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Conserved domains on  [gi|1476587956|ref|NP_001352844|]
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SKI family transcriptional corepressor 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DHD_Skor cd21080
Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and ...
 77-167 2.29e-61

Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and similar proteins; Skor1, also known as functional Smad-suppressing element on chromosome 15 (Fussel-15), LBX1 corepressor 1, or ladybird homeobox corepressor 1, acts as a transcriptional corepressor of LBX1 and inhibits BMP signaling. Skor2, also known as functional Smad-suppressing element on chromosome 18 (Fussel-18), LBX1 corepressor 1-like protein, or ladybird homeobox corepressor 1-like protein, exhibits transcriptional repressor activity. It acts as a transforming growth factor-beta (TGF-beta) antagonist in the nervous system. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


:

Pssm-ID: 410783  Cd Length: 91  Bit Score: 203.06  E-value: 2.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  77 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 156
Cdd:cd21080     1 VGTVILYGVPIVSLVIDGQERLCLAQISNTLLKDYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 80

                          90
                  ....*....|.
gi 1476587956 157 REAERLCKSFL 167
Cdd:cd21080    81 REAERLCKSFL 91
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 180-272 1.24e-47

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


:

Pssm-ID: 198114  Cd Length: 95  Bit Score: 164.46  E-value: 1.24e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  180 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANFNSWRRHLKLSDKSAT 257
Cdd:smart01046   1 SFRVYHECFGKCQGLFVPELYSSPDAPCIQCLECRGMFSPQKFVMHSHRSPEKRTCHwgFDSANWRSYLHVAKDYGTEER 80

                           90
                   ....*....|....*
gi 1476587956  258 DELSHAWEDVKAMFN 272
Cdd:smart01046  81 EKLEQLLEEMKEKFN 95
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 861-936 1.11e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


:

Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 43.33  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 861 AREELQKLLLE-QMELrKKLEREFQSLKDNFQDQMKRELAYREE-------MVQQLQIVRDTLCNELDQER-KARYAIQQ 931
Cdd:pfam03938  20 AQAQLEKKFKKrQAEL-EAKQKELQKLYEELQKDGALLEEEREEkeqelqkKEQELQQLQQKAQQELQKKQqELLQPIQD 98


                  ....*
gi 1476587956 932 KLKEA 936
Cdd:pfam03938  99 KINKA 103
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 659-846 1.37e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 659 PEVDVESNRFPDDEDAQEETEPSAPSAGGGPDGEQPTGPPSATSS---GADGPANSPDGGSPRPRRRLGPPPAGRPAFGD 735
Cdd:PRK07764  597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAapaPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 736 LAAEDLVRRPERSPPSGGGGYELREPCGPLGGPAPAKVFAPERDEHVKSAAVALGPAASYVCTPEAHEPDKEDNHSPADD 815
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1476587956 816 LETRKSYPDQRSISQPSPANTDRGEDGLTLD 846
Cdd:PRK07764  757 QPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
 
Name Accession Description Interval E-value
DHD_Skor cd21080
Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and ...
 77-167 2.29e-61

Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and similar proteins; Skor1, also known as functional Smad-suppressing element on chromosome 15 (Fussel-15), LBX1 corepressor 1, or ladybird homeobox corepressor 1, acts as a transcriptional corepressor of LBX1 and inhibits BMP signaling. Skor2, also known as functional Smad-suppressing element on chromosome 18 (Fussel-18), LBX1 corepressor 1-like protein, or ladybird homeobox corepressor 1-like protein, exhibits transcriptional repressor activity. It acts as a transforming growth factor-beta (TGF-beta) antagonist in the nervous system. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410783  Cd Length: 91  Bit Score: 203.06  E-value: 2.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  77 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 156
Cdd:cd21080     1 VGTVILYGVPIVSLVIDGQERLCLAQISNTLLKDYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 80

                          90
                  ....*....|.
gi 1476587956 157 REAERLCKSFL 167
Cdd:cd21080    81 REAERLCKSFL 91
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 180-272 1.24e-47

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


Pssm-ID: 198114  Cd Length: 95  Bit Score: 164.46  E-value: 1.24e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  180 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANFNSWRRHLKLSDKSAT 257
Cdd:smart01046   1 SFRVYHECFGKCQGLFVPELYSSPDAPCIQCLECRGMFSPQKFVMHSHRSPEKRTCHwgFDSANWRSYLHVAKDYGTEER 80

                           90
                   ....*....|....*
gi 1476587956  258 DELSHAWEDVKAMFN 272
Cdd:smart01046  81 EKLEQLLEEMKEKFN 95
Ski_Sno pfam02437
SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. ...
 75-168 4.46e-43

SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.


Pssm-ID: 460558  Cd Length: 100  Bit Score: 151.66  E-value: 4.46e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  75 NQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMI 154
Cdd:pfam02437   7 NERMETMLEGEVISCFMVGGEERLCLPQILNTLLKDFSLTQINTVCDELIITCVRCTPEQLEILKLLGILPPSVRRCGLI 86

                          90
                  ....*....|....
gi 1476587956 155 TKREAERLCKSFLG 168
Cdd:pfam02437  87 TKTDAERLCDALLH 100
c-SKI_SMAD_bind pfam08782
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 180-271 2.04e-40

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


Pssm-ID: 462602  Cd Length: 94  Bit Score: 143.95  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 180 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANfnsWRRHLKLSDKSAT 257
Cdd:pfam08782   1 SFEVYHECFGKCRGLFVPELYTSPRAACIQCLECRLMFSPQKFVFHSHRSPENRTCHwgFDSAN---WRAYLHLARYLDT 77

                          90
                  ....*....|....*..
gi 1476587956 258 ---DELSHAWEDVKAMF 271
Cdd:pfam08782  78 pdrEKLEQLLEDLKAKF 94
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 861-936 1.11e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 43.33  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 861 AREELQKLLLE-QMELrKKLEREFQSLKDNFQDQMKRELAYREE-------MVQQLQIVRDTLCNELDQER-KARYAIQQ 931
Cdd:pfam03938  20 AQAQLEKKFKKrQAEL-EAKQKELQKLYEELQKDGALLEEEREEkeqelqkKEQELQQLQQKAQQELQKKQqELLQPIQD 98


                  ....*
gi 1476587956 932 KLKEA 936
Cdd:pfam03938  99 KINKA 103
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 854-935 5.87e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 5.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 854 EKDIENLARE--ELQKLLLEQMELRKKLEREFQSLKDnfqdqmkrELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQ 931
Cdd:COG1579    95 QKEIESLKRRisDLEDEILELMERIEELEEELAELEA--------ELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                  ....
gi 1476587956 932 KLKE 935
Cdd:COG1579   167 ELAA 170
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 859-956 8.36e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 8.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  859 NLAREELQKLLLEQMELRKK---LEREFQSLKDNFQDQMKRELAYREEmVQQLQIVRDTlCNELDqERKARyaiqqKLKE 935
Cdd:smart00787 207 DRAKEKLKKLLQEIMIKVKKleeLEEELQELESKIEDLTNKKSELNTE-IAEAEKKLEQ-CRGFT-FKEIE-----KLKE 278

                           90       100
                   ....*....|....*....|.
gi 1476587956  936 AHDALHHFSckMLTPRHCTGN 956
Cdd:smart00787 279 QLKLLQSLT--GWKITKLSGN 297
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 659-846 1.37e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 659 PEVDVESNRFPDDEDAQEETEPSAPSAGGGPDGEQPTGPPSATSS---GADGPANSPDGGSPRPRRRLGPPPAGRPAFGD 735
Cdd:PRK07764  597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAapaPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 736 LAAEDLVRRPERSPPSGGGGYELREPCGPLGGPAPAKVFAPERDEHVKSAAVALGPAASYVCTPEAHEPDKEDNHSPADD 815
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1476587956 816 LETRKSYPDQRSISQPSPANTDRGEDGLTLD 846
Cdd:PRK07764  757 QPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 862-941 4.05e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.97  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 862 REELQKLLLEQMELRKKLEREFQSLKDNFQDQMKR-ELAYREEmVQQLQIVRDTLCNELDQERKARYAIQ--QKLKEAHD 938
Cdd:PRK00409  536 AEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEaEKEAQQA-IKEAKKEADEIIKELRQLQKGGYASVkaHELIEARK 614


                  ...
gi 1476587956 939 ALH 941
Cdd:PRK00409  615 RLN 617
 
Name Accession Description Interval E-value
DHD_Skor cd21080
Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and ...
 77-167 2.29e-61

Dachshund-homology domain found in SKI family transcriptional corepressors, Skor1, Skor2 and similar proteins; Skor1, also known as functional Smad-suppressing element on chromosome 15 (Fussel-15), LBX1 corepressor 1, or ladybird homeobox corepressor 1, acts as a transcriptional corepressor of LBX1 and inhibits BMP signaling. Skor2, also known as functional Smad-suppressing element on chromosome 18 (Fussel-18), LBX1 corepressor 1-like protein, or ladybird homeobox corepressor 1-like protein, exhibits transcriptional repressor activity. It acts as a transforming growth factor-beta (TGF-beta) antagonist in the nervous system. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410783  Cd Length: 91  Bit Score: 203.06  E-value: 2.29e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  77 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 156
Cdd:cd21080     1 VGTVILYGVPIVSLVIDGQERLCLAQISNTLLKDYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 80

                          90
                  ....*....|.
gi 1476587956 157 REAERLCKSFL 167
Cdd:cd21080    81 REAERLCKSFL 91
c-SKI_SMAD_bind smart01046
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 180-272 1.24e-47

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4.


Pssm-ID: 198114  Cd Length: 95  Bit Score: 164.46  E-value: 1.24e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  180 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANFNSWRRHLKLSDKSAT 257
Cdd:smart01046   1 SFRVYHECFGKCQGLFVPELYSSPDAPCIQCLECRGMFSPQKFVMHSHRSPEKRTCHwgFDSANWRSYLHVAKDYGTEER 80

                           90
                   ....*....|....*
gi 1476587956  258 DELSHAWEDVKAMFN 272
Cdd:smart01046  81 EKLEQLLEEMKEKFN 95
Ski_Sno pfam02437
SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. ...
 75-168 4.46e-43

SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.


Pssm-ID: 460558  Cd Length: 100  Bit Score: 151.66  E-value: 4.46e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  75 NQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMI 154
Cdd:pfam02437   7 NERMETMLEGEVISCFMVGGEERLCLPQILNTLLKDFSLTQINTVCDELIITCVRCTPEQLEILKLLGILPPSVRRCGLI 86

                          90
                  ....*....|....
gi 1476587956 155 TKREAERLCKSFLG 168
Cdd:pfam02437  87 TKTDAERLCDALLH 100
c-SKI_SMAD_bind pfam08782
c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through ...
 180-271 2.04e-40

c-SKI Smad4 binding domain; c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4


Pssm-ID: 462602  Cd Length: 94  Bit Score: 143.95  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 180 AFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQ--PDAANfnsWRRHLKLSDKSAT 257
Cdd:pfam08782   1 SFEVYHECFGKCRGLFVPELYTSPRAACIQCLECRLMFSPQKFVFHSHRSPENRTCHwgFDSAN---WRAYLHLARYLDT 77

                          90
                  ....*....|....*..
gi 1476587956 258 ---DELSHAWEDVKAMF 271
Cdd:pfam08782  78 pdrEKLEQLLEDLKAKF 94
DHD_Ski_Sno_Dac cd21074
Dachshund-homology domain found in the Ski/Sno/Dac family of transcriptional regulators; The ...
 77-164 1.05e-33

Dachshund-homology domain found in the Ski/Sno/Dac family of transcriptional regulators; The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. Members of this family include the Ski protein, Ski-like protein (Sno), and Dachshund proteins. Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. Ski-like protein, also known as SKIL or Sno, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development.


Pssm-ID: 410781  Cd Length: 88  Bit Score: 124.33  E-value: 1.05e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  77 VGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITK 156
Cdd:cd21074     1 LVTSTLEGKRIAGFEIDGEERLCLPQILNLVLKDFVQTQIHNRCTKLKIICTRCDQEQLKILKRLGILPPKAKSCGLISK 80


                  ....*...
gi 1476587956 157 REAERLCK 164
Cdd:cd21074    81 SDAERLLN 88
DHD_Ski_Sno cd21079
Dachshund-homology domain found in Ski, Ski-like protein (Sno), and similar proteins; Ski may ...
 79-167 9.04e-26

Dachshund-homology domain found in Ski, Ski-like protein (Sno), and similar proteins; Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. Ski-like protein, also known as SKIL or Sno, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410782  Cd Length: 91  Bit Score: 101.87  E-value: 9.04e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  79 ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKRE 158
Cdd:cd21079     3 ETLLEGETIACFVVGGEKRLCLPQILNTVLRDFSLQQINRVCDDLHIYCSRCTPEQLETLKLAGILPPSAPSCGLITKTD 82


                  ....*....
gi 1476587956 159 AERLCKSFL 167
Cdd:cd21079    83 AERLCSALL 91
DHD_Ski cd21083
Dachshund-homology domain found in Ski and similar proteins; Ski may play a role in terminal ...
 79-167 6.17e-18

Dachshund-homology domain found in Ski and similar proteins; Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410786  Cd Length: 102  Bit Score: 80.11  E-value: 6.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  79 ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKRE 158
Cdd:cd21083    12 ETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTD 91


                  ....*....
gi 1476587956 159 AERLCKSFL 167
Cdd:cd21083    92 AERLCNALL 100
DHD_Sno cd21084
Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins; Ski-like ...
 79-167 6.36e-17

Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins; Ski-like protein, also known as SKIL, Ski-related oncogene (Sno), or Ski-related protein, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410787  Cd Length: 100  Bit Score: 76.92  E-value: 6.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  79 ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKRE 158
Cdd:cd21084    10 QTVLEGESISCFMVGGEKRLCLPQVLNSVLRDFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTD 89


                  ....*....
gi 1476587956 159 AERLCKSFL 167
Cdd:cd21084    90 AQRLCNALL 98
DHD_SKIDA1 cd21082
Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar ...
 78-166 2.61e-09

Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar proteins; SKIDA1 is also known as protein DLN-1. Its biological function remains unclear. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410785  Cd Length: 91  Bit Score: 55.04  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  78 GETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKR 157
Cdd:cd21082     2 GREEVHGVELGYLYINGKQMFALSQVFTDLLPNTPRTTVHKRMDRLKVKKHHCDLEELRKLKALNGIAFHAAKCTLISRE 81


                  ....*....
gi 1476587956 158 EAERLCKSF 166
Cdd:cd21082    82 DVERLYSSY 90
DHD_Dac cd21081
Dachshund-homology domain found in the retinal determination protein Dachshund and similar ...
 84-162 1.28e-06

Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins; Dachshund proteins act as transcription factors involved in the regulation of organogenesis. They may be a regulator of SIX1, SIX6 and probably SIX5. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. It has been postulated that Dachshund proteins may bind to chromatin DNA via their DHD domains.


Pssm-ID: 410784  Cd Length: 95  Bit Score: 47.36  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  84 GVPIVSLVIDGQERLCLAQISNTLLKNY--SYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAER 161
Cdd:cd21081    10 GAKVAAFTVDGEELICLPQAFELFLKHLvgGLHTVYTKLKRLDITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFDT 89


                  .
gi 1476587956 162 L 162
Cdd:cd21081    90 L 90
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 861-936 1.11e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 43.33  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 861 AREELQKLLLE-QMELrKKLEREFQSLKDNFQDQMKRELAYREE-------MVQQLQIVRDTLCNELDQER-KARYAIQQ 931
Cdd:pfam03938  20 AQAQLEKKFKKrQAEL-EAKQKELQKLYEELQKDGALLEEEREEkeqelqkKEQELQQLQQKAQQELQKKQqELLQPIQD 98


                  ....*
gi 1476587956 932 KLKEA 936
Cdd:pfam03938  99 KINKA 103
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 853-932 3.36e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 42.97  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 853 VEKDIENLaREELQKLLLEQMELRKKL---EREFQSLK-----DNFQDQMKRELAY-REEMVQQLQIV---RDTLcneLD 920
Cdd:pfam13851  52 IQQENKRL-TEPLQKAQEEVEELRKQLenyEKDKQSLKnlkarLKVLEKELKDLKWeHEVLEQRFEKVereRDEL---YD 127

                          90
                  ....*....|..
gi 1476587956 921 QERKARYAIQQK 932
Cdd:pfam13851 128 KFEAAIQDVQQK 139
PKK pfam12474
Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino ...
 854-941 4.02e-04

Polo kinase kinase; This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.


Pssm-ID: 463600 [Multi-domain]  Cd Length: 139  Bit Score: 41.39  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 854 EKDIENLAReeLQKLLLEQMELRKKLEREfQSLKDNFQDQMKRELAYREEMVQQLQIVR---DTLCNELDQERKARYAIQ 930
Cdd:pfam12474  24 EKELEQLER--QQKQQIEKLEQRQTQELR-RLPKRIRAEQKKRLKMFRESLKQEKKELKqevEKLPKFQRKEAKRQRKEE 100

                          90
                  ....*....|.
gi 1476587956 931 QKLKEAHDALH 941
Cdd:pfam12474 101 LELEQKHEELE 111
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 854-935 5.87e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 5.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 854 EKDIENLARE--ELQKLLLEQMELRKKLEREFQSLKDnfqdqmkrELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQ 931
Cdd:COG1579    95 QKEIESLKRRisDLEDEILELMERIEELEEELAELEA--------ELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                  ....
gi 1476587956 932 KLKE 935
Cdd:COG1579   167 ELAA 170
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 859-956 8.36e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 42.70  E-value: 8.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956  859 NLAREELQKLLLEQMELRKK---LEREFQSLKDNFQDQMKRELAYREEmVQQLQIVRDTlCNELDqERKARyaiqqKLKE 935
Cdd:smart00787 207 DRAKEKLKKLLQEIMIKVKKleeLEEELQELESKIEDLTNKKSELNTE-IAEAEKKLEQ-CRGFT-FKEIE-----KLKE 278

                           90       100
                   ....*....|....*....|.
gi 1476587956  936 AHDALHHFSckMLTPRHCTGN 956
Cdd:smart00787 279 QLKLLQSLT--GWKITKLSGN 297
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 659-846 1.37e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 659 PEVDVESNRFPDDEDAQEETEPSAPSAGGGPDGEQPTGPPSATSS---GADGPANSPDGGSPRPRRRLGPPPAGRPAFGD 735
Cdd:PRK07764  597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAapaPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 736 LAAEDLVRRPERSPPSGGGGYELREPCGPLGGPAPAKVFAPERDEHVKSAAVALGPAASYVCTPEAHEPDKEDNHSPADD 815
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1476587956 816 LETRKSYPDQRSISQPSPANTDRGEDGLTLD 846
Cdd:PRK07764  757 QPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
853-944 1.51e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 40.96  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 853 VEKDIENLAREELQKlLLEQMELRKKLEREFQSLKDNfQDQMKRELAYREEMVQQLQIVRDTLcneldqerKARYAIQQK 932
Cdd:COG1842    78 LEKGREDLAREALER-KAELEAQAEALEAQLAQLEEQ-VEKLKEALRQLESKLEELKAKKDTL--------KARAKAAKA 147

                          90
                  ....*....|..
gi 1476587956 933 LKEAHDALHHFS 944
Cdd:COG1842   148 QEKVNEALSGID 159
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 853-936 3.60e-03

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 39.43  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 853 VEKDIENLA---REELQKLLLEQMELRKKLEREFQSLKDNFQDQMKRELayrEEMVQQLQIVRDTLCNELDQER-KARYA 928
Cdd:COG2825    44 AQKKLEKEFkkrQAELQKLEKELQALQEKLQKEAATLSEEERQKKEREL---QKKQQELQRKQQEAQQDLQKRQqELLQP 120


                  ....*...
gi 1476587956 929 IQQKLKEA 936
Cdd:COG2825   121 ILEKIQKA 128
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 862-941 4.05e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.97  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476587956 862 REELQKLLLEQMELRKKLEREFQSLKDNFQDQMKR-ELAYREEmVQQLQIVRDTLCNELDQERKARYAIQ--QKLKEAHD 938
Cdd:PRK00409  536 AEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEaEKEAQQA-IKEAKKEADEIIKELRQLQKGGYASVkaHELIEARK 614


                  ...
gi 1476587956 939 ALH 941
Cdd:PRK00409  615 RLN 617
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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