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Conserved domains on  [gi|1512432655|ref|NP_001354177|]
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X-linked retinitis pigmentosa GTPase regulator isoform G [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 48-370 5.28e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.47  E-value: 5.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655  48 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 127
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 128 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 206
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 207 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 285
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 286 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 364
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                  ....*.
gi 1512432655 365 ACGGCH 370
Cdd:COG5184   305 AAGSSH 310
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 48-370 5.28e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.47  E-value: 5.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655  48 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 127
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 128 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 206
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 207 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 285
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 286 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 364
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                  ....*.
gi 1512432655 365 ACGGCH 370
Cdd:COG5184   305 AAGSSH 310
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
168-215 8.73e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.00  E-value: 8.73e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432655 168 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 215
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 48-370 5.28e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.47  E-value: 5.28e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655  48 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 127
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 128 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 206
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 207 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 285
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 286 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 364
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                  ....*.
gi 1512432655 365 ACGGCH 370
Cdd:COG5184   305 AAGSSH 310
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 48-351 1.93e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 220.23  E-value: 1.93e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655  48 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNEG 127
Cdd:COG5184    51 VAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 128 QLGLGDTEERNTFHVISffTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISC 207
Cdd:COG5184   129 QLGDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 208 GYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEiPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGL 286
Cdd:COG5184   207 GGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQVAG-LTGVVAIAAGGSHTCALKSDgTVWCWGDNSYGQLGD 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1512432655 287 GTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 351
Cdd:COG5184   284 GTTTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 47-139 3.60e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 89.65  E-value: 3.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655  47 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTLVSTEGGNVYATGGNNE 126
Cdd:COG5184   251 VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAY 328

                          90
                  ....*....|...
gi 1512432655 127 GQLGLGDTEERNT 139
Cdd:COG5184   329 GQLGDGTTTDRST 341
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
168-215 8.73e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.00  E-value: 8.73e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432655 168 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 215
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
65-111 2.74e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 2.74e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1512432655  65 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 111
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
273-320 3.09e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 58.68  E-value: 3.09e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1512432655 273 VYTFGLGQFGQLGLGTFlFETSEPKVIENIRDQTISYISCGENHTALI 320
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
218-268 6.07e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 57.91  E-value: 6.07e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1512432655 218 DGELYVFGEPENGKLGLPNQLlgNHRTPQLVSEIPE-KVIQVACGGEHTVVL 268
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
152-181 1.52e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.58  E-value: 1.52e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432655 152 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 181
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
116-165 2.86e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.51  E-value: 2.86e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432655 116 GNVYATGGNNEGQLGLGDTEERNTFHVISFFtSEHKIKQLSAGSNTSAAL 165
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL-SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
99-128 7.99e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.88  E-value: 7.99e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432655  99 VKLAACGRNHTLVSTEGGNVYATGGNNEGQ 128
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
324-370 2.96e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 2.96e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1512432655 324 GLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRFIVKLVACGGCH 370
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDH 46
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
255-283 4.94e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.57  E-value: 4.94e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432655 255 VIQVACGGEHTVVLTEN-AVYTFGLGQFGQ 283
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDgRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
48-76 1.16e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*....
gi 1512432655  48 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQ 76
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
205-230 1.84e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 1.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 1512432655 205 ISCGYYHSAFVTTDGELYVFGEPENG 230
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
307-335 5.32e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.79  E-value: 5.32e-04
                          10        20
                  ....*....|....*....|....*....
gi 1512432655 307 ISYISCGENHTALITDIGLMYTFGDGRHG 335
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
56-225 1.52e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655  56 HSAVVTGNNKLYMFGSNNWGQlglGSKSAIskptcvkALKPEK---VKLAAC---GRNHTLVSTEGGNVYATGGNNEGQl 129
Cdd:COG3055    15 EAAAALLDGKVYVAGGLSGGS---ASNSFE-------VYDPATntwSELAPLpgpPRHHAAAVAQDGKLYVFGGFTGAN- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432655 130 glGDTEERNTFHVISFFTSE-HKIKQLSAGSNTSAALTEDGRLFMWGdnseGQIGLKNVSNVCVPQQVTigkpVSWISCG 208
Cdd:COG3055    84 --PSSTPLNDVYVYDPATNTwTKLAPMPTPRGGATALLLDGKIYVVG----GWDDGGNVAWVEVYDPAT----GTWTQLA 153

                         170       180
                  ....*....|....*....|...
gi 1512432655 209 ------YYHSAFVTTDGELYVFG 225
Cdd:COG3055   154 plptprDHLAAAVLPDGKILVIG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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