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Conserved domains on  [gi|1433354023|ref|NP_001352000|]
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GTP:AMP phosphotransferase AK3, mitochondrial isoform 2 [Mus musculus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11995178)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
12-189 7.51e-97

Adenylate kinase;


:

Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 279.96  E-value: 7.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHEL-KTLTQCSWLLD 90
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLeQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  91 GFPRTLPQAEALDK----VYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQREDDKP 165
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVpGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 1433354023 166 ETVIKRLKAYEAQTEPVLQYYQKK 189
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
12-189 7.51e-97

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 279.96  E-value: 7.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHEL-KTLTQCSWLLD 90
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLeQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  91 GFPRTLPQAEALDK----VYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQREDDKP 165
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVpGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 1433354023 166 ETVIKRLKAYEAQTEPVLQYYQKK 189
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 9-212 2.01e-92

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 269.87  E-value: 2.01e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQC--S 86
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNenG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  87 WLLDGFPRTLPQAEALDKV--YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTGI-DDLTGEPLIQREDD 163
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALleEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGcDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1433354023 164 KPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT-ETNKIWPHVYSFLQ 212
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-198 3.92e-92

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 268.92  E-value: 3.92e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTL-TQCSW 87
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPdCANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  88 LLDGFPRTLPQAEALDKV-----YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQRE 161
Cdd:COG0563    82 ILDGFPRTVAQAEALDELlaelgIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVeGVCDKCGGELVQRA 161

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1433354023 162 DDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT 198
Cdd:COG0563   162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 8-198 6.91e-90

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 263.55  E-value: 6.91e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   8 LRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVM-----TRLALHELKTl 82
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIViglvkERLAQPDCKN- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  83 tqcSWLLDGFPRTLPQAEALDKVY-----QIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEP 156
Cdd:PRK00279   80 ---GFLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVeGKCDVCGEE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1433354023 157 LIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT 198
Cdd:PRK00279  157 LIQRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 9-200 1.68e-84

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 249.08  E-value: 1.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLtQCS-- 86
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKP-DCKkg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  87 WLLDGFPRTLPQAEALDKVYQ----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIefnppktGIDDLTGEPLIQRED 162
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL-------GKDDVTGEPLSQRSD 152

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1433354023 163 DKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTET 200
Cdd:cd01428   153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
12-189 7.51e-97

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 279.96  E-value: 7.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHEL-KTLTQCSWLLD 90
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLeQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  91 GFPRTLPQAEALDK----VYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQREDDKP 165
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVpGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 1433354023 166 ETVIKRLKAYEAQTEPVLQYYQKK 189
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 9-212 2.01e-92

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 269.87  E-value: 2.01e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQC--S 86
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNenG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  87 WLLDGFPRTLPQAEALDKV--YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTGI-DDLTGEPLIQREDD 163
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALleEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGcDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1433354023 164 KPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT-ETNKIWPHVYSFLQ 212
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 9-198 3.92e-92

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 268.92  E-value: 3.92e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTL-TQCSW 87
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPdCANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  88 LLDGFPRTLPQAEALDKV-----YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQRE 161
Cdd:COG0563    82 ILDGFPRTVAQAEALDELlaelgIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVeGVCDKCGGELVQRA 161

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1433354023 162 DDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT 198
Cdd:COG0563   162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 8-198 6.91e-90

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 263.55  E-value: 6.91e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   8 LRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVM-----TRLALHELKTl 82
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIViglvkERLAQPDCKN- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  83 tqcSWLLDGFPRTLPQAEALDKVY-----QIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEP 156
Cdd:PRK00279   80 ---GFLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVeGKCDVCGEE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1433354023 157 LIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT 198
Cdd:PRK00279  157 LIQRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 9-200 1.68e-84

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 249.08  E-value: 1.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLtQCS-- 86
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKP-DCKkg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  87 WLLDGFPRTLPQAEALDKVYQ----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIefnppktGIDDLTGEPLIQRED 162
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL-------GKDDVTGEPLSQRSD 152

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1433354023 163 DKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTET 200
Cdd:cd01428   153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
PLN02674 PLN02674
adenylate kinase
 9-192 7.96e-61

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 190.87  E-value: 7.96e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHEL-KTLTQCSW 87
Cdd:PLN02674   33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMkKPSCQKGF 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  88 LLDGFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQRE 161
Cdd:PLN02674  113 ILDGFPRTVVQAQKLDEMLAkqgakIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVpGVDDVTGEPLIQRK 192

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1433354023 162 DDKPETVIKRLKAYEAQTEPVLQYYQKKGVL 192
Cdd:PLN02674  193 DDTAAVLKSRLEAFHKQTEPVIDYYAKKGVV 223
PRK14530 PRK14530
adenylate kinase; Provisional
 9-204 8.17e-50

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 161.88  E-value: 8.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQ-----GTEIGVlAKTFIDQGKLIPDDVMTRLALHELKTLT 83
Cdd:PRK14530    5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMdisdmDTEYDT-PGEYMDAGELVPDAVVNEIVEEALSDAD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  84 qcSWLLDGFPRTLPQAEALDKVYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQRED 162
Cdd:PRK14530   84 --GFVLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEeGVCDECGGELIQRDD 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1433354023 163 DKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTET-NKIW 204
Cdd:PRK14530  162 DTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVW 204
PLN02842 PLN02842
nucleotide kinase
 11-186 1.46e-41

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 147.31  E-value: 1.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  11 VIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMT-----RLALHELKtltQC 85
Cdd:PLN02842    1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIamvtgRLSREDAK---EK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  86 SWLLDGFPRTLPQAEALDKV-YQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPKTgidDLTGEPLIQREDDK 164
Cdd:PLN02842   78 GWLLDGYPRSFAQAQSLEKLkIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPES---EEIKARLITRPDDT 154

                         170       180
                  ....*....|....*....|..
gi 1433354023 165 PETVIKRLKAYEAQTEPVLQYY 186
Cdd:PLN02842  155 EEKVKARLQIYKKNAEAILSTY 176
adk PRK02496
adenylate kinase; Provisional
 9-200 1.42e-40

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 137.19  E-value: 1.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTL-TQCSW 87
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPdAANGW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  88 LLDGFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARwihpasgrvyniefnppktgiddltgepliQRED 162
Cdd:PRK02496   83 ILDGFPRKVTQAAFLDELLQeigqsGERVVNLDVPDDVVVERLLAR------------------------------GRKD 132

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1433354023 163 DKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTET 200
Cdd:PRK02496  133 DTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQS 170
PRK14526 PRK14526
adenylate kinase; Provisional
 8-188 2.15e-40

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 137.29  E-value: 2.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   8 LRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTL-TQCS 86
Cdd:PRK14526    1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIkNNDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  87 WLLDGFPRTLPQAEALDKVYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNIEFNPPK-TGIDDLTGEPLIQREDDKP 165
Cdd:PRK14526   81 FILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKeKGICDVCKGDLYQRKDDKE 160

                         170       180
                  ....*....|....*....|...
gi 1433354023 166 ETVIKRLKAYEAQTEPVLQYYQK 188
Cdd:PRK14526  161 ESLKTRLQEYKLQTKPLIEFYSK 183
PLN02459 PLN02459
probable adenylate kinase
 3-195 3.58e-40

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 138.44  E-value: 3.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   3 ASGRLLRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTL 82
Cdd:PLN02459   25 AKGRNVNWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  83 TQ---CSWLLDGFPRTLPQAEALDKVYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNI-------EFNPPKTGIDDL 152
Cdd:PLN02459  105 EEegeSGFILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVadidlkgEDGRPGIVMPPL 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1433354023 153 TGEP-----LIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETF 195
Cdd:PLN02459  185 LPPPecaskLITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 6-215 5.00e-40

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 136.85  E-value: 5.00e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   6 RLLRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQC 85
Cdd:PTZ00088    5 GPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  86 ---SWLLDGFPRTLPQAEALDKVYQIDTVINLNVPFEVIKQRLTARWIHPASGRVYNI--------EFNP--PKTGIDDL 152
Cdd:PTZ00088   85 cfkGFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIahirsdpyDMPPilPPADCEGC 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1433354023 153 TGEP-LIQREDDKPETVIKRLKAYEAQTEPVLQYYQKKGV-LETFSGTETNKIWPHVYSFLQTKV 215
Cdd:PTZ00088  165 KGNPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENCnLVDFEITRGLRDFDDFYRIVLQRL 229
PRK14527 PRK14527
adenylate kinase; Provisional
 9-200 2.14e-37

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 129.14  E-value: 2.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVI-MGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCSW 87
Cdd:PRK14527    7 KVVIfLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  88 LLDGFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARwihpasGRvyniefnppktgiddltgepLIQRED 162
Cdd:PRK14527   87 IFDGFPRTLAQAEALDRLLEelgarLLAVVLLEVPDEELIRRIVER------AR--------------------QEGRSD 140

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1433354023 163 DKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTET 200
Cdd:PRK14527  141 DNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGT 178
PRK14531 PRK14531
adenylate kinase; Provisional
 9-194 1.76e-36

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 126.46  E-value: 1.76e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCSWL 88
Cdd:PRK14531    4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSGGWL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  89 LDGFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARwihpasGRvyniefnppktgiddltgepliqreDD 163
Cdd:PRK14531   84 LDGFPRTVAQAEALEPLLEelkqpIEAVVLLELDDAVLIERLLAR------GR-------------------------AD 132

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1433354023 164 KPETVIK-RLKAYEAQTEPVLQYYQKKGVLET 194
Cdd:PRK14531  133 DNEAVIRnRLEVYREKTAPLIDHYRQRGLLQS 164
PRK14532 PRK14532
adenylate kinase; Provisional
 11-197 2.57e-33

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 118.39  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  11 VIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCS-WLL 89
Cdd:PRK14532    4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGgAIF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  90 DGFPRTLPQAEALDKVY-----QIDTVINLNVPFEVIKQRLTARWIHPAsgrvyniefnppktgiddltgepliqREDDK 164
Cdd:PRK14532   84 DGFPRTVAQAEALDKMLasrgqKIDVVIRLKVDDEALIERIVKRFEEQG--------------------------RPDDN 137

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1433354023 165 PETVIKRLKAYEAQTEPVLQYYQKKGVLETFSG 197
Cdd:PRK14532  138 PEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDG 170
PRK14528 PRK14528
adenylate kinase; Provisional
 9-200 8.03e-32

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 114.72  E-value: 8.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   9 RAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTlTQCS-- 86
Cdd:PRK14528    3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIRE-ADCKng 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  87 WLLDGFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARWIhpasgrvyniefnppKTGiddltgepliqRE 161
Cdd:PRK14528   82 FLLDGFPRTVEQADALDALLKnegksIDKAINLEVPDGELLKRLLGRAE---------------IEG-----------RA 135

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1433354023 162 DDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTET 200
Cdd:PRK14528  136 DDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGS 174
PRK13808 PRK13808
adenylate kinase; Provisional
 8-197 8.57e-32

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 118.45  E-value: 8.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023   8 LRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMT-----RLALHELKTl 82
Cdd:PRK13808    1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVgiisdRIEQPDAAN- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  83 tqcSWLLDGFPRTLPQAEALD-----KVYQIDTVINLNVPFEVIKQRLTARwihPASGRVyniefnppktgiddlTGEPL 157
Cdd:PRK13808   80 ---GFILDGFPRTVPQAEALDallkdKQLKLDAVVELRVNEGALLARVETR---VAEMRA---------------RGEEV 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1433354023 158 iqREDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSG 197
Cdd:PRK13808  139 --RADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVDG 176
PRK14529 PRK14529
adenylate kinase; Provisional
 11-175 4.58e-31

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 113.66  E-value: 4.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  11 VIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCSWLLD 90
Cdd:PRK14529    4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  91 GFPRTLPQAEALDKVYQ-----IDTVINLNVPFEVIKQRLTARWI------HPAsgrvyNIEFNPPKTGIDD--LTGEPL 157
Cdd:PRK14529   84 GFPRNKVQAEKLWEALQkegmkLDYVIEILLPREVAKNRIMGRRLckndnnHPN-----NIFIDAIKPDGDVcrVCGGEL 158

                         170
                  ....*....|....*....
gi 1433354023 158 IQREDDKPETVI-KRLKAY 175
Cdd:PRK14529  159 STRADDQDEEAInKRHDIY 177
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 12-198 1.58e-29

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 108.61  E-value: 1.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNM-LQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELK-TLTQCSWLL 89
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIkREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQeDGSSKKFLI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  90 DGFPRTLPQAEALDKVY----QIDTVINLNVPFEVIKQRLTARwiHPASGRVyniefnppktgiddltgepliqreDDKP 165
Cdd:TIGR01359  84 DGFPRNEENLEAWEKLMdnkvNFKFVLFFDCPEETMIKRLLKR--GQTSGRV------------------------DDNI 137

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1433354023 166 ETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGT 198
Cdd:TIGR01359 138 ETLKKRFRTYNEETLPIIEHFENKGKVKEINAE 170
PLN02200 PLN02200
adenylate kinase family protein
 12-207 3.93e-27

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 103.82  E-value: 3.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKTLTQCSWLLDG 91
Cdd:PLN02200   48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNKFLIDG 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  92 FPRTLPQAEALDKVYQIDTviNLNVPFEVIKQRLTARWIHPASGRVyniefnppktgiddltgepliqreDDKPETVIKR 171
Cdd:PLN02200  128 FPRTEENRIAFERIIGAEP--NVVLFFDCPEEEMVKRVLNRNQGRV------------------------DDNIDTIKKR 181

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1433354023 172 LKAYEAQTEPVLQYYQKKGVLETFSGTET-NKIWPHV 207
Cdd:PLN02200  182 LKVFNALNLPVIDYYSKKGKLYTINAVGTvDEIFEQV 218
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 12-194 9.74e-27

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 101.43  E-value: 9.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTEIGVLAKTFIDQGKLIPDDV---MTRLALHELKTLTQcSWL 88
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTvldLLKDAMVAALGTSK-GFL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  89 LDGFPRTLPQAEALD-KVYQIDTVINLNVPFEVIKQRLTARwiHPASGRVyniefnppktgiddltgepliqreDDKPET 167
Cdd:TIGR01360  87 IDGYPREVKQGEEFErRIGPPTLVLYFDCSEDTMVKRLLKR--AETSGRV------------------------DDNEKT 140

                         170       180
                  ....*....|....*....|....*..
gi 1433354023 168 VIKRLKAYEAQTEPVLQYYQKKGVLET 194
Cdd:TIGR01360 141 IKKRLETYYKATEPVIAYYETKGKLRK 167
AAA_17 pfam13207
AAA domain;
13-141 1.67e-23

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 91.53  E-value: 1.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  13 MGAPGSGKGTVSSRITKHFELKHLSSGDLLRQNMLQGTeiGVLAKTFIDQGKLIPDDVMTRLALHEL-KTLTQCSWLLDG 91
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIaEEAGEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1433354023  92 FPRTLPQAEALDKV-------YQIDTVINLNVPFEVIKQRLTARwihPASGRVY-NIE 141
Cdd:pfam13207  79 HPRIKTPAGYLPGLpvevlreLKPDAIILLEADPEEILERRLKD---RTRGRDDdSEE 133
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 128-162 3.17e-16

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 69.41  E-value: 3.17e-16
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1433354023 128 RWIHPASGRVYNIEFNPPKT-GIDDLTGEPLIQRED 162
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVeGVCDVCGGELVQRDD 36
AAA_18 pfam13238
AAA domain;
11-128 1.61e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 45.88  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  11 VIMGAPGSGKGTVSSRITKHFELkHLSSGDLLRQNmlqGTEIGVLAKTfiDQGKLIPDDVMTRL--ALHELKTLTQCS-W 87
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGF-GDNVRDLALEN---GLVLGDDPET--RESKRLDEDKLDRLldLLEENAALEEGGnL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1433354023  88 LLDGFpRTLPQAEALDKVYqidtVINLNVPFEVIKQRLTAR 128
Cdd:pfam13238  76 IIDGH-LAELEPERAKDLV----GIVLRASPEELLERLEKR 111
PRK04182 PRK04182
cytidylate kinase; Provisional
 8-44 6.17e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 45.18  E-value: 6.17e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1433354023   8 LRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQ 44
Cdd:PRK04182    1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 11-131 1.12e-05

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 43.78  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  11 VIMGAPGSGKGTVSSRITKHFELKHLsSGDLLR-----QNMLQGteigvlaktfidqgklIP-DDVMTRLALHELKTLTQ 84
Cdd:cd02021     3 VVMGVSGSGKSTVGKALAERLGAPFI-DGDDLHppaniAKMAAG----------------IPlNDEDRWPWLQALTDALL 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1433354023  85 cSWLLDGFPRTLPQAEALDKVYQI----------DTVINLNVPFEVIKQRLTARWIH 131
Cdd:cd02021    66 -AKLASAGEGVVVACSALKRIYRDilrggaanprVRFVHLDGPREVLAERLAARKGH 121
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
11-128 2.93e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 42.98  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354023  11 VIMGAPGSGKGTVSSRITKHFELKHLSSgDLLRQNMLqGTEIGVLAKTfIDQGKLIpDDVMTRLALHELKtlTQCSWLLD 90
Cdd:COG0645     3 LVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRLF-GAGLAPLERS-PEATART-YARLLALARELLA--AGRSVILD 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1433354023  91 -GFPRTL--PQAEALDKVYQID-TVINLNVPFEVIKQRLTAR 128
Cdd:COG0645    77 aTFLRRAqrEAFRALAEEAGAPfVLIWLDAPEEVLRERLEAR 118
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 12-41 2.95e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 42.47  E-value: 2.95e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1433354023  12 IMGAPGSGKGTVSSRITKHFELKHLSSGDL 41
Cdd:cd02020     4 IDGPAGSGKSTVAKLLAKKLGLPYLDTGGI 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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