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Conserved domains on  [gi|1390249182|ref|NP_001350429|]
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solute carrier family 35 member F3 isoform 1 [Mus musculus]

Protein Classification

solute carrier family 35 protein( domain architecture ID 12011759)

solute carrier family 35 protein such as solute carrier family 35 member F3 (SLC35F3), which may be a thiamine transporter; belongs to the DMT (drug/metabolite transporter) superfamily

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhaT super family cl34009
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
212-308 3.69e-09

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


The actual alignment was detected with superfamily member COG0697:

Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 57.54  E-value: 3.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 212 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSV-IGIALVVG 290
Cdd:COG0697    77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156
                          90
                  ....*....|....*...
gi 1390249182 291 SASMSALYKVLFKLLLGS 308
Cdd:COG0697   157 AALSWALYTVLTRRLSRR 174
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
118-273 3.76e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


:

Pssm-ID: 307170  Cd Length: 136  Bit Score: 43.34  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 118 WGVAVVFCVCASWAGSTQLARLTFKTFDAPFTLTW---FATnwnFLFFPLYYaghvckstekqsmkqryreccrFFGDNG 194
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRISPLTLTFWrflIAG---ILLLPFAL----------------------FTGGKL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 195 LTLKVFFTKAAPFGVLWT-LTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 273
Cdd:pfam00892  57 VIPLKSWLALLYLGVLGTfLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
212-308 3.69e-09

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 57.54  E-value: 3.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 212 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSV-IGIALVVG 290
Cdd:COG0697    77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156
                          90
                  ....*....|....*...
gi 1390249182 291 SASMSALYKVLFKLLLGS 308
Cdd:COG0697   157 AALSWALYTVLTRRLSRR 174
SLC35F pfam06027
Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.
215-388 5.99e-06

Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.


Pssm-ID: 283644 [Multi-domain]  Cd Length: 299  Bit Score: 47.83  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 215 NYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYAD---GFHSHS----VIGIAL 287
Cdd:pfam06027  87 NYLVVKAYQYTTMTSVQLLDCWAIPVVLVLSWFFLKTRYRLMHIIGVVVCILGVVMMVGSDvlaGRRAYSgsnpLKGDFL 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 288 VVGSASMSALYKVLFKLLLGSAKFGEaalFLSILGVFNIlFITCIPVILyFTRVEYWNsfddIPW-----GNLCGFSILL 362
Cdd:pfam06027 167 VLAGATLYAVSNVTEEYIVKKLSRVE---FLGMLGLFGA-IISGIQLAI-FERKELYA----IHWdweigLLFVGFALCM 237
                         170       180
                  ....*....|....*....|....*.
gi 1390249182 363 LTFNIVLNFGIAVTYPTLMSLGIVLS 388
Cdd:pfam06027 238 FLLYSLMPILIKMTSATSVNLSLLTS 263
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
118-273 3.76e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 43.34  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 118 WGVAVVFCVCASWAGSTQLARLTFKTFDAPFTLTW---FATnwnFLFFPLYYaghvckstekqsmkqryreccrFFGDNG 194
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRISPLTLTFWrflIAG---ILLLPFAL----------------------FTGGKL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 195 LTLKVFFTKAAPFGVLWT-LTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 273
Cdd:pfam00892  57 VIPLKSWLALLYLGVLGTfLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
212-308 3.69e-09

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 57.54  E-value: 3.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 212 TLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHSV-IGIALVVG 290
Cdd:COG0697    77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156
                          90
                  ....*....|....*...
gi 1390249182 291 SASMSALYKVLFKLLLGS 308
Cdd:COG0697   157 AALSWALYTVLTRRLSRR 174
SLC35F pfam06027
Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.
215-388 5.99e-06

Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.


Pssm-ID: 283644 [Multi-domain]  Cd Length: 299  Bit Score: 47.83  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 215 NYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYAD---GFHSHS----VIGIAL 287
Cdd:pfam06027  87 NYLVVKAYQYTTMTSVQLLDCWAIPVVLVLSWFFLKTRYRLMHIIGVVVCILGVVMMVGSDvlaGRRAYSgsnpLKGDFL 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 288 VVGSASMSALYKVLFKLLLGSAKFGEaalFLSILGVFNIlFITCIPVILyFTRVEYWNsfddIPW-----GNLCGFSILL 362
Cdd:pfam06027 167 VLAGATLYAVSNVTEEYIVKKLSRVE---FLGMLGLFGA-IISGIQLAI-FERKELYA----IHWdweigLLFVGFALCM 237
                         170       180
                  ....*....|....*....|....*.
gi 1390249182 363 LTFNIVLNFGIAVTYPTLMSLGIVLS 388
Cdd:pfam06027 238 FLLYSLMPILIKMTSATSVNLSLLTS 263
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
118-273 3.76e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 43.34  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 118 WGVAVVFCVCASWAGSTQLARLTFKTFDAPFTLTW---FATnwnFLFFPLYYaghvckstekqsmkqryreccrFFGDNG 194
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRISPLTLTFWrflIAG---ILLLPFAL----------------------FTGGKL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 195 LTLKVFFTKAAPFGVLWT-LTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 273
Cdd:pfam00892  57 VIPLKSWLALLYLGVLGTfLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
204-301 1.45e-04

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 43.66  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390249182 204 AAPFGVLWTLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDrfmgvrIVAAILAIAGIVMMTYA-DGFHSHSV 282
Cdd:COG5006    71 LLLYGVALAGMNLLFYLAIARIPLGIAVALEFLGPLAVALLGSRRRRD------LLWVALALAGVVLLLPVgLSGGSLDP 144
                          90
                  ....*....|....*....
gi 1390249182 283 IGIALVVGSASMSALYKVL 301
Cdd:COG5006   145 VGVLFALGAAACWALYILL 163
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
208-274 1.93e-03

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 38.63  E-value: 1.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390249182 208 GVLWTLTNYLYLHAIKKINATDVSVLFCCNKSFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYA 274
Cdd:COG2510    72 GLATGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSLK 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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