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Conserved domains on  [gi|1614230749|ref|NP_001356560|]
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LYR motif-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

LYR motif-containing protein( domain architecture ID 14448730)

LYR motif-containing protein plays a key role in the assembly and function of complexes I, II, and III; LYR motifs are molecular signatures of specific recipient Fe-S proteins or accessory factors that assist Fe-S cluster delivery

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 8-88 4.96e-32

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380756  Cd Length: 70  Bit Score: 107.71  E-value: 4.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1614230749   8 EVLGLYRSIFRLARKWQAtsgqmeDTIKEKQYILNEARTLFRKNKNvssqpLTDTDLIKQCIDECTARIEIGLHYKIPYP 87
Cdd:cd20261     1 EVLSLYRRILRLARTWPA------DTEEEREYILNEARSLFRKNKN-----LTDPEEIEEKIQEAESRLELALHYGIPYP 69


                  .
gi 1614230749  88 R 88
Cdd:cd20261    70 R 70
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 8-88 4.96e-32

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 107.71  E-value: 4.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1614230749   8 EVLGLYRSIFRLARKWQAtsgqmeDTIKEKQYILNEARTLFRKNKNvssqpLTDTDLIKQCIDECTARIEIGLHYKIPYP 87
Cdd:cd20261     1 EVLSLYRRILRLARTWPA------DTEEEREYILNEARSLFRKNKN-----LTDPEEIEEKIQEAESRLELALHYGIPYP 69


                  .
gi 1614230749  88 R 88
Cdd:cd20261    70 R 70
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 7-72 2.90e-07

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 44.49  E-value: 2.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1614230749   7 QEVLGLYRSIFRLARKWQATSGQMedtikekqYILNEARTLFRKNKNVssqplTDTDLIKQCIDEC 72
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPDYNFRE--------YFRRRIRDEFRKNKDL-----TDPEKIEKLLKEG 53
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM1 cd20261
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ...
 8-88 4.96e-32

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380756  Cd Length: 70  Bit Score: 107.71  E-value: 4.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1614230749   8 EVLGLYRSIFRLARKWQAtsgqmeDTIKEKQYILNEARTLFRKNKNvssqpLTDTDLIKQCIDECTARIEIGLHYKIPYP 87
Cdd:cd20261     1 EVLSLYRRILRLARTWPA------DTEEEREYILNEARSLFRKNKN-----LTDPEEIEEKIQEAESRLELALHYGIPYP 69


                  .
gi 1614230749  88 R 88
Cdd:cd20261    70 R 70
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 7-72 2.90e-07

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 44.49  E-value: 2.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1614230749   7 QEVLGLYRSIFRLARKWQATSGQMedtikekqYILNEARTLFRKNKNVssqplTDTDLIKQCIDEC 72
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPDYNFRE--------YFRRRIRDEFRKNKDL-----TDPEKIEKLLKEG 53
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 9-72 8.78e-07

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 42.92  E-value: 8.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1614230749   9 VLGLYRSIFRLARKwqatsgqmEDTIKEKQYILNEARTLFRKNKNVssqplTDTDLIKQCIDEC 72
Cdd:cd20251     1 VLKLYRDLLRLARK--------GLPSRKRDALRQRIREEFRKNKNE-----TDPEKIEELLAEA 51
Complex1_LYR_LYRM2 cd20262
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ...
 6-69 2.73e-04

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380757  Cd Length: 63  Bit Score: 36.75  E-value: 2.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1614230749   6 RQEVLGLYRSIFRLARKWQATSGQMEdtikekqyILNEARTLFRKNKNVssqplTDTDLIKQCI 69
Cdd:cd20262     3 RAQVLSLYRDILRAIRKIPDPSTRRE--------LRDWVREEFERNRNE-----TDEDAIKYLL 53
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 9-71 3.28e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 34.08  E-value: 3.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1614230749   9 VLGLYRSIFRlARKWQATSGQMedTIKEkqyILNEARTLFRKNKNVssqplTDTDLIKQCIDE 71
Cdd:cd20267     1 VLSAYRELLR-ARRWVFKGDTP--ALKA---ARQKIREEFEKNRNE-----TDPEKIAELLKE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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