NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1483569486|ref|NP_001353239|]
View 

importin subunit alpha-6 isoform f [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-307 2.21e-104

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 314.52  E-value: 2.21e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486  36 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 114
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 115 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 194
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 195 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 273
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1483569486 274 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLM 307
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLS 295
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-307 2.21e-104

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 314.52  E-value: 2.21e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486  36 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 114
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 115 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 194
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 195 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 273
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1483569486 274 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLM 307
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLS 295
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-105 5.32e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 84.90  E-value: 5.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486  13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDpdissTVPipeeevvttDMVQMI 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLE-----SLP---------EMVQGV 66

                          90
                  ....*....|...
gi 1483569486  93 FSNNADQQLTATQ 105
Cdd:pfam01749  67 NSDDPELQLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-198 1.14e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.82  E-value: 1.14e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1483569486  162 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-307 2.21e-104

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 314.52  E-value: 2.21e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486  36 IQLRKQKREEQLFKRRNVylprndesmleSPIQDPDISSTVPIPEE-EVVTTDMVQMIFSNNADQQLTATQKFRKLLSKE 114
Cdd:COG5064    34 VELRKQKREELLNKRRNL-----------ADVSEEAESSFIPMEQQfYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 115 PNPPIDQVIQKpGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWAL 194
Cdd:COG5064   103 TSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWAL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 195 GNIAGDNAECRDFVLNC-EILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLA 273
Cdd:COG5064   182 GNIAGDSEGCRDYVLQCgALEPLLGLLLSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLV 261

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1483569486 274 DVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLM 307
Cdd:COG5064   262 DACWAISYLSDGPNEKIQAVLDVGIPGRLVELLS 295
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-105 5.32e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 84.90  E-value: 5.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486  13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDpdissTVPipeeevvttDMVQMI 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLE-----SLP---------EMVQGV 66

                          90
                  ....*....|...
gi 1483569486  93 FSNNADQQLTATQ 105
Cdd:pfam01749  67 NSDDPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-198 8.71e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.92  E-value: 8.71e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1483569486 162 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-198 1.14e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.82  E-value: 1.14e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1483569486  162 HTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:smart00185   4 NKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 144-197 4.23e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 51.60  E-value: 4.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1483569486 144 LQFEAAWALTNIASGTFLHTKVVIeTGAVPIFIKLLNSEHEDVQEQAVWALGNI 197
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAV-PELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 115-157 2.07e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.60  E-value: 2.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1483569486 115 PNPPIDQVIQkPGVVQRFVKFLeRNENCTLQFEAAWALTNIAS 157
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 129-197 3.14e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 44.64  E-value: 3.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1483569486 129 VQRFVKFLERNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNI 197
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT COG1413
HEAT repeat [General function prediction only];
148-284 2.69e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 148 AAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIagDNAECRDFVLNCeilppllellTNSNRL 227
Cdd:COG1413     5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRL--GDPRAVPALLEA----------LKDPDP 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1483569486 228 TTTRNAVWALSNLcrgKNPPPnfskvspcLNVLSRLLFSSDPDVLADVCWALSYLSD 284
Cdd:COG1413    62 EVRAAAAEALGRI---GDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGD 107
HEAT COG1413
HEAT repeat [General function prediction only];
123-202 3.17e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483569486 123 IQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNA 202
Cdd:COG1413    43 LGDPRAVPALLEAL-KDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALGRLGDPAA 110
HEAT COG1413
HEAT repeat [General function prediction only];
123-198 4.93e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 4.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1483569486 123 IQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIASgtflhtkvvieTGAVPIFIKLLNSEHEDVQEQAVWALGNIA 198
Cdd:COG1413    74 IGDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 116-157 9.83e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 9.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1483569486  116 NPPIDQVIQKPGVVQRFVKFLeRNENCTLQFEAAWALTNIAS 157
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELL-KSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 254-284 1.32e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.59  E-value: 1.32e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1483569486 254 SPCLNVLSRLLFSSDPDVLADVCWALSYLSD 284
Cdd:pfam00514  11 AGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 231-282 9.44e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 33.88  E-value: 9.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1483569486 231 RNAVWALSNLC--RGKNPPPNFSKVSPCLnvlSRLLFSSDPDVLADVCWALSYL 282
Cdd:pfam13513   5 EAAALALGSLAegGPDLLAPAVPELLPAL---LPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH