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Conserved domains on  [gi|1394533207|ref|NP_001350745|]
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lipase maturation factor 2 isoform 2 [Homo sapiens]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 97-561 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 561.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207  97 LYFQWDSLLLETGFLAVLVAPLRPASHRKeapqgrqagALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALT 176
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP---------KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 177 YHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNLMTLVL 256
Cdd:pfam06762  72 YHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 257 TTALLDDQHLAAEpghgSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRtihsrttftfhqfsqWL 336
Cdd:pfam06762 152 SLSLLDDAFLYFW----TPESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENGT---------------FL 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 337 KTLTLPTVWLGVASLVWELLSALWRWtqvrgwlRKLSAVVQLSLVGTATVALFLISLVPYSyvepgthgrLWTGAHRLFG 416
Cdd:pfam06762 213 RRVTLPSIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNA 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 417 AVEHLQLANSYGLFRRMTglGGRPEVVLEGSYDGH-HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGPHTHSP 495
Cdd:pfam06762 277 SFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNP 354

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533207 496 WFTSLVLRLLQGKEPVIRLVQsqvaRYPFHKQPPTYVRAQRYKYWFSQPGE---QGQWWRRQWVEEFFP 561
Cdd:pfam06762 355 WFLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGErraTGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 97-561 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 561.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207  97 LYFQWDSLLLETGFLAVLVAPLRPASHRKeapqgrqagALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALT 176
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP---------KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 177 YHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNLMTLVL 256
Cdd:pfam06762  72 YHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 257 TTALLDDQHLAAEpghgSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRtihsrttftfhqfsqWL 336
Cdd:pfam06762 152 SLSLLDDAFLYFW----TPESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENGT---------------FL 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 337 KTLTLPTVWLGVASLVWELLSALWRWtqvrgwlRKLSAVVQLSLVGTATVALFLISLVPYSyvepgthgrLWTGAHRLFG 416
Cdd:pfam06762 213 RRVTLPSIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNA 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 417 AVEHLQLANSYGLFRRMTglGGRPEVVLEGSYDGH-HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGPHTHSP 495
Cdd:pfam06762 277 SFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNP 354

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533207 496 WFTSLVLRLLQGKEPVIRLVQsqvaRYPFHKQPPTYVRAQRYKYWFSQPGE---QGQWWRRQWVEEFFP 561
Cdd:pfam06762 355 WFLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGErraTGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 97-561 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 561.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207  97 LYFQWDSLLLETGFLAVLVAPLRPASHRKeapqgrqagALPHEDLPFWLVRWLLFRLMFASGVVKLTSRCPAWWGLTALT 176
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP---------KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 177 YHYETQCLPTPAAWFAHHLPVWLHKLSVVATFLIEIAVPPLFFAPIRRLRLAAFYSQVLLQVLIIITGNYNFFNLMTLVL 256
Cdd:pfam06762  72 YHYETQPLPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 257 TTALLDDQHLAAEpghgSRKKTATSWPKALLATLSLLLELAVYGLLAYGTVHYFGLEVDWQQRtihsrttftfhqfsqWL 336
Cdd:pfam06762 152 SLSLLDDAFLYFW----TPESRKKPPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKISENGT---------------FL 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 337 KTLTLPTVWLGVASLVWELLSALWRWtqvrgwlRKLSAVVQLSLVGTATVALFLISLVPYSyvepgthgrLWTGAHRLFG 416
Cdd:pfam06762 213 RRVTLPSIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNA 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533207 417 AVEHLQLANSYGLFRRMTglGGRPEVVLEGSYDGH-HWTEIEFMYKPGNLSRPPPVVVPHQPRLDWQMWFAALGPHTHSP 495
Cdd:pfam06762 277 SFNPLHLVNSYGLFGSMT--GGRPEVVIEGSNDGEgPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNP 354

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394533207 496 WFTSLVLRLLQGKEPVIRLVQsqvaRYPFHKQPPTYVRAQRYKYWFSQPGE---QGQWWRRQWVEEFFP 561
Cdd:pfam06762 355 WFLSLLYRLLQNDPEVLGLLD----HNPFPDKPPKYVRAELYRYRFTTPGErraTGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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