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Conserved domains on  [gi|1483452987|ref|NP_001353086|]
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cilia- and flagella-associated protein 337 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 482-853 1.86e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.86e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVTGWERYDYASWKTI-GRAITVFRpqnfnqffiqpeewkggiQHHD 636
Cdd:cd00200     80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSSSRDKTIKVWDVEtGKCLTTLR------------------GHTD 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  637 DILCAAFLPPQTLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfe 715
Cdd:cd00200    137 WVNSVAFSPDGTFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------- 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  716 idtegKNAVMRLCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDG 794
Cdd:cd00200    177 -----TGEVNSVAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDG 241

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483452987  795 WLKIWNieeyclnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 853
Cdd:cd00200    242 TIRVWD-------------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
246-564 7.05e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 7.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319    172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319    246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319    320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397


                   ....*.
gi 1483452987  559 IWDFNG 564
Cdd:COG2319    398 LWDLAT 403
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 482-853 1.86e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.86e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVTGWERYDYASWKTI-GRAITVFRpqnfnqffiqpeewkggiQHHD 636
Cdd:cd00200     80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSSSRDKTIKVWDVEtGKCLTTLR------------------GHTD 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  637 DILCAAFLPPQTLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfe 715
Cdd:cd00200    137 WVNSVAFSPDGTFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------- 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  716 idtegKNAVMRLCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDG 794
Cdd:cd00200    177 -----TGEVNSVAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDG 241

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483452987  795 WLKIWNieeyclnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 853
Cdd:cd00200    242 TIRVWD-------------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
427-855 3.37e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.37e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319     16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  584 lilKKKILVTGWErydyaswktiGRAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWN 662
Cdd:COG2319    173 ---DGKLLASGSD----------DGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWD 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  663 NSTENAHHVL------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFL 730
Cdd:COG2319    233 LATGKLLRTLtghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFS 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  731 KarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnss 809
Cdd:COG2319    298 P--------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA------- 360

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1483452987  810 knkitkAPTLIRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 855
Cdd:COG2319    361 ------TGELLRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
246-564 7.05e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 7.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319    172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319    246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319    320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397


                   ....*.
gi 1483452987  559 IWDFNG 564
Cdd:COG2319    398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 259-561 1.09e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.09e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  259 TGKVQAIAFTAAlislFERPASACEDGEATMtinWAelLSGCHKCCHILEHKlhqgDWVRQVTYNASLDAIISSTTSNTN 338
Cdd:cd00200      9 TGGVTCVAFSPD----GKLLATGSGDGTIKV---WD--LETGELLRTLKGHT----GPVRDVAASADGTYLASGSSDKTI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  339 SVvmaWREKSKKRLN-MTSFNiaQGIHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGHSASVIAVQFFVERKQ 417
Cdd:cd00200     76 RL---WDLETGECVRtLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  418 LFSFSKDKVLRLWDIQ----------HQLSIQRIACSfPKSQDFrclfhfdeahgrLFISFNNQLALLAMKSEASKRV-K 486
Cdd:cd00200    150 VASSSQDGTIKLWDLRtgkcvatltgHTGEVNSVAFS-PDGEKL------------LSSSSDGTIKLWDLSTGKCLGTlR 216

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483452987  487 SHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200    217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-H-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 520-561 6.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 6.01e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1483452987   520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320    1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
521-561 3.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1483452987  521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400    1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-431 8.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.98e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1483452987   394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
393-431 3.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1483452987  393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 482-853 1.86e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.86e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  482 SKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  562 FN-GYCHHTLnVGQDGAV---DISQililKKKILVTGWERYDYASWKTI-GRAITVFRpqnfnqffiqpeewkggiQHHD 636
Cdd:cd00200     80 LEtGECVRTL-TGHTSYVssvAFSP----DGRILSSSSRDKTIKVWDVEtGKCLTTLR------------------GHTD 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  637 DILCAAFLPPQTLVT-GSYDGEIVLWNNSTEnahhvlhpdyqrllkskldtKPQKLLSAgrsqpshpmadHsttgvrnfe 715
Cdd:cd00200    137 WVNSVAFSPDGTFVAsSSQDGTIKLWDLRTG--------------------KCVATLTG-----------H--------- 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  716 idtegKNAVMRLCFLKarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHS-GVGSIIMSTDkmNRYLTTGDLDG 794
Cdd:cd00200    177 -----TGEVNSVAFSP--------DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPD--GYLLASGSEDG 241

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1483452987  795 WLKIWNieeyclnssknkiTKAPTLIRSFQPHEDRISSLeMCEPGGQLLiISSSADCSI 853
Cdd:cd00200    242 TIRVWD-------------LRTGECVQTLSGHTNSVTSL-AWSPDGKRL-ASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
427-855 3.37e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.37e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  427 LRLWDIQHQLSIQRIACSFPKSQDFRCLFHFDEAHGRLFISFNNQLALLAMKSEASKRVKSHEKAVTCVLYNSILKQVIS 506
Cdd:COG2319     16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  507 SDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQi 583
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTLTG-HTGA-VRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLTGHSGAvtSVAFSP- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  584 lilKKKILVTGWErydyaswktiGRAITVFRPQNFNQFFiqpeEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWN 662
Cdd:COG2319    173 ---DGKLLASGSD----------DGTVRLWDLATGKLLR----TLTG---HTGAVRSVAFSPDgKLLASGSADGTVRLWD 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  663 NSTENAHHVL------------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFL 730
Cdd:COG2319    233 LATGKLLRTLtghsgsvrsvafSPDGRLLASGSADGTV-RLWDLATGELLRTLTGHS--------------GGVNSVAFS 297

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  731 KarkntavtGGANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIEeyclnss 809
Cdd:COG2319    298 P--------DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPD--GKTLASGSDDGTVRLWDLA------- 360

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1483452987  810 knkitkAPTLIRSFQPHEDRISSLEMCePGGQLLiISSSADCSICV 855
Cdd:COG2319    361 ------TGELLRTLTGHTGAVTSVAFS-PDGRTL-ASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
365-802 4.53e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 4.53e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  365 AFDYHSRLNLIATAGINNKVCLWNPYVvSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIacs 444
Cdd:COG2319     41 SLAASPDGARLAAGAGDLTLLLLDAAA-GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL--- 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  445 fpksqdfrclfhfdeahgrlfisfnnqlallamkseaskrvKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKI 524
Cdd:COG2319    117 -----------------------------------------TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  525 KQFTGcHGNAeISTMALDANETRLLTGSTDGTVKIWDF-NGYCHHTLNVGQDG--AVDISQililKKKILVTGWERydya 601
Cdd:COG2319    156 RTLTG-HSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGHTGAvrSVAFSP----DGKLLASGSAD---- 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  602 swKTI-------GRAITVFRPqnfnqffiqpeewkggiqHHDDILCAAFLP-PQTLVTGSYDGEIVLWNNSTENAHHVL- 672
Cdd:COG2319    226 --GTVrlwdlatGKLLRTLTG------------------HSGSVRSVAFSPdGRLLASGSADGTVRLWDLATGELLRTLt 285

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  673 -----------HPDYQRLLKSKLDTKPqKLLSAGRSQPSHPMADHSttgvrnfeidtegkNAVMRLCFlkarkntaVTGG 741
Cdd:COG2319    286 ghsggvnsvafSPDGKLLASGSDDGTV-RLWDLATGKLLRTLTGHT--------------GAVRSVAF--------SPDG 342

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1483452987  742 ANLVSCGGSGYVRFWDIYKKQLLAEFLAHSG-VGSIIMSTDkmNRYLTTGDLDGWLKIWNIE 802
Cdd:COG2319    343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGaVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 362-662 7.14e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 7.14e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  362 GIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRI 441
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  442 ACSfpkSQDFRCLfHFDeAHGRLFI--SFNNQLALLAMKSEASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMI 518
Cdd:cd00200     90 TGH---TSYVSSV-AFS-PDGRILSssSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  519 DTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLnVGQDGAVdiSQILILKKKILVTGwer 597
Cdd:cd00200    165 RTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTL-RGHENGV--NSVAFSPDGYLLAS--- 236

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483452987  598 ydYASWKTIGraitVFRPQNFnqffiqpEEWKGGIQHHDDILCAAFLP-PQTLVTGSYDGEIVLWN 662
Cdd:cd00200    237 --GSEDGTIR----VWDLRTG-------ECVQTLSGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
311-665 4.23e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 4.23e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  311 LHQGDWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLNmTSFNIAQGIHAFDYHSRLNLIATAGINNKVCLWNPy 390
Cdd:COG2319     75 LGHTAAVLSVAFSPDGRLLASASADGT---VRLWDLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL- 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  391 VVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSfpksqdfrclfhfdeA 460
Cdd:COG2319    150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAFS---------------P 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  461 HGRLFIS--FNNQLALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGCHGnaEIS 537
Cdd:COG2319    215 DGKLLASgsADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG--GVN 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  538 TMALDANETRLLTGSTDGTVKIWDFN-GYCHHTLN--VGQDGAVDISQililKKKILVTGWErydyaswktiGRAITVFR 614
Cdd:COG2319    293 SVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTghTGAVRSVAFSP----DGKTLASGSD----------DGTVRLWD 358

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1483452987  615 PQNFNQffiqPEEWKGgiqHHDDILCAAFLPP-QTLVTGSYDGEIVLWNNST 665
Cdd:COG2319    359 LATGEL----LRTLTG---HTGAVTSVAFSPDgRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
324-680 4.18e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.99  E-value: 4.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  324 ASLDAIISSTTSNTNSVVMAWREKSKKRLNMTSFNIAQGIHAFDYHSRLnlIATAGINNKVCLWNPyVVSKPVGVLWGHS 403
Cdd:COG2319     44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL--LASASADGTVRLWDL-ATGLLLRTLTGHT 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  404 ASVIAVQFFVERKQLFSFSKDKVLRLWDIQ----------HQLSIQRIACSfpksqdfrclfhfdeAHGRLFIS--FNNQ 471
Cdd:COG2319    121 GAVRSVAFSPDGKTLASGSADGTVRLWDLAtgkllrtltgHSGAVTSVAFS---------------PDGKLLASgsDDGT 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  472 LALLAMKS-EASKRVKSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLT 550
Cdd:COG2319    186 VRLWDLATgKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGS-VRSVAFSPDGRLLAS 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  551 GSTDGTVKIWDFN-GYCHHTLNVGQDG--AVDISQililKKKILVTGwerydyaSWktiGRAITVFRPQNFNQFFiqpeE 627
Cdd:COG2319    264 GSADGTVRLWDLAtGELLRTLTGHSGGvnSVAFSP----DGKLLASG-------SD---DGTVRLWDLATGKLLR----T 325

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483452987  628 WKGgiqHHDDILCAAFLP-PQTLVTGSYDGEIVLWNNSTENAHHVL------------HPDYQRLL 680
Cdd:COG2319    326 LTG---HTGAVRSVAFSPdGKTLASGSDDGTVRLWDLATGELLRTLtghtgavtsvafSPDGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
246-564 7.05e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 7.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  246 LDANESILSFGDITGKVQAIAFTA--ALIslferpASACEDGEATMtinWaELLSGchKCCHILEHklHQGdWVRQVTYN 323
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSPdgKTL------ASGSADGTVRL---W-DLATG--KLLRTLTG--HSG-AVTSVAFS 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  324 ASLDAIISSTTSNTnsvVMAWREKSKKRLnmTSFNIAQG-IHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGH 402
Cdd:COG2319    172 PDGKLLASGSDDGT---VRLWDLATGKLL--RTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDL-ATGKLLRTLTGH 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  403 SASVIAVQFFVERKQLFSFSKDKVLRLWDIQHQLSIQRIAcsfPKSQDFRCL-FHFDeahGRLFI--SFNNQLALLAMKS 479
Cdd:COG2319    246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVaFSPD---GKLLAsgSDDGTVRLWDLAT 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  480 EASKRV-KSHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHGNAeISTMALDANETRLLTGSTDGTVK 558
Cdd:COG2319    320 GKLLRTlTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGA-VTSVAFSPDGRTLASGSADGTVR 397


                   ....*.
gi 1483452987  559 IWDFNG 564
Cdd:COG2319    398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 259-561 1.09e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.09e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  259 TGKVQAIAFTAAlislFERPASACEDGEATMtinWAelLSGCHKCCHILEHKlhqgDWVRQVTYNASLDAIISSTTSNTN 338
Cdd:cd00200      9 TGGVTCVAFSPD----GKLLATGSGDGTIKV---WD--LETGELLRTLKGHT----GPVRDVAASADGTYLASGSSDKTI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  339 SVvmaWREKSKKRLN-MTSFNiaQGIHAFDYHSRLNLIATAGINNKVCLWNPyVVSKPVGVLWGHSASVIAVQFFVERKQ 417
Cdd:cd00200     76 RL---WDLETGECVRtLTGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  418 LFSFSKDKVLRLWDIQ----------HQLSIQRIACSfPKSQDFrclfhfdeahgrLFISFNNQLALLAMKSEASKRV-K 486
Cdd:cd00200    150 VASSSQDGTIKLWDLRtgkcvatltgHTGEVNSVAFS-PDGEKL------------LSSSSDGTIKLWDLSTGKCLGTlR 216

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1483452987  487 SHEKAVTCVLYNSILKQVISSDTGSTVSFWMIDTGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:cd00200    217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-H-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-431 1.42e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  139 HKDTIQKVIFLKNSSHYLTISKEGLLAIWgehlKLQETFPITSDatKLKHLWVTSLVSLENVNKIAVAFTSKEVCFYDLl 218
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW----DLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  219 skEEFACQYKLQGLKGTPICMDY-----------------WYDpLDANESILSFGDITGKVQAIAF--TAALISlferpa 279
Cdd:cd00200     81 --ETGECVRTLTGHTSYVSSVAFspdgrilssssrdktikVWD-VETGKCLTTLRGHTDWVNSVAFspDGTFVA------ 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  280 SACEDGeaTMTInWaELLSGchKCCHILEHklHQGdWVRQVTYNASLDAIISSTTSNTnsvVMAWREKSKKRLN-MTSFN 358
Cdd:cd00200    152 SSSQDG--TIKL-W-DLRTG--KCVATLTG--HTG-EVNSVAFSPDGEKLLSSSSDGT---IKLWDLSTGKCLGtLRGHE 219

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1483452987  359 iaQGIHAFDYHSRLNLIATAGINNKVCLWNpYVVSKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:cd00200    220 --NGVNSVAFSPDGYLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 744-859 4.29e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 4.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483452987  744 LVSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDlDGWLKIWNIEeyclnssknkitkAPTLIRSF 823
Cdd:cd00200     24 LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLE-------------TGECVRTL 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1483452987  824 QPHEDRISSLeMCEPGGQlLIISSSADCSICV----TGVC 859
Cdd:cd00200     90 TGHTSYVSSV-AFSPDGR-ILSSSSRDKTIKVwdveTGKC 127
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 520-561 6.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 6.01e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1483452987   520 TGQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:smart00320    1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
521-561 3.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1483452987  521 GQKIKQFTGcHgNAEISTMALDANETRLLTGSTDGTVKIWD 561
Cdd:pfam00400    1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-431 8.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.98e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1483452987   394 KPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
393-431 3.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1483452987  393 SKPVGVLWGHSASVIAVQFFVERKQLFSFSKDKVLRLWD 431
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 634-662 9.55e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 9.55e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1483452987   634 HHDDILCAAFLP-PQTLVTGSYDGEIVLWN 662
Cdd:smart00320   11 HTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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