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Conserved domains on  [gi|1484505977|ref|NP_001353304|]
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DNA replication licensing factor MCM3 isoform 9 [Homo sapiens]

Protein Classification

DNA replication licensing factor MCM( domain architecture ID 13861893)

DNA replication licensing factor MCM (minichromosome maintenance protein MCM) is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication

EC:  3.6.4.12
Gene Ontology:  GO:0042555|GO:0003678|GO:0006270|GO:0006271|GO:0005524|GO:0016887|GO:0046872|GO:0032508|GO:0003677
PubMed:  8332451|18208397|22841721|17506634

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 177-371 1.22e-73

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member cd17754:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 299  Bit Score: 235.82  E-value: 1.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 256
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllhgtkkkkekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTAR 335
Cdd:cd17754   211 ---------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDDNTKTDKARTSPITAR 263

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17754   264 TLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 109-178 9.94e-17

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member smart00350:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 509  Bit Score: 82.69  E-value: 9.94e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505977  109 KHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRS---VHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKY 178
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRAsftCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPF 73
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 16-104 1.58e-15

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


:

Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 71.94  E-value: 1.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  16 QRDYLDFLD----DEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASI--DA 89
Cdd:pfam14551   1 KRKFKDFLEefreDGDGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELseDP 80

                          90
                  ....*....|....*
gi 1484505977  90 TYAKQYEEFYVGLEG 104
Cdd:pfam14551  81 DYAEEEKEFQVRFYN 95
 
Name Accession Description Interval E-value
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 177-371 1.22e-73

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 235.82  E-value: 1.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 256
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllhgtkkkkekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTAR 335
Cdd:cd17754   211 ---------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDDNTKTDKARTSPITAR 263

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17754   264 TLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
MCM smart00350
minichromosome maintenance proteins;
177-373 4.79e-60

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 206.34  E-value: 4.79e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQE 256
Cdd:smart00350 356 RYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHP-------------------------EE 410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  257 DQQDtqiyekhdnllhgtkkkkEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTAR 335
Cdd:smart00350 411 DEAF------------------EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVR 471

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1484505977  336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 373
Cdd:smart00350 472 QLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 177-370 3.04e-36

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 143.02  E-value: 3.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsqe 256
Cdd:COG1241   436 RFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHR------------------------------- 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTArtsPVTAR 335
Cdd:COG1241   485 ------AGELLEQEIEEETEEVKPEIDPDLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPV---PITAR 555

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 370
Cdd:COG1241   556 QLEALIRLAEASARMRLSDTVTEEDAERAIRLVDS 590
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 286-369 3.34e-22

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 90.68  E-value: 3.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 286 FMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSqdsMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEA 364
Cdd:pfam17855   2 LLRKYIAYAREkIKPKLSEEAREKLVDAYVELRK---ESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEA 78


                  ....*
gi 1484505977 365 VELVQ 369
Cdd:pfam17855  79 IRLLK 83
MCM smart00350
minichromosome maintenance proteins;
109-178 9.94e-17

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 82.69  E-value: 9.94e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505977  109 KHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRS---VHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKY 178
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRAsftCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPF 73
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 16-104 1.58e-15

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 71.94  E-value: 1.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  16 QRDYLDFLD----DEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASI--DA 89
Cdd:pfam14551   1 KRKFKDFLEefreDGDGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELseDP 80

                          90
                  ....*....|....*
gi 1484505977  90 TYAKQYEEFYVGLEG 104
Cdd:pfam14551  81 DYAEEEKEFQVRFYN 95
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 176-373 1.45e-13

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 73.49  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 176 TKYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhryrapgeqdgdAMPLGSAVDILATDDPnfsq 255
Cdd:PTZ00111  612 SRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK-------------DFLLPHMTGSGNDEDT---- 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 256 EDQQDTQIYEkhDNLLHgtKKKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSQDSMSSDT-------- 326
Cdd:PTZ00111  675 YDRSNTMHVE--DESLR--SEKDYNKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITREYVKMRQGNFQTSNLdelehaqe 750

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1484505977 327 ------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 373
Cdd:PTZ00111  751 dddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTF 809
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 114-160 1.15e-12

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 64.81  E-value: 1.15e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1484505977 114 RTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYS 160
Cdd:pfam17207   3 RDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVKIT 49
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 19-163 4.33e-10

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 62.12  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  19 YLDFLDDEEdqgiYQSKVRELISDNQYR--LIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIdatYAKQYE 96
Cdd:COG1241     9 FEEFLRRYK----YRDEILELAQEYPEKrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDLEP---YDVSLG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1484505977  97 EFYVGLEGSFgsKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPA--TKKTIERRYSDLT 163
Cdd:COG1241    82 DAHVRITNLP--ETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAFECPRcgTETYVPQTGEKLQ 148
 
Name Accession Description Interval E-value
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 177-371 1.22e-73

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 235.82  E-value: 1.22e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYrapgeqdgdamplgsavdilatddpnfsqe 256
Cdd:cd17754   161 RYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------------------------ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllhgtkkkkekmvsAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTAR 335
Cdd:cd17754   211 ---------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDDNTKTDKARTSPITAR 263

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17754   264 TLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
MCM smart00350
minichromosome maintenance proteins;
177-373 4.79e-60

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 206.34  E-value: 4.79e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQE 256
Cdd:smart00350 356 RYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHP-------------------------EE 410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  257 DQQDtqiyekhdnllhgtkkkkEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSmSSDTARTSPVTAR 335
Cdd:smart00350 411 DEAF------------------EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESRSSIPITVR 471

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1484505977  336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 373
Cdd:smart00350 472 QLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 178-369 2.61e-40

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 147.87  E-value: 2.61e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 178 YDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDgdamplgsavdilatddpnfsqed 257
Cdd:cd17706   162 YNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEEQV------------------------ 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 258 qqdtqiyekhdnllhgTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQdsmsSDTARTSPVTARTL 337
Cdd:cd17706   218 ----------------KPEEDGIPIDIELLRKYILYARQIHPKISEEAREKLVRWYVELRKE----SERRSTIPITARQL 277

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1484505977 338 ETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 369
Cdd:cd17706   278 ESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVR 309
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 177-370 3.04e-36

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 143.02  E-value: 3.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsqe 256
Cdd:COG1241   436 RFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHR------------------------------- 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQDSMSSDTArtsPVTAR 335
Cdd:COG1241   485 ------AGELLEQEIEEETEEVKPEIDPDLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKKGEDEDSPV---PITAR 555

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY 370
Cdd:COG1241   556 QLEALIRLAEASARMRLSDTVTEEDAERAIRLVDS 590
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 177-371 1.42e-26

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 109.81  E-value: 1.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeQDGDAMPlgSAVDILatdDPNfsqe 256
Cdd:cd17758   160 RYNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVH-------QHNKQPD--SDFEPL---DPK---- 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllhgtkkkkekmvsaaFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPvtaRT 336
Cdd:cd17758   224 -----------------------------LLRAYIALAKRKRPTVPPALADYIVQAYVEMRQEAKRSKDFTFTTP---RT 271

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1484505977 337 LETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17758   272 LLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 177-369 2.04e-25

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 106.70  E-value: 2.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAmplgsavdilatddpnfsqe 256
Cdd:cd17756   161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQSQEN-------------------- 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllhgtkkkkEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRS---QDSMSSDTARTSPV 332
Cdd:cd17756   221 ----------------------EGEIPISKLKRYIAYCRAkCAPRLSEEAAEKLSNHYVTIRKdvrQNELESDNRSSIPI 278

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1484505977 333 TARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 369
Cdd:cd17756   279 TVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQ 315
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 177-368 3.35e-25

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 105.91  E-value: 3.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRApgeqdgDAMplgsavdilatdDPNFSQE 256
Cdd:cd17757   161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKRE------EAI------------EPPFTAE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 DqqdtqiyekhdnllhgtkkkkekmvsaafMKKYIHVAKIIKPVLTQESATYIAEEYSRLRsQDSMSSDTARTSPVTART 336
Cdd:cd17757   223 Q-----------------------------LKRYIAYARTFKPKLTKEAKDELVEQYKELR-QDDASGSTRSSYRITVRQ 272

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1484505977 337 LETLIRLATAHAKARMSKTVDLQDAEEAVELV 368
Cdd:cd17757   273 LESLIRLSEAIARLHCSDEVTPEHVEEAARLL 304
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 176-371 4.34e-25

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 105.60  E-value: 4.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 176 TKYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHryrapgeqdgdamplgsavdilatddpnfsq 255
Cdd:cd17755   161 SRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLY------------------------------- 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 256 edQQDTQIYEKHDnllhgtkkkkekMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSqdsMSSDTARTSPVTA 334
Cdd:cd17755   210 --LEDTPEHIQDE------------VLDVEVLTDYISYAREhIHPKLSEEAAQELVQAYVDMRK---MGSDARKRITATP 272

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1484505977 335 RTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17755   273 RQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 177-369 4.39e-25

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 105.61  E-value: 4.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRyrapgeqdgdamplgsavdilatddpnfsqe 256
Cdd:cd17761   162 RFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHS------------------------------- 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllHGTKKKKEKMVSAAFMKKYIHVA-KIIKPVLTQESATYIAEEYSRLRSQdsmSSDTARTSPVTAR 335
Cdd:cd17761   211 ---------------GGEMREIKPEIDPDLLRKYIAYArKNVRPVLTEEAKQLIKDFYVEMRKS---GQETPSPVPITAR 272

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 369
Cdd:cd17761   273 QLEALVRLSEASARMRLSQEVTLEDAERAIRIML 306
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 286-369 3.34e-22

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 90.68  E-value: 3.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 286 FMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSqdsMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEA 364
Cdd:pfam17855   2 LLRKYIAYAREkIKPKLSEEAREKLVDAYVELRK---ESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEA 78


                  ....*
gi 1484505977 365 VELVQ 369
Cdd:pfam17855  79 IRLLK 83
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 177-368 2.46e-20

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 92.13  E-value: 2.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPgeqdgdamplgsavdilatddpnfsQE 256
Cdd:cd17753   161 RYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSHVRSHP-------------------------EN 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 DQQDTQIYEKHDNLLHGTkkKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRsQDSMSSDTArtsPVTAR 335
Cdd:cd17753   216 DEDREGEEEKNQRQRPKE--TKVEPIPQELLRKYIHYAREkVRPKLNQMDMDKVSRVYADLR-KESMATGSL---PITVR 289

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1484505977 336 TLETLIRLATAHAKARMSKTVDLQDAEEAVELV 368
Cdd:cd17753   290 HLESIIRISEAHAKMHLREYVSEEDVDMAIRVM 322
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 177-371 2.92e-17

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 82.59  E-value: 2.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLrmhryrapgEQDGDAmplgsavdilatddpnfsqe 256
Cdd:cd17760   158 QYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL---------ENKGEP-------------------- 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 257 dqqdtqiyekhdnllhgtkKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATyIAEEYSRLRSQdsmsSDTARTSPVTART 336
Cdd:cd17760   209 -------------------SKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA-ILLRYYQLQRQ----SDCRNAARTTIRM 264

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1484505977 337 LETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17760   265 LESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM smart00350
minichromosome maintenance proteins;
109-178 9.94e-17

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 82.69  E-value: 9.94e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1484505977  109 KHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRS---VHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKY 178
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRAsftCEKCGATLGPEIQSGRETEPTVCPPRECQSPTPF 73
MCM pfam00493
MCM P-loop domain;
177-224 1.64e-16

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 78.73  E-value: 1.64e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1484505977 177 KYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 224
Cdd:pfam00493 177 RYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 16-104 1.58e-15

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 71.94  E-value: 1.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  16 QRDYLDFLD----DEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASI--DA 89
Cdd:pfam14551   1 KRKFKDFLEefreDGDGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELseDP 80

                          90
                  ....*....|....*
gi 1484505977  90 TYAKQYEEFYVGLEG 104
Cdd:pfam14551  81 DYAEEEKEFQVRFYN 95
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 178-371 1.85e-15

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 76.80  E-value: 1.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 178 YDQYKTPMENIGLQDSLLSRFDLLFIMLDqmDPEQDReisDHVLRMHryrapgeqdgdamplgsavdilatddpnfsqed 257
Cdd:cd17759   163 YNKGKTVSENLKMGPALLSRFDLVFILLD--TPSEEH---DHLLSEH--------------------------------- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 258 qqdtqiyekHDnllhgtkkkkekmvsaaFMKKYIHVAK-IIKPVLTQESATYIAEEYSRLRSQdsmsSDTARTSPVTART 336
Cdd:cd17759   205 ---------HQ-----------------LLRKYISYARqYVNPVLSKDASEALQEFYLELRKQ----NQLADSSPITTRQ 254

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1484505977 337 LETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 371
Cdd:cd17759   255 LESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 176-373 1.45e-13

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 73.49  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 176 TKYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhryrapgeqdgdAMPLGSAVDILATDDPnfsq 255
Cdd:PTZ00111  612 SRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK-------------DFLLPHMTGSGNDEDT---- 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977 256 EDQQDTQIYEkhDNLLHgtKKKKEKMVSAAFMKKYIHVAKI-IKPVLTQESATYIAEEYSRLRSQDSMSSDT-------- 326
Cdd:PTZ00111  675 YDRSNTMHVE--DESLR--SEKDYNKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITREYVKMRQGNFQTSNLdelehaqe 750

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1484505977 327 ------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 373
Cdd:PTZ00111  751 dddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTF 809
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 114-160 1.15e-12

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 64.81  E-value: 1.15e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1484505977 114 RTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYS 160
Cdd:pfam17207   3 RDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVKIT 49
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 19-163 4.33e-10

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 62.12  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1484505977  19 YLDFLDDEEdqgiYQSKVRELISDNQYR--LIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIdatYAKQYE 96
Cdd:COG1241     9 FEEFLRRYK----YRDEILELAQEYPEKrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDLEP---YDVSLG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1484505977  97 EFYVGLEGSFgsKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPA--TKKTIERRYSDLT 163
Cdd:COG1241    82 DAHVRITNLP--ETVPIRDIRSDHIGKLISVEGIVRKATEVKPKITEAAFECPRcgTETYVPQTGEKLQ 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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