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Conserved domains on  [gi|1394533542|ref|NP_001350827|]
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alpha-ketoglutarate-dependent dioxygenase FTO isoform 6 [Homo sapiens]

Protein Classification

FTO_NTD and FTO_CTD domain-containing protein( domain architecture ID 10584236)

FTO_NTD and FTO_CTD domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FTO_NTD pfam12933
FTO catalytic domain; This domain is the catalytic AlkB-like domain from the FTO protein. This ...
36-335 1.01e-176

FTO catalytic domain; This domain is the catalytic AlkB-like domain from the FTO protein. This domain catalyzes a demethylase activity with a preference for 3-methylthymidine.


:

Pssm-ID: 463755  Cd Length: 275  Bit Score: 495.81  E-value: 1.01e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542  36 DEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFT 115
Cdd:pfam12933   1 AEFQQLWKTSYSGLVVREPSALPAELHAEVQRAFLTLRKHGCFFRDLVRIGGKDSFTPVSRTLLGEPGMTYKYLNLRLFA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 116 VPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEEL-AAKEKANEDAVPLCMsadfprvgmgssyngqDEVDIK 194
Cdd:pfam12933  81 HPWPTEGKEVKYCDPEIRSACRAVGRLNDYLTSRSIQALEKLrLAKSKENEGGEGLSM----------------DDGGLK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 195 SRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGtvcswkkqpcPEEESEDDSHLEG 274
Cdd:pfam12933 145 GSCEYNVTLLNYMDPQKMSYLKEEPYFGMGKMAVSWHHDENLVDRSTVAVYSYSCEG----------PKEEDEDDQGLEG 214
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1394533542 275 RDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAE 335
Cdd:pfam12933 215 RDPASWHVALKVAWDIETPGLAVPLHSGDCYYMLDDLNATHQHCVLAGSSPRFSSTHRVAE 275
FTO_CTD super family cl15176
FTO C-terminal domain; This domain is found at the C-terminus of the FTO protein which was ...
330-460 1.46e-50

FTO C-terminal domain; This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure. This domain is alpha helical with three helices that form a bundle.


The actual alignment was detected with superfamily member pfam12934:

Pssm-ID: 432887  Cd Length: 170  Bit Score: 169.57  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 330 THRvaEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQN 409
Cdd:pfam12934  45 IHN--EVEFQWIRQFWLQGSRHAAIHDYWHRPIEELEEAWDKMELGTRQALDELRRASRTMETEPRAFDVLLYLLTERQE 122
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1394533542 410 LRREWHARCQSRIARTLPADQKPECRPYWekdDASMPLPFDLTDIVSELRG 460
Cdd:pfam12934 123 LREEWTARYRSPAYQHLPADERPVDRPHF---DDSSPLPFDLEPVIATLEE 170
 
Name Accession Description Interval E-value
FTO_NTD pfam12933
FTO catalytic domain; This domain is the catalytic AlkB-like domain from the FTO protein. This ...
36-335 1.01e-176

FTO catalytic domain; This domain is the catalytic AlkB-like domain from the FTO protein. This domain catalyzes a demethylase activity with a preference for 3-methylthymidine.


Pssm-ID: 463755  Cd Length: 275  Bit Score: 495.81  E-value: 1.01e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542  36 DEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFT 115
Cdd:pfam12933   1 AEFQQLWKTSYSGLVVREPSALPAELHAEVQRAFLTLRKHGCFFRDLVRIGGKDSFTPVSRTLLGEPGMTYKYLNLRLFA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 116 VPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEEL-AAKEKANEDAVPLCMsadfprvgmgssyngqDEVDIK 194
Cdd:pfam12933  81 HPWPTEGKEVKYCDPEIRSACRAVGRLNDYLTSRSIQALEKLrLAKSKENEGGEGLSM----------------DDGGLK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 195 SRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGtvcswkkqpcPEEESEDDSHLEG 274
Cdd:pfam12933 145 GSCEYNVTLLNYMDPQKMSYLKEEPYFGMGKMAVSWHHDENLVDRSTVAVYSYSCEG----------PKEEDEDDQGLEG 214
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1394533542 275 RDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAE 335
Cdd:pfam12933 215 RDPASWHVALKVAWDIETPGLAVPLHSGDCYYMLDDLNATHQHCVLAGSSPRFSSTHRVAE 275
FTO_CTD pfam12934
FTO C-terminal domain; This domain is found at the C-terminus of the FTO protein which was ...
330-460 1.46e-50

FTO C-terminal domain; This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure. This domain is alpha helical with three helices that form a bundle.


Pssm-ID: 432887  Cd Length: 170  Bit Score: 169.57  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 330 THRvaEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQN 409
Cdd:pfam12934  45 IHN--EVEFQWIRQFWLQGSRHAAIHDYWHRPIEELEEAWDKMELGTRQALDELRRASRTMETEPRAFDVLLYLLTERQE 122
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1394533542 410 LRREWHARCQSRIARTLPADQKPECRPYWekdDASMPLPFDLTDIVSELRG 460
Cdd:pfam12934 123 LREEWTARYRSPAYQHLPADERPVDRPHF---DDSSPLPFDLEPVIATLEE 170
 
Name Accession Description Interval E-value
FTO_NTD pfam12933
FTO catalytic domain; This domain is the catalytic AlkB-like domain from the FTO protein. This ...
36-335 1.01e-176

FTO catalytic domain; This domain is the catalytic AlkB-like domain from the FTO protein. This domain catalyzes a demethylase activity with a preference for 3-methylthymidine.


Pssm-ID: 463755  Cd Length: 275  Bit Score: 495.81  E-value: 1.01e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542  36 DEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFT 115
Cdd:pfam12933   1 AEFQQLWKTSYSGLVVREPSALPAELHAEVQRAFLTLRKHGCFFRDLVRIGGKDSFTPVSRTLLGEPGMTYKYLNLRLFA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 116 VPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEEL-AAKEKANEDAVPLCMsadfprvgmgssyngqDEVDIK 194
Cdd:pfam12933  81 HPWPTEGKEVKYCDPEIRSACRAVGRLNDYLTSRSIQALEKLrLAKSKENEGGEGLSM----------------DDGGLK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 195 SRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGtvcswkkqpcPEEESEDDSHLEG 274
Cdd:pfam12933 145 GSCEYNVTLLNYMDPQKMSYLKEEPYFGMGKMAVSWHHDENLVDRSTVAVYSYSCEG----------PKEEDEDDQGLEG 214
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1394533542 275 RDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAE 335
Cdd:pfam12933 215 RDPASWHVALKVAWDIETPGLAVPLHSGDCYYMLDDLNATHQHCVLAGSSPRFSSTHRVAE 275
FTO_CTD pfam12934
FTO C-terminal domain; This domain is found at the C-terminus of the FTO protein which was ...
330-460 1.46e-50

FTO C-terminal domain; This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure. This domain is alpha helical with three helices that form a bundle.


Pssm-ID: 432887  Cd Length: 170  Bit Score: 169.57  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533542 330 THRvaEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQN 409
Cdd:pfam12934  45 IHN--EVEFQWIRQFWLQGSRHAAIHDYWHRPIEELEEAWDKMELGTRQALDELRRASRTMETEPRAFDVLLYLLTERQE 122
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1394533542 410 LRREWHARCQSRIARTLPADQKPECRPYWekdDASMPLPFDLTDIVSELRG 460
Cdd:pfam12934 123 LREEWTARYRSPAYQHLPADERPVDRPHF---DDSSPLPFDLEPVIATLEE 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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