NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1512432669|ref|NP_001354175|]
View 

X-linked retinitis pigmentosa GTPase regulator isoform E [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-341 3.59e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 220.23  E-value: 3.59e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184    51 VAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 118 QLGLGDTEERNTFHVISffTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISC 197
Cdd:COG5184   129 QLGDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 198 GYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEiPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGL 276
Cdd:COG5184   207 GGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQVAG-LTGVVAIAAGGSHTCALKSDgTVWCWGDNSYGQLGD 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1512432669 277 GTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 341
Cdd:COG5184   284 GTTTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-341 3.59e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 220.23  E-value: 3.59e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184    51 VAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 118 QLGLGDTEERNTFHVISffTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISC 197
Cdd:COG5184   129 QLGDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 198 GYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEiPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGL 276
Cdd:COG5184   207 GGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQVAG-LTGVVAIAAGGSHTCALKSDgTVWCWGDNSYGQLGD 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1512432669 277 GTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 341
Cdd:COG5184   284 GTTTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
158-205 5.76e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 5.76e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432669 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 205
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-341 3.59e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 220.23  E-value: 3.59e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184    51 VAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 118 QLGLGDTEERNTFHVISffTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISC 197
Cdd:COG5184   129 QLGDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 198 GYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEiPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGL 276
Cdd:COG5184   207 GGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQVAG-LTGVVAIAAGGSHTCALKSDgTVWCWGDNSYGQLGD 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1512432669 277 GTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 341
Cdd:COG5184   284 GTTTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-341 6.07e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 219.46  E-value: 6.07e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 118 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 196
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 275
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1512432669 276 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 341
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPV 293
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-129 3.90e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 89.65  E-value: 3.90e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669  37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNE 116
Cdd:COG5184   251 VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAY 328

                          90
                  ....*....|...
gi 1512432669 117 GQLGLGDTEERNT 129
Cdd:COG5184   329 GQLGDGTTTDRST 341
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
158-205 5.76e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 5.76e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432669 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 205
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
55-101 1.92e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.15  E-value: 1.92e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1512432669  55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
263-310 2.14e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 2.14e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1512432669 263 VYTFGLGQFGQLGLGTFlFETSEPKVIENIRDQTISYISCGENHTALI 310
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-258 3.97e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 58.68  E-value: 3.97e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1512432669 208 DGELYVFGEPENGKLGLPNQLlgNHRTPQLVSEIPE-KVIQVACGGEHTVVL 258
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
142-171 1.05e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.97  E-value: 1.05e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432669 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 171
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
106-155 2.06e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.90  E-value: 2.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432669 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFtSEHKIKQLSAGSNTSAAL 155
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL-SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
89-118 5.86e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 46.26  E-value: 5.86e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432669  89 VKLAACGRNHTLVSTEGGNVYATGGNNEGQ 118
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
245-273 3.45e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 3.45e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432669 245 VIQVACGGEHTVVLTEN-AVYTFGLGQFGQ 273
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDgRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
38-66 8.58e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 8.58e-06
                          10        20
                  ....*....|....*....|....*....
gi 1512432669  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQ 66
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
195-220 1.39e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 1.39e-05
                          10        20
                  ....*....|....*....|....*.
gi 1512432669 195 ISCGYYHSAFVTTDGELYVFGEPENG 220
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
297-325 4.35e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.17  E-value: 4.35e-04
                          10        20
                  ....*....|....*....|....*....
gi 1512432669 297 ISYISCGENHTALITDIGLMYTFGDGRHG 325
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
46-215 1.62e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669  46 HSAVVTGNNKLYMFGSNNWGQlglGSKSAIskptcvkALKPEK---VKLAAC---GRNHTLVSTEGGNVYATGGNNEGQl 119
Cdd:COG3055    15 EAAAALLDGKVYVAGGLSGGS---ASNSFE-------VYDPATntwSELAPLpgpPRHHAAAVAQDGKLYVFGGFTGAN- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432669 120 glGDTEERNTFHVISFFTSE-HKIKQLSAGSNTSAALTEDGRLFMWGdnseGQIGLKNVSNVCVPQQVTigkpVSWISCG 198
Cdd:COG3055    84 --PSSTPLNDVYVYDPATNTwTKLAPMPTPRGGATALLLDGKIYVVG----GWDDGGNVAWVEVYDPAT----GTWTQLA 153

                         170       180
                  ....*....|....*....|...
gi 1512432669 199 ------YYHSAFVTTDGELYVFG 215
Cdd:COG3055   154 plptprDHLAAAVLPDGKILVIG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH