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Conserved domains on  [gi|1409931601|ref|NP_001351595|]
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leucine-rich repeat-containing protein 53 isoform 2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-183 5.13e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 5.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   43 DALHGLTMLRTLLLEHNQISSsslTDHTFSKLHSLQVLVLSNNALRTLrGSWFRNTSGLTRLQLDGNQITNLTDSSFggt 122
Cdd:COG4886    107 EELSNLTNLESLDLSGNQLTD---LPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG--- 179

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931601  123 NLHSLRYLDLSNNFISYIGkDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQ 183
Cdd:COG4886    180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-183 5.13e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 5.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   43 DALHGLTMLRTLLLEHNQISSsslTDHTFSKLHSLQVLVLSNNALRTLrGSWFRNTSGLTRLQLDGNQITNLTDSSFggt 122
Cdd:COG4886    107 EELSNLTNLESLDLSGNQLTD---LPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG--- 179

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931601  123 NLHSLRYLDLSNNFISYIGkDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQ 183
Cdd:COG4886    180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239
LRR_8 pfam13855
Leucine rich repeat;
99-161 3.43e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 3.43e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1409931601   99 SGLTRLQLDGNQITNLTDSSFGGtnLHSLRYLDLSNNFISYIGKDAFRPLPQLQEVDLSRNRL 161
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-177 2.33e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 2.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   43 DALHGLTMLRTLLLEHNQISSsslTDHtFSKLHSLQVLVLSNNALRTLRGswFRNTSGLTRLQLDGNQITN---LTDSSF 119
Cdd:cd21340     40 ENLEFLTNLTHLYLQNNQIEK---IEN-LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekLTFDPR 113

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931601  120 GGTNL-HSLRYLDLSNNFISYIgkDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILL 177
Cdd:cd21340    114 SLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSL 170
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 35-185 5.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 5.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   35 NGIEDVQEDALHGLTMLRTLLLEHNQISSSSLTDhtFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNL 114
Cdd:PLN00113   390 NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSE--FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG 467

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1409931601  115 TDSSFGGTNLHSLrylDLSNNFISYIGKDAFRPLPQLQEVDLSRNRLA-HMPDVFTPLKQLILLSLDKNQWS 185
Cdd:PLN00113   468 LPDSFGSKRLENL---DLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-183 5.13e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 5.13e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   43 DALHGLTMLRTLLLEHNQISSsslTDHTFSKLHSLQVLVLSNNALRTLrGSWFRNTSGLTRLQLDGNQITNLTDSSFggt 122
Cdd:COG4886    107 EELSNLTNLESLDLSGNQLTD---LPEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG--- 179

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931601  123 NLHSLRYLDLSNNFISYIGkDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQ 183
Cdd:COG4886    180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-185 1.27e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601    1 MTTRVLIITDGYLSSIESTNLSLLFNLALLSLSRNGIEDVQEDALHGLTMLRTLLLEHNQISSSSLTDHTFSKLHSLQVL 80
Cdd:COG4886     22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTEL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   81 VLSNNALrtlrgswFRNTSGLTRLQLDGNQITNLTDSSfggTNLHSLRYLDLSNNFISYIGkDAFRPLPQLQEVDLSRNR 160
Cdd:COG4886    102 DLSGNEE-------LSNLTNLESLDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQ 170

                          170       180
                   ....*....|....*....|....*
gi 1409931601  161 LAHMPDVFTPLKQLILLSLDKNQWS 185
Cdd:COG4886    171 LTDLPEELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
99-161 3.43e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 3.43e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1409931601   99 SGLTRLQLDGNQITNLTDSSFGGtnLHSLRYLDLSNNFISYIGKDAFRPLPQLQEVDLSRNRL 161
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
76-135 1.56e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.56e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   76 SLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSFGGtnLHSLRYLDLSNN 135
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
51-111 4.23e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 4.23e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931601   51 LRTLLLEHNQISSssLTDHTFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQI 111
Cdd:pfam13855    3 LRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-177 2.33e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 2.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   43 DALHGLTMLRTLLLEHNQISSsslTDHtFSKLHSLQVLVLSNNALRTLRGswFRNTSGLTRLQLDGNQITN---LTDSSF 119
Cdd:cd21340     40 ENLEFLTNLTHLYLQNNQIEK---IEN-LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPgekLTFDPR 113

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931601  120 GGTNL-HSLRYLDLSNNFISYIgkDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILL 177
Cdd:cd21340    114 SLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSL 170
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-165 1.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 1.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   45 LHGLTMLRTLLLEHNQISS-SSLTdhtfsKLHSLQVLVLSN-------------NALRTLRGSwfrntsgLTRLQLDGNQ 110
Cdd:cd21340     64 LENLVNLKKLYLGGNRISVvEGLE-----NLTNLEELHIENqrlppgekltfdpRSLAALSNS-------LRVLNISGNN 131

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1409931601  111 ITNLTDSSfggtNLHSLRYLDLSNNFISYIG--KDAFRPLPQLQEVDLSRNRLAHMP 165
Cdd:cd21340    132 IDSLEPLA----PLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
34-87 3.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1409931601   34 RNGIEDVQEDALHGLTMLRTLLLEHNQIssSSLTDHTFSKLHSLQVLVLSNNAL 87
Cdd:pfam13855   10 NNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 35-185 5.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 5.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   35 NGIEDVQEDALHGLTMLRTLLLEHNQISSSSLTDhtFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNL 114
Cdd:PLN00113   390 NSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSE--FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG 467

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1409931601  115 TDSSFGGTNLHSLrylDLSNNFISYIGKDAFRPLPQLQEVDLSRNRLA-HMPDVFTPLKQLILLSLDKNQWS 185
Cdd:PLN00113   468 LPDSFGSKRLENL---DLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 34-162 2.13e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   34 RNGIEDVQEDAL-HGLTM----LRTLLLEHNQISSSSLTD--HTFSKLHSLQVLVLSNNALrtlrgswfrNTSGLTRLQL 106
Cdd:cd00116    117 NNGLGDRGLRLLaKGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGI---------GDAGIRALAE 187

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601  107 DgnqitnLTDSSfggtnlhSLRYLDLSNNFISYIG----KDAFRPLPQLQEVDLSRNRLA 162
Cdd:cd00116    188 G------LKANC-------NLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLT 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-183 3.90e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 3.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   45 LHGLTMLRTLLLEHNQISSSSLTDHTFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSFGGTNL 124
Cdd:COG4886     16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931601  125 HSLRYLDLSNNfisyigkDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQ 183
Cdd:COG4886     96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ 147
PLN03150 PLN03150
hypothetical protein; Provisional
 70-138 7.64e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 7.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931601   70 TFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSFGgtNLHSLRYLDLSNNFIS 138
Cdd:PLN03150   437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLG--QLTSLRILNLNGNSLS 503
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 47-163 9.40e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 9.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   47 GLTMLRTLLLEHNQISSSSLTDHTFSKLHSLQVLVLSNN-----ALRTLRGSWFRNTSgLTRLQLDGNQITNLTDSSFG- 120
Cdd:COG5238    152 GGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNqigdeGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAe 230

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1409931601  121 -GTNLHSLRYLDLSNNFISYIG----KDAFRPLPQLQEVDLSRNRLAH 163
Cdd:COG5238    231 aLKGNKSLTTLDLSNNQIGDEGvialAEALKNNTTVETLYLSGNQIGA 278
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 126-161 1.83e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1409931601  126 SLRYLDLSNNFISYIgkDAFRPLPQLQEVDLSRNRL 161
Cdd:pfam12799    2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNK 35
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-199 3.84e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   34 RNGIEDVQEdaLHGLTMLRTLLLEHNQISSSSltdhTFSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITN 113
Cdd:COG4886    237 NNQLTDLPE--LGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601  114 LTDSSFGGTNLHSLRYLDLSNNFISYIGKDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQWSCTCDLHPL 193
Cdd:COG4886    311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390


                   ....*.
gi 1409931601  194 ARFLRN 199
Cdd:COG4886    391 LLLLTT 396
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 95-159 5.06e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 5.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931601   95 FRNTSGLTRLQLdGNQITNLTDSSFGGTNLHSLrylDLSNNfISYIGKDAFRPLPQLQEVDLSRN 159
Cdd:pfam13306   30 FSNCTSLKSITL-PSSLTSIGSYAFYNCSLTSI---TIPSS-LTSIGEYAFSNCSNLKSITLPSN 89
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-183 7.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 7.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931601   63 SSSLTDHTFsKLHSLQVLVLSNNALR-TLRGSWFRNTSGLTRLQLDGNqitNLTDSSFGGTnLHSLRYLDLSNNFISYIG 141
Cdd:PLN00113    82 SGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN---NFTGSIPRGS-IPNLETLDLSNNMLSGEI 156

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1409931601  142 KDAFRPLPQLQEVDLSRNRL-AHMPDVFTPLKQLILLSLDKNQ 183
Cdd:PLN00113   157 PNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQ 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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