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Conserved domains on  [gi|1393428308|ref|NP_001350608|]
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major facilitator superfamily domain-containing protein 10 isoform b [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 51-305 2.06e-110

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17389:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 391  Bit Score: 327.69  E-value: 2.06e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  51 ESHGRAHDPLYGSWQGG-VDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVAT 129
Cdd:cd17389    27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 130 SYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----------P 199
Cdd:cd17389   107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasftrslgevF 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 200 LEMAPWFALLFAASDLLFIFCFLPETLPlekrapsialgfrdaadllsplallrfsavargqdppsgdrlSSLRRLGLVY 279
Cdd:cd17389   187 FSMPALFALVLALADLLFIFFFLPETLP------------------------------------------SNLRRLGLVY 224

                         250       260
                  ....*....|....*....|....*.
gi 1393428308 280 FLYLFLFSGLEYTLSFLTHQRFQFSR 305
Cdd:cd17389   225 FLYLFLFSGLEFTLTFLTHQRFQYTS 250
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 51-305 2.06e-110

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 327.69  E-value: 2.06e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  51 ESHGRAHDPLYGSWQGG-VDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVAT 129
Cdd:cd17389    27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 130 SYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----------P 199
Cdd:cd17389   107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasftrslgevF 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 200 LEMAPWFALLFAASDLLFIFCFLPETLPlekrapsialgfrdaadllsplallrfsavargqdppsgdrlSSLRRLGLVY 279
Cdd:cd17389   187 FSMPALFALVLALADLLFIFFFLPETLP------------------------------------------SNLRRLGLVY 224

                         250       260
                  ....*....|....*....|....*.
gi 1393428308 280 FLYLFLFSGLEYTLSFLTHQRFQFSR 305
Cdd:cd17389   225 FLYLFLFSGLEFTLTFLTHQRFQYTS 250
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-225 1.79e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 75.38  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGA----SLPLEMAPWFALLFAASDLLFIFCFLPET 225
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGvlaqFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-304 1.96e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.55  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAI 163
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALAL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----PLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALgf 239
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-- 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 240 rdaADLLsplallrfsavargqdppsgdRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFS 304
Cdd:COG2814   201 ---RELL---------------------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241
MFS_1 pfam07690
Major Facilitator Superfamily;
85-249 1.10e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 71.30  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAI 163
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWraaFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188


                  ....*....
gi 1393428308 241 DAADLLSPL 249
Cdd:pfam07690 189 SLIVAWKAL 197
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-233 1.66e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 52.61  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  96 FSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLARS 174
Cdd:PRK11102   39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEFS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393428308 175 QGMAVIGVAFSLGFTLGPMLGASLplemAPWFA--------LLFAASDLLFIFCFLPETLPLEKRAP 233
Cdd:PRK11102  115 RMMSFVTLVMTIAPLLAPIIGGWL----LVWFSwhaifwvlALAAILAAALVFFFIPETLPKERRQP 177
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 51-305 2.06e-110

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 327.69  E-value: 2.06e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  51 ESHGRAHDPLYGSWQGG-VDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVAT 129
Cdd:cd17389    27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 130 SYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----------P 199
Cdd:cd17389   107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFasftrslgevF 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 200 LEMAPWFALLFAASDLLFIFCFLPETLPlekrapsialgfrdaadllsplallrfsavargqdppsgdrlSSLRRLGLVY 279
Cdd:cd17389   187 FSMPALFALVLALADLLFIFFFLPETLP------------------------------------------SNLRRLGLVY 224

                         250       260
                  ....*....|....*....|....*.
gi 1393428308 280 FLYLFLFSGLEYTLSFLTHQRFQFSR 305
Cdd:cd17389   225 FLYLFLFSGLEFTLTFLTHQRFQYTS 250
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 68-304 1.35e-38

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 140.79  E-value: 1.35e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  68 VDWFATAIGMPV--------EKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRS 139
Cdd:cd17330     7 LDALGFGIVFPVlpfyvrefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 140 FAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----PLEMAPWFALLFAASDL 215
Cdd:cd17330    87 LWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLstpyGYALPFLVAAALALLNL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 216 LFIFCFLPetlplekrapsialgfrdaadllsplallrfsavargqdppsgdrlsSLRRLGLVYFLYLFLFSGLEYTLSF 295
Cdd:cd17330   167 VLVLFFLP-----------------------------------------------PLRRLLLVYFLIALAFAGLESVFSL 199


                  ....*....
gi 1393428308 296 LTHQRFQFS 304
Cdd:cd17330   200 FLKDRFGFS 208
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 47-265 1.74e-18

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 85.77  E-value: 1.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  47 PGlleshgrahdpLYGSWQGGVDWFATaigmpvekrynsvlFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMG 126
Cdd:cd17388    23 PT-----------LLREFVGDSADAAT--------------HYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 127 VATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLG---ASLPLEMA 203
Cdd:cd17388    78 AALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGgllGEISPRAP 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 204 PWFALLFAASDLLFIFCFLPETLPLEKR--------APSIALGFRDAADLLSPLALLRFSAVARGQDPPS 265
Cdd:cd17388   158 FLVAAGLNGLNFLLGLFVLPESLPPERRrafrwrraNPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPAT 227
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 41-220 4.92e-18

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 84.20  E-value: 4.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  41 LLLPLLPGLLESHGrahdplygswqggvdwfATAIGMpvekrynsvlfgGLIGSAFSVLQFLCAPLTGATSDCLGRRPVM 120
Cdd:cd17390    14 MILPLLSTHIRSLG-----------------ASPTVI------------GLIGSVYGALQLFSSPLVGSWSDVVGRRPVL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 121 LLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpL 200
Cdd:cd17390    65 LICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL-A 143

                         170       180
                  ....*....|....*....|
gi 1393428308 201 EMAPWFALLFAASDLLFIFC 220
Cdd:cd17390   144 ETDGGFYYVALLCSAIFILN 163
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-225 1.79e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 75.38  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGA----SLPLEMAPWFALLFAASDLLFIFCFLPET 225
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGvlaqFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 85-304 4.57e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.39  E-value: 4.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAI 163
Cdd:cd17325    29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAsdLLFIFCFLPETLPLEKRAPSIALGFRDAA 243
Cdd:cd17325   109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA--ALALLALVLALLLLPEPRPPPNKRAVSAA 186

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428308 244 DLLSPLALLRfsavargqdppsgdRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFS 304
Cdd:cd17325   187 RLRSGLRLLL--------------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
85-304 1.96e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.55  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAI 163
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALAL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL----PLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALgf 239
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-- 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 240 rdaADLLsplallrfsavargqdppsgdRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFS 304
Cdd:COG2814   201 ---RELL---------------------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 90-304 8.47e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 74.91  E-value: 8.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGI-SKGNVSLSTAIVADLG 168
Cdd:cd17474    37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASlpLEMAPW---FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADL 245
Cdd:cd17474   117 EGGERAKAMGLYEAALGLGIAVGPLLGGL--LAAISWrypFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKA 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428308 246 LSPLALLRFSAVArgqdppsgdrlsslrrlglvyFLYLFLFSGLEYTLSFLTHQRFQFS 304
Cdd:cd17474   195 LRGRGLLTFLVSA---------------------FLYFFLYFAFLTYLPFLLELLYGIS 232
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 95-258 4.21e-14

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 72.61  E-value: 4.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  95 AFSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLAR 173
Cdd:cd17320    46 GFALGQLLYGPL----SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAEL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 174 SQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLLFI--FCFLPETLPLEKRAPSIALGFRDAADLLSP 248
Cdd:cd17320   122 AKIFSLLMMILAIAPALAPLLGGLL-LLFFGWraiFVFLALLGLLLLLlvLLFLPETLPEEKRKPLLSSLLRAYKRVLKN 200

                         170
                  ....*....|
gi 1393428308 249 LALLRFSAVA 258
Cdd:cd17320   201 RRFLGYALAL 210
MFS_1 pfam07690
Major Facilitator Superfamily;
85-249 1.10e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 71.30  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAI 163
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLFGWraaFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188


                  ....*....
gi 1393428308 241 DAADLLSPL 249
Cdd:pfam07690 189 SLIVAWKAL 197
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 88-224 5.52e-12

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 66.46  E-value: 5.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  88 FGGLIGSAFSVLQFLCAPLTGATSDCLG--RRPVMLLCLMGVAT----SYAVWATSRSFAAFLASRLIGGISKGNVSLST 161
Cdd:cd17326    37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIVSILIAIVGnilyALAEYFPSNRKYVMLVARFLIGVGAGNVAVLR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 162 AIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGA--------------SLPLEM--AP-WFALLFAASDLLFIFCFLPE 224
Cdd:cd17326   117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAaftpigypgyvigiKLRFNMytAPaWLMAILGIINIILILFFFKE 196
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 90-222 1.42e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.90  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:cd17325   238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALLADIV 317

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLpleMAPW-FALLFAASDLLFIFCFL 222
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFL---YDAFgFATPFLAAAALLLLAAV 369
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 90-258 6.53e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.95  E-value: 6.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLE----MAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAad 244
Cdd:cd17324   117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlgwrAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLL-- 194

                         170
                  ....*....|....
gi 1393428308 245 LLSPLALLRFSAVA 258
Cdd:cd17324   195 LRNPRLRLAYLITF 208
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 84-259 1.33e-10

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 62.24  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  84 NSVLFGGLIgSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLiGGISKGNVSLSTAI 163
Cdd:cd17331    33 DSVVFGYLQ-TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL-PSVFMHAMQAAQMV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAS----DLLFIFCFLPE-TLPLEKRAPSIALG 238
Cdd:cd17331   111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVgsllSIVLVILLIPSnTKSKREKEAKESAS 190

                         170       180
                  ....*....|....*....|.
gi 1393428308 239 FRDAADLLSPLALLRFSAVAR 259
Cdd:cd17331   191 PPSVFNLKEILRLLRLPGVAF 211
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 84-234 1.29e-09

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 59.36  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  84 NSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLClmgVATSYAVWATSR-SFAAFLASRLIGGISKGNVSLSTA 162
Cdd:cd17387    33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLT---VFFTCAPIPLMRiSPWWYFAMISVSGIFSVTFSVIFA 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428308 163 IVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpleMAPW-------FALLFAASDLLFIFCFLPETLPLEKRAPS 234
Cdd:cd17387   110 YVADITTEEERSTAYGLVSATFAASLVTSPALGAYL---SESYgdnlvvlVATIVALLDICFILLAVPESLPEKMRPAS 185
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 90-238 3.59e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 57.62  E-value: 3.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17329    38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFePASEAMIADVT 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMapwFALLFAASDLLFIFCF------LPETLPLEKRAPSIALG 238
Cdd:cd17329   118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS---FRLLFLAAAVLFLLAAlvllflLPETRPKRRAAEKTEIL 190
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
90-242 3.85e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.56  E-value: 3.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGIskGNVSLSTAI---VAD 166
Cdd:COG0738    46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGL--GLGLLDVAAnpyVAA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 167 LGsPLARSQGMAVIGVAFSLGFTLGPMLGASLPL--------EMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALG 238
Cdd:COG0738   124 LG-PETAASRLNLLHAFFSLGALLGPLLGGLLILlglslswhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS 202


                  ....
gi 1393428308 239 FRDA 242
Cdd:COG0738   203 LKSL 206
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
90-223 6.80e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 6.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADLG 168
Cdd:COG2271    48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWF 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPWFALLFAASDLLFIFCFLP 223
Cdd:COG2271   128 PPKERGRALGIFNAGGPLGGALAPPLLGWL-LAAFGWRAAFLILGLPGLLLALLR 181
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-304 9.40e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 56.28  E-value: 9.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLG 168
Cdd:cd06174    34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLF 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFL-----PETLPLEKRAPSIALGFRDAA 243
Cdd:cd06174   114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAIllllvVPDPPESARAKNEEASSKSVL 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428308 244 DLLSPLALLRfsavargqdppsgdrlsSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFS 304
Cdd:cd06174   194 KLLKRVLKNP-----------------GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 96-231 1.29e-08

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 55.85  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  96 FSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIG--GISKGNVsLSTAIVADLGSPLAR 173
Cdd:TIGR00710  53 FAAGQLLWGPL----SDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQafGASAGSV-ISQALVRDIYPGEEL 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393428308 174 SQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW---FALLFAASDLL--FIFCFLPETLPLEKR 231
Cdd:TIGR00710 128 SRIYSILMPVLALAPAVAPLLGGYI-LVWLSWhaiFAFLSLAGILLsaLIFFILPETLPYEAR 189
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 89-212 6.75e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.78  E-value: 6.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  89 GGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADL 167
Cdd:cd17328    36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSpIAPTIIADL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1393428308 168 GSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPW-FALLFAA 212
Cdd:cd17328   116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWrWAFRVTG 161
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 72-252 8.99e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 53.33  E-value: 8.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  72 ATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGG 151
Cdd:cd17477    16 LPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 152 ISKGNVSLST-AIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDL-LFIFCFLPETLPLE 229
Cdd:cd17477    96 IGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLaLVPLLLTRRAAPEI 175

                         170       180
                  ....*....|....*....|...
gi 1393428308 230 KRAPSIALGfrdAADLLSPLALL 252
Cdd:cd17477   176 EEAESISLR---RLLRIAPLALL 195
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-233 1.66e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 52.61  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  96 FSVLQFLCAPLtgatSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLARS 174
Cdd:PRK11102   39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEFS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1393428308 175 QGMAVIGVAFSLGFTLGPMLGASLplemAPWFA--------LLFAASDLLFIFCFLPETLPLEKRAP 233
Cdd:PRK11102  115 RMMSFVTLVMTIAPLLAPIIGGWL----LVWFSwhaifwvlALAAILAAALVFFFIPETLPKERRQP 177
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 90-234 1.98e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 52.63  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLL-CLMGVATSyAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLG 168
Cdd:cd06179    35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGgNLLGVVGS-IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELV 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAP-W------FALLFAASDLLFIFCFLPETLPLEKRAPS 234
Cdd:cd06179   114 PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgWrwifyiNAIFNALALILLFFFYHPPPRPQLHGSST 186
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 90-259 2.08e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 52.17  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGS 169
Cdd:cd17478    34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 170 PLARSQGMAVIGVAFSLGFTLGPMLGASLP-----LEMAPWFALLFAASdLLFIFCFLPETLPLEKRAPSIALGFRDAAD 244
Cdd:cd17478   114 GGRRGLAMSIFSVGGNLGFALGPLIAAALValfggLGLLILLIIPGLAV-ALLLLRLRPLKKPEAKKAAAKSSARSTLKG 192

                         170
                  ....*....|....*
gi 1393428308 245 LLSPLALLRFSAVAR 259
Cdd:cd17478   193 VWRALLLLLIIVFLR 207
emrD PRK11652
multidrug transporter EmrD;
95-240 2.11e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 52.22  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  95 AFSVLQFLCAPLtgatSDCLGRRPVML--LCLMGVATSYAVWATSrsFAAFLASRLIGGISKGNV-SLSTAIVADL--GS 169
Cdd:PRK11652   55 TYGLSQLFYGPL----SDRVGRRPVILvgMSIFILGTLVALFAHS--LTVLIAASAIQGLGTGVGgVMARTLPRDLyeGT 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1393428308 170 PLARSQGMAVIGVAFS--LGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFR 240
Cdd:PRK11652  129 QLRHANSLLNMGILVSplLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYR 201
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 91-226 5.31e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 51.04  E-value: 5.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  91 LIGSAFSVLQFlcAPLtgatSDCLGRRPVMLLCLM-GVATSYAVwATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17323    44 VLGFGLGPLIW--APL----SELYGRRPVYLVSLFiFVIFQIGC-ALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLF 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLGA----SLPLEMAPWFALLFAASDLLFIFCFLPETL 226
Cdd:cd17323   117 TPEERGKAMGVYSLGPLLGPALGPIIGGfitqSLGWRWIFWFLAIISGFCLILIFLFLPIVL 178
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 77-227 5.78e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 50.68  E-value: 5.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  77 MPVEKRYNSVLFGG---LIGSAF-------SVLQflcAPLtGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLAS 146
Cdd:cd17472    16 LPVLSVYAKSLPGAtptLIGLALgiygltqAIFQ---IPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 147 RLI---GGISkgnvSLSTAIVADLGSPLARSQGMA----VIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIF 219
Cdd:cd17472    92 RALqgsGAIS----SVVMALLADLTREENRTKAMAligaSIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILL 167


                  ....*...
gi 1393428308 220 CFLPETLP 227
Cdd:cd17472   168 FFVPDPPK 175
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
91-247 3.46e-06

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 48.40  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  91 LIGSAFsvLQFLCAPLtgatSDCLGRRPVML--LCLMGVATSYAVWAtsRSFAAFLASRLIGGISK---GNVSLS----- 160
Cdd:PRK15402   58 LAGGMF--LQWLLGPL----SDRIGRRPVMLagVAFFILTCLAILLA--QSIEQFTLLRFLQGIGLcfiGAVGYAaiqes 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 161 ---------TAIVAD--LGSPLarsqgmavigvafslgftLGPMLGASLpLEMAPW------FALLfAASDLLFIFCFLP 223
Cdd:PRK15402  130 feeadaikiTALMANvaLLAPL------------------LGPLVGAAL-IHVLPWrgmfvlFAAL-AALSFFGLWRAMP 189

                         170       180
                  ....*....|....*....|....
gi 1393428308 224 ETLPLEKRAPSIALGFRDAADLLS 247
Cdd:PRK15402  190 ETAGRVGEKLSLKELGRDYKLVLK 213
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 90-195 1.13e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 46.79  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVADLG 168
Cdd:cd17502    33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLV 112

                          90       100
                  ....*....|....*....|....*..
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLG 195
Cdd:cd17502   113 PPRERGKYQGYIGAVFGIASVAGPLIG 139
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
90-190 1.14e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADLG 168
Cdd:COG2814   246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELA 325

                          90       100
                  ....*....|....*....|..
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTL 190
Cdd:COG2814   326 PPEARGRASGLYNSAFFLGGPL 347
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 102-234 1.32e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 102 LCAPLTGATSDCLGRRPVMLLCL--MGVATSYAVWATsrSFAAFLASRLIGGISKGNV-SLSTAIVADLGSPLARSQGMA 178
Cdd:cd17473    50 LFAPLAGWLADRFGRKRLLIAGLllYGIGGVAGLFLD--SLYALLASRALLGIGVAGImTLATALIGDYFEGEERAKMLG 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428308 179 VIGVAFSLGFTLGPMLGASLpLEM---APWFALLFAASDLLFIFCFLPETLPLEKRAPS 234
Cdd:cd17473   128 LQSAAMSLGGVVFLLLGGAL-AEIgwrAPFLVYLLALPVLILVLLFLPEPARKSKSAAS 185
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 85-228 1.47e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 46.41  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSvlqflcapltGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAI- 163
Cdd:cd17315    42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLy 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAS---DLLFIFC--FLPETLPL 228
Cdd:cd17315   112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAavpALLQLLLmfFLPESRAL 181
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-222 1.52e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  60 LYGSWQGGVDWFATAIgmpVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRR---PVMLLCLMGVATSYAVWAT 136
Cdd:COG2271   192 VYFALYGFLTWLPTYL---VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALL 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 137 SRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPWFA--LLFAASD 214
Cdd:COG2271   269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-LDATGYQAafLLLAALA 347


                  ....*...
gi 1393428308 215 LLFIFCFL 222
Cdd:COG2271   348 LLAALLAL 355
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 43-252 2.45e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  43 LpllpglleshgrAHDPLYGSWQGGVDWFAtaigmpvekrynsvlfgGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLL 122
Cdd:cd17489    16 L------------PVLPLYAHDLGGSEAVA-----------------GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLI 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 123 CLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST-AIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL-PL 200
Cdd:cd17489    67 GLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAaTLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLyQH 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1393428308 201 EMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALL 252
Cdd:cd17489   147 LGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLP 198
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 104-227 2.58e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 45.74  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 104 APLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIvadLGSPLARSQGMAVIGVA 183
Cdd:cd17374    52 ALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLI---LGTEWTTPRHRALAITL 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1393428308 184 FSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLP 227
Cdd:cd17374   129 TSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP 172
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 105-210 2.59e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 45.64  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 105 PLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGN-VSLSTAIVADLGSPLARSQGMAVIGVA 183
Cdd:cd17503    49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                          90       100
                  ....*....|....*....|....*..
gi 1393428308 184 FSLGFTLGPMLGASLpLEMAPWFALLF 210
Cdd:cd17503   129 ILLAPAIGPTLGGWL-TDNLSWRWIFY 154
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 108-222 3.70e-05

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 45.10  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 108 GATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPlarSQGMAVIGVAFSLG 187
Cdd:cd17446    54 GGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMP---TRVRAVVGTLLGYC 130

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1393428308 188 FTLGPMLGASLPLEMAPWFALLFAASdLLFIFCFL 222
Cdd:cd17446   131 YTLGQLILAGVAYAIRDWRWLQLAVS-LPFFIFFL 164
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 88-222 4.92e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.88  E-value: 4.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  88 FGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC-----LMGVATSYavwatSRSFAAFLASRLIGGISKGNVSLST- 161
Cdd:cd17317    26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGlvlqiVCGVLSAF-----SPSYELFLVLRFLVGVTSAGIFTVGf 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428308 162 AIVADLGSPLARSqgmaVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd17317   101 VLGMEIVGPKYRS----FVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLL 157
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 85-225 6.03e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 44.48  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSvlqflcapltGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVS-LSTAI 163
Cdd:cd17359    44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1393428308 164 VADL------GSPLARSQGMAVIG--VAFSLGFTLGPMLGASLPLEMA----PWFALLFAASdLLFIFCFLPET 225
Cdd:cd17359   114 IAEVapaeirGRLVSLNQLMIVFGqlLAYIVNYLIANAGGADWLGAEGwrwmLGLEAIPAIL-FLLGMLFIPES 186
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 69-255 7.27e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.53  E-value: 7.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  69 DWFAT-AIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATSRSFAA--- 142
Cdd:cd06173    15 DWIFTvALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdlLRALLAAVLALLALLGSLSlwl 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 143 -FLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAAsdLLFIFCF 221
Cdd:cd06173    95 lLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA--LSFLLSA 172

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1393428308 222 LPE-TLPLEKRAPSIALGFRDAADLLSPLALLRFS 255
Cdd:cd06173   173 LLLlFIRRPPPAAPGESSSLLLRDLREGLRYLRRS 207
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 102-222 1.47e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 43.42  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 102 LCAPLTGATSDCLGRRPVMLLCLMGVATSY------AVWATSRSFAAFLASRLIGGISKGNVSLSTAI---VADLGSPLA 172
Cdd:cd17386    45 FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSlilvliVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASfayISDISSEKK 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1393428308 173 RSQGMAVIGVAFSLGFTLGPMLG----ASLPLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd17386   125 RTYRMAILEVALGLGGFLGSLLSghlfKALGYAWSFSISAALLLIALLYILFFL 178
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 116-222 1.81e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 116 RRPVMLLCLMGVATSYAVWATSRSFAAFLA-SRLIGGISKGNVSLSTAI---VADLGSPLARSQGMAVIGVAFSLGFTLG 191
Cdd:cd17471    62 RKPLILLALLAGALGYLLFAFLRNYWVLLLvGVVLLSLGAAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIG 141

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1393428308 192 PMLGASLpleMAPW-FALLFAASDLLFIFCFL 222
Cdd:cd17471   142 PPLAFLL---LDVLgFTGLFLLAALLYLVVAL 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 60-222 1.82e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.18  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  60 LYGSWQGGVDWFATAIGMPVEKRYN-SVLFGGLIGSAFSVLQFLCAPLTGATSD-CLGRRPVMLLCLMGVATSYAVWATS 137
Cdd:cd06174   211 AIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLA 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 138 RSFAAFLASRLIGGISKGNVS-LSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLL 216
Cdd:cd06174   291 PSLLLLLLLLLLLGFGLGGLLpLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLL 370


                  ....*.
gi 1393428308 217 FIFCFL 222
Cdd:cd06174   371 LLAAIL 376
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 71-219 1.84e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  71 FATAIGMPVEKrynsvlfGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATSRSFAAFLASRL 148
Cdd:cd17477   214 YGLRLGLSVAQ-------AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCalLGALAALLLPLVPGLPLALLVLLFL 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1393428308 149 IGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAP-WFALLFAASDLLFIF 219
Cdd:cd17477   287 WGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPhGLFLFLAAVALLFLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-222 2.07e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.95  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWA-TSRSFAAFLASRLIGGISKGNVSLST-A 162
Cdd:COG2223   239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVfA 318

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 163 IVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPWFALLFAASDLLFIFCFL 222
Cdd:COG2223   319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL-LDATGSYTAAFLVFAVLALVALV 377
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 22-296 2.21e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.49  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  22 RRVVTVVFLGLLLDllaftlllpllpglleshgrahdplygswqgGVDWFATAIGMPVEKRY--NSVLFGGLIGSAFSVL 99
Cdd:COG0477    13 RRALLALALGTFLE-------------------------------GLDFTIVNVALPSIAADlgASSAQLGWIVSAYLLG 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 100 QFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADLGSPLARSQGMA 178
Cdd:COG0477    62 RAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGgLMPGALALIAELFPARERGRALG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 179 VIGVAFSLGFTLGPMLGASLpLEMAPW----FALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRF 254
Cdd:COG0477   142 LWGAAIGLGLALGPLLGGLL-VAALGWrwifLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLL 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1393428308 255 SAVARGQDPPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLSFL 296
Cdd:COG0477   221 LLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 103-198 3.00e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.55  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 103 CAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGN-VSLSTAIVADLGSPLARSQGMAVIG 181
Cdd:cd17321    47 LLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWG 126

                          90
                  ....*....|....*..
gi 1393428308 182 VAFSLGFTLGPMLGASL 198
Cdd:cd17321   127 AVVGIGAALGPLLGGLL 143
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 83-219 3.07e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.54  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  83 YNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRS-FAAFLASRLIGGISKGNVSLST 161
Cdd:cd17324   230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSpLLLLVGLVLWGLGFFAAHSALQ 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1393428308 162 AIVADLgSPLARSQGMAVIGVAFSLGFTLGPMLG----ASLPLEMAPWFALLFAASDLLFIF 219
Cdd:cd17324   310 TRVLRL-APEARGLASSLYLAAYNLGGALGAALGglvlDHGGWAGVGWVGAALLLLALLLAL 370
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 90-225 3.22e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 42.25  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATS-RSFAAFLASRLIGGISKGnvsLSTAIVAD 166
Cdd:cd17357    52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISnaLLVVSSLLMFLSKSaKSPELLIFGRFLVGIACG---LSTGFVPM 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393428308 167 LGSPLARSQGMAVIGVAFSLGFTLGPMLGA--SLPLEMAP---WFALLFA----ASDLLFIFCFLPET 225
Cdd:cd17357   129 YLQEISPSELRGALGSLTQIGVTLGILLGQvfGLPSVLGTetlWPYLLFFpgipALLQLAALPFFPES 196
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 104-196 3.35e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 104 APLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVA 183
Cdd:cd17504    48 TPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSAT 127

                          90
                  ....*....|...
gi 1393428308 184 FSLGFTLGPMLGA 196
Cdd:cd17504   128 FGIGAGIGLPLGG 140
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 89-232 3.72e-04

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 42.10  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  89 GGLIGSAFSVLqflcapLTGATSDCLGRRPVMLLCLMGVATSYAVWAT----SRSFAAFLASRLIGGISkGNVSL----S 160
Cdd:cd17449    73 GGFLVGLFSVT------LLGPWSDSVGRRPVLILPSLGLALQAAVYLLvmylQLHVAYFLIGRILSGLL-GDFNGilagC 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 161 TAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASL--------PLEMApwFALLFAASdlLFIFCFLPETLPLEKRA 232
Cdd:cd17449   146 FAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWrkaqgyinPFWLV--LALNLAAA--LYAAFCVGESVKEPKSA 221
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-195 4.25e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLS-TAIVADLG 168
Cdd:cd17489   230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAlQALAVDLV 309

                          90       100
                  ....*....|....*....|....*..
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGPMLG 195
Cdd:cd17489   310 PPHRRGAANGTFFIFFDLGIGLGGLLL 336
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 82-219 5.15e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.77  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  82 RYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLST 161
Cdd:cd17478   225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1393428308 162 AIVADLgspLARSQGMA---VIGVAFSLGFTLGPMLGA---SLPLEMAPWFALLFAASDLLFIF 219
Cdd:cd17478   305 VLAQEL---LPGNVGLAsglMMGLSFGLGGIGAPVLGAladAFGLESVLLILALLPLLGALLAF 365
Sugar_tr pfam00083
Sugar (and other) transporter;
90-225 5.36e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.87  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLC--LMGVATSYAVWATS-RSFAAFLASRLIGGISKGNVS-LSTAIVA 165
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvLFVIGAVLQGAAKGkWSVYQLIVGRVLVGIGVGGASvLAPMYIS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1393428308 166 DLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPW-----FALLFAASDLLFIF-CFLPET 225
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDgwripLGLQLVPALLLIIGlLFLPES 194
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 85-212 8.69e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 8.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAI 163
Cdd:cd17370   232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAA 311

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1393428308 164 VADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAA 212
Cdd:cd17370   312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSA 360
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
84-198 8.94e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  84 NSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAV--WATSRSFAAFLASRLIGGISKGNV-SLS 160
Cdd:COG2211   261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLlfFLGPGNLWLLLVLAALAGIGLGAIlVLP 340

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1393428308 161 TAIVADLGSPLARSQGMAVIGVAFS-------LGFTLGPMLGASL 198
Cdd:COG2211   341 WAMLADVVDYDEWKTGRRREGLYFGiftfaikLGQALAGALAGLL 385
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-226 8.97e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 8.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  87 LFGGLIGSAFSvlqflcapltGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNV-SLSTAIVA 165
Cdd:cd17365    44 LFGMAIGALLA----------GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAmPNAITLVS 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 166 DLGSPLARSQGMAVIgvafSLGFTLGPMLGASLPLEMAPWF----ALLFAASDLLFIFCFLPETL 226
Cdd:cd17365   114 EYAPARRRSLAVTLM----FCGYPLGAALGGFLAAALIPAFgwrsVFLLGGVPPLILLPLLRGTL 174
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 85-226 1.14e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 40.80  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  85 SVLFGGLIGSAFSVLQFlcapltGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGN-VSLSTAI 163
Cdd:TIGR00895  56 FLFSAGLIGMAFGALFF------GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGlMPNLNAL 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428308 164 VADLGSPLARSqgmAVIGVAFSlGFTLGPMLGASLPLEMAP--------WFALLFAASDLLFIFCFLPETL 226
Cdd:TIGR00895 130 VSEYAPKRFRG---TAVGLMFC-GYPIGAAVGGFLAGWLIPvfgwrslfYVGGIAPLLLLLLLMRFLPESI 196
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 66-294 1.24e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.38  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  66 GGVDWFATAIGMPVEKRYNSVLFGglIGSAFSVLQ---FLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAA 142
Cdd:cd17333     9 GLTDALLGILGPSLEEAFNLNVAD--VSVIFSSQNagyLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 143 FLASRLIGGISKG-NVSLSTAIVADLGSplaRSQG--MAVIGVAFSLGFTLGPMLGASLPLEMAPW---FALLFAASDLL 216
Cdd:cd17333    87 FVVLMFLAGLGAGiLDTGANTFVGALFE---ESSAtrLNVLHGFFGLGALIGPLIATSLLTSELSWswaYLIIGLIYLLL 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428308 217 FIFCFLPETLPLEKRAPSIALGFRDAADLlsplallrfsavargqdppsgdrLSSLRRLGLVYF-LYLFLFSGLEYTLS 294
Cdd:cd17333   164 AILILLTLFPELPSARNPQQSVGAFSASA-----------------------SRLLRNPSIILGaLALFLYVGAETAFS 219
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 93-225 1.66e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 40.25  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  93 GSAFSVLQFLCAPLTGATS----DCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAI-VADL 167
Cdd:cd17358    43 FSWFGSLLTLGALIGALLSgklaDRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVyIAEI 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393428308 168 GSPLARS------QGMAVIGVafSLGFTLGPMLgaslplemaPWFALLFAASDLLFIF----CFLPET 225
Cdd:cd17358   123 APKNVRGalgslnQLLVNIGI--LLGYVLGSFL---------PWRTLALIGAIPPVVFlillFFIPES 179
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 72-201 2.09e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.04  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  72 ATAIGMP-----VEKRYNSVLFGGL--IGSAFSVLqflcapLTGATSDCLGRRP-VMLLCLMGVATSyAVWATSRSFAAF 143
Cdd:pfam06609  62 ASASALPnilqdIGQSENQGLFSTLwtMGQAVSIL------MMGRLTDRFGRRPfVIATHIIGLVGA-IVGCTANKFNTL 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1393428308 144 LASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLE 201
Cdd:pfam06609 135 LAAMTLLGVAAGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQ 192
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 90-222 2.36e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADLG 168
Cdd:cd17473   236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLV 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 169 SPLARSQGMAVIGVAFSLGFTLGP-MLGASLPLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd17473   316 PPELRGRAMGIVTSAFFLGQFLSPlVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 84-214 2.79e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.43  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  84 NSVLFGGLIGSafsVLQFLCAPLTGATSDCLGRRPVMLL-CLMGVATSYAVWA---TSRSFAAFLASRLIGGIskgnvsL 159
Cdd:cd17369   264 STVLLAVLIAS---VVAAITIPLFGWLSDRVGRRPVYLAgALLAALFAFPFFWlldTGSTWLIVLAAVVVLGV------L 334

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 160 STAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLplemAPWFALLFAASD 214
Cdd:cd17369   335 HGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGF----APLIATALVAAT 385
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
90-252 2.83e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.47  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGG--ISKGNVSLSTAIVADL 167
Cdd:COG2807    56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagIAVGNVLLPGLIKRWF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308 168 gsPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPW-FALLF-AASDLLFIFCFLPETLPLEKRAPSIALGFRDAADL 245
Cdd:COG2807   136 --PDRVGLMTGLYTAAMGLGAALAAGLTVPL-AAALGWrGALAVwALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLW 212


                  ....*..
gi 1393428308 246 LSPLALL 252
Cdd:COG2807   213 RSPLAWL 219
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 98-226 5.14e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 38.51  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  98 VLQFLCAPLTGATSDCLGRRPVMLLC-LMGVATSYAVW---ATSRSFAAFLASRLIGGISKGnVSLSTAIVAdlgspLAR 173
Cdd:cd17368   269 VANFIWAPLGGALSDRIGRRPVLLVItLAALVTLYPVFawlTAAPSFGRLLLVLLVLSFFFG-MYGGAMVVA-----LVE 342

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 174 SQGMAVIGVAFSLGFTLGPML-GASLPL-----------EMAPWFALLFAASDLLFIFCFLPETL 226
Cdd:cd17368   343 LFPVRVRSTGFSLVYALAVAIfGGFAQFivtwlieltgsPLAPAWYLMGAALLGLLATLMLRETA 407
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 90-222 7.44e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428308  90 GLIGSAFSVLQFLCAPLTGATSDC-LGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKG-NVSLSTAIVADL 167
Cdd:cd17474   237 GLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGlNLPLLTTLVTEL 316

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1393428308 168 GSPLARSQGMAVIGVAFSLGFTLGPMLGASLpLEMAPWFALLFAASDLLFIFCFL 222
Cdd:cd17474   317 APEEERGTASSLYNFVRFLGQAVGPLLFGLL-LEIFGLSAPFLVGAAIALAAAVL 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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