|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
482-853 |
1.86e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 116.28 E-value: 1.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVTGWERYDYASWKTI-GRAITVFRpqnfnqffiqpeewkggiQHHD 636
Cdd:cd00200 80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSSSRDKTIKVWDVEtGKCLTTLR------------------GHTD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 637 DILCAAFLPPQTLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfe 715
Cdd:cd00200 137 WVNSVAFSPDGTFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 716 idtegKNAVMRLCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDG 794
Cdd:cd00200 177 -----TGEVNSVAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDG 241
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1483452987 795 WLKIWNieeyclnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 853
Cdd:cd00200 242 TIRVWD-------------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
427-855 |
3.37e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.48 E-value: 3.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319 16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319 96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 584 lilKKKILVTGWErydyaswktiGRAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWN 662
Cdd:COG2319 173 ---DGKLLASGSD----------DGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 663 NSTENAHHVL------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFL 730
Cdd:COG2319 233 LATGKLLRTLtghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 731 KarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnss 809
Cdd:COG2319 298 P--------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA------- 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1483452987 810 knkitkAPTLIRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 855
Cdd:COG2319 361 ------TGELLRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
246-564 |
7.05e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 7.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319 172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319 320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397
|
....*.
gi 1483452987 559 IWDFNG 564
Cdd:COG2319 398 LWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
259-561 |
1.09e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.55 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 259 TGKVQAIAFTAAlislFERPASACEDGEATMtinWAelLSGCHKCCHILEHKlhqgDWVRQVTYNASLDAIISSTTSNTN 338
Cdd:cd00200 9 TGGVTCVAFSPD----GKLLATGSGDGTIKV---WD--LETGELLRTLKGHT----GPVRDVAASADGTYLASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 339 SVvmaWREKSKKRLN-MTSFNiaQGIHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGHSASVIAVQFFVERKQ 417
Cdd:cd00200 76 RL---WDLETGECVRtLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGTF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 418 LFSFSKDKVLRLWDIQ----------HQLSIQRIACSfPKSQDFrclfhfdeahgrLFISFNNQLALLAMKSEASKRV-K 486
Cdd:cd00200 150 VASSSQDGTIKLWDLRtgkcvatltgHTGEVNSVAFS-PDGEKL------------LSSSSDGTIKLWDLSTGKCLGTlR 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483452987 487 SHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200 217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-H-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
520-561 |
6.01e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 6.01e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1483452987 520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320 1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
521-561 |
3.05e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 3.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1483452987 521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400 1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
394-431 |
8.98e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 8.98e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1483452987 394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
393-431 |
3.40e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 3.40e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1483452987 393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
482-853 |
1.86e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 116.28 E-value: 1.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVTGWERYDYASWKTI-GRAITVFRpqnfnqffiqpeewkggiQHHD 636
Cdd:cd00200 80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSSSRDKTIKVWDVEtGKCLTTLR------------------GHTD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 637 DILCAAFLPPQTLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfe 715
Cdd:cd00200 137 WVNSVAFSPDGTFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 716 idtegKNAVMRLCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDG 794
Cdd:cd00200 177 -----TGEVNSVAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDG 241
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1483452987 795 WLKIWNieeyclnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 853
Cdd:cd00200 242 TIRVWD-------------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
427-855 |
3.37e-28 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 118.48 E-value: 3.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319 16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319 96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 584 lilKKKILVTGWErydyaswktiGRAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWN 662
Cdd:COG2319 173 ---DGKLLASGSD----------DGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 663 NSTENAHHVL------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFL 730
Cdd:COG2319 233 LATGKLLRTLtghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 731 KarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnss 809
Cdd:COG2319 298 P--------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA------- 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1483452987 810 knkitkAPTLIRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 855
Cdd:COG2319 361 ------TGELLRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
365-802 |
4.53e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 115.01 E-value: 4.53e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 365 AFDYHSRLNLIATAGINNKVCLWNPYVvSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIacs 444
Cdd:COG2319 41 SLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL--- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 445 fpksqdfrclfhfdeahgrlfisfnnqlallamkseaskrvKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKI 524
Cdd:COG2319 117 -----------------------------------------TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 525 KQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQililKKKILVTGWERydya 601
Cdd:COG2319 156 RTLTG-HSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGHTGAvrSVAFSP----DGKLLASGSAD---- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 602 swKTI-------GRAITVFRPqnfnqffiqpeewkggiqHHDDILCAAFLP-PQTLVTGSYDGEIVLWNNSTENAHHVL- 672
Cdd:COG2319 226 --GTVrlwdlatGKLLRTLTG------------------HSGSVRSVAFSPdGRLLASGSADGTVRLWDLATGELLRTLt 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 673 -----------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFlkarkntaVTGG 741
Cdd:COG2319 286 ghsggvnsvafSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHT--------------GAVRSVAF--------SPDG 342
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483452987 742 ANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIE 802
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGaVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
362-662 |
7.14e-25 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 105.88 E-value: 7.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 362 GIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI 441
Cdd:cd00200 11 GVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 442 ACSfpkSQDFRCLfHFDeAHGRLFI--SFNNQLALLAMKSEASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMI 518
Cdd:cd00200 90 TGH---TSYVSSV-AFS-PDGRILSssSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 519 DTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLnVGQDGAVdiSQILILKKKILVTGwer 597
Cdd:cd00200 165 RTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTL-RGHENGV--NSVAFSPDGYLLAS--- 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483452987 598 ydYASWKTIGraitVFRPQNFnqffiqpEEWKGGIQHHDDILCAAFLP-PQTLVTGSYDGEIVLWN 662
Cdd:cd00200 237 --GSEDGTIR----VWDLRTG-------ECVQTLSGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
311-665 |
4.23e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 106.15 E-value: 4.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 311 LHQGDWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLNmTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPy 390
Cdd:COG2319 75 LGHTAAVLSVAFSPDGRLLASASADGT---VRLWDLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL- 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 391 VVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSfpksqdfrclfhfdeA 460
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAFS---------------P 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 461 HGRLFIS--FNNQLALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGnaEIS 537
Cdd:COG2319 215 DGKLLASgsADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVN 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 538 TMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLN--VGQDGAVDISQililKKKILVTGWErydyaswktiGRAITVFR 614
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTghTGAVRSVAFSP----DGKTLASGSD----------DGTVRLWD 358
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1483452987 615 PQNFNQffiqPEEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNST 665
Cdd:COG2319 359 LATGEL----LRTLTG---HTGAVTSVAFSPDgRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
324-680 |
4.18e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.99 E-value: 4.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 324 ASLDAIISSTTSNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLnlIATAGINNKVCLWNPyVVSKPVGVLWGHS 403
Cdd:COG2319 44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL--LASASADGTVRLWDL-ATGLLLRTLTGHT 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 404 ASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSfpksqdfrclfhfdeAHGRLFIS--FNNQ 471
Cdd:COG2319 121 GAVRSVAFSPDGKTLASGSADGTVRLWDLAtgkllrtltgHSGAVTSVAFS---------------PDGKLLASgsDDGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 472 LALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLT 550
Cdd:COG2319 186 VRLWDLATgKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGS-VRSVAFSPDGRLLAS 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 551 GSTDGTVKIWDFN-GYCHHTLNVGQDG--AVDISQililKKKILVTGwerydyaSWktiGRAITVFRPQNFNQFFiqpeE 627
Cdd:COG2319 264 GSADGTVRLWDLAtGELLRTLTGHSGGvnSVAFSP----DGKLLASG-------SD---DGTVRLWDLATGKLLR----T 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483452987 628 WKGgiqHHDDILCAAFLP-PQTLVTGSYDGEIVLWNNSTENAHHVL------------HPDYQRLL 680
Cdd:COG2319 326 LTG---HTGAVRSVAFSPdGKTLASGSDDGTVRLWDLATGELLRTLtghtgavtsvafSPDGRTLA 388
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
246-564 |
7.05e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 7.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319 172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319 320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397
|
....*.
gi 1483452987 559 IWDFNG 564
Cdd:COG2319 398 LWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
259-561 |
1.09e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.55 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 259 TGKVQAIAFTAAlislFERPASACEDGEATMtinWAelLSGCHKCCHILEHKlhqgDWVRQVTYNASLDAIISSTTSNTN 338
Cdd:cd00200 9 TGGVTCVAFSPD----GKLLATGSGDGTIKV---WD--LETGELLRTLKGHT----GPVRDVAASADGTYLASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 339 SVvmaWREKSKKRLN-MTSFNiaQGIHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGHSASVIAVQFFVERKQ 417
Cdd:cd00200 76 RL---WDLETGECVRtLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGTF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 418 LFSFSKDKVLRLWDIQ----------HQLSIQRIACSfPKSQDFrclfhfdeahgrLFISFNNQLALLAMKSEASKRV-K 486
Cdd:cd00200 150 VASSSQDGTIKLWDLRtgkcvatltgHTGEVNSVAFS-PDGEKL------------LSSSSDGTIKLWDLSTGKCLGTlR 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483452987 487 SHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200 217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-H-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
139-431 |
1.42e-10 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 63.51 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 139 HKDTIQKVIFLKNSSHYLTISKEGLLAIWgehlKLQETFPITSDatKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLl 218
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW----DLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 219 skEEFACQYKLQGLKGTPICMDY-----------------WYDpLDANESILSFGDITGKVQAIAF--TAALISlferpa 279
Cdd:cd00200 81 --ETGECVRTLTGHTSYVSSVAFspdgrilssssrdktikVWD-VETGKCLTTLRGHTDWVNSVAFspDGTFVA------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 280 SACEDGeaTMTInWaELLSGchKCCHILEHklHQGdWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLN-MTSFN 358
Cdd:cd00200 152 SSSQDG--TIKL-W-DLRTG--KCVATLTG--HTG-EVNSVAFSPDGEKLLSSSSDGT---IKLWDLSTGKCLGtLRGHE 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1483452987 359 iaQGIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:cd00200 220 --NGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
744-859 |
4.29e-05 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 46.56 E-value: 4.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987 744 LVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDlDGWLKIWNIEeyclnssknkitkAPTLIRSF 823
Cdd:cd00200 24 LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLE-------------TGECVRTL 89
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1483452987 824 QPHEDRISSLeMCEPGGQlLIISSSADCSICV----TGVC 859
Cdd:cd00200 90 TGHTSYVSSV-AFSPDGR-ILSSSSRDKTIKVwdveTGKC 127
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
520-561 |
6.01e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 6.01e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1483452987 520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320 1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
521-561 |
3.05e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.25 E-value: 3.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1483452987 521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400 1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
394-431 |
8.98e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.68 E-value: 8.98e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1483452987 394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
393-431 |
3.40e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 3.40e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1483452987 393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
634-662 |
9.55e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.98 E-value: 9.55e-03
10 20 30
....*....|....*....|....*....|
gi 1483452987 634 HHDDILCAAFLP-PQTLVTGSYDGEIVLWN 662
Cdd:smart00320 11 HTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
|
|
|