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Conserved domains on  [gi|1395170578|ref|NP_001350947|]
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cyclin-G1 isoform b [Homo sapiens]

Protein Classification

cyclin-G1( domain architecture ID 15334747)

cyclin-G1 may play a role in growth regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 51-148 4.10e-62

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410286  Cd Length: 98  Bit Score: 191.58  E-value: 4.10e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20583     1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                          90
                  ....*....|....*...
gi 1395170578 131 VSDLMRMEKIVLEKVCWK 148
Cdd:cd20583    81 VSDMMRMEKIILEKLCWK 98
 
Name Accession Description Interval E-value
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 51-148 4.10e-62

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 191.58  E-value: 4.10e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20583     1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                          90
                  ....*....|....*...
gi 1395170578 131 VSDLMRMEKIVLEKVCWK 148
Cdd:cd20583    81 VSDMMRMEKIILEKLCWK 98
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 20-149 9.73e-20

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 82.95  E-value: 9.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  20 LLEQESRCQPKVCglrLIESAHDNGLRMTARLRDFevkdLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGL 99
Cdd:pfam00134   6 LRELELKYLPKPD---YMDQQPDINPKMRAILIDW----LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1395170578 100 SCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKV 149
Cdd:pfam00134  79 TCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 59-143 1.38e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.92  E-value: 1.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578   59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPlatDLIRISQYrFTVSDLMRME 138
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTK---ELVHYTGY-FTEEEILRME 78


                   ....*
gi 1395170578  139 KIVLE 143
Cdd:smart00385  79 RLLLE 83
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
66-143 3.89e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 57.09  E-value: 3.89e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395170578  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLE 143
Cdd:COG5024   227 FGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKY--EEVNCPSIKDLVYATDGAFTRDDIIRAERYMLE 302
 
Name Accession Description Interval E-value
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 51-148 4.10e-62

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 191.58  E-value: 4.10e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20583     1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                          90
                  ....*....|....*...
gi 1395170578 131 VSDLMRMEKIVLEKVCWK 148
Cdd:cd20583    81 VSDMMRMEKIILEKLCWK 98
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 52-145 6.18e-49

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 157.51  E-value: 6.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  52 RDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTV 131
Cdd:cd20523     1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDLIRISQCGCTA 80

                          90
                  ....*....|....
gi 1395170578 132 SDLMRMEKIVLEKV 145
Cdd:cd20523    81 ADLMRMEGIILEKL 94
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 51-145 1.94e-40

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 136.13  E-value: 1.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20584     1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCT 80

                          90
                  ....*....|....*
gi 1395170578 131 VSDLMRMEKIVLEKV 145
Cdd:cd20584    81 VSDLKRMEKIISEKL 95
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 52-147 8.92e-31

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 110.86  E-value: 8.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  52 RDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTV 131
Cdd:cd20526     2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCSV 81

                          90
                  ....*....|....*.
gi 1395170578 132 SDLMRMEKIVLEKVCW 147
Cdd:cd20526    82 AEVLRMERIILDKLHW 97
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 20-149 9.73e-20

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 82.95  E-value: 9.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  20 LLEQESRCQPKVCglrLIESAHDNGLRMTARLRDFevkdLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGL 99
Cdd:pfam00134   6 LRELELKYLPKPD---YMDQQPDINPKMRAILIDW----LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1395170578 100 SCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKV 149
Cdd:pfam00134  79 TCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 59-143 1.38e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.92  E-value: 1.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578   59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPlatDLIRISQYrFTVSDLMRME 138
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTK---ELVHYTGY-FTEEEILRME 78


                   ....*
gi 1395170578  139 KIVLE 143
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 47-144 1.84e-13

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 66.01  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  47 MTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQ 126
Cdd:cd20507    32 ITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKY--EEIYPPEIKDFVYITD 109

                          90
                  ....*....|....*...
gi 1395170578 127 YRFTVSDLMRMEKIVLEK 144
Cdd:cd20507   110 NAYTREEILQMERDILKT 127
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 51-143 6.06e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 63.78  E-value: 6.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQ-YRF 129
Cdd:cd20528     6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYLCnSVY 85

                          90
                  ....*....|....
gi 1395170578 130 TVSDLMRMEKIVLE 143
Cdd:cd20528    86 SKQEYLQMELLILE 99
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 66-147 4.27e-12

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 62.75  E-value: 4.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20567    68 FELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKY--EEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTL 145


                  ..
gi 1395170578 146 CW 147
Cdd:cd20567   146 EF 147
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 65-147 2.43e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 56.56  E-value: 2.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  65 FFGFDTETFSLAVNLLDRFLSKMKVQ---PKHLGCVGLSCFYLAVKSieEERNVPLATDL-IRISQYRFTVSDLMRMEKI 140
Cdd:cd20543    15 RYGFGPLTAYLAVNYLDRFLSSYDLPkdkPWMLQLLAVACLSLAAKM--EETDVPLLVDLqVEEPKYVFEAKTIQRMELL 92


                  ....*..
gi 1395170578 141 VLEKVCW 147
Cdd:cd20543    93 VLSTLEW 99
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 20-143 2.64e-10

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 57.38  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  20 LLEQESRCQPKVCGLRliesahdNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGL 99
Cdd:cd20561    12 LREMEVKCKPKVGYMK-------KQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1395170578 100 SCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLE 143
Cdd:cd20561    85 AAMLLASKF--EEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK 126
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 20-142 4.40e-10

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 56.49  E-value: 4.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  20 LLEQESRCQPKVCGLRlieSAHDNGLRMTARLRDFevkdLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGL 99
Cdd:cd20504    10 LRESELKHRPKPDYMR---KQPDINPSMRSILVDW----LVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1395170578 100 SCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVL 142
Cdd:cd20504    83 ACMFIAAKY--EEIYPPEVEEFVYITDDTYTKKQVLRMEHLVL 123
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 66-144 4.74e-10

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 56.53  E-value: 4.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1395170578  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEK 144
Cdd:cd20568    55 FRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNT 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 59-145 5.87e-10

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 55.40  E-value: 5.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRME 138
Cdd:cd20542     8 LVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKF--EERFPPEVATLCYLTDDSYSKKQVLRME 85


                  ....*..
gi 1395170578 139 KIVLEKV 145
Cdd:cd20542    86 RRVLRRL 92
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 71-147 8.16e-10

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 56.15  E-value: 8.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395170578  71 ETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20515    75 EVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKE---TIPLTAEKLCIyTDNSITLQELLDWELLVLTKLKW 149
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
66-143 3.89e-09

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 57.09  E-value: 3.89e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395170578  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLE 143
Cdd:COG5024   227 FGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKY--EEVNCPSIKDLVYATDGAFTRDDIIRAERYMLE 302
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 66-147 1.08e-08

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 51.62  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20559    13 LRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEELFIQMEMHILNTL 92


                  ..
gi 1395170578 146 CW 147
Cdd:cd20559    93 NW 94
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 66-144 2.94e-08

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 50.40  E-value: 2.94e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1395170578  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEK 144
Cdd:cd20536    16 FNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQ--EEIYPPEVKDLLALCCGAYTREQICNLECIILTK 92
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 59-140 4.10e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 49.72  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPlatDLIRISQYrfTVSDLMRME 138
Cdd:cd00043     6 IRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLK---EIAKVSGV--SEKELRKAE 80


                  ..
gi 1395170578 139 KI 140
Cdd:cd00043    81 KE 82
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 47-143 2.02e-07

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 49.84  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  47 MTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQ 126
Cdd:cd20560    64 ITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKY--EEIYPPEVDEFVYITD 141

                          90
                  ....*....|....*..
gi 1395170578 127 YRFTVSDLMRMEKIVLE 143
Cdd:cd20560   142 DTYTKKQLLRMEHLLLK 158
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 71-145 2.24e-07

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 49.17  E-value: 2.24e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1395170578  71 ETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20508    67 ETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKF--DERCPPCVDDFLYICDDAYTREELLKMEREILKTL 139
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 46-147 5.64e-07

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 47.69  E-value: 5.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  46 RMTARLRDFevkdLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKH-LGCVGLSCFYLAVKsIEEERNvPLATDLIRI 124
Cdd:cd20519    35 RMRAILLDW----LMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTqLQLIGITCLFIAAK-LEEIYP-PKLSEFAYV 108

                          90       100
                  ....*....|....*....|...
gi 1395170578 125 SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20519   109 TDGACTEDEILTMELIILKALNW 131
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 17-147 2.42e-06

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 46.51  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  17 LNALLEQESRCQPKVCGLRLIESahdnglRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGC 96
Cdd:cd20573    26 LQTMLKAEETCLPSVSYFKCVQK------EILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQL 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1395170578  97 VGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20573   100 LGATCMFLASKMKE---TIPLTAEKLCIyTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 71-142 5.68e-06

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 45.09  E-value: 5.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1395170578  71 ETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVL 142
Cdd:cd20562    61 DTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKY--EEICAPQVEEFCYITDNTYTKQEVLEMEIDVL 130
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 17-147 7.44e-06

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 44.98  E-value: 7.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  17 LNALLEQESRCQPKVCGLRLIESahdnglRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGC 96
Cdd:cd20575    27 LQNLLRLEERYVPRVSYFQCVQR------EIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1395170578  97 VGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20575   101 LGAVCMLLASKLRE---TTPLTIEKLCIyTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 44-145 9.04e-06

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 44.47  E-value: 9.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  44 GLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIR 123
Cdd:cd20566    32 GKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKY--EEMYSPEIGDFVY 109

                          90       100
                  ....*....|....*....|..
gi 1395170578 124 ISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20566   110 ITDNAYTKAQIREMEMLILKEL 131
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 69-147 4.08e-05

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 43.06  E-value: 4.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  69 DTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20574    73 EEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKE---TIPLTAEKLCIyTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 59-147 1.51e-04

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 40.24  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieeeRNV-PL-ATDLIRISQYRFTVSDLMR 136
Cdd:cd20517    13 MFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKI----RTVkPItVSKLTYLSCDCFTNLELIN 88

                          90
                  ....*....|.
gi 1395170578 137 MEKIVLEKVCW 147
Cdd:cd20517    89 QEKDILEALKW 99
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 48-214 1.99e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 42.03  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  48 TARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQY 127
Cdd:COG5333    41 ELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIESFEARDLWS 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578 128 RFTVSD---LMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERNSINFERLEAQLKAchcrIIFSKAKPSVLAL 204
Cdd:COG5333   121 EEPKSSrerILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDKYKLLQIAWKIINDALRT----DLCLLYPPHIIAL 196

                         170
                  ....*....|
gi 1395170578 205 SIIALEIQAQ 214
Cdd:COG5333   197 AALLIACEVL 206
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 21-142 4.03e-04

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 39.48  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  21 LEQESRCQPKvcglrliesaHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLS 100
Cdd:cd20565    15 LEEEQAVRPK----------YLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1395170578 101 CFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVL 142
Cdd:cd20565    85 AMFIASKY--EEMYPPEIGDFAFVTDNTYTKHQIRQMEMKIL 124
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 59-147 1.77e-03

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 37.90  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  59 LLSLTQFFGFDTETFSLAVNLLDRF-LSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRM 137
Cdd:cd20580    50 LLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKL--EEIYPPKLHEFAYVTDGACSEDDILDM 127

                          90
                  ....*....|
gi 1395170578 138 EKIVLEKVCW 147
Cdd:cd20580   128 ELIILKALKW 137
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 68-137 2.42e-03

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 36.53  E-value: 2.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1395170578  68 FDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEE----RNVPLATDliriSQYRFtvSDLMRM 137
Cdd:cd20521    20 FSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDiltiREAAWLTD----NTYKY--EDVVRM 87
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 51-147 3.38e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 37.19  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395170578  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFL---SKMKVQPKHlgcVGLSCFYLAVKSieEERNVPLATDLIRISQY 127
Cdd:cd20524    54 LVRYYEKKLLEFCRAFKLPDSVLATALTYFKRFYlknSVMEYHPKE---IMLTCLYLACKV--EEFNISIDQFVGNIKES 128

                          90       100
                  ....*....|....*....|
gi 1395170578 128 RFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20524   129 EKTAEIILEYELLLLQGLNF 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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