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Conserved domains on  [gi|1475409105|ref|NP_001352578|]
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1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform b [Homo sapiens]

Protein Classification

alpha/beta hydrolase domain-containing protein( domain architecture ID 1005082)

alpha/beta hydrolase (abhydrolase) domain-containing protein

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02894 super family cl30398
hydrolase, alpha/beta fold family protein
 53-304 9.02e-44

hydrolase, alpha/beta fold family protein


The actual alignment was detected with superfamily member PLN02894:

Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 154.30  E-value: 9.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  53 NFGDLCTNRPVYAFDLLGFGRSSRPRFDSDA-EEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNH 131
Cdd:PLN02894  124 NFDALASRFRVIAIDQLGWGGSSRPDFTCKStEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAKYALKHPEHVQH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 132 LILVEPWGFPERPDLAD----QDRpiPVWIRALGAAL--TPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYS-----SMFE 200
Cdd:PLN02894  204 LILVGPAGFSSESDDKSewltKFR--ATWKGAVLNHLweSNFTPQKIIRGLGPWGPNLVRRYTTARFGAHStgdilSEEE 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 201 DDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGkmHPDIPVSVIFGARSCIDGNSGtsiQSLRPHSYV--KT 278
Cdd:PLN02894  282 SKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESAS--EWKVPTTFIYGRHDWMNYEGA---VEARKRMKVpcEI 356

                         250       260
                  ....*....|....*....|....*.
gi 1475409105 279 IAILGAGHYVYADQPEEFNQKVKEIC 304
Cdd:PLN02894  357 IRVPQGGHFVFLDNPSGFHSAVLYAC 382
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 53-304 9.02e-44

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 154.30  E-value: 9.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  53 NFGDLCTNRPVYAFDLLGFGRSSRPRFDSDA-EEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNH 131
Cdd:PLN02894  124 NFDALASRFRVIAIDQLGWGGSSRPDFTCKStEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAKYALKHPEHVQH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 132 LILVEPWGFPERPDLAD----QDRpiPVWIRALGAAL--TPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYS-----SMFE 200
Cdd:PLN02894  204 LILVGPAGFSSESDDKSewltKFR--ATWKGAVLNHLweSNFTPQKIIRGLGPWGPNLVRRYTTARFGAHStgdilSEEE 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 201 DDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGkmHPDIPVSVIFGARSCIDGNSGtsiQSLRPHSYV--KT 278
Cdd:PLN02894  282 SKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESAS--EWKVPTTFIYGRHDWMNYEGA---VEARKRMKVpcEI 356

                         250       260
                  ....*....|....*....|....*.
gi 1475409105 279 IAILGAGHYVYADQPEEFNQKVKEIC 304
Cdd:PLN02894  357 IRVPQGGHFVFLDNPSGFHSAVLYAC 382
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 63-293 7.53e-21

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 89.49  E-value: 7.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  63 VYAFDLLGFGRSSRPRFDSDAEEVEnqFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWG-FP 141
Cdd:pfam00561  30 VIALDLRGFGKSSRPKAQDDYRTDD--LAEDLEYILEALGLEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDpPH 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 142 ERPDLADQDRPIPVWIR---ALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFeddtvteyiyhcnVQTPSG 218
Cdd:pfam00561 108 ELDEADRFILALFPGFFdgfVADFAPNPLGRLVAKLLALLLLRLRLLKALPLLNKRFPSGD-------------YALAKS 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1475409105 219 ETAFKNMTIPYgWAKRPMLQRIGKmhPDIPVSVIFGARSCIDGNSGT-SIQSLRPHSYVKTIAilGAGHYVYADQP 293
Cdd:pfam00561 175 LVTGALLFIET-WSTELRAKFLGR--LDEPTLIIWGDQDPLVPPQALeKLAQLFPNARLVVIP--DAGHFAFLEGP 245
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 50-302 6.68e-19

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 83.51  E-value: 6.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  50 WALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEevenQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRV 129
Cdd:COG0596    39 WRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLD----DLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 130 NHLILVepwgfperpdladqdrpipvwiralgaaltpfnplaglriagpfglslvqrlrpdfkrkyssmfeDDTVTEYIY 209
Cdd:COG0596   115 AGLVLV-----------------------------------------------------------------DEVLAALAE 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 210 HCNVQTPSGETAFKNMTIPYGWAKRPMLQRIgkmhpDIPVSVIFGARS-CIDGNSGTSIQSLRPHSYVKTIAilGAGHYV 288
Cdd:COG0596   130 PLRRPGLAPEALAALLRALARTDLRERLARI-----TVPTLVIWGEKDpIVPPALARRLAELLPNAELVVLP--GAGHFP 202

                         250
                  ....*....|....
gi 1475409105 289 YADQPEEFNQKVKE 302
Cdd:COG0596   203 PLEQPEAFAAALRD 216
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 62-156 1.40e-05

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 46.08  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  62 PVYAFDllGFGRSSRPRF-DSDAeevenqfveSIEEWRCALgLDKM---ILLGHNLGGFLAAAYSLKYPSRVNHLILVEP 137
Cdd:cd12808   154 PLAAFD--AFAKQFVPRWlGTDA---------LTLAAYDAL-LDRVgpcIVVAHSQGGGFAFEAARARPDLVRAVVALEP 221

                          90       100
                  ....*....|....*....|..
gi 1475409105 138 WGFPERPDLADqDRPIP---VW 156
Cdd:cd12808   222 SGAPDPAEAAP-LADVPhllVW 242
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 53-304 9.02e-44

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 154.30  E-value: 9.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  53 NFGDLCTNRPVYAFDLLGFGRSSRPRFDSDA-EEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNH 131
Cdd:PLN02894  124 NFDALASRFRVIAIDQLGWGGSSRPDFTCKStEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAKYALKHPEHVQH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 132 LILVEPWGFPERPDLAD----QDRpiPVWIRALGAAL--TPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYS-----SMFE 200
Cdd:PLN02894  204 LILVGPAGFSSESDDKSewltKFR--ATWKGAVLNHLweSNFTPQKIIRGLGPWGPNLVRRYTTARFGAHStgdilSEEE 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 201 DDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGkmHPDIPVSVIFGARSCIDGNSGtsiQSLRPHSYV--KT 278
Cdd:PLN02894  282 SKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESAS--EWKVPTTFIYGRHDWMNYEGA---VEARKRMKVpcEI 356

                         250       260
                  ....*....|....*....|....*.
gi 1475409105 279 IAILGAGHYVYADQPEEFNQKVKEIC 304
Cdd:PLN02894  357 IRVPQGGHFVFLDNPSGFHSAVLYAC 382
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 63-293 7.53e-21

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 89.49  E-value: 7.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  63 VYAFDLLGFGRSSRPRFDSDAEEVEnqFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWG-FP 141
Cdd:pfam00561  30 VIALDLRGFGKSSRPKAQDDYRTDD--LAEDLEYILEALGLEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDpPH 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 142 ERPDLADQDRPIPVWIR---ALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFeddtvteyiyhcnVQTPSG 218
Cdd:pfam00561 108 ELDEADRFILALFPGFFdgfVADFAPNPLGRLVAKLLALLLLRLRLLKALPLLNKRFPSGD-------------YALAKS 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1475409105 219 ETAFKNMTIPYgWAKRPMLQRIGKmhPDIPVSVIFGARSCIDGNSGT-SIQSLRPHSYVKTIAilGAGHYVYADQP 293
Cdd:pfam00561 175 LVTGALLFIET-WSTELRAKFLGR--LDEPTLIIWGDQDPLVPPQALeKLAQLFPNARLVVIP--DAGHFAFLEGP 245
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 50-302 6.68e-19

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 83.51  E-value: 6.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  50 WALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEevenQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRV 129
Cdd:COG0596    39 WRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLD----DLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 130 NHLILVepwgfperpdladqdrpipvwiralgaaltpfnplaglriagpfglslvqrlrpdfkrkyssmfeDDTVTEYIY 209
Cdd:COG0596   115 AGLVLV-----------------------------------------------------------------DEVLAALAE 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 210 HCNVQTPSGETAFKNMTIPYGWAKRPMLQRIgkmhpDIPVSVIFGARS-CIDGNSGTSIQSLRPHSYVKTIAilGAGHYV 288
Cdd:COG0596   130 PLRRPGLAPEALAALLRALARTDLRERLARI-----TVPTLVIWGEKDpIVPPALARRLAELLPNAELVVLP--GAGHFP 202

                         250
                  ....*....|....
gi 1475409105 289 YADQPEEFNQKVKE 302
Cdd:COG0596   203 PLEQPEAFAAALRD 216
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 63-195 8.11e-13

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 66.85  E-value: 8.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  63 VYAFDLLGFGRSSRPR--FDSDAEEVE--NQFVESI-EEWRCAlgldKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEP 137
Cdd:pfam12146  34 VYAYDHRGHGRSDGKRghVPSFDDYVDdlDTFVDKIrEEHPGL----PLFLLGHSMGGLIAALYALRYPDKVDGLILSAP 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1475409105 138 WgfperpdLADQDRPIPVWIRALGAALTPFNPlaGLRIAGPFGLSLVQRlRPDFKRKY 195
Cdd:pfam12146 110 A-------LKIKPYLAPPILKLLAKLLGKLFP--RLRVPNNLLPDSLSR-DPEVVAAY 157
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
63-163 1.81e-12

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 65.41  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  63 VYAFDLLGFGRSSRPR--FDSDAEEVE--NQFVESIEewrcALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPW 138
Cdd:COG2267    58 VLAFDLRGHGRSDGPRghVDSFDDYVDdlRAALDALR----ARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA 133

                          90       100
                  ....*....|....*....|....*.
gi 1475409105 139 gfperpDLADQDRPIPV-WIRALGAA 163
Cdd:COG2267   134 ------YRADPLLGPSArWLRALRLA 153
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 35-140 9.59e-08

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 52.64  E-value: 9.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  35 TPLVLLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEEvenqFVESIEEWRCALGLDKMILLGHNLG 114
Cdd:PRK14875  132 TPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAGSLDE----LAAAVLAFLDALGIERAHLVGHSMG 207

                          90       100
                  ....*....|....*....|....*.
gi 1475409105 115 GFLAAAYSLKYPSRVNHLILVEPWGF 140
Cdd:PRK14875  208 GAVALRLAARAPQRVASLTLIAPAGL 233
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 63-298 5.57e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 49.39  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  63 VYAFDLLGFGRSSRPRFD-SDAEEVENqFVESIEEWRCAlgldkmILLGHNLGGFLAAAYSlkyPSRVNHLILVEPWGFP 141
Cdd:pfam12697  24 VLAPDLPGHGSSSPPPLDlADLADLAA-LLDELGAARPV------VLVGHSLGGAVALAAA---AAALVVGVLVAPLAAP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105 142 erpdlADQDRPIPVWIRALGAALtpfnplaglriaGPFGLSLVQRLRPDFKrkyssmfeDDTVTEYIYHCNVQTPSGETA 221
Cdd:pfam12697  94 -----PGLLAALLALLARLGAAL------------AAPAWLAAESLARGFL--------DDLPADAEWAAALARLAALLA 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1475409105 222 FKNMTIPYGWakrpmlqrigkmhPDIPVSVIFGARSciDGNSGTSIQ-SLRPHSYVKTIAILGAGHYVYaDQPEEFNQ 298
Cdd:pfam12697 149 ALALLPLAAW-------------RDLPVPVLVLAEE--DRLVPELAQrLLAALAGARLVVLPGAGHLPL-DDPEEVAE 210
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 59-141 9.10e-07

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 49.81  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  59 TNRPVYAFDLLGFGRSSRPrfdSDAEEVENQFVESIEewRCAL---GLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILV 135
Cdd:PLN03087  231 STYRLFAVDLLGFGRSPKP---ADSLYTLREHLEMIE--RSVLeryKVKSFHIVAHSLGCILALALAVKHPGAVKSLTLL 305


                  ....*.
gi 1475409105 136 EPWGFP 141
Cdd:PLN03087  306 APPYYP 311
PLN02578 PLN02578
hydrolase
 50-139 1.71e-06

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 49.07  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  50 WALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEwrcaLGLDKMILLGHNLGGFLAAAYSLKYPSRV 129
Cdd:PLN02578  102 WRYNIPELAKKYKVYALDLLGFGWSDKALIEYDAMVWRDQVADFVKE----VVKEPAVLVGNSLGGFTALSTAVGYPELV 177

                          90
                  ....*....|
gi 1475409105 130 NHLILVEPWG 139
Cdd:PLN02578  178 AGVALLNSAG 187
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 62-156 1.40e-05

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 46.08  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  62 PVYAFDllGFGRSSRPRF-DSDAeevenqfveSIEEWRCALgLDKM---ILLGHNLGGFLAAAYSLKYPSRVNHLILVEP 137
Cdd:cd12808   154 PLAAFD--AFAKQFVPRWlGTDA---------LTLAAYDAL-LDRVgpcIVVAHSQGGGFAFEAARARPDLVRAVVALEP 221

                          90       100
                  ....*....|....*....|..
gi 1475409105 138 WGFPERPDLADqDRPIP---VW 156
Cdd:cd12808   222 SGAPDPAEAAP-LADVPhllVW 242
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 65-153 6.12e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 43.83  E-value: 6.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  65 AFDLLGFGRSSRP----RFDSDAeevenQFVESieeWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGF 140
Cdd:PRK03592   58 APDLIGMGASDKPdidyTFADHA-----RYLDA---WFDALGLDDVVLVGHDWGSALGFDWAARHPDRVRGIAFMEAIVR 129

                          90
                  ....*....|....
gi 1475409105 141 PER-PDLADQDRPI 153
Cdd:PRK03592  130 PMTwDDFPPAVREL 143
YpfH COG0400
Predicted esterase [General function prediction only];
66-165 1.18e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 42.20  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  66 FDLLGF-GRSSRPRFDSDAEEVeNQFVESIEEwRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILV------EPW 138
Cdd:COG0400    52 FDLSFLeGREDEEGLAAAAEAL-AAFIDELEA-RYGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALsgylpgEEA 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1475409105 139 GFPERPDLA---------DQDRPIPV--------WIRALGAALT 165
Cdd:COG0400   130 LPAPEAALAgtpvflahgTQDPVIPVerareaaeALEAAGADVT 173
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 57-137 1.67e-04

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 42.95  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  57 LCTNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHnlGGFLAAA--YSLKYPSRVNHLIL 134
Cdd:PLN03084  150 LSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLIDELKSDKVSLVVQ--GYFSPPVvkYASAHPDKIKKLIL 227


                  ...
gi 1475409105 135 VEP 137
Cdd:PLN03084  228 LNP 230
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 62-135 1.78e-04

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 40.20  E-value: 1.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1475409105  62 PVYAFDLLGFGRSSRPRfdsdAEEVENQfvesIEEWRCALGLDKMILLGHNLGGFLAAAY--SLKYPSRVNHLILV 135
Cdd:COG1075    34 PVYALNYPSTNGSIEDS----AEQLAAF----VDAVLAATGAEKVDLVGHSMGGLVARYYlkRLGGAAKVARVVTL 101
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
50-135 5.80e-03

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 37.69  E-value: 5.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475409105  50 WALNFG-------DLCTNRPVYAFDLLGFGRSS---RPRFDSDAEEVENQfvesieewrcalGLDKMILLGHNLGGFLAA 119
Cdd:PRK10349   22 WGLNAEvwrcideELSSHFTLHLVDLPGFGRSRgfgALSLADMAEAVLQQ------------APDKAIWLGWSLGGLVAS 89

                          90
                  ....*....|....*.
gi 1475409105 120 AYSLKYPSRVNHLILV 135
Cdd:PRK10349   90 QIALTHPERVQALVTV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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