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Conserved domains on  [gi|1609039732|ref|NP_001356296|]
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ETS translocation variant 4 isoform 4 [Homo sapiens]

Protein Classification

ETS translocation variant( domain architecture ID 12054215)

ETS translocation variant (ETV) is a transcriptional activator that binds to consensus DNA sequences, such as human ETV1 that binds to the pentanucleotide 5'-CGGA[AT]-3'

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ETS_PEA3_N pfam04621
PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 ...
8-338 1.54e-129

PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.


:

Pssm-ID: 461371  Cd Length: 344  Bit Score: 379.45  E-value: 1.54e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732   8 GYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSlpPLDSEDLFQDLSHFQETWLAEAQVPDsDEQFVPDFHSEN-P 86
Cdd:pfam04621   3 GFYDQQVPFMVPGSSCGEGPLGRPLMDRKRKFMDTEL--AQDSEELFQDLSQLQETWLAEAQVPD-DEQFVPDFQSENlA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732  87 FHSPT-TRIKKEPQSPRTDPaLSCSRKPPLPYHHGEQCLYS-SAYDPPRQIAIKSPAPGALGQSPLQP------FPRAEQ 158
Cdd:pfam04621  80 FHGPPpAKIKREPQSPSSDL-SSCSHEQSFKYPYGEQCLYNySAYDRKPPSGFKPPTPPSTPVSPLQQhsslktPPLQRQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 159 RNFLRSSGTSQP----------------HPGHGYLGEHssVFQQPLD-ICHSF-TSQGGGREPLPaPYQHQLSEPCPPYP 220
Cdd:pfam04621 159 PSPLPLMRQSPPfavprpprgympmppsQPSNSYPIEH--RFQRQLSePCLPFpPPEGGPRDGRP-PYQRQMSEPLVPYP 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 221 QQSFKQEYHDPLYEQAGQPavdqGGVNGHRYPGaGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDgamGYGYEK 300
Cdd:pfam04621 236 PQGFKQEYHDPLYEHGPPP----GGPPPHRFPP-PMMIKQEPRDYGYDSEVPNCQSSYGRSEGFLYPNSHD---GFSYDK 307
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1609039732 301 PLRPFPDDVCVVPEKFEGDIKQEGvGAFREGPPYQRRG 338
Cdd:pfam04621 308 DPRLFYDDTCVVPEKLEGKVKQEP-GVYREGPPYQRRG 344
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
340-423 4.42e-49

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 162.82  E-value: 4.42e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732  340 LQLWQFLVALLDDPTNAHFIAWTGR-GMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYK 418
Cdd:smart00413   2 IQLWQFLLDLLLDPENSDIIKWTDRdEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVYK 81

                   ....*
gi 1609039732  419 FVCEP 423
Cdd:smart00413  82 FVKNP 86
 
Name Accession Description Interval E-value
ETS_PEA3_N pfam04621
PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 ...
8-338 1.54e-129

PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.


Pssm-ID: 461371  Cd Length: 344  Bit Score: 379.45  E-value: 1.54e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732   8 GYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSlpPLDSEDLFQDLSHFQETWLAEAQVPDsDEQFVPDFHSEN-P 86
Cdd:pfam04621   3 GFYDQQVPFMVPGSSCGEGPLGRPLMDRKRKFMDTEL--AQDSEELFQDLSQLQETWLAEAQVPD-DEQFVPDFQSENlA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732  87 FHSPT-TRIKKEPQSPRTDPaLSCSRKPPLPYHHGEQCLYS-SAYDPPRQIAIKSPAPGALGQSPLQP------FPRAEQ 158
Cdd:pfam04621  80 FHGPPpAKIKREPQSPSSDL-SSCSHEQSFKYPYGEQCLYNySAYDRKPPSGFKPPTPPSTPVSPLQQhsslktPPLQRQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 159 RNFLRSSGTSQP----------------HPGHGYLGEHssVFQQPLD-ICHSF-TSQGGGREPLPaPYQHQLSEPCPPYP 220
Cdd:pfam04621 159 PSPLPLMRQSPPfavprpprgympmppsQPSNSYPIEH--RFQRQLSePCLPFpPPEGGPRDGRP-PYQRQMSEPLVPYP 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 221 QQSFKQEYHDPLYEQAGQPavdqGGVNGHRYPGaGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDgamGYGYEK 300
Cdd:pfam04621 236 PQGFKQEYHDPLYEHGPPP----GGPPPHRFPP-PMMIKQEPRDYGYDSEVPNCQSSYGRSEGFLYPNSHD---GFSYDK 307
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1609039732 301 PLRPFPDDVCVVPEKFEGDIKQEGvGAFREGPPYQRRG 338
Cdd:pfam04621 308 DPRLFYDDTCVVPEKLEGKVKQEP-GVYREGPPYQRRG 344
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
340-423 4.42e-49

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 162.82  E-value: 4.42e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732  340 LQLWQFLVALLDDPTNAHFIAWTGR-GMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYK 418
Cdd:smart00413   2 IQLWQFLLDLLLDPENSDIIKWTDRdEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVYK 81

                   ....*
gi 1609039732  419 FVCEP 423
Cdd:smart00413  82 FVKNP 86
Ets pfam00178
Ets-domain;
341-419 7.34e-45

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 151.49  E-value: 7.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 341 QLWQFLVALLDDPTNAHFIAWTGR-GMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF 419
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKeEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
 
Name Accession Description Interval E-value
ETS_PEA3_N pfam04621
PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 ...
8-338 1.54e-129

PEA3 subfamily ETS-domain transcription factor N terminal domain; The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.


Pssm-ID: 461371  Cd Length: 344  Bit Score: 379.45  E-value: 1.54e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732   8 GYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSlpPLDSEDLFQDLSHFQETWLAEAQVPDsDEQFVPDFHSEN-P 86
Cdd:pfam04621   3 GFYDQQVPFMVPGSSCGEGPLGRPLMDRKRKFMDTEL--AQDSEELFQDLSQLQETWLAEAQVPD-DEQFVPDFQSENlA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732  87 FHSPT-TRIKKEPQSPRTDPaLSCSRKPPLPYHHGEQCLYS-SAYDPPRQIAIKSPAPGALGQSPLQP------FPRAEQ 158
Cdd:pfam04621  80 FHGPPpAKIKREPQSPSSDL-SSCSHEQSFKYPYGEQCLYNySAYDRKPPSGFKPPTPPSTPVSPLQQhsslktPPLQRQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 159 RNFLRSSGTSQP----------------HPGHGYLGEHssVFQQPLD-ICHSF-TSQGGGREPLPaPYQHQLSEPCPPYP 220
Cdd:pfam04621 159 PSPLPLMRQSPPfavprpprgympmppsQPSNSYPIEH--RFQRQLSePCLPFpPPEGGPRDGRP-PYQRQMSEPLVPYP 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 221 QQSFKQEYHDPLYEQAGQPavdqGGVNGHRYPGaGVVIKQEQTDFAYDSDVTGCASMYLHTEGFSGPSPGDgamGYGYEK 300
Cdd:pfam04621 236 PQGFKQEYHDPLYEHGPPP----GGPPPHRFPP-PMMIKQEPRDYGYDSEVPNCQSSYGRSEGFLYPNSHD---GFSYDK 307
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1609039732 301 PLRPFPDDVCVVPEKFEGDIKQEGvGAFREGPPYQRRG 338
Cdd:pfam04621 308 DPRLFYDDTCVVPEKLEGKVKQEP-GVYREGPPYQRRG 344
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
340-423 4.42e-49

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 162.82  E-value: 4.42e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732  340 LQLWQFLVALLDDPTNAHFIAWTGR-GMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYK 418
Cdd:smart00413   2 IQLWQFLLDLLLDPENSDIIKWTDRdEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVYK 81

                   ....*
gi 1609039732  419 FVCEP 423
Cdd:smart00413  82 FVKNP 86
Ets pfam00178
Ets-domain;
341-419 7.34e-45

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 151.49  E-value: 7.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609039732 341 QLWQFLVALLDDPTNAHFIAWTGR-GMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF 419
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKeEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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