00200   145 PDGTFV-ASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 163 SGDNTlvnygKVCNDSRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRD 242
Cdd:cd00200   208 TGKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*.
gi 1377224692 243 CNILAW 248
Cdd:cd00200   283 GTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
4-248 5.40e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 5.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFNF-EETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGhTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  83 PRHDYiLATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSS 162
Cdd:COG2319   130 PDGKT-LASGSADGTVRLWDLATGK-LLRTL---------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 163 SGDntlvnygkvCNDSRKGLQFAVSCgcsseFVFVPHGSTIA---------VYAVHSGERLAMLKGHYKSVDCCVFQPNF 233
Cdd:COG2319   193 TGK---------LLRTLTGHTGAVRS-----VAFSPDGKLLAsgsadgtvrLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                         250
                  ....*....|....*
gi 1377224692 234 QELYSGSRDCNILAW 248
Cdd:COG2319   259 RLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
4-160 4.46e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 4.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 339

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1377224692  83 PRHDYiLATASADSRVKLWDVRrASGCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWN 160
Cdd:COG2319   340 PDGKT-LASGSDDGTVRLWDLA-TGELLRTL---------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-248 1.90e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 1.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  45 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWDVrRASGCLLTLdqhngkksqaa 124
Cdd:cd00200    23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL-ETGECVRTL----------- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 125 esanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGdntlvnygkVCNDSRKGLQFAVSCGCSSEF-VFVPHGS-- 201
Cdd:cd00200    90 ----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---------KCLTTLRGHTDWVNSVAFSPDgTFVASSSqd 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1377224692 202 -TIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 248
Cdd:cd00200   157 gTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-160 3.40e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 3.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   3 TSSSFDKTLKVWDTNTLQAADVFNF-EETVYSHHMSPAATKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSW 81
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1377224692  82 SPrHDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqaaesanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWN 160
Cdd:cd00200   228 SP-DGYLLASGSEDGTIRVWDLRTGE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-104 9.11e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 9.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692   4 SSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWS 82
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                          90       100
                  ....*....|....*....|..
gi 1377224692  83 PRHDYiLATASADSRVKLWDVR 104
Cdd:COG2319   382 PDGRT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-248 1.74e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 131 HNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGDNTLVNYGKvcndsRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHS 210
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH-----TGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1377224692 211 GERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 248
Cdd:cd00200    83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-102 1.54e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1377224692   62 SGSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 102
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
45-248 3.90e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 3.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  45 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRAsgCLLTLdqhngkksqaa 124
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA--LLATL----------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692 125 esanTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGdntlvnygkVCNDSRKGLQFAVSCgcsseFVFVPHGSTIA 204
Cdd:COG2319    75 ----LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---------LLLRTLTGHTGAVRS-----VAFSPDGKTLA 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1377224692 205 ---------VYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 248
Cdd:COG2319   137 sgsadgtvrLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 pfam00400
WD domain, G-beta repeat;
63-102 2.88e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 2.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1377224692  63 GSCSHILQGHRQEILAVSWSPRHDYiLATASADSRVKLWD 102
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 59-168 1.30e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1377224692  59 DLKSGSCshILQGHRQEILAVSWSPRHDYILATASADSRVKLWDV---RRA----------------SGCLLT---LDQH 116
Cdd:PTZ00420  113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwniKGNLLSgtcVGKH 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1377224692 117 ----NGKKSQAAESANTaHNGKVNGLCFTSDGL-----HLLTIG-TDNRMR---LW---NSSSGDNTL 168
Cdd:PTZ00420  191 mhiiDPRKQEIASSFHI-HDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWdlkNTTSALVTM 257
PTZ00421 PTZ00421
coronin; Provisional
 60-105 1.87e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1377224692  60 LKSGSCSHI--LQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRR 105
Cdd:PTZ00421  110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-248 7.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 7.84e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1377224692  210 SGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 248
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 129-160 1.87e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.87e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1377224692  129 TAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWN 160
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
211-248 1.91e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1377224692 211 GERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 248
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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