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Conserved domains on  [gi|1390249158|ref|NP_001350423|]
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solute carrier family 12 member 9 isoform 4 [Homo sapiens]

Protein Classification

APC family permease( domain architecture ID 1903533)

APC (amino acid/polyamine/organocation) family permease is involved in the uptake of a specific amino acid and/or polyamine substrate with the concomitant import of a proton

Gene Ontology:  GO:0055085|GO:0022857
TCDB:  2.A.3

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
AA_permease_2 super family cl45918
Amino acid permease;
86-762 2.95e-84

Amino acid permease;


The actual alignment was detected with superfamily member TIGR00930:

Pssm-ID: 459263 [Multi-domain]  Cd Length: 953  Bit Score: 287.76  E-value: 2.95e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158  86 GSSLPPRFGhFTGFNSSTLKDNLGAGYaedytTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAY 165
Cdd:TIGR00930 250 PAFDKPAKG-FFGLGNEIFSENFIPGI-----PGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILT 323
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 166 TFFVYVL--LFFLSSFTCDRTLLQED---------------------YGF---FRAISL---WPPLVLIGIYATALSASM 216
Cdd:TIGR00930 324 TTVVYLGsvVLFGACVVRDATGDKNDtlvtnctsaacfsecahntcsYGLmnnLQVMSLvspFPPLITAGIFSATLSSAL 403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 217 SSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSL 296
Cdd:TIGR00930 404 ASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHA 483
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 297 EWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLR 376
Cdd:TIGR00930 484 SLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLR 563
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 377 LDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLP-SDPVQPQYGAWLslvDRAQVKA 453
Cdd:TIGR00930 564 LEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGkGLMICGSVIQGPrLECVKeAQAAEAKIQTWL---EKNKVKA 640
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 454 FVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFyddappqdhfltdpafsePADSTREgsspalstlfpPPRApgspr 533
Cdd:TIGR00930 641 FYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGY------------------KKDWRQA-----------EPRA----- 686
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 534 alnPQDYVATVADALKMNKNVVLARASGALPPERLSRG---------------SGGTSQLHHVDVWPLNLLRPRGGPGYV 598
Cdd:TIGR00930 687 ---WETYIGIIHDAFDAHLAVVVVRNSEGLPISVLQVQeelendcsedsielnDGKISTQPDMHLEASTQFQKKQGKGTI 763
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 599 DVCGLF-----LLQMATILGMVPAWHSARLRIFlCLGPREAPGAAEGR-LRALLSQLRIRAEVQEVVWGEGAGAGEPEAE 672
Cdd:TIGR00930 764 DVWWLVddgglTLLLPYLLTTKKVWKKCKIRIF-VGAQKDDRSEQEKKdMATLLYKFRIDAEVIVVLMDINAKPQTESME 842
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 673 EEGDFVNSGR-----------------------GDAEAEALARSANALVRAQQgrgtgggPGGPEGGDAegpitALTFLY 729
Cdd:TIGR00930 843 AFEEMIRPFRlhktekdreakdpkmtwtkpwkiTDAELQSNVRKSYRQVRLNE-------LLLEYSRDA-----ALVVLS 910
                         730       740       750
                  ....*....|....*....|....*....|...
gi 1390249158 730 LPRPPADPARYPRYLALLETLTRDLGPTLLVHG 762
Cdd:TIGR00930 911 LPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRG 943
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
86-762 2.95e-84

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 287.76  E-value: 2.95e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158  86 GSSLPPRFGhFTGFNSSTLKDNLGAGYaedytTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAY 165
Cdd:TIGR00930 250 PAFDKPAKG-FFGLGNEIFSENFIPGI-----PGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILT 323
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 166 TFFVYVL--LFFLSSFTCDRTLLQED---------------------YGF---FRAISL---WPPLVLIGIYATALSASM 216
Cdd:TIGR00930 324 TTVVYLGsvVLFGACVVRDATGDKNDtlvtnctsaacfsecahntcsYGLmnnLQVMSLvspFPPLITAGIFSATLSSAL 403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 217 SSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSL 296
Cdd:TIGR00930 404 ASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHA 483
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 297 EWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLR 376
Cdd:TIGR00930 484 SLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLR 563
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 377 LDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLP-SDPVQPQYGAWLslvDRAQVKA 453
Cdd:TIGR00930 564 LEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGkGLMICGSVIQGPrLECVKeAQAAEAKIQTWL---EKNKVKA 640
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 454 FVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFyddappqdhfltdpafsePADSTREgsspalstlfpPPRApgspr 533
Cdd:TIGR00930 641 FYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGY------------------KKDWRQA-----------EPRA----- 686
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 534 alnPQDYVATVADALKMNKNVVLARASGALPPERLSRG---------------SGGTSQLHHVDVWPLNLLRPRGGPGYV 598
Cdd:TIGR00930 687 ---WETYIGIIHDAFDAHLAVVVVRNSEGLPISVLQVQeelendcsedsielnDGKISTQPDMHLEASTQFQKKQGKGTI 763
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 599 DVCGLF-----LLQMATILGMVPAWHSARLRIFlCLGPREAPGAAEGR-LRALLSQLRIRAEVQEVVWGEGAGAGEPEAE 672
Cdd:TIGR00930 764 DVWWLVddgglTLLLPYLLTTKKVWKKCKIRIF-VGAQKDDRSEQEKKdMATLLYKFRIDAEVIVVLMDINAKPQTESME 842
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 673 EEGDFVNSGR-----------------------GDAEAEALARSANALVRAQQgrgtgggPGGPEGGDAegpitALTFLY 729
Cdd:TIGR00930 843 AFEEMIRPFRlhktekdreakdpkmtwtkpwkiTDAELQSNVRKSYRQVRLNE-------LLLEYSRDA-----ALVVLS 910
                         730       740       750
                  ....*....|....*....|....*....|...
gi 1390249158 730 LPRPPADPARYPRYLALLETLTRDLGPTLLVHG 762
Cdd:TIGR00930 911 LPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRG 943
AA_permease pfam00324
Amino acid permease;
38-392 1.86e-62

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 216.80  E-value: 1.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158  38 VCTLGAGLYARASFLTFLLVSGSLASVLISFVaVGPRDIRLTPRpgpngsslppRFGHFTGFNSStlKDNLGAGYAEdyt 117
Cdd:pfam00324 127 INLVGVKWYGEAEFWFALIKIIAIIGFIIVGI-ILLSGGNPNDG----------AIFRYLGDNGG--KNNFPPGFGK--- 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 118 tgavmNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL------------ 185
Cdd:pfam00324 191 -----GFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDpgllndsasaas 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 186 LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGvilAPAKVVSRGGNPWAAVLYSWGLVQLV 265
Cdd:pfam00324 266 PFVIFFKFLGISGLAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLA 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 266 LLAGKLNTlaAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLL 345
Cdd:pfam00324 343 LLLASLNP--AIVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFL 420
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1390249158 346 AALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 392
Cdd:pfam00324 421 YAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
117-334 2.67e-22

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 100.36  E-value: 2.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 117 TTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQED----YGF 192
Cdd:COG0531   184 AGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVSLALTGVVPYDELAASgaplADA 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 193 FRAI--SLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILapAKVVSRGGNPWAAVLYSWGLVQLVLLAGK 270
Cdd:COG0531   264 AEAVfgPWGAILIALGALLSLLGALNASILGASRLLYAMARDGLLPKVF--AKVHPRFGTPVNAILLTGVIALLLLLLGA 341
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1390249158 271 --LNTLAAVVTVFYLVAYAAVDLSCLSLEWaSAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGA 334
Cdd:COG0531   342 asFTALASLASVGVLLAYLLVALAVIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGA 406
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
86-762 2.95e-84

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 287.76  E-value: 2.95e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158  86 GSSLPPRFGhFTGFNSSTLKDNLGAGYaedytTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAY 165
Cdd:TIGR00930 250 PAFDKPAKG-FFGLGNEIFSENFIPGI-----PGPEGGFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILT 323
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 166 TFFVYVL--LFFLSSFTCDRTLLQED---------------------YGF---FRAISL---WPPLVLIGIYATALSASM 216
Cdd:TIGR00930 324 TTVVYLGsvVLFGACVVRDATGDKNDtlvtnctsaacfsecahntcsYGLmnnLQVMSLvspFPPLITAGIFSATLSSAL 403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 217 SSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSL 296
Cdd:TIGR00930 404 ASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHA 483
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 297 EWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLR 376
Cdd:TIGR00930 484 SLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLR 563
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 377 LDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLP-SDPVQPQYGAWLslvDRAQVKA 453
Cdd:TIGR00930 564 LEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGkGLMICGSVIQGPrLECVKeAQAAEAKIQTWL---EKNKVKA 640
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 454 FVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFyddappqdhfltdpafsePADSTREgsspalstlfpPPRApgspr 533
Cdd:TIGR00930 641 FYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGY------------------KKDWRQA-----------EPRA----- 686
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 534 alnPQDYVATVADALKMNKNVVLARASGALPPERLSRG---------------SGGTSQLHHVDVWPLNLLRPRGGPGYV 598
Cdd:TIGR00930 687 ---WETYIGIIHDAFDAHLAVVVVRNSEGLPISVLQVQeelendcsedsielnDGKISTQPDMHLEASTQFQKKQGKGTI 763
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 599 DVCGLF-----LLQMATILGMVPAWHSARLRIFlCLGPREAPGAAEGR-LRALLSQLRIRAEVQEVVWGEGAGAGEPEAE 672
Cdd:TIGR00930 764 DVWWLVddgglTLLLPYLLTTKKVWKKCKIRIF-VGAQKDDRSEQEKKdMATLLYKFRIDAEVIVVLMDINAKPQTESME 842
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 673 EEGDFVNSGR-----------------------GDAEAEALARSANALVRAQQgrgtgggPGGPEGGDAegpitALTFLY 729
Cdd:TIGR00930 843 AFEEMIRPFRlhktekdreakdpkmtwtkpwkiTDAELQSNVRKSYRQVRLNE-------LLLEYSRDA-----ALVVLS 910
                         730       740       750
                  ....*....|....*....|....*....|...
gi 1390249158 730 LPRPPADPARYPRYLALLETLTRDLGPTLLVHG 762
Cdd:TIGR00930 911 LPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRG 943
AA_permease pfam00324
Amino acid permease;
38-392 1.86e-62

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 216.80  E-value: 1.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158  38 VCTLGAGLYARASFLTFLLVSGSLASVLISFVaVGPRDIRLTPRpgpngsslppRFGHFTGFNSStlKDNLGAGYAEdyt 117
Cdd:pfam00324 127 INLVGVKWYGEAEFWFALIKIIAIIGFIIVGI-ILLSGGNPNDG----------AIFRYLGDNGG--KNNFPPGFGK--- 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 118 tgavmNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTL------------ 185
Cdd:pfam00324 191 -----GFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDpgllndsasaas 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 186 LQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGvilAPAKVVSRGGNPWAAVLYSWGLVQLV 265
Cdd:pfam00324 266 PFVIFFKFLGISGLAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLA 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 266 LLAGKLNTlaAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLL 345
Cdd:pfam00324 343 LLLASLNP--AIVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFL 420
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1390249158 346 AALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 392
Cdd:pfam00324 421 YAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
117-334 2.67e-22

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 100.36  E-value: 2.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 117 TTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQED----YGF 192
Cdd:COG0531   184 AGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVSLALTGVVPYDELAASgaplADA 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 193 FRAI--SLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILapAKVVSRGGNPWAAVLYSWGLVQLVLLAGK 270
Cdd:COG0531   264 AEAVfgPWGAILIALGALLSLLGALNASILGASRLLYAMARDGLLPKVF--AKVHPRFGTPVNAILLTGVIALLLLLLGA 341
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1390249158 271 --LNTLAAVVTVFYLVAYAAVDLSCLSLEWaSAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGA 334
Cdd:COG0531   342 asFTALASLASVGVLLAYLLVALAVIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGA 406
SLC12 pfam03522
Solute carrier family 12;
403-651 9.51e-12

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 67.64  E-value: 9.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 403 PLLRLANQL-KKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLslvdRAQ-VKAFVDLTLSPSVRQGAQHLLRISGLGGMK 480
Cdd:pfam03522   3 ALVDFAHLItKNVSLMICGHVVKGRLSQKLRSELQKKAYRWL----RKRkIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 481 PNTLVLGFYDD---APPQD-----HFLTDpAF-----------------SE-PADSTREGSSPALSTLFPPPRAPGSPRA 534
Cdd:pfam03522  79 PNILLMGYKSDwrtCDKEEleeyfNVIHD-AFdlqyavailrlpegldvSHlLQDQDTEELGLGDETNSSYAEQSSEEQS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 535 LNPQDYVATVADALKMNKNVVLARASGALPPERlsRGSGGTSQLHHVDvwPLNLLRPRGGP----------------GYV 598
Cdd:pfam03522 158 TSNSKQDDDKSKLSKKDSNLSLSPDKSTKNPSG--KDSSKSDKLKKKS--PSIILRTASNEkeilnnitqfqkkqkkGTI 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 599 DVC------GLFLLqMATILGMVPAWHSARLRIFlCLGPREAPGAAEGR-LRALLSQLRI 651
Cdd:pfam03522 234 DVWwlyddgGLTLL-LPYILSTRSKWSDCKLRVF-ALGNRKDELEEEQRnMASLLSKFRI 291
AA_permease_2 pfam13520
Amino acid permease;
123-329 7.59e-09

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 58.48  E-value: 7.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 123 NFASVFAVLFnGCTGIMAGANMSGELKDpsRAIPLGTIVAVAYTFFVYVL--LFFLSSFTCDRTLLQEDYGFFRAI---S 197
Cdd:pfam13520 190 VFAGFLGVLW-SFTGFESAANVSEEVKK--RNVPKAIFIGVIIVGVLYILvnIAFFGVVPDDEIALSSGLGQVAALlfqA 266
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 198 LWPP----LVLIGIYATALSASMSSLIGASRILHALARDdlfGVILAPA--KVVSRGGNPWAAVLYSWGLVQLVLL---- 267
Cdd:pfam13520 267 VGGKwgaiIVVILLALSLLGAVNTAIVGASRLLYALARD---GVLPFSRffAKVNKFGSPIRAIILTAILSLILLLlfll 343
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1390249158 268 -AGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASaPNFRPTFslFSWHTCLLGVASCLLMMFL 329
Cdd:pfam13520 344 sPAAYNALLSLSAYGYLLSYLLPIIGLLILRKKR-PDLGRIP--GRWPVAIFGILFSLFLIVA 403
2A0303 TIGR00906
cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides ...
129-300 8.13e-08

cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273330 [Multi-domain]  Cd Length: 557  Bit Score: 55.59  E-value: 8.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 129 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL--WPP---LV 203
Cdd:TIGR00906 238 ATCFFAFIGFDAIATTGEEVKNPQRAIPIGIVTSLLVCFVAYFLMSAALTLMMPYYLLDPDAPFPVAFEYvgWDPakyIV 317
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249158 204 LIGIYATALSASMSSLIGASRILHALARDDLFGVILapAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYL 283
Cdd:TIGR00906 318 AVGALCGMSTSLLGGMFPLPRVIYAMARDGLLFKWL--AQINSKTKTPINATVVSGAIAALMAFLFDLKALVDLLSIGTL 395
                         170
                  ....*....|....*..
gi 1390249158 284 VAYAAVDLSCLSLEWAS 300
Cdd:TIGR00906 396 LAYSLVAACVLILRYQP 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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