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Conserved domains on  [gi|1394533246|ref|NP_001350725|]
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trans-2,3-enoyl-CoA reductase-like isoform 2 [Homo sapiens]

Protein Classification

steroid 5-alpha reductase family protein( domain architecture ID 708466)

steroid 5-alpha reductase family protein similar to Homo sapiens very-long-chain enoyl-CoA reductase and trans-2,3-enoyl-CoA reductase-like

EC:  1.3.1.-
Gene Ontology:  GO:0016491|GO:0042761

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02560 super family cl28409
enoyl-CoA reductase
 79-322 1.26e-55

enoyl-CoA reductase


The actual alignment was detected with superfamily member PLN02560:

Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 183.00  E-value: 1.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246  79 VTQSSTIHDVKQKFHKACPKWYPSR--VGLQLECG---------GPFLKDYITiqsiaaSSIVTLYATDLGQQVSWTTVF 147
Cdd:PLN02560   20 VPDSATVADLKKAIHKRKKKYYPSRqrLTLPLPPGktrptvlddSKSLKDYGL------GDGGTVVFKDLGPQVSYRTLF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 148 LAEYTGPLLIYLLFYLrIPCIYDGKE-SARRLRHPVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWG 226
Cdd:PLN02560   94 FFEYLGPLLIYPLFYF-FPQVYKYFGyPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 227 FTSWIAYYINHPLYTPPsfGNRQITVSAINFLICEAGN---HFINVMLSHPNHTGnnacfpspNYN-PFTWMFFLVSCPN 302
Cdd:PLN02560  173 FGAYIAYFVNHPLYTPV--SETQMKVGFGFGLVCQLANfycHIILRNLRKPDGKG--------GYQiPRGFLFNYVTCAN 242

                         250       260
                  ....*....|....*....|
gi 1394533246 303 YTYEIGSWISFTVMTQTLPG 322
Cdd:PLN02560  243 YTTEIYQWLGFNIATQTVAG 262
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 79-322 1.26e-55

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 183.00  E-value: 1.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246  79 VTQSSTIHDVKQKFHKACPKWYPSR--VGLQLECG---------GPFLKDYITiqsiaaSSIVTLYATDLGQQVSWTTVF 147
Cdd:PLN02560   20 VPDSATVADLKKAIHKRKKKYYPSRqrLTLPLPPGktrptvlddSKSLKDYGL------GDGGTVVFKDLGPQVSYRTLF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 148 LAEYTGPLLIYLLFYLrIPCIYDGKE-SARRLRHPVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWG 226
Cdd:PLN02560   94 FFEYLGPLLIYPLFYF-FPQVYKYFGyPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 227 FTSWIAYYINHPLYTPPsfGNRQITVSAINFLICEAGN---HFINVMLSHPNHTGnnacfpspNYN-PFTWMFFLVSCPN 302
Cdd:PLN02560  173 FGAYIAYFVNHPLYTPV--SETQMKVGFGFGLVCQLANfycHIILRNLRKPDGKG--------GYQiPRGFLFNYVTCAN 242

                         250       260
                  ....*....|....*....|
gi 1394533246 303 YTYEIGSWISFTVMTQTLPG 322
Cdd:PLN02560  243 YTTEIYQWLGFNIATQTVAG 262
Ubl_TECRL cd17125
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also ...
 60-137 2.60e-47

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life?threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). TECRL contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340645  Cd Length: 78  Bit Score: 153.87  E-value: 2.60e-47
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1394533246  60 FEIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAASSIVTLYATDL 137
Cdd:cd17125     1 FEVEILDAQTRKQICVVDKVHPSSTILDVKIKFHKTCPQWYPSRVGLQLERNGPFLKDSCEIQSIAVSSIVTLYFTDL 78
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 212-322 1.19e-05

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 44.70  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 212 TPLKNLIMSCAF--YWGFTS--WIAYY--INHPLYTPPSFgnrqiTVSAINFLICEAGNHFINVMLSHPNHTGNNAcfps 285
Cdd:pfam02544   3 MPLTIVAKAFAFctLNGLIQgrYNSYYqpYAEDWVTDPRF-----LIGIGLFVTGMLINIKSDIILRTLRKPGNTG---- 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1394533246 286 pnYN-PFTWMFFLVSCPNYTYEIGSWISFTVMTQTLPG 322
Cdd:pfam02544  74 --YKiPRGGLFELVSCPNYFGEIMEWIGYALATWSLPA 109
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 79-322 1.26e-55

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 183.00  E-value: 1.26e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246  79 VTQSSTIHDVKQKFHKACPKWYPSR--VGLQLECG---------GPFLKDYITiqsiaaSSIVTLYATDLGQQVSWTTVF 147
Cdd:PLN02560   20 VPDSATVADLKKAIHKRKKKYYPSRqrLTLPLPPGktrptvlddSKSLKDYGL------GDGGTVVFKDLGPQVSYRTLF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 148 LAEYTGPLLIYLLFYLrIPCIYDGKE-SARRLRHPVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWG 226
Cdd:PLN02560   94 FFEYLGPLLIYPLFYF-FPQVYKYFGyPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 227 FTSWIAYYINHPLYTPPsfGNRQITVSAINFLICEAGN---HFINVMLSHPNHTGnnacfpspNYN-PFTWMFFLVSCPN 302
Cdd:PLN02560  173 FGAYIAYFVNHPLYTPV--SETQMKVGFGFGLVCQLANfycHIILRNLRKPDGKG--------GYQiPRGFLFNYVTCAN 242

                         250       260
                  ....*....|....*....|
gi 1394533246 303 YTYEIGSWISFTVMTQTLPG 322
Cdd:PLN02560  243 YTTEIYQWLGFNIATQTVAG 262
Ubl_TECRL cd17125
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also ...
 60-137 2.60e-47

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life?threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). TECRL contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340645  Cd Length: 78  Bit Score: 153.87  E-value: 2.60e-47
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1394533246  60 FEIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAASSIVTLYATDL 137
Cdd:cd17125     1 FEVEILDAQTRKQICVVDKVHPSSTILDVKIKFHKTCPQWYPSRVGLQLERNGPFLKDSCEIQSIAVSSIVTLYFTDL 78
Ubl_TECR cd17124
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed ...
 59-137 4.28e-23

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR homolog (TSC13p) is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340644 [Multi-domain]  Cd Length: 79  Bit Score: 90.78  E-value: 4.28e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533246  59 HFEIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAASSIVTLYATDL 137
Cdd:cd17124     1 FFEVEILDAKTKEKLCFLDKVEPNATIGEIKNLFHKSHPQWYPARQSLRLDPKGKSLKDEDILQNLPVGTTATFYFRDL 79
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 61-137 4.62e-23

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 90.81  E-value: 4.62e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1394533246  61 EIEIFDAQTRKQICILDkVTQSSTIHDVKQKFHKACPKWYPSRVGLQLE-CGGPFLKDYITIQSIAASSIVTLYATDL 137
Cdd:cd01801     1 KIEVVSRKGGKQIITLE-VSSSATVADLKKAIHKKKKKLYPERQRLRLEvPKGKVLKDDKTLSSYGVKDGSTLYFKDL 77
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 212-322 1.19e-05

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 44.70  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533246 212 TPLKNLIMSCAF--YWGFTS--WIAYY--INHPLYTPPSFgnrqiTVSAINFLICEAGNHFINVMLSHPNHTGNNAcfps 285
Cdd:pfam02544   3 MPLTIVAKAFAFctLNGLIQgrYNSYYqpYAEDWVTDPRF-----LIGIGLFVTGMLINIKSDIILRTLRKPGNTG---- 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1394533246 286 pnYN-PFTWMFFLVSCPNYTYEIGSWISFTVMTQTLPG 322
Cdd:pfam02544  74 --YKiPRGGLFELVSCPNYFGEIMEWIGYALATWSLPA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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