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nuclear factor 1 B-type isoform 22 [Homo sapiens]
nuclear factor I( domain architecture ID 12106880)
nuclear factor I (NFI) is a CCAAT-box-binding protein active in transcription and DNA replication
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
CTF_NFI super family | cl25839 | CTF/NF-I family transcription modulation region; |
134-341 | 1.81e-82 | ||||
CTF/NF-I family transcription modulation region; The actual alignment was detected with superfamily member pfam00859: Pssm-ID: 459967 [Multi-domain] Cd Length: 288 Bit Score: 254.45 E-value: 1.81e-82
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NfI_DNAbd_pre-N | pfam10524 | Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ... |
10-47 | 8.67e-19 | ||||
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication. : Pssm-ID: 463134 Cd Length: 41 Bit Score: 79.19 E-value: 8.67e-19
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MH1 super family | cl00055 | N-terminal Mad Homology 1 (MH1) domain; The MH1 is a small DNA-binding domain present in SMAD ... |
68-120 | 1.21e-04 | ||||
N-terminal Mad Homology 1 (MH1) domain; The MH1 is a small DNA-binding domain present in SMAD (small mothers against decapentaplegic) family of proteins, which are signal transducers and transcriptional modulators that mediate multiple signaling pathways. MH1 binds to the DNA major groove in an unusual manner via a beta hairpin structure. It negatively regulates the functions of the MH2 domain, the C-terminal domain of SMAD. Receptor-regulated SMAD proteins (R-SMADs, including SMAD1, SMAD2, SMAD3, SMAD5, and SMAD9) are activated by phosphorylation by transforming growth factor (TGF)-beta type I receptors. The active R-SMAD associates with a common mediator SMAD (Co-SMAD or SMAD4) and other cofactors, which together translocate to the nucleus to regulate gene expression. The inhibitory or antagonistic SMADs (I-SMADs, including SMAD6 and SMAD7) negatively regulate TGF-beta signaling by competing with R-SMADs for type I receptor or Co-SMADs. MH1 domains of R-SMAD and SMAD4 contain a nuclear localization signal as well as DNA-binding activity. The activated R-SMAD/SMAD4 complex then binds with very low affinity to a DNA sequence CAGAC called SMAD-binding element (SBE) via the MH1 domain. The actual alignment was detected with superfamily member smart00523: Pssm-ID: 469592 Cd Length: 109 Bit Score: 41.21 E-value: 1.21e-04
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PRK15127 super family | cl39118 | multidrug efflux RND transporter permease subunit AcrB; |
310-400 | 2.37e-04 | ||||
multidrug efflux RND transporter permease subunit AcrB; The actual alignment was detected with superfamily member PRK15127: Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 43.35 E-value: 2.37e-04
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Name | Accession | Description | Interval | E-value | ||||
CTF_NFI | pfam00859 | CTF/NF-I family transcription modulation region; |
134-341 | 1.81e-82 | ||||
CTF/NF-I family transcription modulation region; Pssm-ID: 459967 [Multi-domain] Cd Length: 288 Bit Score: 254.45 E-value: 1.81e-82
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NfI_DNAbd_pre-N | pfam10524 | Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ... |
10-47 | 8.67e-19 | ||||
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication. Pssm-ID: 463134 Cd Length: 41 Bit Score: 79.19 E-value: 8.67e-19
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DWA | smart00523 | Domain A in dwarfin family proteins; |
68-120 | 1.21e-04 | ||||
Domain A in dwarfin family proteins; Pssm-ID: 214708 Cd Length: 109 Bit Score: 41.21 E-value: 1.21e-04
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PRK15127 | PRK15127 | multidrug efflux RND transporter permease subunit AcrB; |
310-400 | 2.37e-04 | ||||
multidrug efflux RND transporter permease subunit AcrB; Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 43.35 E-value: 2.37e-04
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PTZ00449 | PTZ00449 | 104 kDa microneme/rhoptry antigen; Provisional |
190-339 | 1.43e-03 | ||||
104 kDa microneme/rhoptry antigen; Provisional Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 40.83 E-value: 1.43e-03
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Name | Accession | Description | Interval | E-value | ||||
CTF_NFI | pfam00859 | CTF/NF-I family transcription modulation region; |
134-341 | 1.81e-82 | ||||
CTF/NF-I family transcription modulation region; Pssm-ID: 459967 [Multi-domain] Cd Length: 288 Bit Score: 254.45 E-value: 1.81e-82
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NfI_DNAbd_pre-N | pfam10524 | Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific ... |
10-47 | 8.67e-19 | ||||
Nuclear factor I protein pre-N-terminus; The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organizms. The N-terminal 200 residues contains the DNA-binding and dimerization domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerization-ability and the stimulation of adenovirus DNA replication. Pssm-ID: 463134 Cd Length: 41 Bit Score: 79.19 E-value: 8.67e-19
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DWA | smart00523 | Domain A in dwarfin family proteins; |
68-120 | 1.21e-04 | ||||
Domain A in dwarfin family proteins; Pssm-ID: 214708 Cd Length: 109 Bit Score: 41.21 E-value: 1.21e-04
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PRK15127 | PRK15127 | multidrug efflux RND transporter permease subunit AcrB; |
310-400 | 2.37e-04 | ||||
multidrug efflux RND transporter permease subunit AcrB; Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 43.35 E-value: 2.37e-04
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PTZ00449 | PTZ00449 | 104 kDa microneme/rhoptry antigen; Provisional |
190-339 | 1.43e-03 | ||||
104 kDa microneme/rhoptry antigen; Provisional Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 40.83 E-value: 1.43e-03
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Enamelin | pfam15362 | Enamelin; ENAMELIN is involved in the mineralization and structural organization of enamel. It ... |
214-254 | 1.95e-03 | ||||
Enamelin; ENAMELIN is involved in the mineralization and structural organization of enamel. It is necessary for the extension of enamel during the secretory stage of dental enamel formation. The proteins are expressed in teeth, particularly in odontoblasts, ameloblasts and cementoblasts. Pssm-ID: 464672 [Multi-domain] Cd Length: 907 Bit Score: 40.58 E-value: 1.95e-03
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Blast search parameters | ||||
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