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Conserved domains on  [gi|1587062642|ref|NP_001355849|]
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paired box protein Pax-6 isoform j [Homo sapiens]

Protein Classification

paired box protein( domain architecture ID 11265415)

paired box protein similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
4-153 2.31e-78

Paired Box domain;


:

Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 239.15  E-value: 2.31e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642    4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILG 83
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCV-------------------------SHGCVSKILG 55

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   84 RYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 153
Cdd:smart00351  56 RYYETGSIRPGAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
237-292 1.08e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.50  E-value: 1.08e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062642 237 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 292
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
4-153 2.31e-78

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 239.15  E-value: 2.31e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642    4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILG 83
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCV-------------------------SHGCVSKILG 55

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   84 RYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 153
Cdd:smart00351  56 RYYETGSIRPGAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 5-156 5.03e-77

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 235.78  E-value: 5.03e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILGR 84
Cdd:cd00131     2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRV-------------------------SHGCVSKILNR 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1587062642  85 YYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLA 156
Cdd:cd00131    57 YYETGSIRPGAIGGSKPRVATPEVVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNKA 128
PAX pfam00292
'Paired box' domain;
4-153 5.81e-75

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 230.53  E-value: 5.81e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILG 83
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRV-------------------------SHGCVSKILG 55

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642  84 RYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 153
Cdd:pfam00292  56 RYYETGSIRPGVIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
237-292 1.08e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.50  E-value: 1.08e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062642 237 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 292
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 236-291 3.68e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.62  E-value: 3.68e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062642  236 QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 291
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 237-294 8.35e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.85  E-value: 8.35e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1587062642 237 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREE 294
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
210-313 6.15e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 6.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642 210 ENTNSISSNGEDSDEAqmrlqlKRKlqRNRTsfTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAK 289
Cdd:COG5576    36 DSEMKLERKQDGSSPP------KSK--RRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1587062642 290 WRREEKLRNQRRQASN--------TPSHIPIS 313
Cdd:COG5576   106 EKKKRSGKVEQRPGEEeadlakigSLSTGQIS 137
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
4-153 2.31e-78

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 239.15  E-value: 2.31e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642    4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILG 83
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCV-------------------------SHGCVSKILG 55

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   84 RYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 153
Cdd:smart00351  56 RYYETGSIRPGAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 5-156 5.03e-77

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 235.78  E-value: 5.03e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   5 HSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILGR 84
Cdd:cd00131     2 QGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRV-------------------------SHGCVSKILNR 56

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1587062642  85 YYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLA 156
Cdd:cd00131    57 YYETGSIRPGAIGGSKPRVATPEVVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNKA 128
PAX pfam00292
'Paired box' domain;
4-153 5.81e-75

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 230.53  E-value: 5.81e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642   4 SHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVilpapphsppprpstlnalssfltvSNGCVSKILG 83
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRV-------------------------SHGCVSKILG 55

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642  84 RYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLR 153
Cdd:pfam00292  56 RYYETGSIRPGVIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
237-292 1.08e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 104.50  E-value: 1.08e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062642 237 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRR 292
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 236-291 3.68e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 94.62  E-value: 3.68e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1587062642  236 QRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWR 291
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 237-294 8.35e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 93.85  E-value: 8.35e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1587062642 237 RNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREE 294
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
210-313 6.15e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 63.22  E-value: 6.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1587062642 210 ENTNSISSNGEDSDEAqmrlqlKRKlqRNRTsfTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAK 289
Cdd:COG5576    36 DSEMKLERKQDGSSPP------KSK--RRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAK 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1587062642 290 WRREEKLRNQRRQASN--------TPSHIPIS 313
Cdd:COG5576   106 EKKKRSGKVEQRPGEEeadlakigSLSTGQIS 137
HTH_32 pfam13565
Homeodomain-like domain;
78-152 5.03e-03

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 35.74  E-value: 5.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1587062642  78 VSKILGRYYETG--SIRPRAIGGSKPRVaTPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVctndNIPSVSSINRVL 152
Cdd:pfam13565   2 VYRWRKRYNEEGleGLEDRPRRGRPRKL-TDEQEARLLALLCEEPRWSPRLLAERLEEEFG----VKVSRSTVRRIL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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