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Conserved domains on  [gi|1488045778|ref|NP_001353449|]
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plasma membrane calcium-transporting ATPase 1 isoform 1b [Homo sapiens]

Protein Classification

calcium-translocating P-type ATPase( domain architecture ID 11492721)

calcium-translocating P-type ATPase catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
15-1064 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1449.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   15 KNSLKEANHDGDFGITLAELRALMELRSTDALRK---IQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIP 91
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   92 PKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGdnalcgevsvgEEEGEGETGWIEGAAILLSVVCVVLVTA 171
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVG-----------EDKADTETGWIEGVAILVSVILVVLVTA 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  172 FNDWSKEKQFRGLQsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVK 251
Cdd:TIGR01517  150 VNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIK 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  252 KSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqdgaienrnkakaqdgaam 331
Cdd:TIGR01517  229 KGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG------------------------------------ 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPwlaECTPI 411
Cdd:TIGR01517  273 -------------------------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEE 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  412 YIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY 491
Cdd:TIGR01517  325 DAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  492 INEKHYKKVPEpeaIPPNILSYLVTGISVNCAYTSKILPPEKE-GGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEE 570
Cdd:TIGR01517  405 IGEQRFNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  571 ALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTVIEPMASEGLRTICL 650
Cdd:TIGR01517  482 KVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICL 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  651 AFRDFPaGEPEPEWDNENdivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEd 730
Cdd:TIGR01517  561 AYRDFA-PEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG- 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  731 fLCLEGKDFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01517  636 -LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADV 701
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  811 GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQML 888
Cdd:TIGR01517  702 GFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLL 781
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  889 WVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPlHAPP 968
Cdd:TIGR01517  782 WVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQ 860
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  969 SEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLG 1048
Cdd:TIGR01517  861 GELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLG 940
                         1050
                   ....*....|....*.
gi 1488045778 1049 MGTLLWGQLISTIPTS 1064
Cdd:TIGR01517  941 MLSLIFGVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1103-1149 1.95e-27

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 105.56  E-value: 1.95e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1488045778 1103 GQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPE 1149
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
15-1064 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1449.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   15 KNSLKEANHDGDFGITLAELRALMELRSTDALRK---IQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIP 91
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   92 PKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGdnalcgevsvgEEEGEGETGWIEGAAILLSVVCVVLVTA 171
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVG-----------EDKADTETGWIEGVAILVSVILVVLVTA 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  172 FNDWSKEKQFRGLQsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVK 251
Cdd:TIGR01517  150 VNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIK 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  252 KSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqdgaienrnkakaqdgaam 331
Cdd:TIGR01517  229 KGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG------------------------------------ 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPwlaECTPI 411
Cdd:TIGR01517  273 -------------------------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEE 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  412 YIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY 491
Cdd:TIGR01517  325 DAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  492 INEKHYKKVPEpeaIPPNILSYLVTGISVNCAYTSKILPPEKE-GGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEE 570
Cdd:TIGR01517  405 IGEQRFNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  571 ALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTVIEPMASEGLRTICL 650
Cdd:TIGR01517  482 KVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICL 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  651 AFRDFPaGEPEPEWDNENdivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEd 730
Cdd:TIGR01517  561 AYRDFA-PEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG- 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  731 fLCLEGKDFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01517  636 -LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADV 701
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  811 GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQML 888
Cdd:TIGR01517  702 GFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLL 781
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  889 WVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPlHAPP 968
Cdd:TIGR01517  782 WVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQ 860
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  969 SEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLG 1048
Cdd:TIGR01517  861 GELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLG 940
                         1050
                   ....*....|....*.
gi 1488045778 1049 MGTLLWGQLISTIPTS 1064
Cdd:TIGR01517  941 MLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-928 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1268.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   78 LERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNAlcgevsvgeeegegETGWIEGA 157
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEGEG--------------KTGWIEGV 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  158 AILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK 237
Cdd:cd02081     67 AILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLK 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  238 IDESSLTGESDHVKKSLD---KDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqd 314
Cdd:cd02081    146 IDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  315 gaienrnkakaqdgaamemqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVI 394
Cdd:cd02081    207 ------------------------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFII 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  395 DTFWVQKRPWlaecTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 474
Cdd:cd02081    245 DGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  475 DKTGTLTMNRMTVVQAYInekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvGNKTECALLGLLL 554
Cdd:cd02081    321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  555 DLKRDYQdVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEaKVFRPRDRDDIVK 634
Cdd:cd02081    352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  635 TVIEPMASEGLRTICLAFRDFPAGEPEPE---WDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDN 711
Cdd:cd02081    430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAerdWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDN 509
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  712 INTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDStvsdqRQV 791
Cdd:cd02081    510 INTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEV 584
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  792 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 871
Cdd:cd02081    585 VAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAF 664
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1488045778  872 TGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTM 928
Cdd:cd02081    665 IGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
59-1058 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 666.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   59 ICTKLKTSPnEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSL---------------- 122
Cdd:COG0474     16 VLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISAllgdwvdaivilavvl 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  123 ---GLSFYQppegdnalcgevsvgeeegegetgwiegaaillsvvcvvlvtafnDWSKEKQFRGLQSRIEQeqKFTVIRG 199
Cdd:COG0474     93 lnaIIGFVQ---------------------------------------------EYRAEKALEALKKLLAP--TARVLRD 125
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPLLLSGTHVMEG 269
Cdd:COG0474    126 GKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSadplpedaplGDRGNMVFMGTLVTSG 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  270 SGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdk 349
Cdd:COG0474    206 RGTAVVVATGMNTEFGKIAKLLQEA------------------------------------------------------- 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  350 kkanlpKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLyfvidtfwvQKRPWLAectpiyiqyfvkFFIIGVTVLVV 429
Cdd:COG0474    231 ------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLL---------RGGPLLE------------ALLFAVALAVA 283
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  430 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYkkvpEPEAIPPN 509
Cdd:COG0474    284 AIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDP 359
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  510 ILSYLVTGISVNCAYTskiLPPEKEgglprhVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTVL 589
Cdd:COG0474    360 ALEELLRAAALCSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYPRVD---EIPFDSERKRMSTVH 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  590 KNSDGSYRIFSKGASEIILKKCFKILsANGEAKVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNEND 669
Cdd:COG0474    428 EDPDGKRLLIVKGAPEVVLALCTRVL-TGGGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELDSEDDESD 505
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  670 ivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDflCLEGKDFNRrirneKGE 749
Cdd:COG0474    506 ----LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSD 574
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  750 IE-QERIDKIwpklRVLARSSPTDKHTLVKGIidstvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 826
Cdd:COG0474    575 EElAEAVEDV----DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAA 643
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  827 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEP 906
Cdd:COG0474    644 DIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEP 723
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  907 PTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFfdidsgrnaplHAPPSEHYTIVFNTFVLMQLFN 986
Cdd:COG0474    724 VEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALAR-----------GASLALARTMAFTTLVLSQLFN 792
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1488045778  987 EINARKIHgeRNVFE-GIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLI 1058
Cdd:COG0474    793 VFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
880-1058 5.65e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 171.65  E-value: 5.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  880 SPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSG 959
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  960 RNAplhappsehYTIVFNTFVLMQLFNEINARKIHGERNVFeGIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELS 1037
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1488045778 1038 IEQWLWSIFLGMGTLLWGQLI 1058
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
195-870 1.22e-42

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.09  E-value: 1.22e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQV------IQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK-----------SLDKD 257
Cdd:PRK10517   162 TVLRVINDkgengwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECD 241
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  258 PLLLSGTHVMEGSGRMVVTAVGVNSQtgiiFtllgaggeeeekkdekkkekknkkqdGAIENRnkAKAQDGAAMEMQplk 337
Cdd:PRK10517   242 TLCFMGTNVVSGTAQAVVIATGANTW----F--------------------------GQLAGR--VSEQDSEPNAFQ--- 286
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  338 seeggdgdekdkkkanlpkkeksvlQGkltklavqIGKAGLLMSAITVIILVLYFVIDTFwvQKRPWlaectpiyiqyfV 417
Cdd:PRK10517   287 -------------------------QG--------ISRVSWLLIRFMLVMAPVVLLINGY--TKGDW------------W 319
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  418 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM------------ 485
Cdd:PRK10517   320 EAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtdisgkt 399
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  486 ---TVVQAYINekhykkvpepeaippnilSYLVTGIsvncaytsKILppekeggLPRHVgnkTECALLGLLLDLKRDYQD 562
Cdd:PRK10517   400 serVLHSAWLN------------------SHYQTGL--------KNL-------LDTAV---LEGVDEESARSLASRWQK 443
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  563 VrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIlSANGEAKVFRPRDRDDIvKTVIEPMAS 642
Cdd:PRK10517   444 I-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQV-RHNGEIVPLDDIMLRRI-KRVTDTLNR 511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  643 EGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKC 722
Cdd:PRK10517   512 QGLRVVAVATKYLPAREGDYQRADESD----LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEV 587
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  723 GILHPGedflCLEGKDFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDG 802
Cdd:PRK10517   588 GLDAGE----VLIGSDIET--------LSDDELANLAERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDA 650
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1488045778  803 PALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 870
Cdd:PRK10517   651 PALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1103-1149 1.95e-27

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 105.56  E-value: 1.95e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1488045778 1103 GQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPE 1149
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 1.14e-10

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 58.75  E-value: 1.14e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1488045778    59 ICTKLKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
15-1064 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1449.59  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   15 KNSLKEANHDGDFGITLAELRALMELRSTDALRK---IQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIP 91
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   92 PKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGdnalcgevsvgEEEGEGETGWIEGAAILLSVVCVVLVTA 171
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVG-----------EDKADTETGWIEGVAILVSVILVVLVTA 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  172 FNDWSKEKQFRGLQsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVK 251
Cdd:TIGR01517  150 VNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIK 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  252 KSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqdgaienrnkakaqdgaam 331
Cdd:TIGR01517  229 KGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG------------------------------------ 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPwlaECTPI 411
Cdd:TIGR01517  273 -------------------------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEE 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  412 YIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY 491
Cdd:TIGR01517  325 DAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  492 INEKHYKKVPEpeaIPPNILSYLVTGISVNCAYTSKILPPEKE-GGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEE 570
Cdd:TIGR01517  405 IGEQRFNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  571 ALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTVIEPMASEGLRTICL 650
Cdd:TIGR01517  482 KVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICL 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  651 AFRDFPaGEPEPEWDNENdivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEd 730
Cdd:TIGR01517  561 AYRDFA-PEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG- 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  731 fLCLEGKDFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01517  636 -LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADV 701
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  811 GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQML 888
Cdd:TIGR01517  702 GFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLL 781
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  889 WVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPlHAPP 968
Cdd:TIGR01517  782 WVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQ 860
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  969 SEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLG 1048
Cdd:TIGR01517  861 GELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLG 940
                         1050
                   ....*....|....*.
gi 1488045778 1049 MGTLLWGQLISTIPTS 1064
Cdd:TIGR01517  941 MLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-928 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1268.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   78 LERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNAlcgevsvgeeegegETGWIEGA 157
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEGEG--------------KTGWIEGV 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  158 AILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK 237
Cdd:cd02081     67 AILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLK 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  238 IDESSLTGESDHVKKSLD---KDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqd 314
Cdd:cd02081    146 IDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  315 gaienrnkakaqdgaamemqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVI 394
Cdd:cd02081    207 ------------------------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFII 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  395 DTFWVQKRPWlaecTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 474
Cdd:cd02081    245 DGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  475 DKTGTLTMNRMTVVQAYInekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvGNKTECALLGLLL 554
Cdd:cd02081    321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  555 DLKRDYQdVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEaKVFRPRDRDDIVK 634
Cdd:cd02081    352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  635 TVIEPMASEGLRTICLAFRDFPAGEPEPE---WDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDN 711
Cdd:cd02081    430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAerdWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDN 509
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  712 INTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDStvsdqRQV 791
Cdd:cd02081    510 INTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEV 584
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  792 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 871
Cdd:cd02081    585 VAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAF 664
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1488045778  872 TGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTM 928
Cdd:cd02081    665 IGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
59-1058 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 666.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   59 ICTKLKTSPnEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSL---------------- 122
Cdd:COG0474     16 VLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISAllgdwvdaivilavvl 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  123 ---GLSFYQppegdnalcgevsvgeeegegetgwiegaaillsvvcvvlvtafnDWSKEKQFRGLQSRIEQeqKFTVIRG 199
Cdd:COG0474     93 lnaIIGFVQ---------------------------------------------EYRAEKALEALKKLLAP--TARVLRD 125
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPLLLSGTHVMEG 269
Cdd:COG0474    126 GKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSadplpedaplGDRGNMVFMGTLVTSG 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  270 SGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdk 349
Cdd:COG0474    206 RGTAVVVATGMNTEFGKIAKLLQEA------------------------------------------------------- 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  350 kkanlpKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLyfvidtfwvQKRPWLAectpiyiqyfvkFFIIGVTVLVV 429
Cdd:COG0474    231 ------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLL---------RGGPLLE------------ALLFAVALAVA 283
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  430 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYkkvpEPEAIPPN 509
Cdd:COG0474    284 AIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDP 359
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  510 ILSYLVTGISVNCAYTskiLPPEKEgglprhVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTVL 589
Cdd:COG0474    360 ALEELLRAAALCSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYPRVD---EIPFDSERKRMSTVH 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  590 KNSDGSYRIFSKGASEIILKKCFKILsANGEAKVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNEND 669
Cdd:COG0474    428 EDPDGKRLLIVKGAPEVVLALCTRVL-TGGGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELDSEDDESD 505
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  670 ivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDflCLEGKDFNRrirneKGE 749
Cdd:COG0474    506 ----LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSD 574
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  750 IE-QERIDKIwpklRVLARSSPTDKHTLVKGIidstvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 826
Cdd:COG0474    575 EElAEAVEDV----DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAA 643
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  827 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEP 906
Cdd:COG0474    644 DIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEP 723
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  907 PTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFfdidsgrnaplHAPPSEHYTIVFNTFVLMQLFN 986
Cdd:COG0474    724 VEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALAR-----------GASLALARTMAFTTLVLSQLFN 792
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1488045778  987 EINARKIHgeRNVFE-GIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLI 1058
Cdd:COG0474    793 VFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
70-916 9.85e-160

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 492.51  E-value: 9.85e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   70 GLSGNPAdlERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYqppegdnalcgevsvgeeegeg 149
Cdd:cd02089      1 GLSEEEA--ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGEY---------------------- 56
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  150 etgwIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGI 229
Cdd:cd02089     57 ----VDAIVIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGR 130
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  230 LIQGNDLKIDESSLTGESDHVKKSLDKDP-----------LLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAggeee 298
Cdd:cd02089    131 LIESASLRVEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEE----- 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  299 ekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkkkanlPKKEKSVLQGKLTKLAVQIGKAGL 378
Cdd:cd02089    206 --------------------------------------------------------TEEEKTPLQKRLDQLGKRLAIAAL 229
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  379 lmsAITVIILVLYfvidtfWVQKRPWLAEctpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 458
Cdd:cd02089    230 ---IICALVFALG------LLRGEDLLDM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIR 288
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  459 HLDACETMGNATAICSDKTGTLTMNRMTVVQAYinekhykkvpepeaippnilsylvtgisvncaytskilppekegglp 538
Cdd:cd02089    289 KLPAVETLGSVSVICSDKTGTLTQNKMTVEKIY----------------------------------------------- 321
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  539 rHVGNKTECALLGLLLDLKRDYQDVR------NEIPeealykvytFNSVRKSMSTVLKNSDGsYRIFSKGASEIILKKCF 612
Cdd:cd02089    322 -TIGDPTETALIRAARKAGLDKEELEkkypriAEIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCT 390
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  613 KILSaNGEAKVFRPRDRDDIvKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPD 692
Cdd:cd02089    391 YIYI-NGQVRPLTEEDRAKI-LAVNEEFSEEALRVLAVAYKPLDEDPTESSEDLEND----LIFLGLVGMIDPPRPEVKD 464
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  693 AIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEdfLCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTD 772
Cdd:cd02089    465 AVAECKKAGIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEH 534
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  773 KHTLVKgiidstvSDQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD 850
Cdd:cd02089    535 KLRIVK-------ALQRKgkIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYD 607
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1488045778  851 SISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKP 916
Cdd:cd02089    608 NIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
171-902 2.60e-139

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 434.05  E-value: 2.60e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  171 AFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQViQIPVADITVGDIAQVKYGDLLPADGILIQGnDLKIDESSLTGESDHV 250
Cdd:TIGR01494   14 VKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFVDESSLTGESLPV 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  251 -KKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekkkekknkkqdgaienrnkakaqdGA 329
Cdd:TIGR01494   92 lKTALPDGDAVFAGTINFGGTLIVKVTATGILTTVGKI----------------------------------------AV 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  330 AMEmqplkseEGGDGdekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDtfwvqkrpwlaect 409
Cdd:TIGR01494  132 VVY-------TGFST--------------KTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWD-------------- 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  410 piyIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQ 489
Cdd:TIGR01494  177 ---GNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQK 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  490 AYINEKHYKKvpepeaippnilsylvtgisvncaytsKILPPEKEGGLPRHVGNKTECALLGLLldlkRDYQDVRNEIPE 569
Cdd:TIGR01494  254 VIIIGGVEEA---------------------------SLALALLAASLEYLSGHPLERAIVKSA----EGVIKSDEINVE 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  570 EALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIlsangeakvfrprdrdDIVKTVIEPMASEGLRTIC 649
Cdd:TIGR01494  303 YKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNE----------------NDYDEKVDEYARQGLRVLA 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  650 LAFRDFPagepepewdnendivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILhpge 729
Cdd:TIGR01494  367 FASKKLP---------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID---- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  730 dflclegkdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDSTvsdqrQVVAVTGDGTNDGPALKKAD 809
Cdd:TIGR01494  428 ----------------------------------VFARVKPEEKAAIVEALQEKG-----RTVAMTGDGVNDAPALKKAD 468
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  810 VGFAMGIAgtDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdsplkavqmlw 889
Cdd:TIGR01494  469 VGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI------------- 533
                          730
                   ....*....|...
gi 1488045778  890 vNLIMDTLASLAL 902
Cdd:TIGR01494  534 -ILLPPLLAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
70-1042 6.62e-138

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 439.78  E-value: 6.62e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   70 GLSGNPAdlERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYqppegdnalcgevsvgeeegeg 149
Cdd:cd02080      1 GLTSEEA--AERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHW---------------------- 56
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  150 etgwiEGAAILLSVVCVVLVTAFNDWSK-EKQFRGLQSRIEQEQkfTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADG 228
Cdd:cd02080     57 -----VDAIVIFGVVLINAIIGYIQEGKaEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADL 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  229 ILIQGNDLKIDESSLTGESDHVKKSLDKDP----------LLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeee 298
Cdd:cd02080    130 RLIEARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLLA------ 203
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  299 ekkdekkkekknkkqdgaienrnkakaqdgaamEMQPLKSeeggdgdekdkkkanlPkkeksvLQGKLTKLAVQIGKAGL 378
Cdd:cd02080    204 ---------------------------------EVEQLAT----------------P------LTRQIAKFSKALLIVIL 228
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  379 LMSAITVIIlvlyfvidTFWVQKRPWlaectpiyiqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 458
Cdd:cd02080    229 VLAALTFVF--------GLLRGDYSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIR 288
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  459 HLDACETMGNATAICSDKTGTLTMNRMTVVQAYI--NEkhykkvpepeaippnilSYLvtgisvncaytskilppEKEGG 536
Cdd:cd02080    289 RLPAVETLGSVTVICSDKTGTLTRNEMTVQAIVTlcND-----------------AQL-----------------HQEDG 334
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  537 LPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTvLKNSDGSYRIFSKGASEIILKKCFKILS 616
Cdd:cd02080    335 HWKITGDPTEGALLVLAAKAGLDPDRLASSYPRVD---KIPFDSAYRYMAT-LHRDDGQRVIYVKGAPERLLDMCDQELL 410
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  617 ANGEakvfRPRDRDDIVKTViEPMASEGLRTICLAFRDFPAGEPEPEwdnENDIVTGLTCIAVVGIEDPVRPEVPDAIKK 696
Cdd:cd02080    411 DGGV----SPLDRAYWEAEA-EDLAKQGLRVLAFAYREVDSEVEEID---HADLEGGLTFLGLQGMIDPPRPEAIAAVAE 482
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  697 CQRAGITVRMVTGDNINTARAIATKCGILHPGEdflCLEGKDFNRRIRNEKGEIEQERidkiwpklRVLARSSPTDKHTL 776
Cdd:cd02080    483 CQSAGIRVKMITGDHAETARAIGAQLGLGDGKK---VLTGAELDALDDEELAEAVDEV--------DVFARTSPEHKLRL 551
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  777 VKGIidstvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISK 854
Cdd:cd02080    552 VRAL-------QARgeVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKK 624
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  855 FLQFQLTVNV---VAVIVA-FTGACItqdsPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMK 930
Cdd:cd02080    625 FILFTLPTNLgegLVIIVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIW 700
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  931 NILGHAFYQLVVVFTL-LFAGEKFFDIDSGRnaplhappsehyTIVFNTFVLMQLFNEINARKIHgeRNVFE-GIFNNAI 1008
Cdd:cd02080    701 RILLVSLLMLGGAFGLfLWALDRGYSLETAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKI 766
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|.
gi 1488045778 1009 FCTIVLGTFVVQIIIVQ-------FGGKPfscseLSIEQWL 1042
Cdd:cd02080    767 LFLGIGALILLQLAFTYlpfmnslFGTAP-----IDLVDWA 802
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
63-925 4.70e-128

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 417.85  E-value: 4.70e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   63 LKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQppEGDNALcgevsv 142
Cdd:cd02083     12 FGVDPTRGLS--DEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFE--EGEEGV------ 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  143 geeegegetgwiegaaillsvvcvvlvTAFND----------------WskekQFRGLQSRIEQEQKF-----TVIRGGQ 201
Cdd:cd02083     82 ---------------------------TAFVEpfvillilianavvgvW----QERNAEKAIEALKEYepemaKVLRNGK 130
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  202 VIQ-IPVADITVGDIAQVKYGDLLPADG--ILIQGNDLKIDESSLTGESDHVKKSLD--KDP---------LLLSGTHVM 267
Cdd:cd02083    131 GVQrIRARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVA 210
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  268 EGSGRMVVTAVGVNsqTGIiftllgaggeeeekkdekkkekknkkqdGAIENrnkakaqdgaamEMQplKSEEggdgdek 347
Cdd:cd02083    211 AGKARGVVVGTGLN--TEI----------------------------GKIRD------------EMA--ETEE------- 239
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  348 dkkkanlpkkEKSVLQGKLTKLAVQIGKAgllmsaITVIILVLYFV-IDTF--WVQKRPWLAECtpIYiqyfvkFFIIGV 424
Cdd:cd02083    240 ----------EKTPLQQKLDEFGEQLSKV------ISVICVAVWAInIGHFndPAHGGSWIKGA--IY------YFKIAV 295
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  425 TVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYInekhYKKVPEPe 504
Cdd:cd02083    296 ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFI----LDKVEDD- 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  505 aipPNILSYLVTGISVNCA----YTSKILPPEKEGGLP-----------------------RHVGNKTECA--------- 548
Cdd:cd02083    371 ---SSLNEFEVTGSTYAPEgevfKNGKKVKAGQYDGLVelaticalcndssldyneskgvyEKVGEATETAltvlvekmn 447
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  549 --LLGLLLDLKRDYQDVRNEIPEEALYKVYT--FNSVRKSMStVL---KNSDGSYRIFSKGASEIILKKCFKILSANGEA 621
Cdd:cd02083    448 vfNTDKSGLSKRERANACNDVIEQLWKKEFTleFSRDRKSMS-VYcspTKASGGNKLFVKGAPEGVLERCTHVRVGGGKV 526
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  622 KVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNENDIV---TGLTCIAVVGIEDPVRPEVPDAIKKCQ 698
Cdd:cd02083    527 VPLTAAIKILILKKVWG-YGTDTLRCLALATKDTPPKPEDMDLEDSTKFYkyeTDLTFVGVVGMLDPPRPEVRDSIEKCR 605
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  699 RAGITVRMVTGDNINTARAIATKCGILHPGEDFlclEGKDFNRRIRNEKGEIEQEridKIWPKLRVLARSSPTDKHTLVK 778
Cdd:cd02083    606 DAGIRVIVITGDNKGTAEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVE 679
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  779 giidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 858
Cdd:cd02083    680 -----LLQSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRY 753
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1488045778  859 QLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLIS 925
Cdd:cd02083    754 LISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
196-1026 2.63e-121

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 394.84  E-value: 2.63e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  196 VIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS---LDKDPL---------LLSG 263
Cdd:cd02085     88 CLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTtevIPKASNgdlttrsniAFMG 167
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  264 THVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaameMQplkSEEggd 343
Cdd:cd02085    168 TLVRCGHGKGIVIGTGENSEFGEVFKM------------------------------------------MQ---AEE--- 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  344 gdekdkkkanlpkKEKSVLQGKLTKLAVQigkagllMSAITVIILVLYFVIDtfWVQKRPWLaectpiyiqyfvKFFIIG 423
Cdd:cd02085    200 -------------APKTPLQKSMDKLGKQ-------LSLYSFIIIGVIMLIG--WLQGKNLL------------EMFTIG 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  424 VTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVvqayinekhykkvpep 503
Cdd:cd02085    246 VSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTV---------------- 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  504 eaippnilSYLVTGISVNCAYTSKILPPekegGLPRHvGNKTECALLGLLLDLKRDYQDVRnEIPeealykvytFNSVRK 583
Cdd:cd02085    310 --------TKIVTGCVCNNAVIRNNTLM----GQPTE-GALIALAMKMGLSDIRETYIRKQ-EIP---------FSSEQK 366
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  584 SMSTVLK---NSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIvKTVIEPMASEGLRTICLAfrdfpAGEp 660
Cdd:cd02085    367 WMAVKCIpkyNSDNEEIYFMKGALEQVLDYCTTYNSSDGSALPLTQQQRSEI-NEEEKEMGSKGLRVLALA-----SGP- 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  661 epewDNENDIVTGLtciavVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEdfLCLEGKdfn 740
Cdd:cd02085    440 ----ELGDLTFLGL-----VGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSL--QALSGE--- 505
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  741 rrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTvsdqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTD 820
Cdd:cd02085    506 -----EVDQMSDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG-----AVVAMTGDGVNDAVALKSADIGIAMGRTGTD 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  821 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASL 900
Cdd:cd02085    576 VCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQ 655
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  901 ALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFyqLVVVFTL-LFAGEKFFDIDSGRNAplhappsehyTIVFNTF 979
Cdd:cd02085    656 SLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAA--IIVSGTLwVFWKEMSDDNVTPRDT----------TMTFTCF 723
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*...
gi 1488045778  980 VLMQLFNEINARkiHGERNVFE-GIFNNAIFCTIVLGTFVVQIIIVQF 1026
Cdd:cd02085    724 VFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVIYF 769
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
195-990 8.11e-118

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 388.37  E-value: 8.11e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSL-----------DKDPLLLSG 263
Cdd:TIGR01116   76 KVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSG 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  264 THVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekkkekknkkqdgaienrnkaKAQDGAAmemqplkseeggd 343
Cdd:TIGR01116  156 TLVVAGKARGVVVRTGMSTEIGKI------------------------------------RDEMRAA------------- 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  344 gdekdkkkanlpKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYF---VIDTFWVQKrpwlaectPIYiqyfvkFF 420
Cdd:TIGR01116  187 ------------EQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFndpALGGGWIQG--------AIY------YF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  421 IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKV 500
Cdd:TIGR01116  241 KIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPSSSSL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  501 -----------PEPEAI----PPNILSY--LVTgISVNCAYT--SKILPPEKEGGLPRhVGNKTECA-----------LL 550
Cdd:TIGR01116  321 nefcvtgttyaPEGGVIkddgPVAGGQDagLEE-LATIAALCndSSLDFNERKGVYEK-VGEATEAAlkvlvekmglpAT 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  551 GLLLDLKRDYQDVRNEIPEEALYKVYT--FNSVRKSMStVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRD 628
Cdd:TIGR01116  399 KNGVSSKRRPALGCNSVWNDKFKKLATleFSRDRKSMS-VLCKPSTGNKLFVKGAPEGVLERCTHILNGDGRAVPLTDKM 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  629 RDDIVkTVIEPMAS-EGLRTICLAFRDFPAGEPEPEWD---NENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITV 704
Cdd:TIGR01116  478 KNTIL-SVIKEMGTtKALRCLALAFKDIPDPREEDLLSdpaNFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRV 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  705 RMVTGDNINTARAIATKCGILHPGED--FLCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKgiid 782
Cdd:TIGR01116  557 IMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGPAKQRAACRSAVLFSRVEPSHKSELVE---- 624
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  783 sTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTV 862
Cdd:TIGR01116  625 -LLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISS 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  863 NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLIS-----RTMMKNILGHAF 937
Cdd:TIGR01116  703 NIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITgwlffRYLVVGVYVGLA 782
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1488045778  938 YQLVVVFTLLFAGEKFFDIDSGRNAP--------LHAPPSEHYTIVFNTFVLMQLFNEINA 990
Cdd:TIGR01116  783 TVGGFVWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVLVVIEMFNALNA 843
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
195-1023 1.14e-112

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 374.48  E-value: 1.14e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----LDKDP---------LLL 261
Cdd:cd02086     96 HVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIKDaelvFGKEEdvsvgdrlnLAY 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  262 SGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkKQDGAIENRNKAKaqdgaamemqplKSEEG 341
Cdd:cd02086    176 SSSTVTKGRAKGIVVATGMNTEIGKIAKAL--------------------RGKGGLISRDRVK------------SWLYG 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  342 GDGDEKDKKKANLPKKEKSVLQGKLTKLAVqigkagLLMsAITVIILVLYFVIDTFWVQKRpwlaectpiyiqyfvkFFI 421
Cdd:cd02086    224 TLIVTWDAVGRFLGTNVGTPLQRKLSKLAY------LLF-FIAVILAIIVFAVNKFDVDNE----------------VII 280
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  422 IGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYInekhykkvp 501
Cdd:cd02086    281 YAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWI--------- 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  502 epeaipPNILSYLVTgisVNcaytskilppEKEGGLPRHV-GNKTECALLGLLLdlKRDYQDVRNEIPEEALYKV---YT 577
Cdd:cd02086    352 ------PAALCNIAT---VF----------KDEETDCWKAhGDPTEIALQVFAT--KFDMGKNALTKGGSAQFQHvaeFP 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  578 FNSVRKSMSTV-LKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTViEPMASEGLRTICLAFRDFP 656
Cdd:cd02086    411 FDSTVKRMSVVyYNNQAGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDE-FRKTIIKNV-ESLASQGLRVLAFASRSFT 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  657 A---GEPE---PEWDNEnDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGED 730
Cdd:cd02086    489 KaqfNDDQlknITLSRA-DAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSY 567
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  731 FLCLEGKDFNRRIRNEKGEIEQERIDKIwPKL-RVLARSSPTDKhtlVKGIidSTVSDQRQVVAVTGDGTNDGPALKKAD 809
Cdd:cd02086    568 HYSQEIMDSMVMTASQFDGLSDEEVDAL-PVLpLVIARCSPQTK---VRMI--EALHRRKKFCAMTGDGVNDSPSLKMAD 641
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  810 VGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKA 884
Cdd:cd02086    642 VGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSP 721
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  885 VQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLV---VVFTLLFAGEKFFDIDSGRN 961
Cdd:cd02086    722 VEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTFMGVlclASFTLVIYGIGNGDLGSDCN 801
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1488045778  962 APLHAPPSEHY---TIVFNTFVLMQLF---NEINARK----IHGERNVFEGIF------NNAIFCTIVLGTFVVQIII 1023
Cdd:cd02086    802 ESYNSSCEDVFrarAAVFATLTWCALIlawEVVDMRRsffnMHPDTDSPVKSFfktlwkNKFLFWSVVLGFVSVFPTL 879
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
472-902 1.07e-95

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 309.00  E-value: 1.07e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  472 ICSDKTGTLTMNRMTVVQAYInekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvgnktecallg 551
Cdd:cd01431      2 ICSDKTGTLTKNGMTVTKLFI----------------------------------------------------------- 22
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  552 llldlkrdyqdvrneipeealyKVYTFNSVRKSMSTVLKNsDGSYRIFSKGASEIILKKCFKILSangeakvfrPRDRDD 631
Cdd:cd01431     23 ----------------------EEIPFNSTRKRMSVVVRL-PGRYRAIVKGAPETILSRCSHALT---------EEDRNK 70
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  632 IVKTVIEpMASEGLRTICLAFRDFPAGepepewDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDN 711
Cdd:cd01431     71 IEKAQEE-SAREGLRVLALAYREFDPE------TSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDN 143
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  712 INTARAIATKCGILHPGEDFLCLEGKDfnrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKgiidstvSDQRQ- 790
Cdd:cd01431    144 PLTAIAIAREIGIDTKASGVILGEEAD----------EMSEEELLDLIAKVAVFARVTPEQKLRIVK-------ALQARg 206
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  791 -VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIV 869
Cdd:cd01431    207 eVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFA 286
                          410       420       430
                   ....*....|....*....|....*....|...
gi 1488045778  870 AFTGACITQDSPLKAVQMLWVNLIMDTLASLAL 902
Cdd:cd01431    287 IALALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
192-925 1.03e-88

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 307.74  E-value: 1.03e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  192 QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLD---KDPL------LLS 262
Cdd:cd02608    106 QQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS 185
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  263 gTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseegg 342
Cdd:cd02608    186 -TNCVEGTARGIVINTGDRTVMGRIATL---------------------------------------------------- 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  343 dgdekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDtfWVQKRPWLAECtpiyiqyfvkFFII 422
Cdd:cd02608    213 ----------------ASGLEVGKTPIAREIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLI 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  423 GVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTV---------VQAYI 492
Cdd:cd02608    265 GI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwfdnqiHEADT 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  493 NE-----KHYKKVPEPEAippniLSYLVTGISvncayTSKILPPEKEGGLPRHV--GNKTECALLGLLLDLKRDYQDVRN 565
Cdd:cd02608    342 TEdqsgaSFDKSSATWLA-----LSRIAGLCN-----RAEFKAGQENVPILKRDvnGDASESALLKCIELSCGSVMEMRE 411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  566 ------EIPeealykvytFNSVRKSMSTVLKNSDGS---YRIFSKGASEIILKKCFKILsANGEAKVFRPRDRDDIVKTV 636
Cdd:cd02608    412 rnpkvaEIP---------FNSTNKYQLSIHENEDPGdprYLLVMKGAPERILDRCSTIL-INGKEQPLDEEMKEAFQNAY 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  637 IEpMASEGLRTicLAFRD-------FPAGePEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTG 709
Cdd:cd02608    482 LE-LGGLGERV--LGFCHlylpddkFPEG-FKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTG 557
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  710 DNINTARAIATKCGILhpgedflclegkdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIidstvsdQR 789
Cdd:cd02608    558 DHPITAKAIAKGVGII--------------------------------------VFARTSPQQKLIIVEGC-------QR 592
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  790 Q--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNvVAV 867
Cdd:cd02608    593 QgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPE 671
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1488045778  868 IVAFTgACITQDSPLK--AVQMLWVNLIMDTLASLALATEPPTESLLLRKP----YGR--NKPLIS 925
Cdd:cd02608    672 ITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAYEKAESDIMKRQPrnpkTDKlvNERLIS 736
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
76-939 2.25e-88

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 300.13  E-value: 2.25e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   76 ADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSfyQPPEGdnalcgevsvgeeegegetgwie 155
Cdd:cd07538      5 AEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLG--DPREG----------------------- 59
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  156 gAAILLSVVCVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGND 235
Cdd:cd07538     60 -LILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDD 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  236 LKIDESSLTGESDHVKKSLD----------KDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekk 305
Cdd:cd07538    137 LGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI------------------ 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  306 kekknkkqdgaienrnkAKAQDGAAMEMQPLKSEeggdgdekdkkkanlpkkeksvlQGKLTKLavqIGKAGLLMSAITV 385
Cdd:cd07538    199 -----------------GKSLAEMDDEPTPLQKQ-----------------------TGRLVKL---CALAALVFCALIV 235
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  386 IilvLYFVIDTFWVQKrpwlaectpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACET 465
Cdd:cd07538    236 A---VYGVTRGDWIQA------------------ILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVET 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  466 MGNATAICSDKTGTLTMNRMTVvqayinekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvgnkt 545
Cdd:cd07538    295 LGSITVLCVDKTGTLTKNQMEV---------------------------------------------------------- 316
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  546 ecallgllldlkrdyQDVRNEIPEealykvYTFNSVRKSMSTVLKNSDGsYRIFSKGASEIILKKCfkilsangeakVFR 625
Cdd:cd07538    317 ---------------VELTSLVRE------YPLRPELRMMGQVWKRPEG-AFAAAKGSPEAIIRLC-----------RLN 363
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  626 PRDRDDIVKTVIEpMASEGLRTICLA-FRDFPAGEPEPEWDnendivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITV 704
Cdd:cd07538    364 PDEKAAIEDAVSE-MAGEGLRVLAVAaCRIDESFLPDDLED------AVFIFVGLIGLADPLREDVPEAVRICCEAGIRV 436
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  705 RMVTGDNINTARAIATKCGILH-----PGEDFLCLEGKDFNRRIRNekgeieqeridkiwpkLRVLARSSPTDKHTLVKG 779
Cdd:cd07538    437 VMITGDNPATAKAIAKQIGLDNtdnviTGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQA 500
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  780 IidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQ 859
Cdd:cd07538    501 F-----KANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYV 575
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  860 LTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISrtmmKNILGHAFYQ 939
Cdd:cd07538    576 FAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
178-905 1.89e-87

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 297.02  E-value: 1.89e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  178 EKQFRGLqsRIEQEQKFTVIR--GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLD 255
Cdd:cd07539     82 ERALAAL--LAQQQQPARVVRapAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQVA 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  256 KDP---------LLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdekkkekknkkqdgaienrnkakaq 326
Cdd:cd07539    160 PTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA---------------------------------- 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  327 dgaamemqPLKSEEGgdgdekdkkkanlpkkeksvLQGKLTKLAVQIGKAGL-LMSAITVIILVLYFVIdtfwvqkRPWL 405
Cdd:cd07539    206 --------PVETATG--------------------VQAQLRELTSQLLPLSLgGGAAVTGLGLLRGAPL-------RQAV 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  406 AectpiyiqyfvkffiIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM 485
Cdd:cd07539    251 A---------------DGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRL 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  486 TVVQAyinekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvgnktecallgllldlkrdyQDVRN 565
Cdd:cd07539    316 RVVQV----------------------------------------------------------------------RPPLA 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  566 EIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSAnGEAKVFRPRDRDDIVKtVIEPMASEGL 645
Cdd:cd07539    326 ELP---------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTG-GQVVPLTEADRQAIEE-VNELLAGQGL 394
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  646 RTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL 725
Cdd:cd07539    395 RVLAVAYRTLDAGTTHAVEAVVDD----LELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLP 470
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  726 HPGEdflCLEGKDFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVkgiidSTVSDQRQVVAVTGDGTNDGPAL 805
Cdd:cd07539    471 RDAE---VVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIV-----QALQAAGRVVAMTGDGANDAAAI 534
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  806 KKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAV 885
Cdd:cd07539    535 RAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTR 614
                          730       740
                   ....*....|....*....|
gi 1488045778  886 QMLWVNLIMDTLASLALATE 905
Cdd:cd07539    615 QLLLVNLLTDMFPALALAVE 634
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
192-954 2.23e-84

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 297.09  E-value: 2.23e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  192 QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLD---KDPL-----LLSG 263
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  264 THVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggd 343
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL----------------------------------------------------- 247
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  344 gdekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTfwVQKRPWLAECtpiyiqyfvkFFIIG 423
Cdd:TIGR01106  248 ---------------ASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSL--ILGYTWLEAV----------IFLIG 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  424 VtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYI-NEKHYKKVPE 502
Cdd:TIGR01106  301 I--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdNQIHEADTTE 378
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  503 PEA-IPPNILSYLVTGISVNCAYTSKILPPEKEGGLP---RHV-GNKTECALLGLLLDLKRDYQDVRN------EIPeea 571
Cdd:TIGR01106  379 DQSgVSFDKSSATWLALSRIAGLCNRAVFKAGQENVPilkRAVaGDASESALLKCIELCLGSVMEMRErnpkvvEIP--- 455
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  572 lykvytFNSVRKSMSTVLKNSDGS---YRIFSKGASEIILKKCFKILsANGEAKvfrPRDRD--DIVKTVIEPMASEGLR 646
Cdd:TIGR01106  456 ------FNSTNKYQLSIHENEDPRdprHLLVMKGAPERILERCSSIL-IHGKEQ---PLDEElkEAFQNAYLELGGLGER 525
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  647 TI--C---LAFRDFPAGEpEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATK 721
Cdd:TIGR01106  526 VLgfChlyLPDEQFPEGF-QFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKG 604
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  722 CGILHPG----EDF---LCLEGKDFNRRIRN-------EKGEIEQERIDKIwpkLR-----VLARSSPTDKHTLVKGIid 782
Cdd:TIGR01106  605 VGIISEGnetvEDIaarLNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEGC-- 679
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  783 stvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQL 860
Cdd:TIGR01106  680 -----QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL 754
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  861 TVNV--VAVIVAFTGACITQdsPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGR------NKPLISRTMMKNI 932
Cdd:TIGR01106  755 TSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPktdklvNERLISMAYGQIG 832
                          810       820
                   ....*....|....*....|..
gi 1488045778  933 LGHAFYQLVVVFTLLfAGEKFF 954
Cdd:TIGR01106  833 MIQALGGFFTYFVIL-AENGFL 853
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
196-960 2.78e-80

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 286.14  E-value: 2.78e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  196 VIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSL-------------DKDPLLLS 262
Cdd:TIGR01523  122 VIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFS 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  263 GTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkKQDGAIENRNKAKaqdgaamemQPLKSEEGG 342
Cdd:TIGR01523  202 SSAVTKGRAKGICIATALNSEIGAIAAGL--------------------QGDGGLFQRPEKD---------DPNKRRKLN 252
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  343 DGDEKDKKK---ANLPKKEKSVLQGKLTKLAVqigkaglLMSAITVIILVLYFVIDTFWVQKRpwlaecTPIYiqyfvkf 419
Cdd:TIGR01523  253 KWILKVTKKvtgAFLGLNVGTPLHRKLSKLAV-------ILFCIAIIFAIIVMAAHKFDVDKE------VAIY------- 312
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  420 fiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKK 499
Cdd:TIGR01523  313 ---AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTIS 389
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  500 VP-EPEAIPPNILSylVTGISVNCAYTSK--------ILPPEK----EGGLPRHV------------------------- 541
Cdd:TIGR01523  390 IDnSDDAFNPNEGN--VSGIPRFSPYEYShneaadqdILKEFKdelkEIDLPEDIdmdlfiklletaalaniatvfkdda 467
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  542 -------GNKTECA-------------------LLGLLLDLKRDYQDVRNEIPEEALYKV---YTFNSVRKSMSTVLKNS 592
Cdd:TIGR01523  468 tdcwkahGDPTEIAihvfakkfdlphnaltgeeDLLKSNENDQSSLSQHNEKPGSAQFEFiaeFPFDSEIKRMASIYEDN 547
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  593 DG-SYRIFSKGASEIILKKCFkilSANGEAKV----FRPRDRDDIVKTViEPMASEGLRTICLAFRDFPAGEpepEWDNE 667
Cdd:TIGR01523  548 HGeTYNIYAKGAFERIIECCS---SSNGKDGVkispLEDCDRELIIANM-ESLAAEGLRVLAFASKSFDKAD---NNDDQ 620
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  668 NDIVT--------GLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL--------HPGEDF 731
Cdd:TIGR01523  621 LKNETlnrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDS 700
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  732 LCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVG 811
Cdd:TIGR01523  701 MVMTGSQFD--------ALSDEEVDDLKALCLVIARCAPQTKVKMIEAL-----HRRKAFCAMTGDGVNDSPSLKMANVG 767
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  812 FAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQ 886
Cdd:TIGR01523  768 IAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVE 847
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488045778  887 MLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYqLVVVFTLLFAGeKFFDIDSGR 960
Cdd:TIGR01523  848 ILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFF-LGGSCLASFTG-ILYGFGSGN 919
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
70-916 6.77e-71

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 253.32  E-value: 6.77e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   70 GLSGNPADlERREaVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNalcgevsvgeeegeg 149
Cdd:cd02077      1 GLTNEEAE-ERLE-KYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD--------------- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  150 etgwIEGAAILLSVVCVVLVTAF-NDWSKEKQFRGLQSRIEQeqKFTVIRGGQVIQ-IPVADITVGDIAQVKYGDLLPAD 227
Cdd:cd02077     64 ----LVGALIILLMVLISGLLDFiQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPAD 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  228 GILIQGNDLKIDESSLTGESDHVKKS-----------LDKDPLLLSGTHVMEGSGRMVVTAVGVNsqtgiifTLLGAgge 296
Cdd:cd02077    138 VRIIQSKDLFVSQSSLTGESEPVEKHatakktkdesiLELENICFMGTNVVSGSALAVVIATGND-------TYFGS--- 207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  297 eeekkdekkkekknkkqdgaIENRNKakaqdgaamemqplkseeggdgdeKDKKKANLPKKEKSVlqgkltklavqigkA 376
Cdd:cd02077    208 --------------------IAKSIT------------------------EKRPETSFDKGINKV--------------S 229
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  377 GLLMSAITVIILVLYFVIDtfwVQKRPWLaectpiyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL 456
Cdd:cd02077    230 KLLIRFMLVMVPVVFLING---LTKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVI 294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  457 VRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY-INEKHYKKVPEPEAIppNilSYLVTGIsvncaytskilppekEG 535
Cdd:cd02077    295 VKNLNAIQNFGAMDILCTDKTGTLTQDKIVLERHLdVNGKESERVLRLAYL--N--SYFQTGL---------------KN 355
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  536 GLPRHVGNKTEcalLGLLLDLKRDYQDVrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIl 615
Cdd:cd02077    356 LLDKAIIDHAE---EANANGLIQDYTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHV- 421
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  616 SANGEAKVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIK 695
Cdd:cd02077    422 EVNGEVVPLTDTLREKILAQVEE-LNREGLRVLAIAYKKLPAPEGEYSVKDEKE----LILIGFLAFLDPPKESAAQAIK 496
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  696 KCQRAGITVRMVTGDNINTARAIATKCGIlhPGEDflCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHT 775
Cdd:cd02077    497 ALKKNGVNVKILTGDNEIVTKAICKQVGL--DINR--VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKAR 564
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  776 LVkgiidSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKF 855
Cdd:cd02077    565 II-----QALKKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKY 638
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488045778  856 LQFQLTVN---VVAVIVAftgACITQDSPLKAVQMLWVNLIMDtLASLALATEPPTESlLLRKP 916
Cdd:cd02077    639 IKMTASSNfgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPFDNVDEE-FLKKP 697
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
70-1018 1.33e-63

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 232.12  E-value: 1.33e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   70 GLSgnPADLERREAVFGKNFIPPKKP---KTFLQLVWEALQdvtlIILEIAAIVSLGLSFYQppegDNALcgevsvgeee 146
Cdd:cd02076      1 GLT--SEEAAKRLKEYGPNELPEKKEnpiLKFLSFFWGPIP----WMLEAAAILAAALGDWV----DFAI---------- 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  147 gegetgwiegaaillsVVCVVLVTAFNDWSKEKQFRGLQSRIEQ--EQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLL 224
Cdd:cd02076     61 ----------------ILLLLLINAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIV 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  225 PADGILIQGNDLKIDESSLTGESDHVKKSldKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGiiftllgaggeeeekkdek 304
Cdd:cd02076    125 PADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFG------------------- 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  305 kkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkKKANLPKKEKSvlQGKLTKLAVQIGKAGLLMSAIT 384
Cdd:cd02076    184 ---------------------------------------------KTAALVASAEE--QGHLQKVLNKIGNFLILLALIL 216
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  385 V--IILVLYFVIDTFwvqkrpwlaectpIYIQYFVkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDA 462
Cdd:cd02076    217 VliIVIVALYRHDPF-------------LEILQFV------LVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSA 277
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  463 CETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYK-----------KVPEPEAIPPNILSYLvtgisvncaytskilpp 531
Cdd:cd02076    278 IEELAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKdellllaalasDTENPDAIDTAILNAL----------------- 340
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  532 ekegglprhvgnktecallgllldlkRDYQDVRNEIPEEalyKVYTFNSVRK-SMSTVLKNSDGSYRIfSKGASEIILKK 610
Cdd:cd02076    341 --------------------------DDYKPDLAGYKQL---KFTPFDPVDKrTEATVEDPDGERFKV-TKGAPQVILEL 390
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  611 CFKilsangeakvfrPRDRDDIVKTVIEPMASEGLRTICLAfRDfpagEPEPEWDnendIVTGLTCIavvgieDPVRPEV 690
Cdd:cd02076    391 VGN------------DEAIRQAVEEKIDELASRGYRSLGVA-RK----EDGGRWE----LLGLLPLF------DPPRPDS 443
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  691 PDAIKKCQRAGITVRMVTGDNINTARAIATKCGI---LHPGEDFLCLEGKdfnrriRNEKGEIEQERIDkiwpKLRVLAR 767
Cdd:cd02076    444 KATIARAKELGVRVKMITGDQLAIAKETARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIE----DADGFAE 513
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  768 SSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRN 847
Cdd:cd02076    514 VFPEHKYRIVE-----ALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQ 587
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  848 VYDSISKFLQFQLTVnVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEppteslllRKPYgRNKPLISRt 927
Cdd:cd02076    588 IFQRMKSYVIYRIAE-TLRILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYD--------NVPP-SPRPVRWN- 656
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  928 mMKNILGHAF----YQLVVVFTLLFAGEKFFDIDSGRNaplhaPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEG- 1002
Cdd:cd02076    657 -MPELLGIATvlgvVLTISSFLLLWLLDDQGWFEDIVL-----SAGELQTILYLQLSISGHLTIFVTRTRGPFWRPRPSp 730
                          970
                   ....*....|....*.
gi 1488045778 1003 IFNNAIFCTIVLGTFV 1018
Cdd:cd02076    731 LLFIAVVLTQILATLL 746
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
193-937 7.76e-61

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 221.39  E-value: 7.76e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  193 KFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKslDKDPLLLSGTHVMEGSGR 272
Cdd:cd02609     93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPK--KAGDKLLSGSFVVSGAAY 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  273 MVVTAVGVNSQtgiiftllgaggeeeekkdekkkekknkkqdgaienrnkakaqdgAAMEMQPLKSEeggdgdekdkkka 352
Cdd:cd02609    171 ARVTAVGAESY---------------------------------------------AAKLTLEAKKH------------- 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  353 nlpKKEKSVLQGKLTKLAVQIGKagLLMSAITVIILVLYFVIDTFWVQKrpwlaectpiyiqyfvkffIIG-VTVLVVAV 431
Cdd:cd02609    193 ---KLINSELLNSINKILKFTSF--IIIPLGLLLFVEALFRRGGGWRQA-------------------VVStVAALLGMI 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  432 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYkkvpepEAIPPNIL 511
Cdd:cd02609    249 PEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEAN------EAEAAAAL 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  512 SYLVTGISVNCAyTSKILppekeggLPRHVGNktecallgllldlkrDYQDVRNEIPeealykvytFNSVRKsMSTVLKN 591
Cdd:cd02609    323 AAFVAASEDNNA-TMQAI-------RAAFFGN---------------NRFEVTSIIP---------FSSARK-WSAVEFR 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  592 SDGSYRIfskGASEIILkkcfkilsangeakvfrpRDRDDIVKTVIEPMASEGLRTICLAFrdfpagePEPEWDNENdIV 671
Cdd:cd02609    370 DGGTWVL---GAPEVLL------------------GDLPSEVLSRVNELAAQGYRVLLLAR-------SAGALTHEQ-LP 420
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  672 TGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGilhpgedflcLEGKDFNRRIRNEKGEIE 751
Cdd:cd02609    421 VGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTDEE 490
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  752 QERIDKiwpKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 831
Cdd:cd02609    491 LAEAVE---NYTVFGRVTPEQKRQLVQ-----ALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLL 561
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  832 DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESl 911
Cdd:cd02609    562 DSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRR- 640
                          730       740
                   ....*....|....*....|....*.
gi 1488045778  912 llrkpygrnkplISRTMMKNILGHAF 937
Cdd:cd02609    641 ------------IEGGFLRRVLTKAL 654
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
195-873 7.98e-52

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 195.75  E-value: 7.98e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDkDPLLlSGTHVMEGSGRMV 274
Cdd:COG2217    216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DEVF-AGTINLDGSLRVR 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  275 VTAVGVNSQ-TGIIftllgaggeeeekkdekkkekknkkqdGAIENRNKAKAqdgaamemqplkseeggdgdekdkkkan 353
Cdd:COG2217    293 VTKVGSDTTlARII---------------------------RLVEEAQSSKA---------------------------- 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  354 lpkkeksvlqgKLTKLAVQIgkagllmSAI-TVIILVLYFVidTFWVqkrpWLaectpIYIQYFVKFFIIGVTVLVVAVP 432
Cdd:COG2217    318 -----------PIQRLADRI-------ARYfVPAVLAIAAL--TFLV----WL-----LFGGDFSTALYRAVAVLVIACP 368
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  433 EGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNILS 512
Cdd:COG2217    369 CALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDV---------VPLDGLDEDELLA 439
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  513 Y-----------LVTGIsVNCAytskilpPEKEGGLPRHvgnktecallgllldlkrdyQDVRnEIP--------EEALY 573
Cdd:COG2217    440 LaaaleqgsehpLARAI-VAAA-------KERGLELPEV--------------------EDFE-AIPgkgveatvDGKRV 490
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  574 KVytfnsvrksmstvlknsdGSYRIFSKGASEIilkkcfkilsangeakvfrprdrDDIVKTVIEPMASEGLRTICLAfr 653
Cdd:COG2217    491 LV------------------GSPRLLEEEGIDL-----------------------PEALEERAEELEAEGKTVVYVA-- 527
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  654 dfpagepepeWDNEndivtgltCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflc 733
Cdd:COG2217    528 ----------VDGR--------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI--------- 580
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  734 legkdfnrrirnekgeieqeriDkiwpklRVLARSSPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVGFA 813
Cdd:COG2217    581 ----------------------D------EVRAEVLPEDKAAAVREL-----QAQGKKVAMVGDGINDAPALAAADVGIA 627
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  814 MGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:COG2217    628 MG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
880-1058 5.65e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 171.65  E-value: 5.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  880 SPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSG 959
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  960 RNAplhappsehYTIVFNTFVLMQLFNEINARKIHGERNVFeGIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELS 1037
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1488045778 1038 IEQWLWSIFLGMGTLLWGQLI 1058
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
174-873 1.63e-47

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 180.87  E-value: 1.63e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  174 DWSKEKQFRGLQSRIEQEQKF-TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKK 252
Cdd:cd02079    106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  253 SLDkDPLLlSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQDgaame 332
Cdd:cd02079    185 GAG-DTVF-AGTINLNGPLTIEVTKTGEDTTLAKIIRLV-------------------------------EEAQS----- 226
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  333 mqplkseeggdgdekdkkkanlpkkEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVqkrpWLAectpiy 412
Cdd:cd02079    227 -------------------------SKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLAL----YRA------ 271
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  413 iqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYI 492
Cdd:cd02079    272 -----------LAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEP 340
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  493 nekhYKKVPEPEAIppNILSYLVTGIS-------VNcAYTSKILPPEKegglprhvgnktecallgllldlkrdYQDVRn 565
Cdd:cd02079    341 ----LEGFSEDELL--ALAAALEQHSEhplaraiVE-AAEEKGLPPLE--------------------------VEDVE- 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  566 EIPEEALYKVYtfnsvrksmstvlknSDGSYRIfskGASEIIlkkcfkilsangeakvfrprdRDDIVKTVIEPMASEGL 645
Cdd:cd02079    387 EIPGKGISGEV---------------DGREVLI---GSLSFA---------------------EEEGLVEAADALSDAGK 427
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  646 RTICLAFRDfpaGEPepewdnendivtgltcIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL 725
Cdd:cd02079    428 TSAVYVGRD---GKL----------------VGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGID 488
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  726 HpgedflclegkdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGiidstVSDQRQVVAVTGDGTNDGPAL 805
Cdd:cd02079    489 E-------------------------------------VHAGLLPEDKLAIVKA-----LQAEGGPVAMVGDGINDAPAL 526
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1488045778  806 KKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:cd02079    527 AQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
174-873 5.68e-47

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 177.82  E-value: 5.68e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  174 DWSKEKQFRGLQSRIEQ--EQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVK 251
Cdd:TIGR01525   36 ERAKSRASDALSALLALapSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  252 KSldKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdgaam 331
Cdd:TIGR01525  115 KK--EGDEVFAGTINGDGSLTIRVTKLGEDSTLAQIVELV-------------------------------EEAQ----- 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKrpwlaectpi 411
Cdd:TIGR01525  157 -------------------------SSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYR---------- 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  412 yiqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAy 491
Cdd:TIGR01525  202 -----------ALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDI- 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  492 inekhykkVPEPEAIPPNILSY-----------LVTGIsvncaytskilppeKEGGLPRHVGNKTEcallgllldlkrdy 560
Cdd:TIGR01525  270 --------EPLDDASEEELLALaaaleqssshpLARAI--------------VRYAKERGLELPPE-------------- 313
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  561 qDVRnEIPEEALykvytfnsvrksmstvlknsdgsyRIFSKGASEIILKKCFKIlsANGEAKVFRPRDRDDIVKTVIEpm 640
Cdd:TIGR01525  314 -DVE-EVPGKGV------------------------EATVDGGREVRIGNPRFL--GNRELAIEPISASPDLLNEGES-- 363
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  641 aseGLRTICLAFRDfpagepepewdnenDIVTGltciaVVGIEDPVRPEVPDAIKKCQRAG-ITVRMVTGDNINTARAIA 719
Cdd:TIGR01525  364 ---QGKTVVFVAVD--------------GELLG-----VIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVA 421
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  720 TKCGIlhpgedflclegkDFNrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDstvsdQRQVVAVTGDGT 799
Cdd:TIGR01525  422 AELGI-------------DDE-----------------------VHAELLPEDKLAIVKKLQE-----EGGPVAMVGDGI 460
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488045778  800 NDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:TIGR01525  461 NDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
195-842 2.19e-44

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 171.89  E-value: 2.19e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDkDPLLlSGTHVMEGSGRMV 274
Cdd:cd02094    142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DKVI-GGTINGNGSLLVR 218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  275 VTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaIEN--RNKAKAQdgaamemqplkseeggdgdekdkkka 352
Cdd:cd02094    219 ATRVGADTTLAQIIRL--------------------------VEEaqGSKAPIQ-------------------------- 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  353 nlpkkeksvlqgkltKLAVQIgkagllmSAI---TVIIL-VLYFVIdTFWVQKRPWLAECtpiyiqyfvkfFIIGVTVLV 428
Cdd:cd02094    247 ---------------RLADRV-------SGVfvpVVIAIaILTFLV-WLLLGPEPALTFA-----------LVAAVAVLV 292
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  429 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVqayinekhyKKVPEPEAIPP 508
Cdd:cd02094    293 IACPCALGLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT---------DVVPLPGDDED 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  509 NILSY-----------LVTGISVNCaytskilppeKEGGLPrhvgnktecallgllldlkrdyqdvrneipeeaLYKVYT 577
Cdd:cd02094    364 ELLRLaasleqgsehpLAKAIVAAA----------KEKGLE---------------------------------LPEVED 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  578 FNSVR-KSMSTVLknsdGSYRIFSkGASEIILKKCFKILSANGEAkvfrprdrddivktviEPMASEGLRTICLAFrdfp 656
Cdd:cd02094    401 FEAIPgKGVRGTV----DGRRVLV-GNRRLMEENGIDLSALEAEA----------------LALEEEGKTVVLVAV---- 455
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  657 agepepewDNEndivtgltCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHpgedflcleg 736
Cdd:cd02094    456 --------DGE--------LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGIDE---------- 509
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  737 kdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGi 816
Cdd:cd02094    510 ---------------------------VIAEVLPEDKAEKVK-----KLQAQGKKVAMVGDGINDAPALAQADVGIAIG- 556
                          650       660
                   ....*....|....*....|....*.
gi 1488045778  817 AGTDVAKEASDIILTDDNFTSIVKAV 842
Cdd:cd02094    557 SGTDVAIESADIVLMRGDLRGVVTAI 582
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
195-870 1.22e-42

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.09  E-value: 1.22e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQV------IQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK-----------SLDKD 257
Cdd:PRK10517   162 TVLRVINDkgengwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECD 241
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  258 PLLLSGTHVMEGSGRMVVTAVGVNSQtgiiFtllgaggeeeekkdekkkekknkkqdGAIENRnkAKAQDGAAMEMQplk 337
Cdd:PRK10517   242 TLCFMGTNVVSGTAQAVVIATGANTW----F--------------------------GQLAGR--VSEQDSEPNAFQ--- 286
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  338 seeggdgdekdkkkanlpkkeksvlQGkltklavqIGKAGLLMSAITVIILVLYFVIDTFwvQKRPWlaectpiyiqyfV 417
Cdd:PRK10517   287 -------------------------QG--------ISRVSWLLIRFMLVMAPVVLLINGY--TKGDW------------W 319
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  418 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM------------ 485
Cdd:PRK10517   320 EAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtdisgkt 399
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  486 ---TVVQAYINekhykkvpepeaippnilSYLVTGIsvncaytsKILppekeggLPRHVgnkTECALLGLLLDLKRDYQD 562
Cdd:PRK10517   400 serVLHSAWLN------------------SHYQTGL--------KNL-------LDTAV---LEGVDEESARSLASRWQK 443
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  563 VrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIlSANGEAKVFRPRDRDDIvKTVIEPMAS 642
Cdd:PRK10517   444 I-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQV-RHNGEIVPLDDIMLRRI-KRVTDTLNR 511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  643 EGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKC 722
Cdd:PRK10517   512 QGLRVVAVATKYLPAREGDYQRADESD----LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEV 587
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  723 GILHPGedflCLEGKDFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDG 802
Cdd:PRK10517   588 GLDAGE----VLIGSDIET--------LSDDELANLAERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDA 650
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1488045778  803 PALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 870
Cdd:PRK10517   651 PALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
171-873 2.68e-41

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 160.95  E-value: 2.68e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  171 AFNDWSKEKQFRGLQSRIEQE-QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDH 249
Cdd:TIGR01512   33 TLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS-VDESALTGESVP 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  250 VKKSLDKDplLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdga 329
Cdd:TIGR01512  112 VEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNLV-------------------------------EEAQ--- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  330 amemqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQigkaglLMSAITVIILVLYFVidtFWVQKRPWLAEct 409
Cdd:TIGR01512  156 ---------------------------SRKAPTQRFIDRFARY------YTPAVLAIALAAALV---PPLLGAGPFLE-- 197
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  410 piyiqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQ 489
Cdd:TIGR01512  198 ---------WIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD 268
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  490 AyinekhykkVPEPEAIPPNILSYL---------VTGISVNCAYTSKILPPEKEgglprhvgnktecallgllldlkrdy 560
Cdd:TIGR01512  269 V---------HPADGHSESEVLRLAaaaeqgsthPLARAIVDYARARELAPPVE-------------------------- 313
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  561 qDVRnEIPEEALYKVYtfnsvrksmstvlknsdgsyrifskgaseiilkkcfkilsANGEAKVFRPRDRDDIVKTVIEPM 640
Cdd:TIGR01512  314 -DVE-EVPGEGVRAVV----------------------------------------DGGEVRIGNPRSLSEAVGASIAVP 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  641 ASEGlRTICLAFRDfpagepepewdnenDIVTGLtciavVGIEDPVRPEVPDAIKKCQRAGI-TVRMVTGDNINTARAIA 719
Cdd:TIGR01512  352 ESAG-KTIVLVARD--------------GTLLGY-----IALSDELRPDAAEAIAELKALGIkRLVMLTGDRRAVAEAVA 411
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  720 TKCGILhpgedflclegkdfnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKGIIDstvsdQRQVVAVTGDGT 799
Cdd:TIGR01512  412 RELGID-------------------------------------EVHAELLPEDKLEIVKELRE-----KAGPVAMVGDGI 449
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488045778  800 NDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:TIGR01512  450 NDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILLALFG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
199-870 1.92e-38

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 152.43  E-value: 1.92e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  199 GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKSLDkDPLLlSGTHVMEGSGRMVVTAV 278
Cdd:TIGR01511   99 DGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DPVI-AGTVNGTGSLVVRATAT 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  279 GVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdgaamemqplkseeggdgdekdkkkanlpkKE 358
Cdd:TIGR01511  176 GEDTTLAQIVRLV-------------------------------RQAQ------------------------------QS 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  359 KSVLQGkltkLAVQIgkAGLLMSAItVIILVLYFVIdtfWVQKrpwlaectpiyiqyfvkfFIIGVTVLVVAVPEGLPLA 438
Cdd:TIGR01511  195 KAPIQR----LADKV--AGYFVPVV-IAIALITFVI---WLFA------------------LEFAVTVLIIACPCALGLA 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  439 VTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNILSYLvtgi 518
Cdd:TIGR01511  247 TPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDV---------HVFGDRDRTELLALA---- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  519 svncaytskilppekeGGLPRHVGNKTECAllgllldlkrdyqdVRNEIpEEALYKVYTFNSVRKsmstvlknsdgsyrI 598
Cdd:TIGR01511  314 ----------------AALEAGSEHPLAKA--------------IVSYA-KEKGITLVTVSDFKA--------------I 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  599 FSKGASEIILKKCFKIlsanGEAKVFRPrdrddivKTVIEPMASEGLRTICLAFRDFPAgepepewdnendivtgltcIA 678
Cdd:TIGR01511  349 PGIGVEGTVEGTKIQL----GNEKLLGE-------NAIKIDGKAGQGSTVVLVAVNGEL-------------------AG 398
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeridki 758
Cdd:TIGR01511  399 VFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI---------------------------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  759 wpklRVLARSSPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 838
Cdd:TIGR01511  445 ----DVRAEVLPDDKAALIKKL-----QEKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDV 514
                          650       660       670
                   ....*....|....*....|....*....|..
gi 1488045778  839 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 870
Cdd:TIGR01511  515 ATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
196-870 8.18e-36

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 145.52  E-value: 8.18e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  196 VIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESdhvkKSLDKDP--LLLSGTHVMEGSGRM 273
Cdd:cd07552    135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  274 VVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdgaamemqplkseeggdgdekdkkkan 353
Cdd:cd07552    210 KVTKTGEDSYLSQVMELV-------------------------------AQAQ--------------------------- 231
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  354 lpkKEKSvlqgKLTKLAVQIgkAGLLMSaITVIILVLYFVIdtfwvqkrpWLaectpiYIQYFVKFFIIGVTVLVVAVPE 433
Cdd:cd07552    232 ---ASKS----RAENLADKV--AGWLFY-IALGVGIIAFII---------WL------ILGDLAFALERAVTVLVIACPH 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  434 GL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKvpepeaippN 509
Cdd:cd07552    287 ALglaiPLVVARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEYDED---------E 353
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  510 ILSY-----------LVTGIsVNCAYTSKILPPEKEG-------GLPRHVGNKtecallgllldlkrDYQDVRNEIPEEA 571
Cdd:cd07552    354 ILSLaaaleagsehpLAQAI-VSAAKEKGIRPVEVENfenipgvGVEGTVNGK--------------RYQVVSPKYLKEL 418
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  572 LYKVYTfnsvrksmstvlknsdgsyrifskgasEIilkkcFKILSANGEAKVFRPRDRDdivktviepmaseglrticla 651
Cdd:cd07552    419 GLKYDE---------------------------EL-----VKRLAQQGNTVSFLIQDGE--------------------- 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  652 frdfpagepepewdnendivtgltCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILhpgedf 731
Cdd:cd07552    446 ------------------------VIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID------ 495
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  732 lclegkdfnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVG 811
Cdd:cd07552    496 -------------------------------EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVG 539
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1488045778  812 FAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 870
Cdd:cd07552    540 IAIG-AGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
171-944 2.27e-34

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 142.69  E-value: 2.27e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  171 AFNDWSKEKQFRGLQSRieqeqKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK----IDESSLTGE 246
Cdd:cd02073     67 GYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDglcyVETANLDGE 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  247 SDH-VKKSLDKDPLLLSGTHVMEGSGRMVV--------TAVGVNSQTGIIFTLLGaggeeeekkdekkkekknkkqdgaI 317
Cdd:cd02073    142 TNLkIRQALPETALLLSEEDLARFSGEIECeqpnndlyTFNGTLELNGGRELPLS------------------------P 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  318 EN--------RNKAKAQdGAAmemqplkseeggdgdekdkkkanlpkkeksVLQGKLTKLAVQIGKAGLLMSAITVII-- 387
Cdd:cd02073    198 DNlllrgctlRNTEWVY-GVV------------------------------VYTGHETKLMLNSGGTPLKRSSIEKKMnr 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  388 -LVLYFVI-----------DTFWV----QKRPWLAECTPI--YIQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYSV 447
Cdd:cd02073    247 fIIAIFCIlivmclisaigKGIWLskhgRDLWYLLPKEERspALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKFL 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  448 --------KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHY--------------KKVP 501
Cdd:cd02073    322 qsffinwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYgfflalalchtvvpEKDD 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  502 EP-----EAIPPNILSyLVTGI-SVNCAYTSKilppekegglprhvgnktecallglllDLKRDYQDVRNEIPEEALYKV 575
Cdd:cd02073    402 HPgqlvyQASSPDEAA-LVEAArDLGFVFLSR---------------------------TPDTVTINALGEEEEYEILHI 453
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  576 YTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCfkilsANGEAKVFRPrdrddiVKTVIEPMASEGLRTICLAFRDF 655
Cdd:cd02073    454 LEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERL-----SPSSLELVEK------TQEHLEDFASEGLRTLCLAYREI 522
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  656 PAGEPEpEWDNE-------------------NDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTAR 716
Cdd:cd02073    523 SEEEYE-EWNEKydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAI 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  717 AIATKCGILHPG-EDF-LCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLA------RSSPTDKHTLVKGIIDSTvsdq 788
Cdd:cd02073    602 NIGYSCRLLSEDmENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSK---- 669
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  789 RQVVAVTGDGTNDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLT 861
Cdd:cd02073    670 KAVTLAIGDGANDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFY 741
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  862 VNVVAVIV-----AFTGAciTQDSPLKAVQMLWVNLIMDTLASLALAT--EPPTESLLLRKP----YGRNKPLIS-RTMM 929
Cdd:cd02073    742 KNIAFYLTqfwyqFFNGF--SGQTLYDSWYLTLYNVLFTSLPPLVIGIfdQDVSAETLLRYPelykPGQLNELFNwKVFL 819
                          890
                   ....*....|....*
gi 1488045778  930 KNILgHAFYQLVVVF 944
Cdd:cd02073    820 YWIL-DGIYQSLIIF 833
E1-E2_ATPase pfam00122
E1-E2 ATPase;
195-452 2.58e-32

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 124.22  E-value: 2.58e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKslDKDPLLLSGTHVMEGSGRMV 274
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  275 VTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkkkaNL 354
Cdd:pfam00122   85 VTATGEDTELGRIARLV-------------------------------------------------------------EE 103
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  355 PKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWvqkrpwlaectpiyiqyfvkfFIIGVTVLVVAVPEG 434
Cdd:pfam00122  104 AKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRA---------------------LLRALAVLVAACPCA 162
                          250
                   ....*....|....*...
gi 1488045778  435 LPLAVTISLAYSVKKMMK 452
Cdd:pfam00122  163 LPLATPLALAVGARRLAK 180
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
195-929 7.50e-32

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 134.77  E-value: 7.50e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIR------GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK---------------S 253
Cdd:PRK15122   151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVEKydtlgavagksadalA 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  254 LDKDPLL------LSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekkkekknkkqdgaienrnkAKAqd 327
Cdd:PRK15122   231 DDEGSLLdlpnicFMGTNVVSGTATAVVVATGSRTYFGSL-----------------------------------AKS-- 273
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  328 gaamemqplkseeggdgdekdkkkanlpkkeksvLQGKLTKLAVQIGKAG---LLMSAITVIILVLyFVIDTFwvQKRPW 404
Cdd:PRK15122   274 ----------------------------------IVGTRAQTAFDRGVNSvswLLIRFMLVMVPVV-LLINGF--TKGDW 316
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  405 LAECTpiyiqyfvkfFiigvtVLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 481
Cdd:PRK15122   317 LEALL----------F-----ALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLT 381
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  482 MNRMtvvqayINEKHYKKVPEPEaipPNIL------SYLVTGIsvncaytsKILppekeggLPRHVgnkTECALLGLLLD 555
Cdd:PRK15122   382 QDRI------ILEHHLDVSGRKD---ERVLqlawlnSFHQSGM--------KNL-------MDQAV---VAFAEGNPEIV 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  556 LKRDYQDVrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILsangEAKVFRPRD--RDDIV 633
Cdd:PRK15122   435 KPAGYRKV-DELP---------FDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVR----DGDTVRPLDeaRRERL 500
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  634 KTVIEPMASEGLRTICLAFRDFPAGEPEPEW--DNEND-IVTG-LTCIavvgieDPVRPEVPDAIKKCQRAGITVRMVTG 709
Cdd:PRK15122   501 LALAEAYNADGFRVLLVATREIPGGESRAQYstADERDlVIRGfLTFL------DPPKESAAPAIAALRENGVAVKVLTG 574
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  710 DN-INTARaIATKCGiLHPGEDflcLEGKDFNRRIRNEKGEIEQERIdkiwpklrVLARSSPTDKHTLVKgiidsTVSDQ 788
Cdd:PRK15122   575 DNpIVTAK-ICREVG-LEPGEP---LLGTEIEAMDDAALAREVEERT--------VFAKLTPLQKSRVLK-----ALQAN 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  789 RQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----N 863
Cdd:PRK15122   637 GHTVGFLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgN 713
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1488045778  864 VVAVIVAftGACITQdSPLKAVQMLWVNLIMDtLASLALatepPTESL---LLRKPYGRNKPLISRTMM 929
Cdd:PRK15122   714 VFSVLVA--SAFIPF-LPMLAIHLLLQNLMYD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
171-1071 1.24e-30

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 131.35  E-value: 1.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  171 AFNDWSkekqfRGLQSRIEQEQKFTVIRG-GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK----IDESSLTG 245
Cdd:TIGR01652   69 AIEDIR-----RRRRDKEVNNRLTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDG 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  246 ESD-HVKKSLDKDPLLLSGTHVMEGSGRmvVTAVGVNSQtgiIFTLLGaggeeeekkdekkkekkNKKQDGAienRNKAK 324
Cdd:TIGR01652  144 ETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG-----------------NMTINGD---RQYPL 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  325 AQDGAAMEMQPLKSEE---------GGDgdEKDKKKANLPKKEKSVLQGKLTKLAVQIgkAGLLMsaITVIILVLYFVID 395
Cdd:TIGR01652  199 SPDNILLRGCTLRNTDwvigvvvytGHD--TKLMRNATQAPSKRSRLEKELNFLIIIL--FCLLF--VLCLISSVGAGIW 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  396 TFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVV---AVPegLPLAVTISLAYSVKKMMKDNNL------------VRHL 460
Cdd:TIGR01652  273 NDAHGKDLWYIRLDVSERNAAANGFFSFLTFLILfssLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtpasVRTS 350
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  461 DACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHY-KKVPEPEAIppniLSYLVtGISVNCAYTSKILPPEKEGGLPR 539
Cdd:TIGR01652  351 NLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgDGFTEIKDG----IRERL-GSYVENENSMLVESKGFTFVDPR 425
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  540 HVGN------KTECA---------------LLGLLLDLKRDYQdvrNEIP-EEALYK----------------------- 574
Cdd:TIGR01652  426 LVDLlktnkpNAKRInefflalalchtvvpEFNDDGPEEITYQ---AASPdEAALVKaardvgfvffertpksislliem 502
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  575 -----------VYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIIlkkcFKILSANGEAKVfrprdrdDIVKTVIEPMASE 643
Cdd:TIGR01652  503 hgetkeyeilnVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVI----FKRLSSGGNQVN-------EETKEHLENYASE 571
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  644 GLRTICLAFRDFPAGEPEpEWDNEND-------------------IVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITV 704
Cdd:TIGR01652  572 GLRTLCIAYRELSEEEYE-EWNEEYNeastaltdreekldvvaesIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKI 650
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  705 RMVTGDNINTARAIATKCGILHPGEDFL---------CLEGKDFNRRIRNEKGEIEQERIDK---------------IWP 760
Cdd:TIGR01652  651 WVLTGDKVETAINIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDE 730
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  761 KLR------------VLA-RSSPTDKHTLVKGIIDSTvsdQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEA 825
Cdd:TIGR01652  731 ELEkeflqlalkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMA 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  826 SDIILTddNFTSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQ---MLWVNLIMDTLASLA 901
Cdd:TIGR01652  805 SDFAIG--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQFWYSFYNGFSGQTLYEgwyMVLYNVFFTALPVIS 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  902 LAT--EPPTESLLLRKP--YG---RNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYT- 973
Cdd:TIGR01652  883 LGVfdQDVSASLSLRYPqlYRegqKGQGFSTKTFWGWMLDGIYQSLVIFFFPMFAYILGDFVSSGSVDDFSSVGVIVFTa 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  974 --IVFNTFVLMqlfnEINArkihgernvfegiFNNAIFCTIVlGTFVVQIIIVqfggkPFSCSELSIEQWLWSIFLGMGT 1051
Cdd:TIGR01652  963 lvVIVNLKIAL----EINR-------------WNWISLITIW-GSILVWLIFV-----IVYSSIFPSPAFYKAAPRVMGT 1019
                         1050      1060
                   ....*....|....*....|....*.
gi 1488045778 1052 ------LLWGQLISTIPTSRLKFLKE 1071
Cdd:TIGR01652 1020 fgfwlvLLVIVLISLLPRFTYKAIQR 1045
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
174-873 2.10e-30

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 128.16  E-value: 2.10e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  174 DWSKEKQFRGL-QSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKK 252
Cdd:cd07550     81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  253 SldKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaIENRNKAKAQdgaame 332
Cdd:cd07550    160 R--EGDLVFASTVVEEGQLVIRAERVGRETRAARIAEL--------------------------IEQSPSLKAR------ 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  333 mqplkseeggdgdekdkkkanlpkkeksvLQGKLTKLAVQIGKAGLLMSAITviilvlyfvidtfWVQKRPWLAECTPIY 412
Cdd:cd07550    206 -----------------------------IQNYAERLADRLVPPTLGLAGLV-------------YALTGDISRAAAVLL 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  413 IQYfvkffiigvtvlVVAVPEGLPLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyi 492
Cdd:cd07550    244 VDF------------SCGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI-- 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  493 nekhykkVPEPEAIPPNILSYLVTGI------SVNCAYTSKIlppEKEGG-LPRHvgnktecallgllldlkrdyqdvrn 565
Cdd:cd07550    306 -------ITFDGRLSEEDLLYLAASAeehfphPVARAIVREA---EERGIeHPEH------------------------- 350
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  566 eipEEALYKvytfnsVRKSMSTVLKNSD---GSYRIFskGASEIILKkcfkilsangeakvfrprdrdDIVKTVIEPMAS 642
Cdd:cd07550    351 ---EEVEYI------VGHGIASTVDGKRirvGSRHFM--EEEEIILI---------------------PEVDELIEDLHA 398
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  643 EGLRTICLAFRDFPAGepepewdnendivtgltciaVVGIEDPVRPEVPDAIKKCQRAG-ITVRMVTGDNINTARAIAtk 721
Cdd:cd07550    399 EGKSLLYVAIDGRLIG--------------------VIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA-- 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  722 cgilhpgedflclegkdfnrrirnekgeiEQERIDkiwpklRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTND 801
Cdd:cd07550    457 -----------------------------EQLGID------RYHAEALPEDKAEIVE-----KLQAEGRTVAFVGDGIND 496
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1488045778  802 GPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:cd07550    497 SPALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
179-948 4.45e-30

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 129.41  E-value: 4.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  179 KQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKY--GDLLPADGILIQGnDLKIDESSLTGESDHVKK---- 252
Cdd:TIGR01657  216 KQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SCIVNESMLTGESVPVLKfpip 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  253 ------------SLDKDPLLLSGTHVM-------EGSGRMVVTAVGVN-SQTGIIFTLLgaggeeeekkdekkkekknkk 312
Cdd:TIGR01657  295 dngdddedlflyETSKKHVLFGGTKILqirpypgDTGCLAIVVRTGFStSKGQLVRSIL--------------------- 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  313 qdgaienrnkakaqdgaamemqplkseeggdgdekdkkkanLPKKEKSVLQGKLTKLAvqigkagLLMSAITVIILVlyF 392
Cdd:TIGR01657  354 -----------------------------------------YPKPRVFKFYKDSFKFI-------LFLAVLALIGFI--Y 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  393 VIDTFWVQKRPwlaectpiyiqyfVKFFIIGVT-VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA 471
Cdd:TIGR01657  384 TIIELIKDGRP-------------LGKIILRSLdIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDV 450
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  472 ICSDKTGTLTMNRMTVVQAYI---NEKHYKKVPEPEAIPPNILSYLVTgisvNCAYTSKIlppekEGGLprhVGNKTECA 548
Cdd:TIGR01657  451 CCFDKTGTLTEDGLDLRGVQGlsgNQEFLKIVTEDSSLKPSITHKALA----TCHSLTKL-----EGKL---VGDPLDKK 518
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  549 ----------LLGLLLDLKRDYQDVRNEIPEEALY--KVYTFNSVRKSMSTVLK-NSDGSYRIFSKGASEIILKKCfkil 615
Cdd:TIGR01657  519 mfeatgwtleEDDESAEPTSILAVVRTDDPPQELSiiRRFQFSSALQRMSVIVStNDERSPDAFVKGAPETIQSLC---- 594
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  616 sangeAKVFRPRDRDDIVKTVIepmaSEGLRTICLAFRDFpagePEPEWD-----NENDIVTGLTCIAVVGIEDPVRPEV 690
Cdd:TIGR01657  595 -----SPETVPSDYQEVLKSYT----REGYRVLALAYKEL----PKLTLQkaqdlSRDAVESNLTFLGFIVFENPLKPDT 661
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  691 PDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL------------------------HPGEDF--------------- 731
Cdd:TIGR01657  662 KEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnpsntlilaeaeppesgkpnqikfEVIDSIpfastqveipyplgq 741
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  732 ------------LCLEGKDFNRRIRNEKgeieqERIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGT 799
Cdd:TIGR01657  742 dsvedllasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDGA 811
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  800 NDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSIskfLQFQLT-VNVVAVIVAFTGACITQ 878
Cdd:TIGR01657  812 NDCGALKQADVGISLSEAEASVA--AP--------FTSKLASI---SCVPNVI---REGRCAlVTSFQMFKYMALYSLIQ 875
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  879 ----------DSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRnkpLISRTMMKNILGhafyQLVVVFTLLF 948
Cdd:TIGR01657  876 fysvsilyliGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVLI----QFVLHILSQV 948
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
179-948 1.18e-28

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 123.90  E-value: 1.18e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  179 KQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKY-GDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDKD 257
Cdd:cd07542     74 KQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCI-VNESMLTGESVPVTKTPLPD 152
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  258 P-----------------LLLSGTHVME--GSGRMVVTAVGVnsQTGIiftllgaggeeeekkdekkkekknkkqdgaie 318
Cdd:cd07542    153 EsndslwsiysiedhskhTLFCGTKVIQtrAYEGKPVLAVVV--RTGF-------------------------------- 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  319 nrNKAKAQDGAAMeMQPlkseeggdgdekdkKKANLpkkeksvlqgKLTK-----LAVQIGKAGLLMsAITVIILVLYFV 393
Cdd:cd07542    199 --NTTKGQLVRSI-LYP--------------KPVDF----------KFYRdsmkfILFLAIIALIGF-IYTLIILILNGE 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  394 idtfwvqkrpwlaectpiyiqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNAT 470
Cdd:cd07542    251 ---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINICG 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  471 AI---CSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILppEKEGGLPrhVG----- 542
Cdd:cd07542    304 KInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSL--TLIDGEL--VGdpldl 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  543 ---NKTECALlgllldlkrdyqdvrnEIpeealYKVYTFNSVRKSMSTVLK-NSDGSYRIFSKGASEIILKKCFKilsan 618
Cdd:cd07542    380 kmfEFTGWSL----------------EI-----LRQFPFSSALQRMSVIVKtPGDDSMMAFTKGAPEMIASLCKP----- 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  619 geAKVfrPRDRDDIVKTviepMASEGLRTICLAFRDFPAGEPEpEWDNENDIV-TGLTCIAVVGIEDPVRPEVPDAIKKC 697
Cdd:cd07542    434 --ETV--PSNFQEVLNE----YTKQGFRVIALAYKALESKTWL-LQKLSREEVeSDLEFLGLIVMENRLKPETAPVINEL 504
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  698 QRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKdfnrrirNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLV 777
Cdd:cd07542    505 NRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAV-------KPEDDDSASLTWTLLLKGTVFARMSPDQKSELV 577
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  778 KGI--IDSTvsdqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSISK- 854
Cdd:cd07542    578 EELqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASVA--AP--------FTSKVPDI---SCVPTVIKEg 637
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  855 -------FLQFQLTvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRnkpLIS 925
Cdd:cd07542    638 raalvtsFSCFKYM--ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVS 712
                          810       820
                   ....*....|....*....|...
gi 1488045778  926 RTMMKNILGHAFYQLVVVFTLLF 948
Cdd:cd07542    713 PPVLVSLLGQIVLILLFQVIGFL 735
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
195-900 1.69e-28

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 122.53  E-value: 1.69e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDKDplLLSGThvmegsgrmv 274
Cdd:cd07545     99 LVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS-VNQAAITGESLPVEKGVGDE--VFAGT---------- 165
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  275 vtavgVNsqtgiiftllgaggeeeekkdekkkekknkkQDGAIENRNKAKAQDGAAMEMQPLKSEEGGdgdekdkkkanl 354
Cdd:cd07545    166 -----LN-------------------------------GEGALEVRVTKPAEDSTIARIIHLVEEAQA------------ 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  355 pkkEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFwvqkrPWlaectpIYIqyfvkffiiGVTVLVVAVPEG 434
Cdd:cd07545    198 ---ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGGAWF-----TW------IYR---------GLALLVVACPCA 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  435 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTmnrmtvvqayinekhyKKVPEpeaippnilsyl 514
Cdd:cd07545    255 LVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLT----------------KGKPV------------ 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  515 VTGIsvncaytsKILPPEKEGGLPRHVGNktecallglllDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMStvlknsdg 594
Cdd:cd07545    307 VTDV--------VVLGGQTEKELLAIAAA-----------LEYRSEHPLASAIVKKAEQRGLTLSAVEEFTA-------- 359
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  595 syrIFSKGASEIILKKCFKIlsanGEAKVFRPRDRDDIV--KTVIEPMASEGlRTICLafrdfpagepepewdnendIVT 672
Cdd:cd07545    360 ---LTGRGVRGVVNGTTYYI----GSPRLFEELNLSESPalEAKLDALQNQG-KTVMI-------------------LGD 412
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  673 GLTCIAVVGIEDPVRPEVPDAIKKCQRAGI--TVrMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekGEI 750
Cdd:cd07545    413 GERILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTGDNPQTAQAIAAQVGV-----------------------SDI 468
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  751 EQERIdkiwpklrvlarssPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIIL 830
Cdd:cd07545    469 RAELL--------------PQDKLDAIEAL-----QAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIAL 529
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  831 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitqdsplkaVQMLWVNLIMDTLASL 900
Cdd:cd07545    530 MGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLVIPG-----------WLTLWMAVFADMGASL 588
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1103-1149 1.95e-27

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 105.56  E-value: 1.95e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1488045778 1103 GQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPE 1149
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
198-873 8.57e-26

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 114.27  E-value: 8.57e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  198 RGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKSLDKDplLLSGTHVMEGSGRMVVTA 277
Cdd:cd07551    119 RDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRVTK 195
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  278 VGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQDgaamemqplkseeggdgdekdkkkanlpkk 357
Cdd:cd07551    196 LSSDTVFAKIVQLV-------------------------------EEAQS------------------------------ 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  358 EKSVLQGKLTKLavQIGKAGLLMSAITVIILVLYFVIDtfWvqkrPWLAEctpiyiqyfvkfFIIGVTVLVVAVPEGLPL 437
Cdd:cd07551    215 EKSPTQSFIERF--ERIYVKGVLLAVLLLLLLPPFLLG--W----TWADS------------FYRAMVFLVVASPCALVA 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  438 AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEkhykkvPEPEAippnilsyLVTG 517
Cdd:cd07551    275 STPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVIPAE------GVDEE--------ELLQ 340
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  518 ISVNCAYTSkilppekEGGLPRHVGNKTEcallgLLLDLKRDYQDVRNEIpeealykvytfnsvrksmstvlknsdgsyr 597
Cdd:cd07551    341 VAAAAESQS-------EHPLAQAIVRYAE-----ERGIPRLPAIEVEAVT------------------------------ 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  598 ifSKGASEIILKKCFKIlsanGEAKVFRPRDRDDIVKTVIEPMASEGlRTICLAFRDfpagepepewdnenDIVtgltcI 677
Cdd:cd07551    379 --GKGVTATVDGQTYRI----GKPGFFGEVGIPSEAAALAAELESEG-KTVVYVARD--------------DQV-----V 432
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  678 AVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeriDK 757
Cdd:cd07551    433 GLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI-------------------------------DE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  758 IWPKLRvlarssPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTS 837
Cdd:cd07551    482 VVANLL------PEDKVAIIR-----ELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSK 549
                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1488045778  838 IVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:cd07551    550 LPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
192-873 3.90e-24

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 108.95  E-value: 3.90e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  192 QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSldKDPLLLSGTHVMEGSG 271
Cdd:cd07544    110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKR--PGDRVMSGAVNGDSAL 186
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  272 RMVVTAVGVNSQTGIIFTLLGAggeeeekkdekkkekknkkqdgaienrnkAKAQDGAAMEMqplkseeggdGDekdkkk 351
Cdd:cd07544    187 TMVATKLAADSQYAGIVRLVKE-----------------------------AQANPAPFVRL----------AD------ 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  352 anlpkkeksVLQGKLTKLAVQIGKAGllmsaitviilvlyfvidtfwvqkrpWLAECTPiyiqyfVKFfiigVTVLVVAV 431
Cdd:cd07544    222 ---------RYAVPFTLLALAIAGVA--------------------------WAVSGDP------VRF----AAVLVVAT 256
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  432 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNIL 511
Cdd:cd07544    257 PCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDV---------VPAPGVDADEVL 327
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  512 SyLVTgiSVNcAYTSKILppekegglprhvgnktecallgllldlkrdyqdvrneipEEALYKVYTFNSVRKSMSTVLKN 591
Cdd:cd07544    328 R-LAA--SVE-QYSSHVL---------------------------------------ARAIVAAARERELQLSAVTELTE 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  592 SDGsyrifsKGASEIILKKCFKILSangeakvfrprdrddivktviepmaseglrticlafRDFPAGEPEPEWDNENDIV 671
Cdd:cd07544    365 VPG------AGVTGTVDGHEVKVGK------------------------------------LKFVLARGAWAPDIRNRPL 402
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  672 TGLTC--------IAVVGIEDPVRPEVPDAIKKCQRAGIT-VRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrr 742
Cdd:cd07544    403 GGTAVyvsvdgkyAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGI------------------ 464
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  743 irnekgeieqeriDKiwpklrVLARSSPTDKHTLVKGIidstvsDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 822
Cdd:cd07544    465 -------------DE------VRAELLPEDKLAAVKEA------PKAGPTIMVGDGVNDAPALAAADVGIAMGARGSTAA 519
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1488045778  823 KEASDIILTDDNFTSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 873
Cdd:cd07544    520 SEAADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
195-904 8.09e-23

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 104.79  E-value: 8.09e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKSldkdplllSGTHVMEGSgrmv 274
Cdd:cd07546    102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKA--------AGDKVFAGS---- 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  275 vtavgVNSqtgiiftllgaggeeeekkdekkkekknkkqDGAIENRNKAKAQDGAAMEMQPLKseeggdgDEKDKKKANL 354
Cdd:cd07546    169 -----INV-------------------------------DGVLRIRVTSAPGDNAIDRILHLI-------EEAEERRAPI 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  355 PKKeksvlqgkLTKLAVQIGKAGLLMSAITVIILVLYFVIDtfWvqkRPWlaectpIYIqyfvkffiiGVTVLVVAVPEG 434
Cdd:cd07546    206 ERF--------IDRFSRWYTPAIMAVALLVIVVPPLLFGAD--W---QTW------IYR---------GLALLLIGCPCA 257
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  435 L----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNI 510
Cdd:cd07546    258 LvistPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTDV---------VPLTGISEAEL 324
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  511 LSyLVTGISVNCAYTskilppekeggLPRHVGNKTECALLgllldlkrdyqdvrneIPEEAlykvytfnSVRKSMStvlk 590
Cdd:cd07546    325 LA-LAAAVEMGSSHP-----------LAQAIVARAQAAGL----------------TIPPA--------EEARALV---- 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  591 nsdgsyrifSKGASEIILKKCFKILSANGEAKVFRPRdrddiVKTVIEPMASEGlRTICLAFRdfpagepepewdneNDI 670
Cdd:cd07546    365 ---------GRGIEGQVDGERVLIGAPKFAADRGTLE-----VQGRIAALEQAG-KTVVVVLA--------------NGR 415
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  671 VTGLtciavVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkDFNRRIRnekgei 750
Cdd:cd07546    416 VLGL-----IALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-------------DFRAGLL------ 471
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  751 eqeridkiwpklrvlarssPTDKHTLVKGIidstvsDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 830
Cdd:cd07546    472 -------------------PEDKVKAVREL------AQHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAAL 525
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1488045778  831 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQdsplkavqmLWVNLIMDTLASlALAT 904
Cdd:cd07546    526 THNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
199-822 1.42e-22

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 104.59  E-value: 1.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  199 GGQVIQIPVADITVGDIAQVKY-GDLLPADGILIQGNdLKIDESSLTGES----------DHVKKSLD-----KDPLLLS 262
Cdd:cd02082     94 GYQEITIASNMIVPGDIVLIKRrEVTLPCDCVLLEGS-CIVTEAMLTGESvpigkcqiptDSHDDVLFkyessKSHTLFQ 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  263 GTHVM-----EGSG-RMVVTAVGVNSQTGIIFtllgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqpl 336
Cdd:cd02082    173 GTQVMqiippEDDIlKAIVVRTGFGTSKGQLI------------------------------------------------ 204
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  337 kseeggdgdekdkkkanlpkkeKSVLQGKLTKLAVQigkaglLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIqyF 416
Cdd:cd02082    205 ----------------------RAILYPKPFNKKFQ------QQAVKFTLLLATLALIGFLYTLIRLLDIELPPLFI--A 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  417 VKFFIIgvtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMtVVQAYINEKH 496
Cdd:cd02082    255 FEFLDI----LTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQLKGQ 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  497 YKKVPEPEAIPPNILSYLVTGISVnCAYTSKIlppekEGGLprhVGNKTECALLGLLLDLkRDYQDVRNEIPEEA----- 571
Cdd:cd02082    330 NQTFDPIQCQDPNNISIEHKLFAI-CHSLTKI-----NGKL---LGDPLDVKMAEASTWD-LDYDHEAKQHYSKSgtkrf 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  572 -LYKVYTFNSVRKSMSTVLK-----NSDGSYRIFSKGASEIILKKCFKIlsangeakvfrPRDRDDIVKTVIEpmasEGL 645
Cdd:cd02082    400 yIIQVFQFHSALQRMSVVAKevdmiTKDFKHYAFIKGAPEKIQSLFSHV-----------PSDEKAQLSTLIN----EGY 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  646 RTICLAFRDFPAGEPEPEWDNEND-IVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGI 724
Cdd:cd02082    465 RVLALGYKELPQSEIDAFLDLSREaQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEI 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  725 LHPGEDFLCLEGkdfnrrIRNEKGEIEQERIDKIwPKLRVLARSSPTDKHTLVKGIIDSTvsdqrQVVAVTGDGTNDGPA 804
Cdd:cd02082    545 INRKNPTIIIHL------LIPEIQKDNSTQWILI-IHTNVFARTAPEQKQTIIRLLKESD-----YIVCMCGDGANDCGA 612
                          650
                   ....*....|....*...
gi 1488045778  805 LKKADVGFAMGIAGTDVA 822
Cdd:cd02082    613 LKEADVGISLAEADASFA 630
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
418-814 1.54e-21

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 101.31  E-value: 1.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  418 KFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTMNRMtVV 488
Cdd:cd07543    260 KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VV 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  489 Q--AYINEKHyKKVPEPEAIPPNILSYLVTGISVNCAYTSKIL--PPEKegGLPRHVGNKTECALLGLLLDLKrdyqdvr 564
Cdd:cd07543    330 EgvAGLNDGK-EVIPVSSIEPVETILVLASCHSLVKLDDGKLVgdPLEK--ATLEAVDWTLTKDEKVFPRSKK------- 399
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  565 neIPEEALYKVYTFNSVRKSMSTV-----LKNSDGSYRIFSKGASEIIlKKCFKILsangeakvfrPRDRDDIVKTviep 639
Cdd:cd07543    400 --TKGLKIIQRFHFSSALKRMSVVasykdPGSTDLKYIVAVKGAPETL-KSMLSDV----------PADYDEVYKE---- 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  640 MASEGLRTICLAFRDFPAGEPEPEWD-NENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAI 718
Cdd:cd07543    463 YTRQGSRVLALGYKELGHLTKQQARDyKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHV 542
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  719 ATKCGIlhpgedflclegkdfnrrIRNEKGEIEQERIDKIW-----PKLRVLARSSPTDKHTLVkgiidSTVSDQRQVVA 793
Cdd:cd07543    543 AKELGI------------------VDKPVLILILSEEGKSNewkliPHVKVFARVAPKQKEFII-----TTLKELGYVTL 599
                          410       420
                   ....*....|....*....|.
gi 1488045778  794 VTGDGTNDGPALKKADVGFAM 814
Cdd:cd07543    600 MCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
191-869 1.91e-20

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 97.67  E-value: 1.91e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  191 EQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK----IDESSLTGESD-HVKKSLDKDPLLLSGTH 265
Cdd:cd07536     82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  266 VMEGSGrmVVTAVGVNSQtgiIFTLLGaggeeeekkdekkkekkNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGd 345
Cdd:cd07536    162 LMKISA--YVECQKPQMD---IHSFEG-----------------NFTLEDSDPPIHESLSIENTLLRASTLRNTGWVIG- 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  346 ekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGL-----------LMSAITVIILVLYFVIDT---FWvqkRPWLAEcTPI 411
Cdd:cd07536    219 -------------VVVYTGKETKLVMNTSNAKNkvglldlelnrLTKALFLALVVLSLVMVTlqgFW---GPWYGE-KNW 281
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  412 YIQY----FVKFFIIGVTVLVV---AVPEGLPLAVTISLAYSVKKMMKDNNL----------VRHLDACETMGNATAICS 474
Cdd:cd07536    282 YIKKmdttSDNFGRNLLRFLLLfsyIIPISLRVNLDMVKAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLT 361
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  475 DKTGTLTMNRMTVVQAYINEKHYkkvpepeaippnilsylvtgisvncaytskilppekeGGlprhvgnktecallglll 554
Cdd:cd07536    362 DKTGTLTQNEMIFKRCHIGGVSY-------------------------------------GG------------------ 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  555 dlkrdyQDVRNEIPEealykVYTFNSVRKSMSTVLKN-SDGSYRIFSKGASEIIlkkcFKILSANGEAKVFrprdrddiv 633
Cdd:cd07536    387 ------QVLSFCILQ-----LLEFTSDRKRMSVIVRDeSTGEITLYMKGADVAI----SPIVSKDSYMEQY--------- 442
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  634 KTVIEPMASEGLRTICLAFRDFPAGEPEpEW------------DNENDIVT-------GLTCIAVVGIEDPVRPEVPDAI 694
Cdd:cd07536    443 NDWLEEECGEGLRTLCVAKKALTENEYQ-EWesryteaslslhDRSLRVAEvveslerELELLGLTAIEDRLQAGVPETI 521
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  695 KKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCL--EGKDFNRR--------IRNEKGE--------------- 749
Cdd:cd07536    522 ETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQDIHLLrqDTSRGERAaitqhahlELNAFRRkhdvalvidgdslev 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  750 ----IEQERID-KIWPKLRVLARSSPTDKHTLVKgIIDStvSDQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VA 822
Cdd:cd07536    602 alkyYRHEFVElACQCPAVICCRVSPTQKARIVT-LLKQ--HTGRRTLAI-GDGGNDVSMIQAADCG--VGISGKEgkQA 675
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*...
gi 1488045778  823 KEASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV 869
Cdd:cd07536    676 SLAADYSIT--QFRHLGRLLLvHGRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
199-846 8.79e-19

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 91.94  E-value: 8.79e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  199 GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNdLKIDESSLTGESDHV-KKSLDKDPLLLSGTHVMegSGRMVVTa 277
Cdd:cd02078    103 DGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPViRESGGDRSSVTGGTKVL--SDRIKVR- 178
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  278 vgVNSQTGIIFTllgaggeeeekkdekkkekknkkqDGAIENRNKAKAQdgaamemqplkseeggdgdekdkKKANlpkk 357
Cdd:cd02078    179 --ITANPGETFL------------------------DRMIALVEGASRQ-----------------------KTPN---- 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  358 eksvlqgkltKLAVQIgkaglLMSAITVIILVlyfVIDTFWvqkrpwlaectPIYIQYFVKffiIGVTVLV---VA-VPE 433
Cdd:cd02078    206 ----------EIALTI-----LLVGLTLIFLI---VVATLP-----------PFAEYSGAP---VSVTVLVallVClIPT 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  434 ---GLPLAVTISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM-NRMTVvqayinekhykkvpepEAIPpn 509
Cdd:cd02078    254 tigGLLSAIGIA---GMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQAT----------------EFIP-- 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  510 ilsylVTGISVN----CAYTSKILPPEKEGglprhvgnktecalLGLLLDLKRDYQDVRNEIPEEAlyKVYTFnSVRKSM 585
Cdd:cd02078    313 -----VGGVDEKeladAAQLASLADETPEG--------------RSIVILAKQLGGTERDLDLSGA--EFIPF-SAETRM 370
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  586 STVlkNSDGSYRIfSKGASEIILKKcfkILSANGEAkvfrPRDRDDIVKTViepmASEGLRTICLAfrdfpagepepewd 665
Cdd:cd02078    371 SGV--DLPDGTEI-RKGAVDAIRKY---VRSLGGSI----PEELEAIVEEI----SKQGGTPLVVA-------------- 422
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  666 nENDIVTGltciaVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgEDFLclegkdfnrrirn 745
Cdd:cd02078    423 -EDDRVLG-----VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL------------- 479
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  746 ekgeieqeridkiwpklrvlARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEA 825
Cdd:cd02078    480 --------------------AEAKPEDKLELIR-----KEQAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEA 533
                          650       660
                   ....*....|....*....|.
gi 1488045778  826 SDIILTDDNFTSIVKAVMWGR 846
Cdd:cd02078    534 GNMVDLDSDPTKLIEVVEIGK 554
copA PRK10671
copper-exporting P-type ATPase CopA;
205-842 2.14e-16

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 84.79  E-value: 2.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  205 IPVADITVGDIAQVKYGDLLPADGILIQGnDLKIDESSLTGESDHVKKSldKDPLLLSGTHVMEGSgrMVVTAVGVNSQT 284
Cdd:PRK10671   336 VPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKG--EGDSVHAGTVVQDGS--VLFRASAVGSHT 410
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  285 giiftllgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkkkaNLPKKEKSVLQG 364
Cdd:PRK10671   411 --------------------------------------------------------------------TLSRIIRMVRQA 422
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  365 KLTKlaVQIGKAGLLMSAITVIILVLYFVIDT---FWVQKRPWLaectpiyiqyfVKFFIIGVTVLVVAVPEGLPLAVTI 441
Cdd:PRK10671   423 QSSK--PEIGQLADKISAVFVPVVVVIALVSAaiwYFFGPAPQI-----------VYTLVIATTVLIIACPCALGLATPM 489
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  442 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYInekhYKKVPEPEAIppNILSYLVTGISVN 521
Cdd:PRK10671   490 SIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVVAVKT----FNGVDEAQAL--RLAAALEQGSSHP 563
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  522 CAYTskILppEKEGGLprhvgnktecallgllldlkrdyqdvrneipeeALYKVYTFNSVR-KSMSTVLknsDGSYRIFS 600
Cdd:PRK10671   564 LARA--IL--DKAGDM---------------------------------TLPQVNGFRTLRgLGVSGEA---EGHALLLG 603
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  601 KGAseiilkkcfkILSANGEAKvfrprdrdDIVKTVIEPMASEGLRTICLAfrdfpagepepewdnendiVTGlTCIAVV 680
Cdd:PRK10671   604 NQA----------LLNEQQVDT--------KALEAEITAQASQGATPVLLA-------------------VDG-KAAALL 645
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  681 GIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeriDkiwp 760
Cdd:PRK10671   646 AIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI-------------------------------D---- 690
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  761 klRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVK 840
Cdd:PRK10671   691 --EVIAGVLPDGKAEAIK-----RLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGVAD 762

                   ..
gi 1488045778  841 AV 842
Cdd:PRK10671   763 AL 764
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
682-846 3.13e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 83.82  E-value: 3.13e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  682 IEDPVRPEVPDAIKKCQRAGIT-VRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeriDKIWP 760
Cdd:cd07548    426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  761 KLrvlarsSPTDKHTLVKGIIDSTvsdqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVK 840
Cdd:cd07548    475 EL------LPEDKVEKVEELKAES----KGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                   ....*.
gi 1488045778  841 AVMWGR 846
Cdd:cd07548    545 AIKIAR 550
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
200-884 3.97e-16

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 83.56  E-value: 3.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVkkSLDKDPLLLSGTHVMEGSGRMVVTAVG 279
Cdd:cd02092    135 GSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPV--TVAPGDLVQAGAMNLSGPLRLRATAAG 211
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  280 VNsqtgiifTLLgaggeeeekkdekkkekknkkqdgaienrnkakAQDGAAMEMqplkSEEGgdgdekdkkkanlpkkek 359
Cdd:cd02092    212 DD-------TLL---------------------------------AEIARLMEA----AEQG------------------ 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  360 svlQGKLTKLAvqiGKAGLLMSAITVIILVLYFVIdtfwvqkrpWLAECTPIYiqyfvKFFIIGVTVLVVAVPEGLPLAV 439
Cdd:cd02092    230 ---RSRYVRLA---DRAARLYAPVVHLLALLTFVG---------WVAAGGDWR-----HALLIAVAVLIITCPCALGLAV 289
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  440 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkvpepEAIPPNILSYLvtgis 519
Cdd:cd02092    290 PAVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGA-------------HAISADLLALA----- 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  520 vncaytskilppekeGGLPRHvgnktecallgllldlkrdyqdvrneipeealykvytfnsVRKSMSTVLKNSDGSYRIF 599
Cdd:cd02092    352 ---------------AALAQA----------------------------------------SRHPLSRALAAAAGARPVE 376
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  600 SKGASEIilkkcfkilSANG-EAKVfrprdrddivktviepmaseGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIA 678
Cdd:cd02092    377 LDDAREV---------PGRGvEGRI--------------------DGARVRLGRPAWLGASAGVSTASELALSKGGEEAA 427
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHpgedflclegkdfnrrirnekgeieqeridki 758
Cdd:cd02092    428 RFPFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED-------------------------------- 475
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  759 wpklrVLARSSPTDKHTLVkgiidSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSI 838
Cdd:cd02092    476 -----WRAGLTPAEKVARI-----EELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPV 544
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*.
gi 1488045778  839 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 884
Cdd:cd02092    545 PEAIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
51-120 1.97e-15

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 71.82  E-value: 1.97e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778   51 ESYGDVYGICTKLKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIV 120
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGLT--EAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
679-915 2.55e-15

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 81.08  E-value: 2.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgEDFLclegkdfnrrirnekgeieqeridki 758
Cdd:TIGR01497  440 VIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI-------------------------- 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  759 wpklrvlARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 838
Cdd:TIGR01497  490 -------AEATPEDKIALIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKL 556
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  839 VKAVMWGRNVYDSISKFLQFQLTVNVV---AVIVAFTGACITQ---------DSPLKAV--QMLWVNLIMDTLASLAL-- 902
Cdd:TIGR01497  557 IEVVHIGKQLLITRGALTTFSIANDVAkyfAIIPAIFAAAYPQlqalnimclHSPDSAIlsALIFNALIIPALIPLALkg 636
                          250
                   ....*....|....
gi 1488045778  903 -ATEPPTESLLLRK 915
Cdd:TIGR01497  637 vSYRPLTASALLRR 650
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
677-831 2.86e-15

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 80.81  E-value: 2.86e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  677 IAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkDFNrrirnekgeieqerid 756
Cdd:PRK11033   560 LGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-------------DFR---------------- 610
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1488045778  757 kiwpklrvlARSSPTDKhtlVKGIidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 831
Cdd:PRK11033   611 ---------AGLLPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
528-611 5.49e-15

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 71.48  E-value: 5.49e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  528 ILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTVLKN-SDGSYRIFSKGASEI 606
Cdd:pfam13246    7 AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLpDDGKYRLFVKGAPEI 83

                   ....*
gi 1488045778  607 ILKKC 611
Cdd:pfam13246   84 ILDRC 88
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
409-858 7.29e-15

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 79.76  E-value: 7.29e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  409 TPIYIQYFvKFFIIGVTVLVVAvpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTM 482
Cdd:cd07541    267 GPWYIYLF-RFLILFSSIIPIS------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQ 339
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  483 NRMtvvqayinekHYKKVP-EPEAIPPNILSYlvtgisvncaytsKILppekegglprhvgnktecallgllldlkrdyq 561
Cdd:cd07541    340 NEM----------VFKKLHlGTVSYGGQNLNY-------------EIL-------------------------------- 364
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  562 dvrneipeealyKVYTFNSVRKSMSTVLKN-SDGSYRIFSKGASEIILKkcfkILSANgeakvfrprdrdDIVKTVIEPM 640
Cdd:cd07541    365 ------------QIFPFTSESKRMGIIVREeKTGEITFYMKGADVVMSK----IVQYN------------DWLEEECGNM 416
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  641 ASEGLRTICLAFRDFPAGEPEpEWDNEND-------------------IVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAG 701
Cdd:cd07541    417 AREGLRTLVVAKKKLSEEEYQ-AFEKRYNaaklsihdrdlkvaevvesLERELELLCLTGVEDKLQEDVKPTLELLRNAG 495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  702 ITVRMVTGDNINTARAIATKCGI------LH-------PGEDFLCLegkDFNRRIRNEK------------GEIEQERID 756
Cdd:cd07541    496 IKIWMLTGDKLETATCIAKSSKLvsrgqyIHvfrkvttREEAHLEL---NNLRRKHDCAlvidgeslevclKYYEHEFIE 572
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  757 KIWPKLRVLA-RSSPTDKHTLVKGIIDSTvsdQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTD 832
Cdd:cd07541    573 LACQLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ 645
                          490       500
                   ....*....|....*....|....*..
gi 1488045778  833 dnFTSIVKAVMW-GRNVYDSISKFLQF 858
Cdd:cd07541    646 --FSHIGRLLLWhGRNSYKRSAKLAQF 670
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
200-884 3.50e-12

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 70.62  E-value: 3.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNdLKIDESSLTGESDHVKKslDKDPLLLSGTHVMEGSGRMVVTAVG 279
Cdd:cd07553    136 GSRIKTRADQIKSGDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPRIV--ERGDKVPAGTSLENQAFEIRVEHSL 212
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  280 VNSQTGIIFtllgaggeeeekkdekkkekknkkqdgaienrNKAKAQDGAAMEMQPLKSEEGGdgdekdkkkanlpkkek 359
Cdd:cd07553    213 AESWSGSIL--------------------------------QKVEAQEARKTPRDLLADKIIH----------------- 243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  360 svlqgkltklavqigkagllmsAITVIILVLYFVIDTFWVQkrpwlaectpIYIQYFVKFFIigvTVLVVAVPEGLPLAV 439
Cdd:cd07553    244 ----------------------YFTVIALLIAVAGFGVWLA----------IDLSIALKVFT---SVLIVACPCALALAT 288
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  440 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkvpEPEAIPPNILSYlvtgIS 519
Cdd:cd07553    289 PFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGIDRLALRA----IS 353
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  520 VNCAYTskilppekegglpRHVGNKTecallgllldlkrdyqdVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGS-YRI 598
Cdd:cd07553    354 AIEAHS-------------RHPISRA-----------------IREHLMAKGLIKAGASELVEIVGKGVSGNSSGSlWKL 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  599 FSKgaseiilkkCFKIlsANGEAKVFRPRDRddivktviepmaseglrticlafrdfpagepepewdnendivtglTCIA 678
Cdd:cd07553    404 GSA---------PDAC--GIQESGVVIARDG---------------------------------------------RQLL 427
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGiLHPGEdflclegkdfnrrirnekgeieqeridki 758
Cdd:cd07553    428 DLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLG-LDPRQ----------------------------- 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  759 wpklrVLARSSPTDKHTLVKgiidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 838
Cdd:cd07553    478 -----LFGNLSPEEKLAWIE-------SHSPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGI 544
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*.
gi 1488045778  839 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACitqdSPLKA 884
Cdd:cd07553    545 RDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLALSGWI----SPLVA 586
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 1.14e-10

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 58.75  E-value: 1.14e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1488045778    59 ICTKLKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
667-864 1.19e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 65.88  E-value: 1.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  667 ENDIVTGltciaVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILhpgedflclegkdfnrrirne 746
Cdd:PRK14010   428 EDNEILG-----VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------- 481
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  747 kgeieqeridkiwpklRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 826
Cdd:PRK14010   482 ----------------RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAA 539
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1488045778  827 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 864
Cdd:PRK14010   540 NLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDI 577
PLN03190 PLN03190
aminophospholipid translocase; Provisional
420-718 1.90e-10

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 65.69  E-value: 1.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  420 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTMNRMT 486
Cdd:PLN03190   394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  487 VVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILP---------PEKEGG----------------LPRHV 541
Cdd:PLN03190   471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPqllelsksgKDTEEAkhvhdfflalaacntiVPIVV 550
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  542 GNKTECALLGLlldlkrDYQ------------------------------DVRNEIPEEALYKVYTFNSVRKSMSTVLKN 591
Cdd:PLN03190   551 DDTSDPTVKLM------DYQgespdeqalvyaaaaygfmliertsghiviDIHGERQRFNVLGLHEFDSDRKRMSVILGC 624
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  592 SDGSYRIFSKGASEIIlkkcFKILSANGEAKVFRPrdrddiVKTVIEPMASEGLRTICLAFRDFPAGEPEpEWDNE---- 667
Cdd:PLN03190   625 PDKTVKVFVKGADTSM----FSVIDRSLNMNVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFE-QWHFSfeaa 693
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1488045778  668 ---------------NDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAI 718
Cdd:PLN03190   694 staligraallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
587-809 7.44e-07

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 51.05  E-value: 7.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  587 TVLKNSDGSYRIFSKGASEIILKKcfkilsANGEAKVFRPRDRDDIVKTVIEpmaseGLRTICLAFRDFPAGEPEPEWDN 666
Cdd:pfam00702   11 TLTDGEPVVTEAIAELASEHPLAK------AIVAAAEDLPIPVEDFTARLLL-----GKRDWLEELDILRGLVETLEAEG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  667 ENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFnrrirne 746
Cdd:pfam00702   80 LTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV------- 152
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1488045778  747 kgeieqeridkiwpklrvlARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKAD 809
Cdd:pfam00702  153 -------------------GKPKPEIYLAALE-----RLGVKPEEVLMVGDGVNDIPAAKAAG 191
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
688-834 4.75e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 45.51  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  688 PEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPgedFLCLEG---KDFNRRIRNEKGeIEQERIDKIWPKLR- 763
Cdd:COG0561     22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGaliYDPDGEVLYERP-LDPEDVREILELLRe 97
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  764 ------VLARSSPT---------DK----HTLVK--GIidstvsDQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVA 822
Cdd:COG0561     98 hglhlqVVVRSGPGfleilpkgvSKgsalKKLAErlGI------PPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEV 169
                          170
                   ....*....|..
gi 1488045778  823 KEASDIIlTDDN 834
Cdd:COG0561    170 KAAADYV-TGSN 180
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
743-841 1.53e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.84  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1488045778  743 IRNEKGEIEQ--ERIDKIWPKLRVLARSSP---------TDKHTLVKGIIDSTVSDQRQVVAVtGDGTNDGPALKKADVG 811
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 1488045778  812 FAMGIAgTDVAKEASDIILTDDNFTSIVKA 841
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
787-834 1.74e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 41.49  E-value: 1.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1488045778  787 DQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 834
Cdd:TIGR00099  203 SLEDVIAF-GDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
787-834 8.16e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 8.16e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1488045778  787 DQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 834
Cdd:cd07516    198 SLEEVIAF-GDNENDLSMLEYAGLGVAMGNA-IDEVKEAADYV-TLTN 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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