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Conserved domains on  [gi|1388872080|ref|NP_001350206|]
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zinc finger protein 619 isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-269 1.73e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.73e-05
                          10        20
                  ....*....|....*....|....*
gi 1388872080 245 LIRHQRIHTGEKPFKCKECGKAFSC 269
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-316 5.22e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 158 HSDFHLHQRVHTN-EKPYTCKECGKTFRYNSKLSRHQ--KIHTGE--KPYSCEE--CGQAFSQNSHLLQHQKLHGGQRPY 230
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 231 ECTDCGKTFSYNSKLI--RHQRIHtgekPFKCKECGKAFSCSYDCII-----------HERIHNGEKPYECK--ECGKSL 295
Cdd:COG5048   353 KEKLLNSSSKFSPLLNnePPQSLQ----QYKDLKNDKKSETLSNSCIrnfkrdsnlslHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|.
gi 1388872080 296 SSNSVLIQHQRIHTGEKPYEC 316
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-407 2.02e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|...
gi 1388872080 385 LVQHQRVHTGEKPYECKECGKAF 407
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-381 1.92e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|..
gi 1388872080 360 HQRIHNGEKPYECQECGKTFSQ 381
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
KRAB super family cl42959
krueppel associated box;
4-22 2.17e-03

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.42  E-value: 2.17e-03
                           10
                   ....*....|....*....
gi 1388872080    4 FPFPKPDLIFQLEQGEAAW 22
Cdd:smart00349  42 FQVPKPDLISQLEQGEEPW 60
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-269 1.73e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.73e-05
                          10        20
                  ....*....|....*....|....*
gi 1388872080 245 LIRHQRIHTGEKPFKCKECGKAFSC 269
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-316 5.22e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 158 HSDFHLHQRVHTN-EKPYTCKECGKTFRYNSKLSRHQ--KIHTGE--KPYSCEE--CGQAFSQNSHLLQHQKLHGGQRPY 230
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 231 ECTDCGKTFSYNSKLI--RHQRIHtgekPFKCKECGKAFSCSYDCII-----------HERIHNGEKPYECK--ECGKSL 295
Cdd:COG5048   353 KEKLLNSSSKFSPLLNnePPQSLQ----QYKDLKNDKKSETLSNSCIrnfkrdsnlslHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|.
gi 1388872080 296 SSNSVLIQHQRIHTGEKPYEC 316
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-323 1.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.30e-04
                          10        20
                  ....*....|....*....|...
gi 1388872080 301 LIQHQRIHTGEKPYECKECGKAF 323
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-407 2.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|...
gi 1388872080 385 LVQHQRVHTGEKPYECKECGKAF 407
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-381 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|..
gi 1388872080 360 HQRIHNGEKPYECQECGKTFSQ 381
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
KRAB smart00349
krueppel associated box;
4-22 2.17e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.42  E-value: 2.17e-03
                           10
                   ....*....|....*....
gi 1388872080    4 FPFPKPDLIFQLEQGEAAW 22
Cdd:smart00349  42 FQVPKPDLISQLEQGEEPW 60
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-269 1.73e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.73e-05
                          10        20
                  ....*....|....*....|....*
gi 1388872080 245 LIRHQRIHTGEKPFKCKECGKAFSC 269
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-316 5.22e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 158 HSDFHLHQRVHTN-EKPYTCKECGKTFRYNSKLSRHQ--KIHTGE--KPYSCEE--CGQAFSQNSHLLQHQKLHGGQRPY 230
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 231 ECTDCGKTFSYNSKLI--RHQRIHtgekPFKCKECGKAFSCSYDCII-----------HERIHNGEKPYECK--ECGKSL 295
Cdd:COG5048   353 KEKLLNSSSKFSPLLNnePPQSLQ----QYKDLKNDKKSETLSNSCIrnfkrdsnlslHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|.
gi 1388872080 296 SSNSVLIQHQRIHTGEKPYEC 316
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-323 1.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.30e-04
                          10        20
                  ....*....|....*....|...
gi 1388872080 301 LIQHQRIHTGEKPYECKECGKAF 323
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-407 2.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|...
gi 1388872080 385 LVQHQRVHTGEKPYECKECGKAF 407
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-213 3.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.00e-04
                          10        20
                  ....*....|....*....|....*
gi 1388872080 189 LSRHQKIHTGEKPYSCEECGQAFSQ 213
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 230-252 5.83e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 5.83e-04
                          10        20
                  ....*....|....*....|...
gi 1388872080 230 YECTDCGKTFSYNSKLIRHQRIH 252
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-427 7.45e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 162 HLHQRVHTNEKPYTC--KECGKTFRYNSKLSRHQKIHTGEKPYSCE-ECGQAFSQNSH--------------LLQHQKLH 224
Cdd:COG5048    50 TRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSsslsssssnsndnnLLSSHSLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 225 GGQRPYE-CTDCGKTFSYNSKLIRHQRIHTGEK-------PFKCKECGKAFSCSYDCIIHERIHNGEKPYECKECGKSLS 296
Cdd:COG5048   130 PSSRDPQlPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSY 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 297 SNSVLIQHQRIHTGEKPYECKECGKAFHRSSVFLQHQRFHTGEQLYKCNECWKTFSCSSRFIVHQRIHNGE-------KP 369
Cdd:COG5048   210 SIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLP 289

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388872080 370 YECQECGKTFSQKITLVQHQR--VHTGE--KPYECKE--CGKAFRWNASFIQHQKWHTRKKLIN 427
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-381 1.23e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 132 HLITKQGFAKEQVFYKCGECGSYYNPHSDFHLHQRVHTNEKPYTCKECGKTFRYNSKLSRHQKIHTGE-------KPYSC 204
Cdd:COG5048   213 SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKS 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 205 EECGQAFSQNSHLLQHQ--KLHGGQ--RPYECT--DCGKTFSYNSKLIRHQRIHTGEKPFKCKEcgkafscsydcIIHER 278
Cdd:COG5048   293 KQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKL-----------LNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 279 IHNGEKPYEckecgkslssNSVLIQHQRIHTGEKPYEC--KECGKAFHRSSVFLQHQRFHTGEQ--LYKCNECWKTFSCS 354
Cdd:COG5048   362 KFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRH 431

                         250       260
                  ....*....|....*....|....*..
gi 1388872080 355 SRFIVHQRIHNGEKPYECQECGKTFSQ 381
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 174-196 1.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|...
gi 1388872080 174 YTCKECGKTFRYNSKLSRHQKIH 196
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-381 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|..
gi 1388872080 360 HQRIHNGEKPYECQECGKTFSQ 381
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
KRAB smart00349
krueppel associated box;
4-22 2.17e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 36.42  E-value: 2.17e-03
                           10
                   ....*....|....*....
gi 1388872080    4 FPFPKPDLIFQLEQGEAAW 22
Cdd:smart00349  42 FQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-258 3.06e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1388872080 200 KPYSCEECGQAFSQNSHLLQHQKLHGGQRPYECTD--CGKTFSYNSKLIRHQRIHTGEKPF 258
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 190-267 3.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388872080 190 SRHQKIhTGEKPYSCE--ECGQAFsQNSHLLQHQKLHGGQRPyectdcgkTFSYNSKLIRHQRIHTGEKPFKCKECGKAF 267
Cdd:COG5189   339 SRMLKV-KDGKPYKCPveGCNKKY-KNQNGLKYHMLHGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-185 3.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|..
gi 1388872080 164 HQRVHTNEKPYTCKECGKTFRY 185
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-241 4.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.97e-03
                          10        20
                  ....*....|....*....|....*.
gi 1388872080 216 HLLQHQKLHGGQRPYECTDCGKTFSY 241
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 370-392 7.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|...
gi 1388872080 370 YECQECGKTFSQKITLVQHQRVH 392
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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