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Conserved domains on  [gi|1483453077|ref|NP_001353183|]
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vacuolar protein sorting-associated protein 53 homolog isoform 4 [Homo sapiens]

Protein Classification

Vps53-like N-terminal domain-containing protein( domain architecture ID 140795)

Vps53-like N-terminal domain-containing protein similar to Arabidopsis thaliana vacuolar protein sorting-associated protein 53 B that is involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles

Gene Ontology:  GO:0015031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps53_N super family cl20262
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 6-254 7.38e-100

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


The actual alignment was detected with superfamily member pfam04100:

Pssm-ID: 427710  Cd Length: 372  Bit Score: 305.14  E-value: 7.38e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077   6 VKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWL 83
Cdd:pfam04100 165 ISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEEAAWL 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077  84 DKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKR 163
Cdd:pfam04100 245 DKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKFLDKR 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077 164 FsgctltdgtlkklespppstnpfleDEPTPEMEELAtekgdldqpkkpkapdnpFHGIVSKCFEPHLYVYIESQDKNLG 243
Cdd:pfam04100 325 F-------------------------SKKTPEPKELA------------------FHGAISSCFEPHLTLYINSQEKTLS 361

                         250
                  ....*....|.
gi 1483453077 244 ELIDRFVADFK 254
Cdd:pfam04100 362 ELFDKFVSEPK 372
 
Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 6-254 7.38e-100

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 427710  Cd Length: 372  Bit Score: 305.14  E-value: 7.38e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077   6 VKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWL 83
Cdd:pfam04100 165 ISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEEAAWL 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077  84 DKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKR 163
Cdd:pfam04100 245 DKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKFLDKR 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077 164 FsgctltdgtlkklespppstnpfleDEPTPEMEELAtekgdldqpkkpkapdnpFHGIVSKCFEPHLYVYIESQDKNLG 243
Cdd:pfam04100 325 F-------------------------SKKTPEPKELA------------------FHGAISSCFEPHLTLYINSQEKTLS 361

                         250
                  ....*....|.
gi 1483453077 244 ELIDRFVADFK 254
Cdd:pfam04100 362 ELFDKFVSEPK 372
 
Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 6-254 7.38e-100

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 427710  Cd Length: 372  Bit Score: 305.14  E-value: 7.38e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077   6 VKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQDVAWL 83
Cdd:pfam04100 165 ISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEEAAWL 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077  84 DKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKR 163
Cdd:pfam04100 245 DKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKFLDKR 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483453077 164 FsgctltdgtlkklespppstnpfleDEPTPEMEELAtekgdldqpkkpkapdnpFHGIVSKCFEPHLYVYIESQDKNLG 243
Cdd:pfam04100 325 F-------------------------SKKTPEPKELA------------------FHGAISSCFEPHLTLYINSQEKTLS 361

                         250
                  ....*....|.
gi 1483453077 244 ELIDRFVADFK 254
Cdd:pfam04100 362 ELFDKFVSEPK 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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