NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1609559148|ref|NP_001356337|]
View 

DNA excision repair protein ERCC-1 isoform 1 [Homo sapiens]

Protein Classification

ERCC1_C-like and uvrC domain-containing protein( domain architecture ID 16909578)

ERCC1_C-like and uvrC domain-containing protein

CATH:  3.40.50.10130
Gene Ontology:  GO:1990841|GO:0001094|GO:0003677|GO:0006289|GO:0070522

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ERCC1_C-like cd22325
Central domain of ERCC1; ERCC1 is a subunit of the DNA structure-specific endonuclease ...
 99-226 2.99e-92

Central domain of ERCC1; ERCC1 is a subunit of the DNA structure-specific endonuclease XPF-ERCC1, which incises a damaged DNA strand on the 5' side of a lesion during nucleotide excision repair. It also plays roles in DNA interstrand crosslink repair and homologous recombination. The ERCC1 central domain modeled here interacts tightly with XPF and may be involved in binding to single-stranded DNA. It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


:

Pssm-ID: 411729  Cd Length: 128  Bit Score: 270.15  E-value: 2.99e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  99 NSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDP 178
Cdd:cd22325     1 NSIIVSPRQKGNPVLKHIRNVPWEYGDIVPDYVLGKSTCALFLSLKYHRLHPEYIHERIKELGKSYKLRILLVLVDVEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1609559148 179 QQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEK 226
Cdd:cd22325    81 HSALKELTKLAILNDCTLILAWSPEEAARYLETYKSYENKPADLIKER 128
PRK00024 super family cl31993
DNA repair protein RadC;
250-281 1.16e-04

DNA repair protein RadC;


The actual alignment was detected with superfamily member PRK00024:

Pssm-ID: 178801 [Multi-domain]  Cd Length: 224  Bit Score: 42.75  E-value: 1.16e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1609559148 250 SQTLLTTFGSLEQLIAASREDLALCPGLGPQK 281
Cdd:PRK00024   47 ARELLQRFGSLRGLLDASLEELQSIKGIGPAK 78
 
Name Accession Description Interval E-value
ERCC1_C-like cd22325
Central domain of ERCC1; ERCC1 is a subunit of the DNA structure-specific endonuclease ...
 99-226 2.99e-92

Central domain of ERCC1; ERCC1 is a subunit of the DNA structure-specific endonuclease XPF-ERCC1, which incises a damaged DNA strand on the 5' side of a lesion during nucleotide excision repair. It also plays roles in DNA interstrand crosslink repair and homologous recombination. The ERCC1 central domain modeled here interacts tightly with XPF and may be involved in binding to single-stranded DNA. It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411729  Cd Length: 128  Bit Score: 270.15  E-value: 2.99e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  99 NSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDP 178
Cdd:cd22325     1 NSIIVSPRQKGNPVLKHIRNVPWEYGDIVPDYVLGKSTCALFLSLKYHRLHPEYIHERIKELGKSYKLRILLVLVDVEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1609559148 179 QQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEK 226
Cdd:cd22325    81 HSALKELTKLAILNDCTLILAWSPEEAARYLETYKSYENKPADLIKER 128
Rad10 pfam03834
Binding domain of DNA repair protein Ercc1 (rad10/Swi10); Ercc1 and XPF (xeroderma pigmentosum ...
 100-213 4.80e-80

Binding domain of DNA repair protein Ercc1 (rad10/Swi10); Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain. Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex.


Pssm-ID: 461070  Cd Length: 114  Bit Score: 238.53  E-value: 4.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148 100 SIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQ 179
Cdd:pfam03834   1 TILVNPRQKGNPLLKHIRNVPWEYGDIVPDYVIGSTTCVLFLSLKYHRLHPEYIHTRIKKLGKSYKLRILLVLVDVEDHE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1609559148 180 QALKELAKMCILADCTLILAWSPEEAGRYLETYK 213
Cdd:pfam03834  81 DALRELTKICILNNLTLILAWSFEEAARYLETYK 114
rad10 TIGR00597
DNA repair protein rad10; All proteins in this family for which functions are known are ...
 99-210 1.21e-72

DNA repair protein rad10; All proteins in this family for which functions are known are components in a multiprotein endonuclease complex (usually made up of Rad1 and Rad10 homologs). This complex is used primarily for nucleotide excision repair but also for some aspects of recombination repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129685  Cd Length: 112  Bit Score: 219.71  E-value: 1.21e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  99 NSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDP 178
Cdd:TIGR00597   1 NSILVNPRQKGNPLLKHVRNVPWEYGDVIPDYVLGQGTCALFLSLRYHNLHPDYIHRRLQSLGKNFNLRILLVQVDVKNP 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1609559148 179 QQALKELAKMCILADCTLILAWSPEEAGRYLE 210
Cdd:TIGR00597  81 QQALKELAKMCILNDCTLILAWSFEEAARYLE 112
RAD10 COG5241
Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, ...
 95-282 6.27e-51

Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, and repair];


Pssm-ID: 227566 [Multi-domain]  Cd Length: 224  Bit Score: 168.25  E-value: 6.27e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  95 GAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVI-PDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLgKNFALRVLLVQV 173
Cdd:COG5241    30 GSQSLEIDVSPLQKGNPQLSRRINSNWVYNAFIkPDEWTDSKATDLFLSLRFHSTRPEYIVLRISKL-KSYKERPLLNHV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148 174 DVKDPQQALKELAKMCILAdcTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDfvsRVTECLTTVKSVNKTDSQTL 253
Cdd:COG5241   109 DSTNWRASIQELVSTTGIN--TIYLDYSVEERSRYFLTLTYHKLYSDYIIRRMQSLD---RSNEFLILIFIVNKSDSEDT 183

                         170       180
                  ....*....|....*....|....*....
gi 1609559148 254 LTTFGSLEQLIAASREDLALCPGLGPQKV 282
Cdd:COG5241   184 LNDIGKLCRFNGASRDEFELLLGFGFEKA 212
PRK00024 PRK00024
DNA repair protein RadC;
250-281 1.16e-04

DNA repair protein RadC;


Pssm-ID: 178801 [Multi-domain]  Cd Length: 224  Bit Score: 42.75  E-value: 1.16e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1609559148 250 SQTLLTTFGSLEQLIAASREDLALCPGLGPQK 281
Cdd:PRK00024   47 ARELLQRFGSLRGLLDASLEELQSIKGIGPAK 78
RadC COG2003
DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif [Replication, ...
 250-285 2.02e-03

DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif [Replication, recombination and repair];


Pssm-ID: 441606 [Multi-domain]  Cd Length: 224  Bit Score: 38.89  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1609559148 250 SQTLLTTFGSLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:COG2003    47 AKELLARFGSLRGLLRASVEELRKIKGIGEAKAAQL 82
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 259-285 2.81e-03

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 34.70  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....*..
gi 1609559148 259 SLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAI 27
 
Name Accession Description Interval E-value
ERCC1_C-like cd22325
Central domain of ERCC1; ERCC1 is a subunit of the DNA structure-specific endonuclease ...
 99-226 2.99e-92

Central domain of ERCC1; ERCC1 is a subunit of the DNA structure-specific endonuclease XPF-ERCC1, which incises a damaged DNA strand on the 5' side of a lesion during nucleotide excision repair. It also plays roles in DNA interstrand crosslink repair and homologous recombination. The ERCC1 central domain modeled here interacts tightly with XPF and may be involved in binding to single-stranded DNA. It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411729  Cd Length: 128  Bit Score: 270.15  E-value: 2.99e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  99 NSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDP 178
Cdd:cd22325     1 NSIIVSPRQKGNPVLKHIRNVPWEYGDIVPDYVLGKSTCALFLSLKYHRLHPEYIHERIKELGKSYKLRILLVLVDVEDP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1609559148 179 QQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEK 226
Cdd:cd22325    81 HSALKELTKLAILNDCTLILAWSPEEAARYLETYKSYENKPADLIKER 128
XPF_nuclease_ERCC1 cd20079
XPF-like nuclease domain of DNA excision repair protein ERCC1; ERCC1 is a non-catalytic ...
 100-214 2.77e-90

XPF-like nuclease domain of DNA excision repair protein ERCC1; ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. In conjunction with SLX4, ERCC1 is responsible for the first step in the repair of interstrand cross-links (ICL), as well as for homology-directed repair (HDR) of DNA double-strand breaks. ERCC1 participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 also plays a critical role in targeting the XPF-ERCC1 complex to DNA. XPF-ERRC1 and its yeast homolog Rad1-Rad10 play key roles in the excision of DNA lesions and are required for certain types of homologous recombination events and for the repair of DNA cross-links. The critical motif, DX(n)ERKX(3)D, for endonuclease activity is absent in the nuclease domain of ERCC1.


Pssm-ID: 410855  Cd Length: 115  Bit Score: 264.62  E-value: 2.77e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148 100 SIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQ 179
Cdd:cd20079     1 SILVNPRQRGNPILKFVRNVPWEFGDIVPDYVLGQTTCALFLSLRYHNLHPDYIHERLKQLGKSYELRVLLVQVDVKDPH 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1609559148 180 QALKELAKMCILADCTLILAWSPEEAGRYLETYKA 214
Cdd:cd20079    81 HALKELAKICILADCTLILAWSPEEAGRYLETYKA 115
Rad10 pfam03834
Binding domain of DNA repair protein Ercc1 (rad10/Swi10); Ercc1 and XPF (xeroderma pigmentosum ...
 100-213 4.80e-80

Binding domain of DNA repair protein Ercc1 (rad10/Swi10); Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain. Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex.


Pssm-ID: 461070  Cd Length: 114  Bit Score: 238.53  E-value: 4.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148 100 SIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQ 179
Cdd:pfam03834   1 TILVNPRQKGNPLLKHIRNVPWEYGDIVPDYVIGSTTCVLFLSLKYHRLHPEYIHTRIKKLGKSYKLRILLVLVDVEDHE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1609559148 180 QALKELAKMCILADCTLILAWSPEEAGRYLETYK 213
Cdd:pfam03834  81 DALRELTKICILNNLTLILAWSFEEAARYLETYK 114
rad10 TIGR00597
DNA repair protein rad10; All proteins in this family for which functions are known are ...
 99-210 1.21e-72

DNA repair protein rad10; All proteins in this family for which functions are known are components in a multiprotein endonuclease complex (usually made up of Rad1 and Rad10 homologs). This complex is used primarily for nucleotide excision repair but also for some aspects of recombination repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129685  Cd Length: 112  Bit Score: 219.71  E-value: 1.21e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  99 NSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDP 178
Cdd:TIGR00597   1 NSILVNPRQKGNPLLKHVRNVPWEYGDVIPDYVLGQGTCALFLSLRYHNLHPDYIHRRLQSLGKNFNLRILLVQVDVKNP 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1609559148 179 QQALKELAKMCILADCTLILAWSPEEAGRYLE 210
Cdd:TIGR00597  81 QQALKELAKMCILNDCTLILAWSFEEAARYLE 112
RAD10 COG5241
Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, ...
 95-282 6.27e-51

Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, and repair];


Pssm-ID: 227566 [Multi-domain]  Cd Length: 224  Bit Score: 168.25  E-value: 6.27e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148  95 GAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVI-PDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLgKNFALRVLLVQV 173
Cdd:COG5241    30 GSQSLEIDVSPLQKGNPQLSRRINSNWVYNAFIkPDEWTDSKATDLFLSLRFHSTRPEYIVLRISKL-KSYKERPLLNHV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148 174 DVKDPQQALKELAKMCILAdcTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDfvsRVTECLTTVKSVNKTDSQTL 253
Cdd:COG5241   109 DSTNWRASIQELVSTTGIN--TIYLDYSVEERSRYFLTLTYHKLYSDYIIRRMQSLD---RSNEFLILIFIVNKSDSEDT 183

                         170       180
                  ....*....|....*....|....*....
gi 1609559148 254 LTTFGSLEQLIAASREDLALCPGLGPQKV 282
Cdd:COG5241   184 LNDIGKLCRFNGASRDEFELLLGFGFEKA 212
XPF_nuclease-like cd19940
nuclease domain of XPF/MUS81 family proteins; The XPF/MUS81 family belongs to 3'-flap ...
 100-214 1.52e-37

nuclease domain of XPF/MUS81 family proteins; The XPF/MUS81 family belongs to 3'-flap endonuclease that act upon 3'-flap structures and involved in DNA repair pathways that are necessary for the removal of UV-light-induced DNA lesions and cross-links between DNA strands. Family members exist either as heterodimers or as homodimers in their functionally competent states which consist of a catalytic and a noncatalytic subunit. The catalytic subunits have a DX(n)RKX(3)D motif. This motif is required for metal-dependent endonuclease activity but not for DNA junction binding. The equivalent regions of the noncatalytic subunits (ERCC1, EME1, and FAAP24) have diverged. The noncatalytic subunits have roles such as binding ssDNA or an ability to target the endonuclease to defined DNA structures or sites of DNA damage.


Pssm-ID: 410849 [Multi-domain]  Cd Length: 126  Bit Score: 130.19  E-value: 1.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1609559148 100 SIIVSPRQRGNPVLKFVRN--VPWEFGDVI-PDYVLGQSTCALFLSLRYHNLHPD--YIHGRLQSLGKNFALRVLLVQVD 174
Cdd:cd19940     1 SIVVDPRERRSELLSELQRlgVQVEFEDLAvGDYVLSNRTCVERKSLSDLVSSINkgRLREQLQRLTRKFERRVLLVEKD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1609559148 175 VK------DPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKA 214
Cdd:cd19940    81 RSkfrsmvSSVQALSALTKLQLLTGIRLLIVASPKETADLLEELTQ 126
PRK00024 PRK00024
DNA repair protein RadC;
250-281 1.16e-04

DNA repair protein RadC;


Pssm-ID: 178801 [Multi-domain]  Cd Length: 224  Bit Score: 42.75  E-value: 1.16e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1609559148 250 SQTLLTTFGSLEQLIAASREDLALCPGLGPQK 281
Cdd:PRK00024   47 ARELLQRFGSLRGLLDASLEELQSIKGIGPAK 78
RadC COG2003
DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif [Replication, ...
 250-285 2.02e-03

DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif [Replication, recombination and repair];


Pssm-ID: 441606 [Multi-domain]  Cd Length: 224  Bit Score: 38.89  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1609559148 250 SQTLLTTFGSLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:COG2003    47 AKELLARFGSLRGLLRASVEELRKIKGIGEAKAAQL 82
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 259-285 2.81e-03

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 34.70  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....*..
gi 1609559148 259 SLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAI 27
HHH_5 pfam14520
Helix-hairpin-helix domain;
239-285 3.51e-03

Helix-hairpin-helix domain;


Pssm-ID: 434010 [Multi-domain]  Cd Length: 57  Bit Score: 35.16  E-value: 3.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1609559148 239 LTTVKSVNKTDSQTLLTT-FGSLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:pfam14520   4 LLSISGIGPKTALALLSAgIGTVEDLAEADVDELAEIPGIGEKTAQRI 51
HHH_2 pfam12826
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ...
 245-280 4.54e-03

Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 432812 [Multi-domain]  Cd Length: 64  Bit Score: 35.19  E-value: 4.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1609559148 245 VNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQ 280
Cdd:pfam12826  11 VGETTAKLLARRFGSLDALAEASLEELLEVDDIGPE 46
uvrC PRK14666
excinuclease ABC subunit C; Provisional
 239-285 5.02e-03

excinuclease ABC subunit C; Provisional


Pssm-ID: 237782 [Multi-domain]  Cd Length: 694  Bit Score: 38.71  E-value: 5.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1609559148 239 LTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:PRK14666  639 LQRVEGIGPATARLLWERFGSLQAMAAAGEEGLAAVPGIGPARAAAL 685
UvrC COG0322
Excinuclease UvrABC, nuclease subunit [Replication, recombination and repair];
251-285 8.22e-03

Excinuclease UvrABC, nuclease subunit [Replication, recombination and repair];


Pssm-ID: 440091 [Multi-domain]  Cd Length: 603  Bit Score: 37.80  E-value: 8.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1609559148 251 QTLLTTFGSLEQLIAASREDLALCPGLGPQKVRAL 285
Cdd:COG0322   562 KALLKHFGSLKAIKEASVEELAAVPGISKKLAEAI 596
uvrC PRK00558
excinuclease ABC subunit UvrC;
251-279 9.98e-03

excinuclease ABC subunit UvrC;


Pssm-ID: 234792 [Multi-domain]  Cd Length: 598  Bit Score: 37.40  E-value: 9.98e-03
                          10        20
                  ....*....|....*....|....*....
gi 1609559148 251 QTLLTTFGSLEQLIAASREDLALCPGLGP 279
Cdd:PRK00558  557 KALLKHFGSLKAIKEASVEELAKVPGISK 585
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH