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Conserved domains on  [gi|1525820738|ref|NP_001354397|]
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activating molecule in BECN1-regulated autophagy protein 1 isoform 5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-198 1.19e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.19e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPtiSG-LIASGCLDGEVRIWDLHGGSESW-FTDS 136
Cdd:COG2319    210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--DGrLLASGSADGTVRLWDLATGELLRtLTGH 287

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1525820738  137 NNAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:COG2319    288 SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKTLASG 348
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-198 1.19e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.19e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPtiSG-LIASGCLDGEVRIWDLHGGSESW-FTDS 136
Cdd:COG2319    210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--DGrLLASGSADGTVRLWDLATGELLRtLTGH 287

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1525820738  137 NNAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:COG2319    288 SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-198 3.64e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 3.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSES-WFTDSN 137
Cdd:cd00200    141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLgTLRGHE 219

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1525820738  138 NAIASLAFHPTAQLLLIATANE-IHFWDWSRREPfavVKTASEME-RVRLVRFDPLGHYLLTA 198
Cdd:cd00200    220 NGVNSVAFSPDGYLLASGSEDGtIRVWDLRTGEC---VQTLSGHTnSVTSLAWSPDGKRLASG 279
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-124 1.25e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 1.25e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1525820738    84 TGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWD 124
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-124 1.27e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 1.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1525820738   85 GKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWD 124
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
59-198 1.19e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.19e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPtiSG-LIASGCLDGEVRIWDLHGGSESW-FTDS 136
Cdd:COG2319    210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--DGrLLASGSADGTVRLWDLATGELLRtLTGH 287

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1525820738  137 NNAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:COG2319    288 SGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
59-198 5.82e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 5.82e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSESW-FTDSN 137
Cdd:COG2319    168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRtLTGHS 246

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1525820738  138 NAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:COG2319    247 GSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHS--GGVNSVAFSPDGKLLASG 306
WD40 COG2319
WD40 repeat [General function prediction only];
59-198 1.54e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.91  E-value: 1.54e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSESW-FTDSN 137
Cdd:COG2319    126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRtLTGHT 204

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1525820738  138 NAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:COG2319    205 GAVRSVAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLTGHS--GSVRSVAFSPDGRLLASG 264
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-198 3.64e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 3.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSES-WFTDSN 137
Cdd:cd00200    141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLgTLRGHE 219

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1525820738  138 NAIASLAFHPTAQLLLIATANE-IHFWDWSRREPfavVKTASEME-RVRLVRFDPLGHYLLTA 198
Cdd:cd00200    220 NGVNSVAFSPDGYLLASGSEDGtIRVWDLRTGEC---VQTLSGHTnSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-198 1.10e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSESW-FTDSN 137
Cdd:cd00200     99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVAtLTGHT 177

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1525820738  138 NAIASLAFHPTAQLLLIATA-NEIHFWDWSrrePFAVVKTASEME-RVRLVRFDPLGHYLLTA 198
Cdd:cd00200    178 GEVNSVAFSPDGEKLLSSSSdGTIKLWDLS---TGKCLGTLRGHEnGVNSVAFSPDGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
59-166 3.81e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 3.81e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSES-WFTDSN 137
Cdd:COG2319    294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLrTLTGHT 372

                           90       100       110
                   ....*....|....*....|....*....|
gi 1525820738  138 NAIASLAFHPTAQLLLIATA-NEIHFWDWS 166
Cdd:COG2319    373 GAVTSVAFSPDGRTLASGSAdGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
38-198 7.58e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 7.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   38 RWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLD 117
Cdd:COG2319     63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-GKTLASGSAD 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738  118 GEVRIWDLHGGSE-SWFTDSNNAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYL 195
Cdd:COG2319    142 GTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHT--GAVRSVAFSPDGKLL 219


                   ...
gi 1525820738  196 LTA 198
Cdd:COG2319    220 ASG 222
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-198 2.21e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 2.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHGGSESW-FTDSN 137
Cdd:cd00200     15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRtLTGHT 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1525820738  138 NAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:cd00200     94 SYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHT--DWVNSVAFSPDGTFVASS 153
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-198 1.29e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 1.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISgLIASGCLDGEVRIWDLH-GGSESWFTDSN 137
Cdd:cd00200     57 VAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVEtGKCLTTLRGHT 135

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1525820738  138 NAIASLAFHPTAQLLLIATAN-EIHFWDwsrrepfavVKTASEMER-------VRLVRFDPLGHYLLTA 198
Cdd:cd00200    136 DWVNSVAFSPDGTFVASSSQDgTIKLWD---------LRTGKCVATltghtgeVNSVAFSPDGEKLLSS 195
WD40 COG2319
WD40 repeat [General function prediction only];
59-127 9.93e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 9.93e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWDLHG 127
Cdd:COG2319    336 VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
43-198 1.08e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 1.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   43 EGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRI 122
Cdd:COG2319     26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRL 104

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1525820738  123 WDLHGGSE-SWFTDSNNAIASLAFHPTAQLLLIATA-NEIHFWDWSRREPFAVVKTASemERVRLVRFDPLGHYLLTA 198
Cdd:COG2319    105 WDLATGLLlRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHS--GAVTSVAFSPDGKLLASG 180
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-124 5.18e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 5.18e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1525820738   59 LAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIaSGCLDGEVRIWD 124
Cdd:cd00200    225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-124 1.25e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 1.25e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1525820738    84 TGKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWD 124
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-124 1.27e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 1.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1525820738   85 GKCVHSLIGHRRTPWCVTFHPTiSGLIASGCLDGEVRIWD 124
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-198 1.30e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525820738   87 CVHSLIGHRRTPWCVTFHPtISGLIASGCLDGEVRIWDLHGGS-ESWFTDSNNAIASLAFHPTAQLLLIA-TANEIHFWD 164
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGElLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWD 79

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1525820738  165 WSRREPFAVVKTASEMerVRLVRFDPLGHYLLTA 198
Cdd:cd00200     80 LETGECVRTLTGHTSY--VSSVAFSPDGRILSSS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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