NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1576727538|ref|NP_001355635|]
View 

chromatin remodeling regulator CECR2 isoform 2 [Mus musculus]

Protein Classification

bromodomain-containing protein( domain architecture ID 10144732)

bromodomain-containing protein may act as transcription regulator involved in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources

CATH:  1.20.920.10
Gene Ontology:  GO:0005515
PubMed:  31582847|28847823|34548613|1350857|26472704

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 418-518 3.05e-54

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 183.91  E-value: 3.05e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  418 DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDS 497
Cdd:cd05509      1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                           90       100
                   ....*....|....*....|.
gi 1576727538  498 SEYTKMSDNLERCFHRAMTKH 518
Cdd:cd05509     81 TEYYKCANKLEKFFWKKLKEL 101
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 558-1031 2.05e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 2.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  558 RDTEGSSRKQ------PPVENGGKSLPPARRAASSGDDQSRSSIQLPPEV--GTSHGQGFSRPLHC---GRVP-SHAPPL 625
Cdd:PHA03247  2602 VDDRGDPRGPappsplPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERprDDPAPGRVSRPRRArrlGRAAqASSPPQ 2681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  626 NQMRPAAPGTFGSLQgsdptnlhgSSRIPEAPPGEPLQHPPFAIQApvgisnhrgsLLSAPDLSNMGSHVPSLQLGQMNC 705
Cdd:PHA03247  2682 RPRRRAARPTVGSLT---------SLADPPPPPPTPEPAPHALVSA----------TPLPPGPAAARQASPALPAAPAPP 2742

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  706 PSQDGNMYPPAPFQAGFIPSRHGGTPARPPDFPESSEIP--PGHIYHSYKYLNRAHPAVWNGNHGTTNPGRLGPDEKPHL 783
Cdd:PHA03247  2743 AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  784 GPGPSHHPHTLGhmmdgrvmrQPIPPnqwTKQSSFLPHGVPSSGYMQPpcksaghrlqppptpAPSPRFRGPSQALRGAQ 863
Cdd:PHA03247  2823 SPAGPLPPPTSA---------QPTAP---PPPPGPPPPSLPLGGSVAP---------------GGDVRRRPPSRSPAAKP 2875

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  864 GGESMMDSPEMIA---MQQLSSRVCPPGVPYHPRQPTPPQLPGPFPQVAHSASVCVSAPKPALDNPGSTQEMTETHEPEE 940
Cdd:PHA03247  2876 AAPARPPVRRLARpavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  941 DPAEPLPgheEKAASICSSEGVYLKQLPHPAPPLQASCTrqSSPQERETEDSQLKSDASDSA-----DTYKTSKNKNTWP 1015
Cdd:PHA03247  2956 SGAVPQP---WLGALVPGRVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSRVSSWASSLAlheetDPPPVSLKQTLWP 3030

                          490
                   ....*....|....*.
gi 1576727538 1016 LDNSYSSPAVQGCLRD 1031
Cdd:PHA03247  3031 PDDTEDSDADSLFDSD 3046
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 418-518 3.05e-54

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 183.91  E-value: 3.05e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  418 DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDS 497
Cdd:cd05509      1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                           90       100
                   ....*....|....*....|.
gi 1576727538  498 SEYTKMSDNLERCFHRAMTKH 518
Cdd:cd05509     81 TEYYKCANKLEKFFWKKLKEL 101
BROMO smart00297
bromo domain;
418-518 1.23e-31

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 119.69  E-value: 1.23e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538   418 DDFTAMYKVLDVVKAHKD----SWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKY 493
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDshplSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90       100
                    ....*....|....*....|....*
gi 1576727538   494 NGDSSEYTKMSDNLERCFHRAMTKH 518
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFFEKKLREL 107
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 396-540 1.76e-24

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 107.20  E-value: 1.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  396 SHLDLNSPMREGKKTKDLFELDDDFTAMY--KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLY 473
Cdd:COG5076    124 AHLKTSVKKRKTPKIEDELLYADNKAIAKfkKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRY 203

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1576727538  474 CNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLErcfhRAMTKHFPGEDGDTDEEFWIKEDEKREK 540
Cdd:COG5076    204 KSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELE----KYFLKLIEEIPEEMLELSIKPGREEREE 266
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 425-505 2.25e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 89.68  E-value: 2.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  425 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMS 504
Cdd:pfam00439    3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82


                   .
gi 1576727538  505 D 505
Cdd:pfam00439   83 E 83
PHA03247 PHA03247
large tegument protein UL36; Provisional
 558-1031 2.05e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 2.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  558 RDTEGSSRKQ------PPVENGGKSLPPARRAASSGDDQSRSSIQLPPEV--GTSHGQGFSRPLHC---GRVP-SHAPPL 625
Cdd:PHA03247  2602 VDDRGDPRGPappsplPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERprDDPAPGRVSRPRRArrlGRAAqASSPPQ 2681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  626 NQMRPAAPGTFGSLQgsdptnlhgSSRIPEAPPGEPLQHPPFAIQApvgisnhrgsLLSAPDLSNMGSHVPSLQLGQMNC 705
Cdd:PHA03247  2682 RPRRRAARPTVGSLT---------SLADPPPPPPTPEPAPHALVSA----------TPLPPGPAAARQASPALPAAPAPP 2742

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  706 PSQDGNMYPPAPFQAGFIPSRHGGTPARPPDFPESSEIP--PGHIYHSYKYLNRAHPAVWNGNHGTTNPGRLGPDEKPHL 783
Cdd:PHA03247  2743 AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  784 GPGPSHHPHTLGhmmdgrvmrQPIPPnqwTKQSSFLPHGVPSSGYMQPpcksaghrlqppptpAPSPRFRGPSQALRGAQ 863
Cdd:PHA03247  2823 SPAGPLPPPTSA---------QPTAP---PPPPGPPPPSLPLGGSVAP---------------GGDVRRRPPSRSPAAKP 2875

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  864 GGESMMDSPEMIA---MQQLSSRVCPPGVPYHPRQPTPPQLPGPFPQVAHSASVCVSAPKPALDNPGSTQEMTETHEPEE 940
Cdd:PHA03247  2876 AAPARPPVRRLARpavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  941 DPAEPLPgheEKAASICSSEGVYLKQLPHPAPPLQASCTrqSSPQERETEDSQLKSDASDSA-----DTYKTSKNKNTWP 1015
Cdd:PHA03247  2956 SGAVPQP---WLGALVPGRVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSRVSSWASSLAlheetDPPPVSLKQTLWP 3030

                          490
                   ....*....|....*.
gi 1576727538 1016 LDNSYSSPAVQGCLRD 1031
Cdd:PHA03247  3031 PDDTEDSDADSLFDSD 3046
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 613-945 2.76e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  613 LHCGRVPSHAPPLNQMRPAAPGTFGSLQGSDPTNLHGssriPEAPPGEPLQHPPFAIQAPVGISNHRGSLLSAPdlsnmg 692
Cdd:pfam03154  237 LHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHG----QMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQ------ 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  693 SHVPSLQLGQMNCPSQDGNMYPPAPFQA-GFIPSRHGGTPARPPDFPESSEIPPGHIYHSYKYLNRAHPAVWNGNHGTTN 771
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTPPSQSQLqSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQM 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  772 PGRLGPDE--KPhLGPGPSHHPHTlghmmdgrvmRQPiPPNQWTKQSSFLPhgvpsSGYMQPP--CKSAGHRLQPPPTPA 847
Cdd:pfam03154  387 NSNLPPPPalKP-LSSLSTHHPPS----------AHP-PPLQLMPQSQQLP-----PPPAQPPvlTQSQSLPPPAASHPP 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  848 PSPRFRGPSQAlrgaqggesmmDSPEMIAMQQLSSRVCPPGVPyhprqPTPPQLPGPFPQVAHSASVCVSAPKPALDN-- 925
Cdd:pfam03154  450 TSGLHQVPSQS-----------PFPQHPFVPGGPPPITPPSGP-----PTSTSSAMPGIQPPSSASVSSSGPVPAAVScp 513

                          330       340
                   ....*....|....*....|....
gi 1576727538  926 --PGSTQE--MTETHEPEEDPAEP 945
Cdd:pfam03154  514 lpPVQIKEeaLDEAEEPESPPPPP 537
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 418-518 3.05e-54

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 183.91  E-value: 3.05e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  418 DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDS 497
Cdd:cd05509      1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                           90       100
                   ....*....|....*....|.
gi 1576727538  498 SEYTKMSDNLERCFHRAMTKH 518
Cdd:cd05509     81 TEYYKCANKLEKFFWKKLKEL 101
BROMO smart00297
bromo domain;
418-518 1.23e-31

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 119.69  E-value: 1.23e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538   418 DDFTAMYKVLDVVKAHKD----SWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKY 493
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDshplSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90       100
                    ....*....|....*....|....*
gi 1576727538   494 NGDSSEYTKMSDNLERCFHRAMTKH 518
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 422-515 2.42e-31

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 118.63  E-value: 2.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  422 AMYKVLDVVKAH--KDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSE 499
Cdd:cd04369      4 KLRSLLDALKKLkrDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSP 83

                           90
                   ....*....|....*.
gi 1576727538  500 YTKMSDNLERCFHRAM 515
Cdd:cd04369     84 IYKDAKKLEKLFEKLL 99
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 430-515 2.78e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 104.32  E-value: 2.78e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  430 VKAHKDSWPFLEPVD--ESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNL 507
Cdd:cd05500     16 LKRLKDARPFLVPVDpvKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRL 95


                   ....*...
gi 1576727538  508 ERCFHRAM 515
Cdd:cd05500     96 QAAFEKHL 103
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 396-540 1.76e-24

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 107.20  E-value: 1.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  396 SHLDLNSPMREGKKTKDLFELDDDFTAMY--KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLY 473
Cdd:COG5076    124 AHLKTSVKKRKTPKIEDELLYADNKAIAKfkKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRY 203

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1576727538  474 CNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLErcfhRAMTKHFPGEDGDTDEEFWIKEDEKREK 540
Cdd:COG5076    204 KSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELE----KYFLKLIEEIPEEMLELSIKPGREEREE 266
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 425-515 2.10e-23

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 96.20  E-value: 2.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  425 KVLDVVKAHKDS---WPFLEPVDESY--APNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSE 499
Cdd:cd05499      7 EVLKELMKPKHSaynWPFLDPVDPVAlnIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTD 86

                           90
                   ....*....|....*.
gi 1576727538  500 YTKMSDNLERCFHRAM 515
Cdd:cd05499     87 VYMMGHQLEEVFNDKW 102
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 426-511 3.53e-23

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 95.13  E-value: 3.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  426 VLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSD 505
Cdd:cd05503      8 ILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGH 87


                   ....*.
gi 1576727538  506 NLERCF 511
Cdd:cd05503     88 NMRKFF 93
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 422-512 3.76e-23

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 95.92  E-value: 3.76e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  422 AMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYT 501
Cdd:cd05504     16 ALEQLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVY 95

                           90
                   ....*....|.
gi 1576727538  502 KMSDNLERCFH 512
Cdd:cd05504     96 KAGTRLQRFFI 106
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 435-510 1.03e-22

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 94.25  E-value: 1.03e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1576727538  435 DSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDN-LERC 510
Cdd:cd05511     17 DSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEmLELA 93
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 433-520 4.35e-22

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 92.74  E-value: 4.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  433 HKDSWPFLEPVDESyAPNYYQIIKIPMDISSMEKKL---NGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLER 509
Cdd:cd05502     19 HELSLPFHEPVSPS-VPNYYKIIKTPMDLSLIRKKLqpkSPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELEL 97

                           90
                   ....*....|.
gi 1576727538  510 CFHRAMTKHFP 520
Cdd:cd05502     98 FFEEQLKEILP 108
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 425-505 2.25e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 89.68  E-value: 2.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  425 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMS 504
Cdd:pfam00439    3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82


                   .
gi 1576727538  505 D 505
Cdd:pfam00439   83 E 83
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 422-498 1.67e-20

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 88.27  E-value: 1.67e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  422 AMYKVLDVV----KAH-KDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGD 496
Cdd:cd05510      7 EFYESLDKVlnelKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSD 86


                   ..
gi 1576727538  497 SS 498
Cdd:cd05510     87 PS 88
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 437-511 2.10e-20

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 87.33  E-value: 2.10e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1576727538  437 WPFLEPVDESY--APNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLERCF 511
Cdd:cd05498     22 WPFYKPVDPEAlgLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDVF 98
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 429-512 1.02e-19

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 85.55  E-value: 1.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  429 VVKA---HKDSWPFLEPVDESY--APNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKM 503
Cdd:cd05497     13 VLKAlwkHKFAWPFQQPVDAVKlnLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLM 92


                   ....*....
gi 1576727538  504 SDNLERCFH 512
Cdd:cd05497     93 AQTLEKLFL 101
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 419-511 4.05e-16

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 75.27  E-value: 4.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  419 DFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSS 498
Cdd:cd05505      1 ELQKCEEILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGS 80

                           90
                   ....*....|...
gi 1576727538  499 EYTKMSDNLERCF 511
Cdd:cd05505     81 YVLSCMRKTEQCC 93
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 425-511 1.93e-15

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 73.13  E-value: 1.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  425 KVLDVVKAHKDSWPFLEPVDESY--APNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTK 502
Cdd:cd05506      7 TLLRKLMKHKWGWVFNAPVDVVAlgLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHT 86


                   ....*....
gi 1576727538  503 MSDNLERCF 511
Cdd:cd05506     87 MAKELLKIF 95
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 426-515 3.97e-15

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 72.86  E-value: 3.97e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  426 VLDVVKAHKDSWPFLEPVDESY--APNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKM 503
Cdd:cd05495     12 LEKLYKQDPESLPFRQPVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKY 91

                           90
                   ....*....|..
gi 1576727538  504 SDNLERCFHRAM 515
Cdd:cd05495     92 CTKLAEVFEQEI 103
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 425-495 1.29e-13

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 68.19  E-value: 1.29e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1576727538  425 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNG 495
Cdd:cd05512      8 KTLDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNA 78
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 449-509 1.61e-13

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 67.86  E-value: 1.61e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1576727538  449 PNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLER 509
Cdd:cd05518     37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEK 97
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 438-504 5.96e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 66.61  E-value: 5.96e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1576727538  438 PFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMS 504
Cdd:cd05528     23 AFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDPADKLI 89
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 425-494 7.39e-13

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 66.71  E-value: 7.39e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  425 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYN 494
Cdd:cd05496     12 ELVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 439-507 1.26e-12

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 65.12  E-value: 1.26e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1576727538  439 FLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNL 507
Cdd:cd05513     22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAKKL 90
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 423-517 8.72e-12

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 63.22  E-value: 8.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  423 MYKVLDVVKAHKD------SWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGD 496
Cdd:cd05516      6 MNKIVDVVIKYKDsdgrqlAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLE 85

                           90       100
                   ....*....|....*....|.
gi 1576727538  497 SSEYTKMSDNLERCFHRAMTK 517
Cdd:cd05516     86 GSLIYEDSIVLQSVFKSARQK 106
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 444-513 1.12e-11

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 62.64  E-value: 1.12e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  444 DESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLERCFHR 513
Cdd:cd05522     33 DKAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEKEARL 102
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 422-510 2.27e-11

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 62.00  E-value: 2.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  422 AMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYT 501
Cdd:cd05507      7 AILLVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVY 86


                   ....*....
gi 1576727538  502 KMSDNLERC 510
Cdd:cd05507     87 LMAVEMQRE 95
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 423-514 4.66e-11

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 60.78  E-value: 4.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  423 MYKVLDVVKAHKD------SWPFLE-PVDESYaPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNG 495
Cdd:cd05515      5 LWELYNAVKNYTDgrgrrlSLIFMRlPSKSEY-PDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNE 83

                           90
                   ....*....|....*....
gi 1576727538  496 DSSEYTKMSDNLERCFHRA 514
Cdd:cd05515     84 PDSQIYKDALTLQKVLLET 102
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 438-504 1.47e-10

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 59.32  E-value: 1.47e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1576727538  438 PFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMS 504
Cdd:cd05508     22 PFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAA 88
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 423-509 3.93e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 58.12  E-value: 3.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  423 MYKVLDVVKAHKD------SWPFLE-PVDESYaPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNG 495
Cdd:cd05520      5 LWQLYDTIRNARNnqgqllAEPFLKlPSKRKY-PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNV 83

                           90
                   ....*....|....
gi 1576727538  496 DSSEYTKMSDNLER 509
Cdd:cd05520     84 PNSRIYKDAEKLQK 97
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 420-513 9.49e-10

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 58.12  E-value: 9.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  420 FTAMYKVLDVVKAHKDSwPFLEPVDE-SYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSS 498
Cdd:cd05529     30 ISGLDKLLLSLQLEIAE-YFEYPVDLrAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNS 108

                           90
                   ....*....|....*
gi 1576727538  499 EYTKMSDNLERCFHR 513
Cdd:cd05529    109 EIAKKAKRLSDWLLR 123
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 449-514 2.15e-09

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 56.24  E-value: 2.15e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576727538  449 PNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLERCFHRA 514
Cdd:cd05525     39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQA 104
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 439-498 1.89e-08

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 53.50  E-value: 1.89e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  439 FLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSS 498
Cdd:cd05519     27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGS 86
PHA03247 PHA03247
large tegument protein UL36; Provisional
 558-1031 2.05e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 2.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  558 RDTEGSSRKQ------PPVENGGKSLPPARRAASSGDDQSRSSIQLPPEV--GTSHGQGFSRPLHC---GRVP-SHAPPL 625
Cdd:PHA03247  2602 VDDRGDPRGPappsplPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERprDDPAPGRVSRPRRArrlGRAAqASSPPQ 2681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  626 NQMRPAAPGTFGSLQgsdptnlhgSSRIPEAPPGEPLQHPPFAIQApvgisnhrgsLLSAPDLSNMGSHVPSLQLGQMNC 705
Cdd:PHA03247  2682 RPRRRAARPTVGSLT---------SLADPPPPPPTPEPAPHALVSA----------TPLPPGPAAARQASPALPAAPAPP 2742

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  706 PSQDGNMYPPAPFQAGFIPSRHGGTPARPPDFPESSEIP--PGHIYHSYKYLNRAHPAVWNGNHGTTNPGRLGPDEKPHL 783
Cdd:PHA03247  2743 AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  784 GPGPSHHPHTLGhmmdgrvmrQPIPPnqwTKQSSFLPHGVPSSGYMQPpcksaghrlqppptpAPSPRFRGPSQALRGAQ 863
Cdd:PHA03247  2823 SPAGPLPPPTSA---------QPTAP---PPPPGPPPPSLPLGGSVAP---------------GGDVRRRPPSRSPAAKP 2875

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  864 GGESMMDSPEMIA---MQQLSSRVCPPGVPYHPRQPTPPQLPGPFPQVAHSASVCVSAPKPALDNPGSTQEMTETHEPEE 940
Cdd:PHA03247  2876 AAPARPPVRRLARpavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  941 DPAEPLPgheEKAASICSSEGVYLKQLPHPAPPLQASCTrqSSPQERETEDSQLKSDASDSA-----DTYKTSKNKNTWP 1015
Cdd:PHA03247  2956 SGAVPQP---WLGALVPGRVAVPRFRVPQPAPSREAPAS--STPPLTGHSLSRVSSWASSLAlheetDPPPVSLKQTLWP 3030

                          490
                   ....*....|....*.
gi 1576727538 1016 LDNSYSSPAVQGCLRD 1031
Cdd:PHA03247  3031 PDDTEDSDADSLFDSD 3046
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 451-519 2.23e-08

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 53.20  E-value: 2.23e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1576727538  451 YYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDsSEYTKMSDNLERCFHRAMTKHF 519
Cdd:cd05501     33 YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKD-DDFGQVGITLEKKFEKNFKEVF 100
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 419-504 4.54e-08

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 52.83  E-value: 4.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  419 DFTAMYKVLDVVKAH---KDSWPFLEPVD--ESYAPNYYQIIKIPMDISSMEKKL------NGGLYCNKEEFVNDMKTMF 487
Cdd:cd05494      1 DYEALERVLRELKRHrrnEDAWPFLEPVNppRRGAPDYRDVIKRPMSFGTKVNNIvetgarDLEDLQIVQEDPADKQIDD 80

                           90
                   ....*....|....*..
gi 1576727538  488 RNCRkynGDSSEYTKMS 504
Cdd:cd05494     81 EGRR---SPSNIYAVEA 94
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 442-510 1.85e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 48.09  E-value: 1.85e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1576727538  442 PVDESYaPNYYQIIKIPMDISSMEKKLNGglYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLERC 510
Cdd:cd05521     32 PLRKDY-PDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKY 97
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 427-512 4.85e-06

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 50.57  E-value: 4.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  427 LDVVKAHKDSWPFLEPVDESYAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGdSSEYTKMSDN 506
Cdd:COG5076    272 ITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNCVMYNG-EVTDYYKNAN 350


                   ....*.
gi 1576727538  507 LERCFH 512
Cdd:COG5076    351 VLEDFV 356
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 613-945 2.76e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  613 LHCGRVPSHAPPLNQMRPAAPGTFGSLQGSDPTNLHGssriPEAPPGEPLQHPPFAIQAPVGISNHRGSLLSAPdlsnmg 692
Cdd:pfam03154  237 LHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHG----QMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQ------ 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  693 SHVPSLQLGQMNCPSQDGNMYPPAPFQA-GFIPSRHGGTPARPPDFPESSEIPPGHIYHSYKYLNRAHPAVWNGNHGTTN 771
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTPPSQSQLqSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQM 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  772 PGRLGPDE--KPhLGPGPSHHPHTlghmmdgrvmRQPiPPNQWTKQSSFLPhgvpsSGYMQPP--CKSAGHRLQPPPTPA 847
Cdd:pfam03154  387 NSNLPPPPalKP-LSSLSTHHPPS----------AHP-PPLQLMPQSQQLP-----PPPAQPPvlTQSQSLPPPAASHPP 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  848 PSPRFRGPSQAlrgaqggesmmDSPEMIAMQQLSSRVCPPGVPyhprqPTPPQLPGPFPQVAHSASVCVSAPKPALDN-- 925
Cdd:pfam03154  450 TSGLHQVPSQS-----------PFPQHPFVPGGPPPITPPSGP-----PTSTSSAMPGIQPPSSASVSSSGPVPAAVScp 513

                          330       340
                   ....*....|....*....|....
gi 1576727538  926 --PGSTQE--MTETHEPEEDPAEP 945
Cdd:pfam03154  514 lpPVQIKEeaLDEAEEPESPPPPP 537
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 449-523 8.24e-05

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 43.48  E-value: 8.24e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576727538  449 PNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRK-YNGDSSEYTKMSDnLERCFHRAMTKHFPGED 523
Cdd:cd05524     39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAyYKPDSPEHKDACK-LWELFLSARNEVLSGGE 113
PHA03378 PHA03378
EBNA-3B; Provisional
 555-839 8.49e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 8.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  555 TRSRDTEGSSRKQPPVENGGKSLPPARRAASSGDDQSRSSIQLPPEVG-TSHGQGFSRPLHCGRVPSHAPPlNQMRP--A 631
Cdd:PHA03378   611 TQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEiTPYKPTWTQIGHIPYQPSPTGA-NTMLPiqW 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  632 APGTFgslqgSDPTNLHGSSRIPEAPPG------------EPLQHPPFAIQAPVGISNHRGSLLSAPDLSNMGSHVPSLQ 699
Cdd:PHA03378   690 APGTM-----QPPPRAPTPMRPPAAPPGraqrpaaatgraRPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRA 764

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  700 LGQMNCPSQDGNMYPPapfQAGFIPS---RHGGTPARPPDFPESSEI-----PPGHIYHSYKYLNR-AHPAVWNGNHGTT 770
Cdd:PHA03378   765 RPPAAAPGAPTPQPPP---QAPPAPQqrpRGAPTPQPPPQAGPTSMQlmpraAPGQQGPTKQILRQlLTGGVKRGRPSLK 841

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  771 NPGRLgpDEKPHLGPGPSHHPHTLGHMMDGRVMRQPI-PPNQWTKQSSFlPHGVPSSGYMQPPCKSAGHR 839
Cdd:PHA03378   842 KPAAL--ERQAAAGPTPSPGSGTSDKIVQAPVFYPPVlQPIQVMRQLGS-VRAAAASTVTQAPTEYTGER 908
PHA03247 PHA03247
large tegument protein UL36; Provisional
 717-1209 1.02e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  717 PFQAGFIPSRHGGTPARPPDFPESSEIPPGhIYHSYKYLNRAHPAVWNGNHGTTN---------PGRLGPDEKPHLG--- 784
Cdd:PHA03247  2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPA-ILPDEPVGEPVHPRMLTWIRGLEElasddagdpPPPLPPAAPPAAPdrs 2567

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  785 -PGPSHHPHTLGHMMDGRVMRQPIPPNQWTKQSSFLPHGVPSSGYMQPPCKSAGHRLQPPPTPAPSPRFRGPSQALRGAQ 863
Cdd:PHA03247  2568 vPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  864 GGESMMDSP---EMIAMQQLSSRVCPPGVPYHPRQPTPPQLPGPFPQVAHSASVCVSAPKPALDNPGSTQEMTETHEPEE 940
Cdd:PHA03247  2648 PPERPRDDPapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA 2727

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538  941 D-------PAEPLPGHEEKAASICSSEGvylkqlPHPAPPLQASCTRQSSPQERET-EDSQLKSDASDSADTYKTSKNKN 1012
Cdd:PHA03247  2728 ArqaspalPAAPAPPAVPAGPATPGGPA------RPARPPTTAGPPAPAPPAAPAAgPPRRLTRPAVASLSESRESLPSP 2801

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538 1013 TWPLDNSYSSPAVQGCLRDLSivAETGNLPENGVVGEASPCRSEGKgldgsgSEKPLCPRGktlqeAVPCTGPNATTPPC 1092
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAA--SPAGPLPPPTSAQPTAPPPPPGP------PPPSLPLGG-----SVAPGGDVRRRPPS 2868

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576727538 1093 TDPSLMAATvnqfsPLYMPgieySNSATQYPMSPSLQGLAsmmggkssgsQPQSFPPRGFQANGPHPglfPRYRPQQGMR 1172
Cdd:PHA03247  2869 RSPAAKPAA-----PARPP----VRRLARPAVSRSTESFA----------LPPDQPERPPQPQAPPP---PQPQPQPPPP 2926

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 1576727538 1173 YSYQPPSQPSYHPYQRTPYYTCPQGFSDWQRSLPSQR 1209
Cdd:PHA03247  2927 PQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW 2963
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 449-511 3.04e-03

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 38.57  E-value: 3.04e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1576727538  449 PNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFRNCRKYNGDSSEYTKMSDNLERCF 511
Cdd:cd05517     37 PDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH