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Conserved domains on  [gi|1496160299|ref|NP_001353831|]
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t-SNARE domain-containing protein 1 isoform e [Homo sapiens]

Protein Classification

Myb_DNA-bind_5 and Syntaxin_2 domain-containing protein( domain architecture ID 10620649)

Myb_DNA-bind_5 and Syntaxin_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Syntaxin_2 pfam14523
Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p ...
 265-366 8.52e-29

Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p protein.


:

Pssm-ID: 464199  Cd Length: 101  Bit Score: 108.90  E-value: 8.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299 265 SANVFRINSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPqerlQQERPQLDRLKT 344
Cdd:pfam14523   2 SSNLFKINSNVSTLEKLVKQLGTKRDTQELRDKLHKLIEKTNELIKETSELLKKLSSLENLSSD----SQQKLQKEKLSR 77

                          90       100
                  ....*....|....*....|..
gi 1496160299 345 QLSDAIQCYGVVQKKIAEKSRA 366
Cdd:pfam14523  78 DFKEALQEFQKLQRQYAEKEKA 99
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 124-201 3.60e-26

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


:

Pssm-ID: 433544  Cd Length: 78  Bit Score: 101.20  E-value: 3.60e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1496160299 124 RKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGD 201
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLAK 78
 
Name Accession Description Interval E-value
Syntaxin_2 pfam14523
Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p ...
 265-366 8.52e-29

Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p protein.


Pssm-ID: 464199  Cd Length: 101  Bit Score: 108.90  E-value: 8.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299 265 SANVFRINSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPqerlQQERPQLDRLKT 344
Cdd:pfam14523   2 SSNLFKINSNVSTLEKLVKQLGTKRDTQELRDKLHKLIEKTNELIKETSELLKKLSSLENLSSD----SQQKLQKEKLSR 77

                          90       100
                  ....*....|....*....|..
gi 1496160299 345 QLSDAIQCYGVVQKKIAEKSRA 366
Cdd:pfam14523  78 DFKEALQEFQKLQRQYAEKEKA 99
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 124-201 3.60e-26

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 101.20  E-value: 3.60e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1496160299 124 RKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGD 201
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLAK 78
SynN smart00503
Syntaxin N-terminal domain; Three-helix domain that (in Sso1p) slows the rate of its reaction ...
 258-365 9.28e-09

Syntaxin N-terminal domain; Three-helix domain that (in Sso1p) slows the rate of its reaction with the SNAP-25 homologue Sec9p


Pssm-ID: 214699 [Multi-domain]  Cd Length: 117  Bit Score: 53.12  E-value: 9.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299  258 QELFQEMSANVFRINSSVTSLERSLQSLGTPSDT-QELRDSLHTAQQETNKTIAASASSVKQMAELL----RSSCPQERL 332
Cdd:smart00503   7 FEKVEEIRANIQKISQNVAELQKLHEELLTPPDAdKELREKLERLIDDIKRLAKEIRAKLKELEKENlenrASGSASDRT 86

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1496160299  333 QQErpQLDRLKTQLSDAIQCYGVVQKKIAEKSR 365
Cdd:smart00503  87 RKA--QTEKLRKKFKEVMNEFQRLQRKYREREK 117
SynN cd00179
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the ...
 257-365 5.12e-08

Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may be identified by a specific member of the syntaxin family; syntaxins contain a moderately well conserved amino-terminal domain, called Habc, whose structure is an antiparallel three-helix bundle; a linker of about 30 amino acids connects this to the carboxy-terminal region, designated H3 (t_SNARE), of the syntaxin cytoplasmic domain; the highly conserved H3 region forms a single, long alpha-helix when it is part of the core SNARE complex and anchors the protein on the cytoplasmic surface of cellular membranes; H3 is not included in defining this domain


Pssm-ID: 238105 [Multi-domain]  Cd Length: 151  Bit Score: 51.90  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299 257 LQELFQEMSANVFRINSSVTSLERSLQSLGTPSD-TQELRDSLHTAQQETNKTiaasASSVKQMAELLRSSCPQER---- 331
Cdd:cd00179     4 FFEEVEEIRGNIDKISEDVEELQKLHSQLLTAPDaDPELKQELESLVQEIKKL----AKEIKGKLKELEESNEQNEalng 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1496160299 332 ---LQQERPQLDRLKTQLSDAIQCYGVVQKKIAEKSR 365
Cdd:cd00179    80 ssvDRIRKTQHSGLSKKFVEVMTEFNKAQRKYRERYK 116
 
Name Accession Description Interval E-value
Syntaxin_2 pfam14523
Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p ...
 265-366 8.52e-29

Syntaxin-like protein; This domain includes syntaxin-like domains including from the Vam3p protein.


Pssm-ID: 464199  Cd Length: 101  Bit Score: 108.90  E-value: 8.52e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299 265 SANVFRINSSVTSLERSLQSLGTPSDTQELRDSLHTAQQETNKTIAASASSVKQMAELLRSSCPqerlQQERPQLDRLKT 344
Cdd:pfam14523   2 SSNLFKINSNVSTLEKLVKQLGTKRDTQELRDKLHKLIEKTNELIKETSELLKKLSSLENLSSD----SQQKLQKEKLSR 77

                          90       100
                  ....*....|....*....|..
gi 1496160299 345 QLSDAIQCYGVVQKKIAEKSRA 366
Cdd:pfam14523  78 DFKEALQEFQKLQRQYAEKEKA 99
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 124-201 3.60e-26

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 101.20  E-value: 3.60e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1496160299 124 RKPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEPTRRYRVWSRILQAVNALGYCRRDVVDLKHKWRDLRAVVRRKLGD 201
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLAK 78
SynN smart00503
Syntaxin N-terminal domain; Three-helix domain that (in Sso1p) slows the rate of its reaction ...
 258-365 9.28e-09

Syntaxin N-terminal domain; Three-helix domain that (in Sso1p) slows the rate of its reaction with the SNAP-25 homologue Sec9p


Pssm-ID: 214699 [Multi-domain]  Cd Length: 117  Bit Score: 53.12  E-value: 9.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299  258 QELFQEMSANVFRINSSVTSLERSLQSLGTPSDT-QELRDSLHTAQQETNKTIAASASSVKQMAELL----RSSCPQERL 332
Cdd:smart00503   7 FEKVEEIRANIQKISQNVAELQKLHEELLTPPDAdKELREKLERLIDDIKRLAKEIRAKLKELEKENlenrASGSASDRT 86

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1496160299  333 QQErpQLDRLKTQLSDAIQCYGVVQKKIAEKSR 365
Cdd:smart00503  87 RKA--QTEKLRKKFKEVMNEFQRLQRKYREREK 117
SynN cd00179
Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the ...
 257-365 5.12e-08

Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may be identified by a specific member of the syntaxin family; syntaxins contain a moderately well conserved amino-terminal domain, called Habc, whose structure is an antiparallel three-helix bundle; a linker of about 30 amino acids connects this to the carboxy-terminal region, designated H3 (t_SNARE), of the syntaxin cytoplasmic domain; the highly conserved H3 region forms a single, long alpha-helix when it is part of the core SNARE complex and anchors the protein on the cytoplasmic surface of cellular membranes; H3 is not included in defining this domain


Pssm-ID: 238105 [Multi-domain]  Cd Length: 151  Bit Score: 51.90  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1496160299 257 LQELFQEMSANVFRINSSVTSLERSLQSLGTPSD-TQELRDSLHTAQQETNKTiaasASSVKQMAELLRSSCPQER---- 331
Cdd:cd00179     4 FFEEVEEIRGNIDKISEDVEELQKLHSQLLTAPDaDPELKQELESLVQEIKKL----AKEIKGKLKELEESNEQNEalng 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1496160299 332 ---LQQERPQLDRLKTQLSDAIQCYGVVQKKIAEKSR 365
Cdd:cd00179    80 ssvDRIRKTQHSGLSKKFVEVMTEFNKAQRKYRERYK 116
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 125-193 3.77e-05

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 41.87  E-value: 3.77e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1496160299 125 KPNFCPQETEVLVSKVSKHHQLLFGTGLLKAEptrryRVWSRILQAVNALGYcRRDVVDLKHKWRDLRA 193
Cdd:pfam13837   1 RNKWTEEETLALIEIWGERLELRFQESKKRNK-----KLWEEIAEKMAELGY-NRSPEQCKEKWENLKK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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