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Conserved domains on  [gi|1494862059|ref|NP_001353770|]
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leucine-rich repeat-containing protein 7 isoform 9 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12156045)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-418 3.80e-48

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 178.20  E-value: 3.80e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFgelpevLDQIQNLRELWMDN 221
Cdd:COG4886     49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  222 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Cdd:COG4886    123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  302 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQKLRVLNLS 381
Cdd:COG4886    203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1494862059  382 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 418
Cdd:COG4886    281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
PDZ_canonical super family cl49608
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
 1405-1436 1.40e-16

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


The actual alignment was detected with superfamily member cd06749:

Pssm-ID: 483948 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.40e-16
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1494862059 1405 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1436
Cdd:cd06749      1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
26-247 1.05e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   26 EEIIS-VLDYSHcsLQQVPKevfNFERTLEELYLDANQIEELPKQLFNCQALRKLSIpdNDLSNLPTTIASLvnLKELDI 104
Cdd:PRK15370   199 EQITTlILDNNE--LKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDL 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  105 SKNGVQEFPENIKccKCLTIIEASVNPISKLPDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKS 184
Cdd:PRK15370   270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494862059  185 MHklAQLERLDLGNNEFGELPEVLDqiQNLRELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 247
Cdd:PRK15370   344 LP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-418 3.80e-48

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 178.20  E-value: 3.80e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFgelpevLDQIQNLRELWMDN 221
Cdd:COG4886     49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  222 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Cdd:COG4886    123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  302 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQKLRVLNLS 381
Cdd:COG4886    203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1494862059  382 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 418
Cdd:COG4886    281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-413 6.33e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.10  E-value: 6.33e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   41 QVPKEVFNFeRTLEELYLDANQIE-ELPKQLFNCQALRKL---------SIPDN--DLSNL--------------PTTIA 94
Cdd:PLN00113   203 QIPRELGQM-KSLKWIYLGYNNLSgEIPYEIGGLTSLNHLdlvynnltgPIPSSlgNLKNLqylflyqnklsgpiPPSIF 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   95 SLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPDGFTQL--LNLTQLYLNDaFLEFLPANFGRLVKLRI 170
Cdd:PLN00113   282 SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLprLQVLQLWSNK-FSGEIPKNLGKHNNLTV 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  171 LELRENHLK-TLPKSMHKLAQLERLDLGNNEF-GELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKN-- 245
Cdd:PLN00113   361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNnl 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  246 --RIETVDMDISGCEALEdlLLSSNMLQQLPDSIGLlKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESlpst 322
Cdd:PLN00113   441 qgRINSRKWDMPSLQMLS--LARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSG---- 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  323 igylhslrtlavdenflpELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAA 400
Cdd:PLN00113   514 ------------------EIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575

                          410
                   ....*....|...
gi 1494862059  401 LWLSDNQSKALIP 413
Cdd:PLN00113   576 VNISHNHLHGSLP 588
PDZ_densin_erbin-like cd06749
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
 1405-1436 1.40e-16

PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467231 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.40e-16
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1494862059 1405 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1436
Cdd:cd06749      1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-247 1.05e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   26 EEIIS-VLDYSHcsLQQVPKevfNFERTLEELYLDANQIEELPKQLFNCQALRKLSIpdNDLSNLPTTIASLvnLKELDI 104
Cdd:PRK15370   199 EQITTlILDNNE--LKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDL 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  105 SKNGVQEFPENIKccKCLTIIEASVNPISKLPDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKS 184
Cdd:PRK15370   270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494862059  185 MHklAQLERLDLGNNEFGELPEVLDqiQNLRELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 247
Cdd:PRK15370   344 LP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-310 3.19e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 3.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  114 ENIKCCKCLTIIEASVNPISKLPdGFTQLLNLTQLYLNDAFLEFLPaNFGRLVKLrilelrenhlktlpksmhklaqlER 193
Cdd:cd21340     18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNL-----------------------KK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  194 LDLGNNEFGELpEVLDQIQNLRELWMDNNALQ------VLPGSIGKLKM-LVYLDMSKNRIETVDmDISGCEALEDLLLS 266
Cdd:cd21340     73 LYLGGNRISVV-EGLENLTNLEELHIENQRLPpgekltFDPRSLAALSNsLRVLNISGNNIDSLE-PLAPLRNLEQLDAS 150

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1494862059  267 SNMLQQLPDSIGLLKK---LTTLKVDDNQLTMLP----NTIGNLSLLEEFD 310
Cdd:cd21340    151 NNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-218 1.81e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 1.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   56 LYLDANQIEELPKqLFNCQALRKLSIPDNDLSNLPTtIASLVNLKELDISKNGVQEFpENIKCCKCLTIIEASVNPISKL 135
Cdd:cd21340      7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  136 pDGFTQLLNLTQLYL------NDAFLEFLPANFGRLVK-LRILELRENHLKTLpKSMHKLAQLERLDLGNNEFGELPEVL 208
Cdd:cd21340     84 -EGLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170
                   ....*....|
gi 1494862059  209 DQIQNLRELW 218
Cdd:cd21340    162 DLLSSWPSLR 171
LRR_8 pfam13855
Leucine rich repeat;
144-201 5.32e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 5.32e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  144 NLTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEF 201
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
51-107 1.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059   51 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 107
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-418 3.80e-48

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 178.20  E-value: 3.80e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFgelpevLDQIQNLRELWMDN 221
Cdd:COG4886     49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  222 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Cdd:COG4886    123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  302 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQKLRVLNLS 381
Cdd:COG4886    203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1494862059  382 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 418
Cdd:COG4886    281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-402 9.55e-46

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 170.88  E-value: 9.55e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   48 NFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNgvqefpENIKCCKCLTIIEA 127
Cdd:COG4886     47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  128 SVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEV 207
Cdd:COG4886    121 SGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  208 LDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDmDISGCEALEDLLLSSNMLQQLPDSIGlLKKLTTLK 287
Cdd:COG4886    201 LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLD 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  288 VDDNQLTMLP----NTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE 363
Cdd:COG4886    279 LSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1494862059  364 FLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALW 402
Cdd:COG4886    359 LSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-407 1.35e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 164.72  E-value: 1.35e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  135 LPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNL 214
Cdd:COG4886      1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  215 relwmDNNALQVLPGSIGKLKMLVYLDMSKNRietvdmDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLT 294
Cdd:COG4886     81 -----LLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  295 MLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQK 374
Cdd:COG4886    150 DLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTN 229

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1494862059  375 LRVLNLSDNRLKNLPfSFTKLKELAALWLSDNQ 407
Cdd:COG4886    230 LETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQ 261
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-342 1.66e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 161.64  E-value: 1.66e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   53 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 132
Cdd:COG4886    115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  133 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPkSMHKLAQLERLDLGNNEFGELPEvLDQIQ 212
Cdd:COG4886    195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLT 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  213 NLRELWMDNNALQVLP----GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 288
Cdd:COG4886    273 NLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1494862059  289 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPEL 342
Cdd:COG4886    353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-413 6.33e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.10  E-value: 6.33e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   41 QVPKEVFNFeRTLEELYLDANQIE-ELPKQLFNCQALRKL---------SIPDN--DLSNL--------------PTTIA 94
Cdd:PLN00113   203 QIPRELGQM-KSLKWIYLGYNNLSgEIPYEIGGLTSLNHLdlvynnltgPIPSSlgNLKNLqylflyqnklsgpiPPSIF 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   95 SLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPDGFTQL--LNLTQLYLNDaFLEFLPANFGRLVKLRI 170
Cdd:PLN00113   282 SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLprLQVLQLWSNK-FSGEIPKNLGKHNNLTV 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  171 LELRENHLK-TLPKSMHKLAQLERLDLGNNEF-GELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKN-- 245
Cdd:PLN00113   361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNnl 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  246 --RIETVDMDISGCEALEdlLLSSNMLQQLPDSIGLlKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESlpst 322
Cdd:PLN00113   441 qgRINSRKWDMPSLQMLS--LARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSG---- 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  323 igylhslrtlavdenflpELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAA 400
Cdd:PLN00113   514 ------------------EIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575

                          410
                   ....*....|...
gi 1494862059  401 LWLSDNQSKALIP 413
Cdd:PLN00113   576 VNISHNHLHGSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-414 5.10e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.39  E-value: 5.10e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   53 LEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLS-NLPTTIASLVNLKELDISKNG-VQEFPENIKCCKCLTIIEASV 129
Cdd:PLN00113   142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGY 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  130 NPIS-KLPDGFTQLLNLTQLYL--NDAFLEfLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEF-GEL 204
Cdd:PLN00113   222 NNLSgEIPYEIGGLTSLNHLDLvyNNLTGP-IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLsGEI 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  205 PEVLDQIQNLRELWMDNN--------------ALQVL-----------PGSIGKLKMLVYLDMSKNRIeTVDMDISGCEA 259
Cdd:PLN00113   301 PELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLGKHNNLTVLDLSTNNL-TGEIPEGLCSS 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  260 --LEDLLLSSNMLQ-QLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESLPSTIGY-LHSLRTLAV 334
Cdd:PLN00113   380 gnLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQGRINSRKWdMPSLQMLSL 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  335 DEN-FLPELPREIGScKNVTVMSLRSNKL-EFLPEEIGQMQKLRVLNLSDNRLKN-LPFSFTKLKELAALWLSDNQSKAL 411
Cdd:PLN00113   460 ARNkFFGGLPDSFGS-KRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQ 538


                   ...
gi 1494862059  412 IPL 414
Cdd:PLN00113   539 IPA 541
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
56-300 6.08e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 89.76  E-value: 6.08e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   56 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 134
Cdd:PRK15370   204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  135 LPDGftqllnltqlylndaflefLPAnfgrlvKLRILELRENHLKTLPKsmHKLAQLERLDLGNNEFGELPEVLDqiQNL 214
Cdd:PRK15370   277 LPEN-------------------LPE------ELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLP--PGL 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  215 RELWMDNNALQVLPGSIGklKMLVYLDMSKNRIETVDMDISgcEALEDLLLSSNMLQQLPDSigLLKKLTTLKVDDNQLT 294
Cdd:PRK15370   328 KTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPEN--LPAALQIMQASRNNLV 401


                   ....*.
gi 1494862059  295 MLPNTI 300
Cdd:PRK15370   402 RLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-413 6.55e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.29  E-value: 6.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   99 LKELDISKNGVQ-EFPENI-KCCKCLTIIEASVNPIS-KLPDGFTQLLNLTQLYlNDAFLEFLPANFGRLVKLRILELRE 175
Cdd:PLN00113    95 IQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS-NNMLSGEIPNDIGSFSSLKVLDLGG 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  176 NHLK-TLPKSMHKLAQLERLDLGNNEF-GELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKNrietvdm 252
Cdd:PLN00113   174 NVLVgKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYN------- 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  253 disgcealedlllssNMLQQLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELE-SLPSTIGYLHSLR 330
Cdd:PLN00113   247 ---------------NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLE 311

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  331 TLAV-DENFLPELPREIGSCKNVTVMSLRSNKLEF-LPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQ 407
Cdd:PLN00113   312 ILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNS 391


                   ....*.
gi 1494862059  408 SKALIP 413
Cdd:PLN00113   392 LEGEIP 397
PDZ_densin_erbin-like cd06749
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
 1405-1436 1.40e-16

PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467231 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.40e-16
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1494862059 1405 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1436
Cdd:cd06749      1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-247 1.05e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   26 EEIIS-VLDYSHcsLQQVPKevfNFERTLEELYLDANQIEELPKQLFNCQALRKLSIpdNDLSNLPTTIASLvnLKELDI 104
Cdd:PRK15370   199 EQITTlILDNNE--LKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDL 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  105 SKNGVQEFPENIKccKCLTIIEASVNPISKLPDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKS 184
Cdd:PRK15370   270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494862059  185 MHklAQLERLDLGNNEFGELPEVLDqiQNLRELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 247
Cdd:PRK15370   344 LP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-310 3.19e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 3.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  114 ENIKCCKCLTIIEASVNPISKLPdGFTQLLNLTQLYLNDAFLEFLPaNFGRLVKLrilelrenhlktlpksmhklaqlER 193
Cdd:cd21340     18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNL-----------------------KK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  194 LDLGNNEFGELpEVLDQIQNLRELWMDNNALQ------VLPGSIGKLKM-LVYLDMSKNRIETVDmDISGCEALEDLLLS 266
Cdd:cd21340     73 LYLGGNRISVV-EGLENLTNLEELHIENQRLPpgekltFDPRSLAALSNsLRVLNISGNNIDSLE-PLAPLRNLEQLDAS 150

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1494862059  267 SNMLQQLPDSIGLLKK---LTTLKVDDNQLTMLP----NTIGNLSLLEEFD 310
Cdd:cd21340    151 NNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-332 7.65e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 7.65e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  142 LLNLTQLYLNDAFLEFLPaNFGRLVKLRILELRENHLKTLPKsmhklaqlerldlgnnefgelpevLDQIQNLRELWMDN 221
Cdd:cd21340      1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN------------------------LEFLTNLTHLYLQN 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  222 NALQVLPGsIGKLKMLVYLDMSKNRIETVDmDISGCEALEDLLLSSnmlQQL---------PDSI-GLLKKLTTLKVDDN 291
Cdd:cd21340     56 NQIEKIEN-LENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIEN---QRLppgekltfdPRSLaALSNSLRVLNISGN 130

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1494862059  292 QLTMLpNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTL 332
Cdd:cd21340    131 NIDSL-EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSL 170
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-218 1.81e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 1.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   56 LYLDANQIEELPKqLFNCQALRKLSIPDNDLSNLPTtIASLVNLKELDISKNGVQEFpENIKCCKCLTIIEASVNPISKL 135
Cdd:cd21340      7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  136 pDGFTQLLNLTQLYL------NDAFLEFLPANFGRLVK-LRILELRENHLKTLpKSMHKLAQLERLDLGNNEFGELPEVL 208
Cdd:cd21340     84 -EGLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170
                   ....*....|
gi 1494862059  209 DQIQNLRELW 218
Cdd:cd21340    162 DLLSSWPSLR 171
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
212-424 7.09e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.58  E-value: 7.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  212 QNLRELWMDNNALQVLPGSIGKLKMLVYLDmsKNRIETVDMDISGceALEDLLLSSNMLQQLPDSigLLKKLTTLKVDDN 291
Cdd:PRK15370   178 NNKTELRLKILGLTTIPACIPEQITTLILD--NNELKSLPENLQG--NIKTLYANSNQLTSIPAT--LPDTIQEMELSIN 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  292 QLTMLPNTIGnlSLLEEFDCSCNELESLPSTIGylHSLRTLAVDENFLPELPREIGSckNVTVMSLRSNKLEFLPEEIGq 371
Cdd:PRK15370   252 RITELPERLP--SALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP- 324

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1494862059  372 mQKLRVLNLSDNRLKNLPFSFTklKELAALWLSDNQskalIPLQTEAHPETKQ 424
Cdd:PRK15370   325 -PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQ----ITVLPETLPPTIT 370
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
79-304 1.34e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 69.42  E-value: 1.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   79 LSIPDNDLSNLPttiASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL--------------N 144
Cdd:PRK15387   227 LVIPDNNLTSLP---ALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWifgnqltslpvlppG 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  145 LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSmhklaqLERLDLGNNEFGELPEVLDQiqnLRELWMDNNAL 224
Cdd:PRK15387   304 LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLPTLPSE---LYKLWAYNNRL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  225 QVLPGSIGKLKMLVyldMSKNRIETVDMDISgceALEDLLLSSNMLQQLPdsiGLLKKLTTLKVDDNQLTMLPNTIGNLS 304
Cdd:PRK15387   375 TSLPALPSGLKELI---VSGNRLTSLPVLPS---ELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLS 445
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 166-406 1.22e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.60  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  166 VKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEvldqiqnlrelwmdnnALQVLPGSIGKLKMLVYLDMSKN 245
Cdd:cd00116     28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPR----------------GLQSLLQGLTKGCGLQELDLSDN 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  246 RIEtvdmdISGCEALEDLLLSSNmLQQLpdsigllkKLTTLKVDDNQLTMLPNTIGNLSL-LEEFDCSCNEL-----ESL 319
Cdd:cd00116     92 ALG-----PDGCGVLESLLRSSS-LQEL--------KLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLegascEAL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  320 PSTIGYLHSLRTLAVDENFL-----PELPREIGSCKNVTVMSLRSNKLE-----FLPEEIGQMQKLRVLNLSDNRLKNLP 389
Cdd:cd00116    158 AKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAG 237

                          250       260
                   ....*....|....*....|...
gi 1494862059  390 FS------FTKLKELAALWLSDN 406
Cdd:cd00116    238 AAalasalLSPNISLLTLSLSCN 260
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 32-300 1.03e-08

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 60.27  E-value: 1.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   32 LDYSHCS-LQQVPKEVFNFERtLEELYLD-ANQIEELPKQLfNCQALRKLSIpdNDLSNLPTTIASLVNLKELDISKNGV 109
Cdd:PLN03210   662 LKLSDCSsLVELPSSIQYLNK-LEDLDMSrCENLEILPTGI-NLKSLYRLNL--SGCSRLKSFPDISTNISWLDLDETAI 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  110 QEFPENIKCCKCLTII--EASVNPISKLPDGFTQLL-----NLTQLYLND--AFLEfLPANFGRLVKLRILELRE-NHLK 179
Cdd:PLN03210   738 EEFPSNLRLENLDELIlcEMKSEKLWERVQPLTPLMtmlspSLTRLFLSDipSLVE-LPSSIQNLHKLEHLEIENcINLE 816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  180 TLPKSMHkLAQLERLDL-GNNEFGELPEVldqIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK-NRIETVDMDISGC 257
Cdd:PLN03210   817 TLPTGIN-LESLESLDLsGCSRLRTFPDI---STNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKL 892

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1494862059  258 EALEDLLLSSnmLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 300
Cdd:PLN03210   893 KHLETVDFSD--CGALTEASWNGSPSEVAMATDNIHSKLPSTV 933
LRR_8 pfam13855
Leucine rich repeat;
144-201 5.32e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 5.32e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  144 NLTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEF 201
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
132-406 1.60e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  132 ISKLPDGFTQllNLTQLYLNDAFLEFLPAnfgRLVKLRILELRENHLKTLPKSMHKLAQLErldLGNNEFGELPEVldqI 211
Cdd:PRK15387   213 LTTLPDCLPA--HITTLVIPDNNLTSLPA---LPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLPAL---P 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  212 QNLRELWMDNNALQVLPGSIGKLKMLvylDMSKNRIETVDMDISgceALEDLLLSSNMLQQLPDsigLLKKLTTLKVDDN 291
Cdd:PRK15387   282 SGLCKLWIFGNQLTSLPVLPPGLQEL---SVSDNQLASLPALPS---ELCKLWAYNNQLTSLPT---LPSGLQELSVSDN 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  292 QLTMLPNTIGNLSLLEEFDCSCNELESLPStigylhSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPeeigq 371
Cdd:PRK15387   353 QLASLPTLPSELYKLWAYNNRLTSLPALPS------GLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLP----- 421

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1494862059  372 mQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 406
Cdd:PRK15387   422 -SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGN 455
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 29-217 2.00e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 2.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   29 ISVLDYSHCSLQQVPKEVF-NFER--TLEELYLDANQIEELP-----KQLFNCQ-ALRKLSIPDNDLSNLPTTIASLV-- 97
Cdd:cd00116     83 LQELDLSDNALGPDGCGVLeSLLRssSLQELKLNNNGLGDRGlrllaKGLKDLPpALEKLVLGRNRLEGASCEALAKAlr 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   98 ---NLKELDISKNGVQEFpenikcckcltiieasvnPISKLPDGFTQLLNLTQLYLNDAFLE-----FLPANFGRLVKLR 169
Cdd:cd00116    163 anrDLKELNLANNGIGDA------------------GIRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLE 224

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059  170 ILELRENHLK-----TLPKSMHKLAQ-LERLDLGNNEFGE-----LPEVLDQIQNLREL 217
Cdd:cd00116    225 VLNLGDNNLTdagaaALASALLSPNIsLLTLSLSCNDITDdgakdLAEVLAEKESLLEL 283
PLN03150 PLN03150
hypothetical protein; Provisional
 272-347 2.00e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 2.00e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059  272 QLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELE-SLPSTIGYLHSLRTLAVDENFLP-ELPREIG 347
Cdd:PLN03150   433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-143 2.16e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 2.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   53 LEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKCCkcLTIIEASVNPI 132
Cdd:PRK15370   327 LKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPAA--LQIMQASRNNL 400

                           90
                   ....*....|.
gi 1494862059  133 SKLPDGFTQLL 143
Cdd:PRK15370   401 VRLPESLPHFR 411
PLN03150 PLN03150
hypothetical protein; Provisional
 319-385 2.41e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.13  E-value: 2.41e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059  319 LPSTIGYLHSLRTLAVDENFLP-ELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQKLRVLNLSDNRL 385
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 140-386 3.28e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 3.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  140 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH-------KLAQLERLDLGNNEFGELP----EVL 208
Cdd:cd00116     25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQsllqgltKGCGLQELDLSDNALGPDGcgvlESL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  209 DQIQNLRELWMDNNALQVLPG--SIGKLKM----LVYLDMSKNRIETvdmdiSGCEALEDLLLSsnmlqqlpdsiglLKK 282
Cdd:cd00116    105 LRSSSLQELKLNNNGLGDRGLrlLAKGLKDlppaLEKLVLGRNRLEG-----ASCEALAKALRA-------------NRD 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  283 LTTLKVDDNQLtmlpNTIGNLSLLEEFDCSCNeleslpstigylhsLRTLAVDENFLpelpREIG---------SCKNVT 353
Cdd:cd00116    167 LKELNLANNGI----GDAGIRALAEGLKANCN--------------LEVLDLNNNGL----TDEGasalaetlaSLKSLE 224

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1494862059  354 VMSLRSNKL------EFLPEEIGQMQKLRVLNLSDNRLK 386
Cdd:cd00116    225 VLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
212-270 3.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.71e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1494862059  212 QNLRELWMDNNALQVL-PGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEALEDLLLSSNML 270
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
351-407 5.55e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 5.55e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059  351 NVTVMSLRSNKLEFLPEEI-GQMQKLRVLNLSDNRLKNL-PFSFTKLKELAALWLSDNQ 407
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
237-293 4.36e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 4.36e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059  237 LVYLDMSKNRIETVDMDI-SGCEALEDLLLSSNMLQQL-PDSIGLLKKLTTLKVDDNQL 293
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
328-385 4.45e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 4.45e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  328 SLRTLAVDENFLPELPREI-GSCKNVTVMSLRSNKLEFL-PEEIGQMQKLRVLNLSDNRL 385
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
51-107 1.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494862059   51 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 107
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 303-413 1.26e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  303 LSLLEEFDCSCNELE-SLPSTIGYL-HSLRTLAV-DENFLPELPReiGSCKNVTVMSLRSNKLEF-LPEEIGQMQKLRVL 378
Cdd:PLN00113    92 LPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLsNNNFTGSIPR--GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVL 169

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1494862059  379 NLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 413
Cdd:PLN00113   170 DLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGQIP 205
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-294 3.50e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 3.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059   35 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFnCQALRKlsipdndlsnlPTTIASLVnLKELDISKNGVQEFPE 114
Cdd:COG5238    164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEEL-AEALTQ-----------NTTVTTLW-LKRNPIGDEGAEILAE 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  115 NIKCCKCLTIIEASVNPISKlpDGFTQLL-------NLTQLYLNdafleflpanfGRlvklrilELRENHLKTLPKSMHK 187
Cdd:COG5238    231 ALKGNKSLTTLDLSNNQIGD--EGVIALAealknntTVETLYLS-----------GN-------QIGAEGAIALAKALQG 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  188 LAQLERLDLGNNEFGE-----LPEVLDQIQNLRELWMDNNALQV-----LPGSIGKLKMLVYLDMSKNRIETVDMD---- 253
Cdd:COG5238    291 NTTLTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQIGDEGAIalak 370

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1494862059  254 -ISGCEALEDLLLSSNML-----QQLPDSIgLLKKLTTLKVDDNQLT 294
Cdd:COG5238    371 yLEGNTTLRELNLGKNNIgkqgaEALIDAL-QTNRLHTLILDGNLIG 416
PLN03150 PLN03150
hypothetical protein; Provisional
 364-413 1.03e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 1.03e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1494862059  364 FLPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 413
Cdd:PLN03150   433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIP 483
PDZ4_Scribble-like cd06701
PDZ domain 4 of Drosophila Scribble, human Scribble homolog, and related domains; PDZ (PSD-95 ...
 1407-1436 1.43e-03

PDZ domain 4 of Drosophila Scribble, human Scribble homolog, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 4 of Drosophila Scribble (also known as LAP4), human Scribble homolog (also known as hScrib, LAP4, CriB1, ScrB1 and Vartul), and related domains. They belong to the LAP family, which describes proteins that contain either one or four PDZ domains and 16 LRRs (leucine-rich repeats) and function in controlling cell shape, size and subcellular protein localization. In Drosophila, the Scribble complex, comprising Scribble, discs large, and lethal giant larvae, plays a role in apico-basal cell polarity, in other forms of polarity, including regulation of the actin cytoskeleton, cell signaling and vesicular trafficking, and in tumor development. Mammalian Scribble is important in many aspects of cancer development. Scribble and its homologs can be downregulated or overexpressed in cancer; they have a role in cancer beyond their function in loss of cell polarity. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This Scribble-like family PDZ4 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467185 [Multi-domain]  Cd Length: 98  Bit Score: 39.52  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1494862059 1407 VRIEKNPG--LGFSISGGISGQ-GNPFKPSDKG 1436
Cdd:cd06701      7 LTIVKEPGekLGISIRGGAKGHaGNPLDPTDEG 39
PLN03150 PLN03150
hypothetical protein; Provisional
 135-208 1.78e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1494862059  135 LPDGFTQLLNLTQLYLNDAFLE-FLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDL-GNNEFGELPEVL 208
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLnGNSLSGRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 373-406 1.83e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1494862059  373 QKLRVLNLSDNRLKNLPFsFTKLKELAALWLSDN 406
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 166-398 5.53e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 5.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  166 VKLRILELRENHL-KTLPKSMHKLAQL----ERLDLGNNEFGELPEVLDQI-QNLRELWMDNNALQVLPGSIgKLKMLVY 239
Cdd:PLN03210   537 ITLDIDEIDELHIhENAFKGMRNLLFLkfytKKWDQKKEVRWHLPEGFDYLpPKLRLLRWDKYPLRCMPSNF-RPENLVK 615

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  240 LDMSKNRIETVDMDISGCEALEDL-LLSSNMLQQLPDsigllkklttlkvddnqLTMLPNtignlslLEEFD-CSCNELE 317
Cdd:PLN03210   616 LQMQGSKLEKLWDGVHSLTGLRNIdLRGSKNLKEIPD-----------------LSMATN-------LETLKlSDCSSLV 671

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494862059  318 SLPSTIGYLHSLRTLavdenflpelprEIGSCKNvtvmslrsnkLEFLPEEIgQMQKLRVLNLSD-NRLKNLPFSFTKLK 396
Cdd:PLN03210   672 ELPSSIQYLNKLEDL------------DMSRCEN----------LEILPTGI-NLKSLYRLNLSGcSRLKSFPDISTNIS 728


                   ..
gi 1494862059  397 EL 398
Cdd:PLN03210   729 WL 730
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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